DE69429062T2 - Thrombin-inhibitoren - Google Patents

Thrombin-inhibitoren

Info

Publication number
DE69429062T2
DE69429062T2 DE69429062T DE69429062T DE69429062T2 DE 69429062 T2 DE69429062 T2 DE 69429062T2 DE 69429062 T DE69429062 T DE 69429062T DE 69429062 T DE69429062 T DE 69429062T DE 69429062 T2 DE69429062 T2 DE 69429062T2
Authority
DE
Germany
Prior art keywords
pct
sec
date
thrombin inhibitors
pub
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69429062T
Other languages
English (en)
Other versions
DE69429062D1 (de
Inventor
Juergen Hemberger
Roy Sawyer
Sabine Wolf
Johannes Dodt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Application granted granted Critical
Publication of DE69429062D1 publication Critical patent/DE69429062D1/de
Publication of DE69429062T2 publication Critical patent/DE69429062T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/855—Proteins from animals other than mammals or birds
DE69429062T 1993-05-07 1994-05-03 Thrombin-inhibitoren Expired - Lifetime DE69429062T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939309509A GB9309509D0 (en) 1993-05-07 1993-05-07 Thrombin inhibitors
PCT/EP1994/001404 WO1994026777A1 (en) 1993-05-07 1994-05-03 Thrombin inhibitors

Publications (2)

Publication Number Publication Date
DE69429062D1 DE69429062D1 (de) 2001-12-20
DE69429062T2 true DE69429062T2 (de) 2002-06-20

Family

ID=10735154

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69429062T Expired - Lifetime DE69429062T2 (de) 1993-05-07 1994-05-03 Thrombin-inhibitoren

Country Status (22)

Country Link
US (1) US5583111A (de)
EP (1) EP0652900B1 (de)
JP (1) JP3537437B2 (de)
KR (1) KR100335536B1 (de)
AT (1) ATE208793T1 (de)
AU (1) AU682368B2 (de)
CA (1) CA2139652C (de)
CZ (1) CZ287794B6 (de)
DE (1) DE69429062T2 (de)
DK (1) DK0652900T3 (de)
ES (1) ES2167364T3 (de)
GB (1) GB9309509D0 (de)
HU (1) HU226243B1 (de)
NO (1) NO318017B1 (de)
PL (1) PL179215B1 (de)
PT (1) PT652900E (de)
RU (1) RU2138275C1 (de)
SK (1) SK282860B6 (de)
TW (1) TW369541B (de)
UA (1) UA43831C2 (de)
WO (1) WO1994026777A1 (de)
ZA (1) ZA943171B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU783087B2 (en) * 1999-08-06 2005-09-22 Genentech Inc. Peptide antagonists of factor VIIA
GB9930659D0 (en) * 1999-12-24 2000-02-16 Bio Discovery Ltd Inhibitors of complement activation
FR2834293B1 (fr) * 2002-01-03 2005-02-04 Ricarimpex Extraits de sangsues a effet psychosomatique
US7164002B2 (en) 2002-02-06 2007-01-16 Genentech, Inc. FVIIa antagonists
CA2623565A1 (en) 2005-09-28 2007-04-05 Biovascular, Inc. Methods and compositions for blocking platelet and cell adhesion, cell migration and inflammation
US20110034396A1 (en) * 2005-09-28 2011-02-10 Biovascular, Inc. Methods and compositions for inhibiting cell migration and treatment of inflammatory conditions
CN101095697A (zh) * 2006-06-28 2008-01-02 李振国 水蛭和/或地龙分子量5800道尔顿以下的提取物
TWI540132B (zh) * 2009-06-08 2016-07-01 亞培公司 Ｂｃｌ-２族群抑制劑之口服醫藥劑型
RU2519741C2 (ru) * 2012-06-25 2014-06-20 Общество с ограниченной ответственностью Научно-внедренческая фирма "Гируд И.Н." (ООО НВФ "Гируд И.Н.") Фармацевтическая композиция, обладающая противотромботическим, тромболитическим, иммуномодулирующим, противовоспалительным действиями, нормализующая липидный и углеводный обмен
US8784896B2 (en) 2012-09-17 2014-07-22 Biopep Solutions, Inc Antioxidant therapy with a whole, leech saliva extract
CN108395475B (zh) * 2018-03-29 2021-09-10 苏州至汇生物科技有限公司 一种基于亲和层析的水蛭素分离纯化方法
CN116987181B (zh) * 2023-09-27 2023-12-08 北京元延医药科技股份有限公司 高生物学活性的天然水蛭素和高收率制备它们的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4390630A (en) * 1980-10-28 1983-06-28 The Regents Of The University Of California Hementin--a fibrinolytic agent
DE3689525D1 (de) * 1985-07-17 1994-02-24 Hoechst Ag Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel.
GB8826428D0 (en) * 1988-11-11 1988-12-14 Biopharm Ltd Antithrombin
AU645804B2 (en) * 1990-04-06 1994-01-27 Merck Patent Gmbh Treatment of thrombotic events

Also Published As

Publication number Publication date
HU226243B1 (en) 2008-07-28
PL307088A1 (en) 1995-05-02
SK895A3 (en) 1995-05-10
ZA943171B (en) 1995-01-11
PL179215B1 (pl) 2000-08-31
CA2139652C (en) 2003-03-18
KR100335536B1 (ko) 2002-11-11
HU9500038D0 (en) 1995-03-28
US5583111A (en) 1996-12-10
UA43831C2 (uk) 2002-01-15
ATE208793T1 (de) 2001-11-15
NO950075L (no) 1995-01-06
AU682368B2 (en) 1997-10-02
DE69429062D1 (de) 2001-12-20
KR950702579A (ko) 1995-07-29
CA2139652A1 (en) 1994-11-24
RU95105983A (ru) 1997-02-27
JPH07508765A (ja) 1995-09-28
HUT70215A (en) 1995-09-28
EP0652900A1 (de) 1995-05-17
WO1994026777A1 (en) 1994-11-24
ES2167364T3 (es) 2002-05-16
CZ287794B6 (en) 2001-02-14
SK282860B6 (sk) 2002-12-03
GB9309509D0 (en) 1993-06-23
AU6795094A (en) 1994-12-12
DK0652900T3 (da) 2002-02-25
EP0652900B1 (de) 2001-11-14
RU2138275C1 (ru) 1999-09-27
JP3537437B2 (ja) 2004-06-14
TW369541B (en) 1999-09-11
CZ4295A3 (en) 1995-10-18
NO318017B1 (no) 2005-01-24
PT652900E (pt) 2002-05-31
NO950075D0 (no) 1995-01-06

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