NO314617B1 - Protrombin-tidsreagens samt fremgangsmåter for fremstiling derav - Google Patents
Protrombin-tidsreagens samt fremgangsmåter for fremstiling derav Download PDFInfo
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- NO314617B1 NO314617B1 NO19931708A NO931708A NO314617B1 NO 314617 B1 NO314617 B1 NO 314617B1 NO 19931708 A NO19931708 A NO 19931708A NO 931708 A NO931708 A NO 931708A NO 314617 B1 NO314617 B1 NO 314617B1
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- mol
- tissue factor
- prothrombin time
- stated
- detergent
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- CGVLVOOFCGWBCS-RGDJUOJXSA-N n-octyl β-d-thioglucopyranoside Chemical compound CCCCCCCCS[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O CGVLVOOFCGWBCS-RGDJUOJXSA-N 0.000 description 1
- 239000013610 patient sample Substances 0.000 description 1
- 238000005502 peroxidation Methods 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- WWUZIQQURGPMPG-KRWOKUGFSA-N sphingosine Chemical compound CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)CO WWUZIQQURGPMPG-KRWOKUGFSA-N 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000001732 thrombotic effect Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 239000002753 trypsin inhibitor Substances 0.000 description 1
- 241000701447 unidentified baculovirus Species 0.000 description 1
- 239000002691 unilamellar liposome Substances 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 238000003260 vortexing Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/5432—Liposomes or microcapsules
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/745—Assays involving non-enzymic blood coagulation factors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2405/00—Assays, e.g. immunoassays or enzyme assays, involving lipids
- G01N2405/04—Phospholipids, i.e. phosphoglycerides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Dispersion Chemistry (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61211890A | 1990-11-13 | 1990-11-13 | |
| US07/784,326 US5314695A (en) | 1990-11-13 | 1991-10-29 | Tissue factor based prothrombin time reagent |
| PCT/US1991/008174 WO1992008479A1 (fr) | 1990-11-13 | 1991-11-04 | Reactif de temps de prothrombine base sur la thromboplastine tissulaire |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO931708D0 NO931708D0 (no) | 1993-05-11 |
| NO931708L NO931708L (no) | 1993-07-08 |
| NO314617B1 true NO314617B1 (no) | 2003-04-22 |
Family
ID=27086686
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19931708A NO314617B1 (no) | 1990-11-13 | 1993-05-11 | Protrombin-tidsreagens samt fremgangsmåter for fremstiling derav |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5314695A (fr) |
| EP (1) | EP0564495B2 (fr) |
| JP (1) | JP3441456B2 (fr) |
| KR (1) | KR100196107B1 (fr) |
| AT (1) | ATE179608T1 (fr) |
| AU (2) | AU9090791A (fr) |
| CA (1) | CA2096109C (fr) |
| DE (1) | DE69131204T3 (fr) |
| DK (1) | DK0564495T4 (fr) |
| ES (1) | ES2133310T5 (fr) |
| FI (1) | FI109764B (fr) |
| GR (1) | GR3030906T3 (fr) |
| IE (1) | IE913955A1 (fr) |
| MX (1) | MX9102042A (fr) |
| NO (1) | NO314617B1 (fr) |
| NZ (2) | NZ264556A (fr) |
| PT (1) | PT99499B (fr) |
| WO (1) | WO1992008479A1 (fr) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2097199C (fr) * | 1991-10-04 | 2001-05-08 | Pamela L. Hawkins | Preparation de reactifs pour la determination du temps de prothrombine a partir d'un facteur tissulaire humain recombinant et de phospholipides synthetiques et naturels purifies |
| US6036955A (en) * | 1992-03-05 | 2000-03-14 | The Scripps Research Institute | Kits and methods for the specific coagulation of vasculature |
| US5877289A (en) * | 1992-03-05 | 1999-03-02 | The Scripps Research Institute | Tissue factor compositions and ligands for the specific coagulation of vasculature |
| US6093399A (en) * | 1992-03-05 | 2000-07-25 | Board Of Regents, The University Of Texas System | Methods and compositions for the specific coagulation of vasculature |
| US6749853B1 (en) | 1992-03-05 | 2004-06-15 | Board Of Regents, The University Of Texas System | Combined methods and compositions for coagulation and tumor treatment |
| AU674139B2 (en) * | 1992-04-13 | 1996-12-12 | Ortho Diagnostic Systems Inc. | Synthetic phospholipid reagent |
| EP0570356B1 (fr) * | 1992-05-15 | 1999-02-17 | IMMUNO Aktiengesellschaft | Réactif pour la détermination du temps de thromboplastinee partiellement active (IIPa) |
| DE4243729A1 (de) * | 1992-12-23 | 1994-06-30 | Behringwerke Ag | Verfahren zur Reaktivierung von gereinigten Membranproteinen |
| PL181102B1 (pl) * | 1993-01-29 | 2001-05-31 | Dahlbaeck Bjoern | Sposób oznaczania w próbce funkcjonalnej aktywności wybranego składnika koagulacji krwi |
| US7393682B1 (en) | 1993-03-19 | 2008-07-01 | The Johns Hopkins University School Of Medicine | Polynucleotides encoding promyostatin polypeptides |
| US5780248A (en) | 1993-07-15 | 1998-07-14 | Ortho Diagnostic Systems, Inc. | Foil sealed cassette for agglutination reactions and liner therefor |
| IL115849A0 (en) * | 1994-11-03 | 1996-01-31 | Merz & Co Gmbh & Co | Tangential filtration preparation of liposomal drugs and liposome product thereof |
| AT403437B (de) * | 1995-02-15 | 1998-02-25 | Immuno Ag | Physiologisch aktive gewebefaktor-präparation |
| US6379975B1 (en) | 1996-11-27 | 2002-04-30 | T.A.C. Thrombosis And Coagulation Aktiebolag | Methods and reagents for determining protein S |
| BR9806793A (pt) * | 1997-01-22 | 2000-05-16 | Univ Texas | Processos e composições de fator tissular para coagulação e tratamento de tumores. |
| IL132529A0 (en) * | 1997-04-23 | 2001-03-19 | Instrumentation Lab Spa | A method of preparing a liquid or a lyophilized reagent and a reagent produced thereby |
| DE19720853A1 (de) * | 1997-05-17 | 1998-11-19 | Dade Behring Marburg Gmbh | Erhöhung der FVII Empfindlichkeit eines Thromboplastinreagenzes |
| US6891082B2 (en) | 1997-08-01 | 2005-05-10 | The Johns Hopkins University School Of Medicine | Transgenic non-human animals expressing a truncated activintype II receptor |
| US6656475B1 (en) | 1997-08-01 | 2003-12-02 | The Johns Hopkins University School Of Medicine | Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same |
| US6245573B1 (en) | 1998-02-12 | 2001-06-12 | University Of Medicine And Dentistry Of New Jersey | Rapid assessment of the coagulant activity of blood |
| DE19811016A1 (de) * | 1998-03-13 | 1999-09-16 | Dade Behring Marburg Gmbh | Gebrauchsfertiges Prothrombinzeitreagenz auf der Basis von rekombinantem Gewebsfaktor |
| US6733985B1 (en) * | 1999-05-19 | 2004-05-11 | International Technidyne Corporation | Preparation of stable liquid and dried synthetic prothrombin time reagents |
| DE60011274T2 (de) * | 1999-09-03 | 2005-07-07 | Roche Diagnostics Corp., Indianapolis | Verfahren, reagenz und messkartusche zur bestimmung der gerinnungszeit |
| US6576610B1 (en) | 1999-10-04 | 2003-06-10 | Nuvas, Llc | Use of a context-dependent functional entity to enhance the efficacy of an agent |
| US6248353B1 (en) | 1999-12-10 | 2001-06-19 | Dade Behring Inc. | Reconstitution of purified membrane proteins into preformed liposomes |
| US20030147944A1 (en) * | 1999-12-10 | 2003-08-07 | Mayer Lawrence D | Lipid carrier compositions with protected surface reactive functions |
| US6855509B2 (en) * | 2000-12-19 | 2005-02-15 | Instrumentation Laboratory Company | Protein S functional assay and kit therefor |
| US6596543B2 (en) | 2001-03-22 | 2003-07-22 | Dade Behring Inc. | Use of liposomes of defined composition and size for the preparation of prothrombin time reagents |
| EP2272946B9 (fr) | 2002-02-25 | 2015-06-24 | Vaxiion Therapeutics, LLC | Compositions et méthodes de minicellules |
| WO2003078650A2 (fr) * | 2002-03-12 | 2003-09-25 | The Johns Hopkins University | Regulation de l'activite de la transcriptase inverse par les ions manganeux et methodes de modulation de cette regulation |
| US20030232075A1 (en) * | 2002-05-06 | 2003-12-18 | University Of Minnesota, A Minnesota Corporation | Compositions for producing factor Xa |
| US20040091952A1 (en) * | 2002-07-25 | 2004-05-13 | Sysmex Corporation | Reagent kit for detecting lupus anticoagulant |
| US7358337B2 (en) * | 2002-08-16 | 2008-04-15 | International Technidyne Corporation | Assay for low molecular weight heparin |
| US7049087B2 (en) * | 2002-11-05 | 2006-05-23 | Lifescan, Inc. | Method for manufacturing a tissue factor-based prothrombin time reagent |
| WO2005014618A2 (fr) * | 2003-08-08 | 2005-02-17 | Immunomedics, Inc. | Anticorps bispecifiques pour induire l'apoptose de cellules tumorales et malades |
| ATE395603T1 (de) * | 2004-02-06 | 2008-05-15 | Sysmex Corp | Reagenziensatz zum nachweis von lupus- antikoagulant. |
| JP4617458B2 (ja) * | 2004-02-10 | 2011-01-26 | 財団法人ヒューマンサイエンス振興財団 | 中空糸透析カラムを利用したリポソームの製造方法 |
| US20050221414A1 (en) | 2004-03-31 | 2005-10-06 | Katalin Varadi | Kit for measuring the thrombin generation in a sample of a patient's blood or plasma |
| US7794713B2 (en) | 2004-04-07 | 2010-09-14 | Lpath, Inc. | Compositions and methods for the treatment and prevention of hyperproliferative diseases |
| US7148067B2 (en) * | 2004-08-31 | 2006-12-12 | The Board Of Trustees Of The University Of Illinois | Thromboplastin reagents |
| US7635754B2 (en) * | 2004-09-22 | 2009-12-22 | Aerovance, Inc. | Interleukin-9 and interleukin-4 chimeric antagonist muteins and methods of using same |
| WO2006088741A2 (fr) * | 2005-02-16 | 2006-08-24 | The Board Of Trustees Of The University Of Illinois | Procoagulant universel |
| AT501650A1 (de) * | 2005-02-22 | 2006-10-15 | Technoclone Ges M B H | Verfahren zur bestimmung der gerinnungsaktivierung sowie gerät zur durchführung des verfahrens |
| CN101171034B (zh) | 2005-03-03 | 2014-06-18 | 免疫医疗公司 | 人源化l243抗体 |
| JP2008531692A (ja) * | 2005-03-04 | 2008-08-14 | ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイ | 凝固及び線維素溶解カスケードのモジュレーター |
| JP2007091625A (ja) * | 2005-09-28 | 2007-04-12 | Shino Test Corp | 血液凝固反応促進剤 |
| JP5017622B2 (ja) * | 2005-11-30 | 2012-09-05 | 株式会社シノテスト | 血液凝固反応抑制剤 |
| US7862812B2 (en) | 2006-05-31 | 2011-01-04 | Lpath, Inc. | Methods for decreasing immune response and treating immune conditions |
| US20120196827A1 (en) | 2006-06-12 | 2012-08-02 | Oncomethylome Sciences S.A. | Methylation markers for early detection and prognosis of colon cancers |
| JP5073270B2 (ja) * | 2006-11-14 | 2012-11-14 | シスメックス株式会社 | 凝固検査用試薬及びその製造方法 |
| US8821861B2 (en) * | 2007-10-05 | 2014-09-02 | The Board Of Trustees Of The University Of Illinois | Fibrin sealant |
| WO2009061697A1 (fr) | 2007-11-09 | 2009-05-14 | The Board Of Trustees Of The University Of Illinois | Antagoniste d'anticoagulant et procoagulant anti-hémophilique |
| KR20180013993A (ko) | 2008-06-25 | 2018-02-07 | 벡션 테라퓨틱스 엘엘씨 | 조절된 유전자 자살 메커니즘 조성물 및 방법 |
| EP2576813A1 (fr) | 2010-05-28 | 2013-04-10 | Diagon Kft. | Procédé pour la préparation biphasique de liposomes et son utilisation dans la fabrication de réactifs de diagnostic |
| WO2012057765A1 (fr) | 2010-10-28 | 2012-05-03 | The Board Of Regents Of The University Of Texas System | Anticorps monoclonaux recombinants anti-cd19 |
| AU2012217728B2 (en) | 2011-02-15 | 2017-04-27 | Vaxiion Therapeutics, Llc | Therapeutic compositions and methods for antibody and Fc-containing targeting molecule-based targeted delivery of bioactive molecules by bacterial minicells |
| ES2806605T3 (es) | 2011-09-23 | 2021-02-18 | Univ Loma Linda | Cepas bacterianas que expresan genes de metilasa y sus usos |
| CN102565427A (zh) * | 2011-12-28 | 2012-07-11 | 苏州良辰生物医药科技有限公司 | 一种凝血酶原时间测定试剂的制备方法 |
| WO2014039745A1 (fr) | 2012-09-07 | 2014-03-13 | Children's Medical Center Corporation | Souris reporter spécifique de cellules souches hématopoïétiques et ses utilisations |
| KR102627631B1 (ko) | 2012-10-02 | 2024-01-22 | 벡션 테라퓨틱스 엘엘씨 | 면역 조절성 미니세포 및 사용 방법 |
| JP6250306B2 (ja) * | 2013-05-28 | 2017-12-20 | 株式会社Ｌｓｉメディエンス | リポ化トロンボプラスチン含有血液凝固能測定試薬及び測定方法 |
| CN113577323B (zh) * | 2015-08-04 | 2024-02-20 | 瓦克星治疗有限责任公司 | 基于细菌小细胞的生物药物的电离辐射灭菌以及使用方法 |
| CN108603889B (zh) | 2016-02-12 | 2021-08-31 | 仪器实验室公司 | 双组分“即混即用”液体促凝血酶原激酶试剂及其制造方法和使用方法 |
| JP6652873B2 (ja) * | 2016-03-30 | 2020-02-26 | シスメックス株式会社 | プロトロンビン時間測定用試薬、その製造方法およびプロトロンビン時間の測定方法 |
| JP6626761B2 (ja) * | 2016-03-30 | 2019-12-25 | シスメックス株式会社 | プロトロンビン時間測定用試薬およびその製造方法 |
| AU2017365028A1 (en) | 2016-11-23 | 2019-06-20 | Vaxiion Therapeutics, Llc | Immunomodulatory and oncolytic minicells and methods of use |
| CN106680339A (zh) * | 2016-12-28 | 2017-05-17 | 北京乐普医疗科技有限责任公司 | 一种基于电化学方法的凝血酶原时间测试卡及其制备方法 |
| CN109239373A (zh) * | 2018-08-15 | 2019-01-18 | 迪瑞医疗科技股份有限公司 | 一种组织因子酯化物试剂及其制备方法与应用 |
| CN109613279A (zh) * | 2018-12-06 | 2019-04-12 | 太原博奥特生物技术有限公司 | 一种新型鞣花酸化合物及利用鞣花酸化合物制备活化部分凝血活酶时间测定试剂 |
| CN110244066A (zh) * | 2019-07-01 | 2019-09-17 | 北京乐普医疗科技有限责任公司 | 一种干式电化学法凝血酶原时间检测卡及制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL123584C (fr) * | 1958-05-16 | |||
| DE2916711A1 (de) † | 1979-04-25 | 1980-11-06 | Behringwerke Ag | Blutgerinnungsfaktoren und verfahren zu ihrer herstellung |
| IT1212900B (it) * | 1983-11-17 | 1989-11-30 | Valle Francesco Della | Uso terapeutico della fosfatidilserina in malattie del sistema nervoso centrale senza effetti sulla coagulazione sanguigna |
| US4857319A (en) * | 1985-01-11 | 1989-08-15 | The Regents Of The University Of California | Method for preserving liposomes |
| US5017556A (en) * | 1986-11-04 | 1991-05-21 | Genentech, Inc. | Treatment of bleeding disorders using lipid-free tissue factor protein |
| IE81149B1 (en) † | 1987-02-12 | 2000-05-03 | Genentech Inc | Methods and deoxyribonucleic acid for the preparation of tissue factor protein |
| US5223427A (en) † | 1987-03-31 | 1993-06-29 | The Scripps Research Institute | Hybridomas producing monoclonal antibodies reactive with human tissue-factor glycoprotein heavy chain |
| US4865984A (en) † | 1988-02-08 | 1989-09-12 | Mount Sinai School Of Medicine Of The City University Of New York | Dynamic continuous flow enzyme reactor |
-
1991
- 1991-10-29 US US07/784,326 patent/US5314695A/en not_active Expired - Lifetime
- 1991-11-04 DK DK92901065T patent/DK0564495T4/da active
- 1991-11-04 ES ES92901065T patent/ES2133310T5/es not_active Expired - Lifetime
- 1991-11-04 CA CA002096109A patent/CA2096109C/fr not_active Expired - Lifetime
- 1991-11-04 DE DE69131204T patent/DE69131204T3/de not_active Expired - Lifetime
- 1991-11-04 WO PCT/US1991/008174 patent/WO1992008479A1/fr active IP Right Grant
- 1991-11-04 AU AU90907/91A patent/AU9090791A/en not_active Abandoned
- 1991-11-04 KR KR1019930701454A patent/KR100196107B1/ko not_active IP Right Cessation
- 1991-11-04 JP JP50127192A patent/JP3441456B2/ja not_active Expired - Lifetime
- 1991-11-04 EP EP92901065A patent/EP0564495B2/fr not_active Expired - Lifetime
- 1991-11-04 AT AT92901065T patent/ATE179608T1/de not_active IP Right Cessation
- 1991-11-13 NZ NZ264556A patent/NZ264556A/en not_active IP Right Cessation
- 1991-11-13 PT PT99499A patent/PT99499B/pt not_active IP Right Cessation
- 1991-11-13 NZ NZ240577A patent/NZ240577A/en not_active IP Right Cessation
- 1991-11-13 MX MX9102042A patent/MX9102042A/es unknown
- 1991-11-13 IE IE395591A patent/IE913955A1/en not_active IP Right Cessation
-
1993
- 1993-05-11 NO NO19931708A patent/NO314617B1/no not_active IP Right Cessation
- 1993-05-12 FI FI932148A patent/FI109764B/fi not_active IP Right Cessation
-
1996
- 1996-02-12 AU AU44489/96A patent/AU4448996A/en not_active Abandoned
-
1999
- 1999-08-02 GR GR990401987T patent/GR3030906T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GR3030906T3 (en) | 1999-11-30 |
| FI109764B (fi) | 2002-10-15 |
| CA2096109C (fr) | 2004-01-06 |
| DK0564495T3 (da) | 1999-11-15 |
| AU9090791A (en) | 1992-06-11 |
| EP0564495B2 (fr) | 2006-12-27 |
| NO931708D0 (no) | 1993-05-11 |
| FI932148A (fi) | 1993-06-03 |
| AU4448996A (en) | 1996-05-09 |
| FI932148A0 (fi) | 1993-05-12 |
| PT99499A (pt) | 1992-11-30 |
| NO931708L (no) | 1993-07-08 |
| MX9102042A (es) | 1994-01-31 |
| ATE179608T1 (de) | 1999-05-15 |
| US5314695A (en) | 1994-05-24 |
| DK0564495T4 (da) | 2007-04-30 |
| JPH06502649A (ja) | 1994-03-24 |
| ES2133310T5 (es) | 2007-08-16 |
| ES2133310T3 (es) | 1999-09-16 |
| NZ264556A (en) | 1996-07-26 |
| DE69131204D1 (de) | 1999-06-10 |
| EP0564495B1 (fr) | 1999-05-06 |
| IE913955A1 (en) | 1992-05-20 |
| WO1992008479A1 (fr) | 1992-05-29 |
| NZ240577A (en) | 1996-07-26 |
| DE69131204T3 (de) | 2007-05-24 |
| KR100196107B1 (ko) | 1999-06-15 |
| EP0564495A1 (fr) | 1993-10-13 |
| JP3441456B2 (ja) | 2003-09-02 |
| EP0564495A4 (fr) | 1994-12-21 |
| PT99499B (pt) | 1999-04-30 |
| DE69131204T2 (de) | 1999-12-23 |
| CA2096109A1 (fr) | 1992-05-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |