IE872694L - Factor ix-peptides - Google Patents

Factor ix-peptides

Info

Publication number
IE872694L
IE872694L IE872694A IE269487A IE872694L IE 872694 L IE872694 L IE 872694L IE 872694 A IE872694 A IE 872694A IE 269487 A IE269487 A IE 269487A IE 872694 L IE872694 L IE 872694L
Authority
IE
Ireland
Prior art keywords
asp
gln
gly
tyr
lys
Prior art date
Application number
IE872694A
Original Assignee
Bandag Licensing Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bandag Licensing Corp filed Critical Bandag Licensing Corp
Publication of IE872694L publication Critical patent/IE872694L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/644—Coagulation factor IXa (3.4.21.22)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6432—Coagulation factor Xa (3.4.21.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21006—Coagulation factor Xa (3.4.21.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21022—Coagulation factor IXa (3.4.21.22)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention relates to polypeptides which contain the EGF domain of factor IX or a subsequence thereof and are suitable for the specific inhibition of the binding of coagulation factor IX or its activated form IXa to endothelial cell surfaces. The invention also relates to pharmaceutical products which contain such polypeptides. The polypeptides and the pharmaceutical products make it possible to treat thrombotic disorders without impairing the protective extravascular coagulation and comprise the following amino-acid sequences: Asp-Gly-Asp-Gln-Cys, Lys-Gln-Tyr-Val-Asp-Gly-Asp-Gln-Cys, Phe-Trp-Lys-Gln-Tyr-Val-Asp-Gly-Asp-Gln-NH2, Lys-Gln-Tyr-Val-Asp-Gly-Asp-Gln-Cys-Glu-Ser-Asn-NH2 and Lys-Gln-Tyr-Val-Asp-Gly-Asp-Gln-NH2. [EP0263529A1]
IE872694A 1986-10-09 1987-10-08 Factor ix-peptides IE872694L (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91677386A 1986-10-09 1986-10-09
US93058886A 1986-11-13 1986-11-13
US8332287A 1987-08-10 1987-08-10

Publications (1)

Publication Number Publication Date
IE872694L true IE872694L (en) 1988-04-09

Family

ID=27374504

Family Applications (1)

Application Number Title Priority Date Filing Date
IE872694A IE872694L (en) 1986-10-09 1987-10-08 Factor ix-peptides

Country Status (6)

Country Link
EP (1) EP0263529A1 (en)
AU (1) AU607714B2 (en)
DK (1) DK525787A (en)
IE (1) IE872694L (en)
IL (1) IL84126A0 (en)
NZ (1) NZ222084A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4403057C1 (en) * 1994-02-02 1994-12-08 Biotest Pharma Gmbh Platelet-stabilising factor IX fragments, the preparation thereof and pharmaceutical compositions containing them
DE4435520A1 (en) * 1994-10-04 1996-04-11 Immuno Ag Process for the separation of recombinant pro-factor IX from recombinant factor IX

Also Published As

Publication number Publication date
AU7948187A (en) 1988-04-14
DK525787A (en) 1988-04-10
EP0263529A1 (en) 1988-04-13
IL84126A0 (en) 1988-03-31
AU607714B2 (en) 1991-03-14
DK525787D0 (en) 1987-10-07
NZ222084A (en) 1991-06-25

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