IE872694L - Factor ix-peptides - Google Patents
Factor ix-peptidesInfo
- Publication number
- IE872694L IE872694L IE872694A IE269487A IE872694L IE 872694 L IE872694 L IE 872694L IE 872694 A IE872694 A IE 872694A IE 269487 A IE269487 A IE 269487A IE 872694 L IE872694 L IE 872694L
- Authority
- IE
- Ireland
- Prior art keywords
- asp
- gln
- gly
- tyr
- lys
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/644—Coagulation factor IXa (3.4.21.22)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6432—Coagulation factor Xa (3.4.21.6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21006—Coagulation factor Xa (3.4.21.6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21022—Coagulation factor IXa (3.4.21.22)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
The invention relates to polypeptides which contain the EGF domain of factor IX or a subsequence thereof and are suitable for the specific inhibition of the binding of coagulation factor IX or its activated form IXa to endothelial cell surfaces. The invention also relates to pharmaceutical products which contain such polypeptides. The polypeptides and the pharmaceutical products make it possible to treat thrombotic disorders without impairing the protective extravascular coagulation and comprise the following amino-acid sequences: Asp-Gly-Asp-Gln-Cys, Lys-Gln-Tyr-Val-Asp-Gly-Asp-Gln-Cys, Phe-Trp-Lys-Gln-Tyr-Val-Asp-Gly-Asp-Gln-NH2, Lys-Gln-Tyr-Val-Asp-Gly-Asp-Gln-Cys-Glu-Ser-Asn-NH2 and Lys-Gln-Tyr-Val-Asp-Gly-Asp-Gln-NH2.
[EP0263529A1]
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91677386A | 1986-10-09 | 1986-10-09 | |
US93058886A | 1986-11-13 | 1986-11-13 | |
US8332287A | 1987-08-10 | 1987-08-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
IE872694L true IE872694L (en) | 1988-04-09 |
Family
ID=27374504
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE872694A IE872694L (en) | 1986-10-09 | 1987-10-08 | Factor ix-peptides |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0263529A1 (en) |
AU (1) | AU607714B2 (en) |
DK (1) | DK525787A (en) |
IE (1) | IE872694L (en) |
IL (1) | IL84126A0 (en) |
NZ (1) | NZ222084A (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4403057C1 (en) * | 1994-02-02 | 1994-12-08 | Biotest Pharma Gmbh | Platelet-stabilising factor IX fragments, the preparation thereof and pharmaceutical compositions containing them |
DE4435520A1 (en) * | 1994-10-04 | 1996-04-11 | Immuno Ag | Process for the separation of recombinant pro-factor IX from recombinant factor IX |
-
1987
- 1987-10-07 IL IL84126A patent/IL84126A0/en unknown
- 1987-10-07 NZ NZ222084A patent/NZ222084A/en unknown
- 1987-10-07 DK DK525787A patent/DK525787A/en not_active Application Discontinuation
- 1987-10-08 AU AU79481/87A patent/AU607714B2/en not_active Expired - Fee Related
- 1987-10-08 IE IE872694A patent/IE872694L/en unknown
- 1987-10-09 EP EP87114793A patent/EP0263529A1/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
AU607714B2 (en) | 1991-03-14 |
EP0263529A1 (en) | 1988-04-13 |
IL84126A0 (en) | 1988-03-31 |
DK525787D0 (en) | 1987-10-07 |
NZ222084A (en) | 1991-06-25 |
AU7948187A (en) | 1988-04-14 |
DK525787A (en) | 1988-04-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1175909A3 (en) | Therapeutic methods and compositions based on serrate proteins and nucleic acids | |
EP0935963A3 (en) | The use of MMP-13 selective inhibitors for the treatment of osteoarthritis and other matrix metalloproteinase-mediated disorders | |
IE891798L (en) | Novel ó-glucosidase inhibitors | |
BG103977A (en) | Low molecular rotamase enzymic activity inhibitors | |
EP0374440A3 (en) | Inhibitors of lysyl oxidase | |
WO2001079464A3 (en) | Nucleic acids encoding polypeptides having haloperoxidase activity | |
EP1652931A3 (en) | Recombinant adenoviruses, preparation and uses thereof for the treatment and/or prevention ofs cancers | |
EP0308937A3 (en) | Activated aluminum chloride hydroxide | |
EP0335637A3 (en) | Nerve growth factor peptides | |
NZ215096A (en) | Renin inhibiting peptide derivatives, pepstatin analogues | |
BG104267A (en) | Aminoterminally incised rantes as haemokin antagonists | |
AR244544A1 (en) | Amino acid beta-lyase enzyme inhibitors as deodorants | |
EP0220107A3 (en) | Use of angiotensin-converting enzyme inhibitors in macular degeneration | |
EP0319315A3 (en) | The von willebrand factor binding domain of factor viii | |
AU4218389A (en) | Peptide compounds | |
TW369541B (en) | Thrombin inhibitors | |
IE872694L (en) | Factor ix-peptides | |
DK270489D0 (en) | PROTEIN WITH THROMBIN INHIBITIVE EFFECTS, PROCEDURE FOR ITS INSULATION, AND ITS USE AS A MEDICINE | |
EP0576915A3 (en) | Cyclopentanperhydrophenanthren-17beta-(3-furyl)-3-derivatives and pharmaceutical compositions comprising same for the treatment of cardiovascular disorders | |
EP0104546A3 (en) | Therapeutic dipeptides | |
IE902276L (en) | Serpin variants | |
AR240485A1 (en) | ACTIVATING COMPOSITIONS, EXEMPTED FROM TITANIUM, PROCEDURE TO OBTAIN THEM AND PROCEDURE TO ACTIVATE METALLIC SURFACES PRIOR TO THEIR PHOSPHATATION TO THE ZIONC USING SUCH PHOSPHATES. | |
DE68911908D1 (en) | METHOD FOR DELAYING THE OLD BAKING OF BAKING PRODUCTS. | |
DK0412951T3 (en) | Peptides that block cell adhesion to S-alminin | |
WO1998018818A3 (en) | Hepatitis b inhibitors |