FI109764B - Kudostekijään perustuva protrombiiniaikareagenssi - Google Patents

Kudostekijään perustuva protrombiiniaikareagenssi Download PDF

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Publication number
FI109764B
FI109764B FI932148A FI932148A FI109764B FI 109764 B FI109764 B FI 109764B FI 932148 A FI932148 A FI 932148A FI 932148 A FI932148 A FI 932148A FI 109764 B FI109764 B FI 109764B
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FI
Finland
Prior art keywords
mol
tissue factor
reagent
mmol
prothrombin time
Prior art date
Application number
FI932148A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI932148A0 (fi
FI932148A (fi
Inventor
Scott Martin Brown
Original Assignee
Corvas Int Inc
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Publication date
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Application filed by Corvas Int Inc filed Critical Corvas Int Inc
Publication of FI932148A0 publication Critical patent/FI932148A0/fi
Publication of FI932148A publication Critical patent/FI932148A/fi
Application granted granted Critical
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/5432—Liposomes or microcapsules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2405/00—Assays, e.g. immunoassays or enzyme assays, involving lipids
    • G01N2405/04—Phospholipids, i.e. phosphoglycerides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Dispersion Chemistry (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
FI932148A 1990-11-13 1993-05-12 Kudostekijään perustuva protrombiiniaikareagenssi FI109764B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US61211890A 1990-11-13 1990-11-13
US61211890 1990-11-13
US78432691 1991-10-29
US07/784,326 US5314695A (en) 1990-11-13 1991-10-29 Tissue factor based prothrombin time reagent
US9108174 1991-11-04
PCT/US1991/008174 WO1992008479A1 (fr) 1990-11-13 1991-11-04 Reactif de temps de prothrombine base sur la thromboplastine tissulaire

Publications (3)

Publication Number Publication Date
FI932148A0 FI932148A0 (fi) 1993-05-12
FI932148A FI932148A (fi) 1993-06-03
FI109764B true FI109764B (fi) 2002-10-15

Family

ID=27086686

Family Applications (1)

Application Number Title Priority Date Filing Date
FI932148A FI109764B (fi) 1990-11-13 1993-05-12 Kudostekijään perustuva protrombiiniaikareagenssi

Country Status (18)

Country Link
US (1) US5314695A (fr)
EP (1) EP0564495B2 (fr)
JP (1) JP3441456B2 (fr)
KR (1) KR100196107B1 (fr)
AT (1) ATE179608T1 (fr)
AU (2) AU9090791A (fr)
CA (1) CA2096109C (fr)
DE (1) DE69131204T3 (fr)
DK (1) DK0564495T4 (fr)
ES (1) ES2133310T5 (fr)
FI (1) FI109764B (fr)
GR (1) GR3030906T3 (fr)
IE (1) IE913955A1 (fr)
MX (1) MX9102042A (fr)
NO (1) NO314617B1 (fr)
NZ (2) NZ240577A (fr)
PT (1) PT99499B (fr)
WO (1) WO1992008479A1 (fr)

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US6093399A (en) * 1992-03-05 2000-07-25 Board Of Regents, The University Of Texas System Methods and compositions for the specific coagulation of vasculature
US5877289A (en) * 1992-03-05 1999-03-02 The Scripps Research Institute Tissue factor compositions and ligands for the specific coagulation of vasculature
US6036955A (en) * 1992-03-05 2000-03-14 The Scripps Research Institute Kits and methods for the specific coagulation of vasculature
US6749853B1 (en) 1992-03-05 2004-06-15 Board Of Regents, The University Of Texas System Combined methods and compositions for coagulation and tumor treatment
AU674139B2 (en) * 1992-04-13 1996-12-12 Ortho Diagnostic Systems Inc. Synthetic phospholipid reagent
ES2130244T3 (es) * 1992-05-15 1999-07-01 Immuno Ag Reactivo para la determinacion del tiempo de tromboplastina parcialmente activa (iipa).
DE4243729A1 (de) * 1992-12-23 1994-06-30 Behringwerke Ag Verfahren zur Reaktivierung von gereinigten Membranproteinen
DK0690991T4 (da) 1993-01-29 2004-02-16 T A C Thrombosis And Coagulati Ny antikoagulant-cofaktor-aktivitet
US7393682B1 (en) 1993-03-19 2008-07-01 The Johns Hopkins University School Of Medicine Polynucleotides encoding promyostatin polypeptides
US5780248A (en) 1993-07-15 1998-07-14 Ortho Diagnostic Systems, Inc. Foil sealed cassette for agglutination reactions and liner therefor
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AT403437B (de) * 1995-02-15 1998-02-25 Immuno Ag Physiologisch aktive gewebefaktor-präparation
US6379975B1 (en) 1996-11-27 2002-04-30 T.A.C. Thrombosis And Coagulation Aktiebolag Methods and reagents for determining protein S
US6156321A (en) 1997-01-22 2000-12-05 Board Of Regents, The University Of Texas System Tissue factor methods and compositions for coagulation and tumor treatment
CA2288058A1 (fr) * 1997-04-23 1998-10-29 Instrumentation Laboratory, S.P.A. Reactif pour la determination du temps de prothrombine a base d'un facteur tissulaire recombine de lapin
DE19720853A1 (de) * 1997-05-17 1998-11-19 Dade Behring Marburg Gmbh Erhöhung der FVII Empfindlichkeit eines Thromboplastinreagenzes
US6656475B1 (en) 1997-08-01 2003-12-02 The Johns Hopkins University School Of Medicine Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same
US6891082B2 (en) 1997-08-01 2005-05-10 The Johns Hopkins University School Of Medicine Transgenic non-human animals expressing a truncated activintype II receptor
US6245573B1 (en) 1998-02-12 2001-06-12 University Of Medicine And Dentistry Of New Jersey Rapid assessment of the coagulant activity of blood
DE19811016A1 (de) * 1998-03-13 1999-09-16 Dade Behring Marburg Gmbh Gebrauchsfertiges Prothrombinzeitreagenz auf der Basis von rekombinantem Gewebsfaktor
US6733985B1 (en) * 1999-05-19 2004-05-11 International Technidyne Corporation Preparation of stable liquid and dried synthetic prothrombin time reagents
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US6248353B1 (en) 1999-12-10 2001-06-19 Dade Behring Inc. Reconstitution of purified membrane proteins into preformed liposomes
CA2393595A1 (fr) * 1999-12-10 2001-06-14 Gigi Chiu Compositions d'excipient a base de lipides ayant des fonctions de reaction au moyen d'une surface protegee
US6855509B2 (en) * 2000-12-19 2005-02-15 Instrumentation Laboratory Company Protein S functional assay and kit therefor
US6596543B2 (en) 2001-03-22 2003-07-22 Dade Behring Inc. Use of liposomes of defined composition and size for the preparation of prothrombin time reagents
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WO2003078650A2 (fr) * 2002-03-12 2003-09-25 The Johns Hopkins University Regulation de l'activite de la transcriptase inverse par les ions manganeux et methodes de modulation de cette regulation
US20030232075A1 (en) * 2002-05-06 2003-12-18 University Of Minnesota, A Minnesota Corporation Compositions for producing factor Xa
US20040091952A1 (en) * 2002-07-25 2004-05-13 Sysmex Corporation Reagent kit for detecting lupus anticoagulant
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CN102565427A (zh) * 2011-12-28 2012-07-11 苏州良辰生物医药科技有限公司 一种凝血酶原时间测定试剂的制备方法
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JP6250306B2 (ja) * 2013-05-28 2017-12-20 株式会社Ｌｓｉメディエンス リポ化トロンボプラスチン含有血液凝固能測定試薬及び測定方法
CN113577323B (zh) * 2015-08-04 2024-02-20 瓦克星治疗有限责任公司 基于细菌小细胞的生物药物的电离辐射灭菌以及使用方法
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JP6652873B2 (ja) * 2016-03-30 2020-02-26 シスメックス株式会社 プロトロンビン時間測定用試薬、その製造方法およびプロトロンビン時間の測定方法
JP6626761B2 (ja) * 2016-03-30 2019-12-25 シスメックス株式会社 プロトロンビン時間測定用試薬およびその製造方法
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CN106680339A (zh) * 2016-12-28 2017-05-17 北京乐普医疗科技有限责任公司 一种基于电化学方法的凝血酶原时间测试卡及其制备方法
CN109239373A (zh) * 2018-08-15 2019-01-18 迪瑞医疗科技股份有限公司 一种组织因子酯化物试剂及其制备方法与应用
CN109613279A (zh) * 2018-12-06 2019-04-12 太原博奥特生物技术有限公司 一种新型鞣花酸化合物及利用鞣花酸化合物制备活化部分凝血活酶时间测定试剂
CN110244066A (zh) * 2019-07-01 2019-09-17 北京乐普医疗科技有限责任公司 一种干式电化学法凝血酶原时间检测卡及制备方法

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Also Published As

Publication number Publication date
FI932148A0 (fi) 1993-05-12
CA2096109A1 (fr) 1992-05-14
JP3441456B2 (ja) 2003-09-02
IE913955A1 (en) 1992-05-20
DK0564495T3 (da) 1999-11-15
AU4448996A (en) 1996-05-09
US5314695A (en) 1994-05-24
PT99499B (pt) 1999-04-30
ES2133310T3 (es) 1999-09-16
MX9102042A (es) 1994-01-31
DE69131204T3 (de) 2007-05-24
NO931708D0 (no) 1993-05-11
NZ240577A (en) 1996-07-26
EP0564495A1 (fr) 1993-10-13
ATE179608T1 (de) 1999-05-15
CA2096109C (fr) 2004-01-06
JPH06502649A (ja) 1994-03-24
KR100196107B1 (ko) 1999-06-15
NO931708L (no) 1993-07-08
NZ264556A (en) 1996-07-26
DE69131204D1 (de) 1999-06-10
WO1992008479A1 (fr) 1992-05-29
ES2133310T5 (es) 2007-08-16
EP0564495B2 (fr) 2006-12-27
DK0564495T4 (da) 2007-04-30
EP0564495B1 (fr) 1999-05-06
EP0564495A4 (fr) 1994-12-21
DE69131204T2 (de) 1999-12-23
FI932148A (fi) 1993-06-03
AU9090791A (en) 1992-06-11
PT99499A (pt) 1992-11-30
NO314617B1 (no) 2003-04-22
GR3030906T3 (en) 1999-11-30

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