NO311635B1 - Vandig legemiddelpreparat med evne til reversibel varmeherdende gel - Google Patents
Vandig legemiddelpreparat med evne til reversibel varmeherdende gel Download PDFInfo
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- NO311635B1 NO311635B1 NO19953189A NO953189A NO311635B1 NO 311635 B1 NO311635 B1 NO 311635B1 NO 19953189 A NO19953189 A NO 19953189A NO 953189 A NO953189 A NO 953189A NO 311635 B1 NO311635 B1 NO 311635B1
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- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 210000001742 aqueous humor Anatomy 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 235000003704 aspartic acid Nutrition 0.000 description 1
- 230000002567 autonomic effect Effects 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 229960001950 benzethonium chloride Drugs 0.000 description 1
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
- UREBDLICKHMUKA-DVTGEIKXSA-N betamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-DVTGEIKXSA-N 0.000 description 1
- 229940067596 butylparaben Drugs 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 210000003467 cheek Anatomy 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 1
- 229960000520 diphenhydramine Drugs 0.000 description 1
- KCIDZIIHRGYJAE-YGFYJFDDSA-L dipotassium;[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] phosphate Chemical compound [K+].[K+].OC[C@H]1O[C@H](OP([O-])([O-])=O)[C@H](O)[C@@H](O)[C@H]1O KCIDZIIHRGYJAE-YGFYJFDDSA-L 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 210000000613 ear canal Anatomy 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 description 1
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 description 1
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229940050410 gluconate Drugs 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 229940093915 gynecological organic acid Drugs 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 210000003928 nasal cavity Anatomy 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 229940067107 phenylethyl alcohol Drugs 0.000 description 1
- 235000011007 phosphoric acid Nutrition 0.000 description 1
- 229920002523 polyethylene Glycol 1000 Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 229940083542 sodium Drugs 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- LROWVYNUWKVTCU-STWYSWDKSA-M sodium sorbate Chemical compound [Na+].C\C=C\C=C\C([O-])=O LROWVYNUWKVTCU-STWYSWDKSA-M 0.000 description 1
- 235000019250 sodium sorbate Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- RXDJVBXMOZKSHS-UHFFFAOYSA-N tetracene-5,12-dicarbaldehyde Chemical compound C1=CC=C2C=C3C(C=O)=C(C=CC=C4)C4=C(C=O)C3=CC2=C1 RXDJVBXMOZKSHS-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 210000003708 urethra Anatomy 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Materials For Medical Uses (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11234593 | 1993-04-16 | ||
| PCT/JP1993/001636 WO1994023750A1 (en) | 1993-04-16 | 1993-11-10 | Reversible, thermally gelling water-base medicinal composition |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO953189L NO953189L (no) | 1995-08-14 |
| NO953189D0 NO953189D0 (no) | 1995-08-14 |
| NO311635B1 true NO311635B1 (no) | 2001-12-27 |
Family
ID=14584369
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19953189A NO311635B1 (no) | 1993-04-16 | 1995-08-14 | Vandig legemiddelpreparat med evne til reversibel varmeherdende gel |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5624962A (fi) |
| EP (1) | EP0694310B1 (fi) |
| KR (1) | KR0162025B1 (fi) |
| CN (1) | CN1048393C (fi) |
| AT (1) | ATE189772T1 (fi) |
| AU (1) | AU668447B2 (fi) |
| CA (1) | CA2153234C (fi) |
| DE (1) | DE69327878T2 (fi) |
| DK (1) | DK0694310T3 (fi) |
| ES (1) | ES2141775T3 (fi) |
| FI (1) | FI112778B (fi) |
| HK (1) | HK1017805A1 (fi) |
| HU (1) | HU220864B1 (fi) |
| IL (1) | IL107626A (fi) |
| NO (1) | NO311635B1 (fi) |
| RU (1) | RU2108112C1 (fi) |
| WO (1) | WO1994023750A1 (fi) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6436425B1 (en) | 1988-11-16 | 2002-08-20 | Mdv Technologies, Inc. | Method and non-gelling composition for inhibiting post-surgical adhesions |
| US5346703A (en) | 1990-08-07 | 1994-09-13 | Mediventures, Inc. | Body cavity drug delivery with thermo-irreversible polyoxyalkylene and ionic polysaccharide gels |
| US5318780A (en) * | 1991-10-30 | 1994-06-07 | Mediventures Inc. | Medical uses of in situ formed gels |
| US5708023A (en) * | 1994-03-28 | 1998-01-13 | The Trustees Of Columbia University In The City Of New York | Zinc gluconate gel compositions |
| EP0782850A4 (en) * | 1994-10-13 | 1998-03-04 | Wakamoto Pharma Co Ltd | LYOPHILIZED PREPARATION FOR PRODUCING A REVERSIBLE THERMOGELING MEDICINAL WATER-BASED |
| DE19511322C2 (de) | 1995-03-28 | 1999-09-02 | Mann Gerhard Chem Pharm Fab | Sterile Augengele mit einem Gehalt an mittelkettigen Triglyceriden und Verfahren zu deren Herstellung |
| US5843470A (en) | 1995-10-06 | 1998-12-01 | Mdv Technologies, Inc. | Method and composition for inhibiting post-surgical adhesions |
| CA2232855C (en) * | 1997-04-10 | 2007-10-09 | Roche Consumer Health (Worldwide) Sa | Pharmaceutical formulation |
| KR20010012188A (ko) * | 1997-05-14 | 2001-02-15 | 요시다 쇼지 | 재분산성이 양호한 수성 현탁액제 |
| JP2001526246A (ja) * | 1997-12-23 | 2001-12-18 | アライアンス・ファーマスーティカル・コーポレイション | 薬剤送達及び／又は癒着防止のための方法及び組成物 |
| US6197347B1 (en) | 1998-06-29 | 2001-03-06 | Andrx Pharmaceuticals, Inc. | Oral dosage for the controlled release of analgesic |
| ES2155027B1 (es) * | 1999-05-24 | 2001-12-01 | Univ Pais Vasco | Geles para propositos multiples, reversibles y degradables. |
| ES2273702T3 (es) * | 1999-06-11 | 2007-05-16 | Cytyc Corporation | Composicion liquido en gel para cartografiar un conducto galactoforo mamario antes de la escxision quirurgica del conducto o de otro tejido mamario. |
| US20020061281A1 (en) * | 1999-07-06 | 2002-05-23 | Osbakken Robert S. | Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis |
| US6576224B1 (en) * | 1999-07-06 | 2003-06-10 | Sinuspharma, Inc. | Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis |
| JP2001158750A (ja) * | 1999-12-02 | 2001-06-12 | Lion Corp | 眼科用組成物及び抗アレルギー薬の持続性向上方法 |
| JP3450805B2 (ja) * | 2000-08-08 | 2003-09-29 | わかもと製薬株式会社 | 水性医薬組成物 |
| US7420030B2 (en) | 2000-09-08 | 2008-09-02 | The Board Of Regents Of The University Of Texas System | Aminopeptidase A (APA) targeting peptides for the treatment of cancer |
| EP1328214A4 (en) * | 2000-09-20 | 2009-07-29 | Shahinian Lee Jr | NASAL, INHALABLE AND LOCAL OPHTHALMIC PREPARATIONS AND MEDICATIONS WITH SPONTANEOUS CONSERVATION |
| JP4820024B2 (ja) * | 2001-01-10 | 2011-11-24 | 昭和薬品化工株式会社 | 局所麻酔用組成物 |
| EP1418932A4 (en) * | 2001-07-18 | 2006-03-15 | Univ Texas | ANTI-ANGIOGENIC STATE IN MOUSE AND HUMAN BEINGS SUFFERING FROM CELL DEGENERATION OF THE RETINAL PHOTORECEPTOR |
| US20040048243A1 (en) * | 2001-09-07 | 2004-03-11 | Wadih Arap | Methods and compositions for in vitro targeting |
| US6846846B2 (en) | 2001-10-23 | 2005-01-25 | The Trustees Of Columbia University In The City Of New York | Gentle-acting skin disinfectants |
| AU2003216213B2 (en) | 2002-02-07 | 2008-10-02 | The Trustees Of Columbia University In The City Of New York | Zinc salt compositions for the prevention of mucosal irritation from spermicides and microbicides |
| US7879365B2 (en) * | 2002-02-07 | 2011-02-01 | The Trustees Of Columbia University In The City Of New York | Zinc salt compositions for the prevention of dermal and mucosal irritation |
| US7745425B2 (en) * | 2002-02-07 | 2010-06-29 | The Trustees Of Columbia University In The City Of New York | Non-irritating compositions containing zinc salts |
| CN1638734A (zh) * | 2002-02-22 | 2005-07-13 | 参天制药株式会社 | 微粒结膜下给药的药物释放系统 |
| US20030211173A1 (en) * | 2002-05-08 | 2003-11-13 | Veach Tom C. | Lubrication composition |
| JPWO2004026953A1 (ja) * | 2002-09-18 | 2006-01-19 | わかもと製薬株式会社 | 透明な可逆性熱ゲル化水性組成物 |
| US7220431B2 (en) | 2002-11-27 | 2007-05-22 | Regents Of The University Of Minnesota | Methods and compositions for applying pharmacologic agents to the ear |
| JP2004196787A (ja) * | 2002-12-04 | 2004-07-15 | Santen Pharmaceut Co Ltd | 結膜下デポによるドラッグデリバリーシステム |
| AU2003289011A1 (en) * | 2002-12-10 | 2004-06-30 | Showa Yakuhin Kako Co., Ltd. | Composition for topical anesthesia |
| US20050085446A1 (en) * | 2003-04-14 | 2005-04-21 | Babu M.K. M. | Fluoroquinolone formulations and methods of making and using the same |
| JP4669960B2 (ja) * | 2003-06-03 | 2011-04-13 | 株式会社 メドレックス | 局所麻酔薬を含有する口中用または咽頭部用製剤 |
| AU2004258899B2 (en) * | 2003-07-17 | 2009-09-03 | The Trustees Of Columbia University In The City Of New York | Antimicrobial compositons containing synergistic combinations of quaternary ammonium compounds and essential oils and/or constituents thereof |
| KR101160702B1 (ko) * | 2003-08-20 | 2012-06-28 | 산텐 세이야꾸 가부시키가이샤 | 미립자 테논낭하 투여 약물 전달 시스템 |
| FR2860718B1 (fr) * | 2003-10-09 | 2006-02-24 | Jean Pascal Conduzorgues | Nouvelle formulation et ses applications dans le domaines cosmetiques ou pharmaceutiques |
| EP1708668A1 (en) * | 2004-01-15 | 2006-10-11 | Oral Bioscience Pty. Limited | Oral anaesthetic gel |
| US7658947B2 (en) * | 2004-06-25 | 2010-02-09 | Kimberly-Clark Worldwide, Inc. | Thermo-gelling composition |
| JP2007277095A (ja) * | 2004-07-02 | 2007-10-25 | Wakamoto Pharmaceut Co Ltd | アジスロマイシン含有可逆性熱ゲル化水性組成物 |
| US7459416B2 (en) * | 2004-07-12 | 2008-12-02 | Panasonic Corporation | Fluid bearing unit and spindle motor using the same |
| BRPI0608690B8 (pt) | 2005-03-10 | 2021-05-25 | 3M Innovative Properties Co | uso de uma composição antimicrobiana |
| JP4979258B2 (ja) * | 2005-04-08 | 2012-07-18 | ロート製薬株式会社 | アシタザノラスト含有水性組成物 |
| CN100463668C (zh) * | 2005-05-09 | 2009-02-25 | 凌沛学 | 可逆性热凝胶化水性药物组合物 |
| CN100430069C (zh) * | 2005-07-28 | 2008-11-05 | 凌沛学 | 一种中药及其复方的可逆性热凝胶化水性药物组合物 |
| WO2007046318A1 (ja) * | 2005-10-17 | 2007-04-26 | Kowa Co., Ltd. | インドメタシンを含有する外用液剤 |
| EA008737B1 (ru) * | 2005-12-07 | 2007-08-31 | Леонид Андреевич Кожемякин | Средство для профилактики и лечения конъюнктивитов и кератитов различной этиологии (варианты), способ его применения |
| US7759327B2 (en) | 2006-01-06 | 2010-07-20 | The Trustees Of Columbia University In The City Of New York | Compositions containing zinc salts for coating medical articles |
| US20070249546A1 (en) * | 2006-04-22 | 2007-10-25 | Sawaya Assad S | Ophthalmic and related aqueous solutions containing antifungal agents, uses therefor and methods for preparing them |
| US20070253909A1 (en) * | 2006-05-01 | 2007-11-01 | Medi-Flex, Inc. | Aqueous Antiseptic Solution and Compatible Cationic Dye for Staining Skin |
| US20080108674A1 (en) * | 2006-05-01 | 2008-05-08 | Enturia, Inc. | Cationic antiseptic and dye formulation |
| US20070254854A1 (en) * | 2006-05-01 | 2007-11-01 | Medi-Flex, Inc. | Aqueous Antiseptic Solution and Compatible Anionic Dye for Staining Skin |
| TW200808375A (en) * | 2006-05-12 | 2008-02-16 | Otsuka Pharma Co Ltd | Hydrogel suspension and manufacturing process thereof |
| EA014780B1 (ru) * | 2007-01-05 | 2011-02-28 | Промед Экспортс Пвт. Лтд. | Офтальмическая композиция |
| DE102007002073A1 (de) * | 2007-01-09 | 2008-07-10 | Matthias Habenicht | Mittel zur Pflege und antimikrobiellen Behandlung der Haut |
| EP2172224A4 (en) * | 2007-06-26 | 2013-01-16 | Wakamoto Pharma Co Ltd | AQUEOUS COMPOSITION |
| US9456980B2 (en) * | 2007-08-29 | 2016-10-04 | Wakamoto Pharmaceutical Co., Ltd. | Latanoprost-containing aqueous pharmaceutical composition |
| RU2600863C2 (ru) * | 2007-12-10 | 2016-10-27 | Сентисс Фарма Прайвит Лимитед | Офтальмическая композиция, включающая фенилэфрин |
| AU2009246870B2 (en) * | 2008-05-14 | 2013-08-01 | Otonomy, Inc. | Controlled release corticosteroid compositions and methods for the treatment of otic disorders |
| US10517839B2 (en) * | 2008-06-09 | 2019-12-31 | Cornell University | Mast cell inhibition in diseases of the retina and vitreous |
| TW201023912A (en) * | 2008-12-05 | 2010-07-01 | Alcon Res Ltd | Pharmaceutical suspension |
| WO2010101992A1 (en) * | 2009-03-03 | 2010-09-10 | Alcon Research, Ltd. | Pharmaceutical composition for delivery of receptor tyrosine kinase inhibiting (rtki) compounds to the eye |
| US8912236B2 (en) * | 2009-03-03 | 2014-12-16 | Alcon Research, Ltd. | Pharmaceutical composition for delivery of receptor tyrosine kinase inhibiting (RTKi) compounds to the eye |
| CA2753837A1 (en) * | 2009-03-03 | 2010-09-10 | Alcon Research, Ltd. | Pharmaceutical composition for delivery of receptor tyrosine kinase inhibiting (rtki) compounds to the eye |
| WO2010135731A1 (en) * | 2009-05-22 | 2010-11-25 | Kaufman Herbert E | Preparations and methods for ameliorating or reducing presbyopia |
| US8299079B2 (en) | 2009-05-22 | 2012-10-30 | Kaufman Herbert E | Preparations and methods for ameliorating or reducing presbyopia |
| CN103079595B (zh) | 2010-08-27 | 2015-11-25 | 若素制药株式会社 | 滴眼用水性组合物 |
| TWI544922B (zh) | 2011-05-19 | 2016-08-11 | 愛爾康研究有限公司 | 高濃度歐羅派特錠（ｏｌｏｐａｔａｄｉｎｅ）眼用組成物 |
| WO2013169458A1 (en) * | 2012-05-11 | 2013-11-14 | Bausch & Lomb Incorporated | Pharmaceutical compositions and methods for treating, controlling, ameliorating, or reversing conditions of dry eye |
| RU2485939C1 (ru) * | 2012-06-19 | 2013-06-27 | Станислав Анатольевич Кедик | Офтальмологический препарат в виде глазных капель, содержащий дисульфирам и таурин |
| US10507245B2 (en) * | 2012-07-19 | 2019-12-17 | Luis Felipe Vejarano Restrepo | Ophthalmic formulation and method for ameliorating presbyopia |
| RU2517033C1 (ru) * | 2013-03-05 | 2014-05-27 | федеральное государственное бюджетное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации | Композиция для комплексного лечения больных с первичной открытоугольной глаукомой и заболеваниями глазной поверхности |
| CN103239390B (zh) * | 2013-05-15 | 2014-08-06 | 中国人民解放军第三军医大学第二附属医院 | 托吡卡胺眼用温度敏感原位凝胶及其制备方法 |
| EP3082868A1 (en) * | 2013-12-20 | 2016-10-26 | The Procter & Gamble Company | Stable liquid medication containing diphenhydramine |
| JP6714247B2 (ja) * | 2017-10-06 | 2020-06-24 | 有限会社ジーエヌコーポレーション | 尿道狭窄治療剤および尿道狭窄治療方法 |
| CN117618462A (zh) * | 2018-05-29 | 2024-03-01 | 学校法人神野学园 | 外用组合物 |
| CN113242734A (zh) * | 2018-11-26 | 2021-08-10 | 艾葳生物科技有限公司 | 用于药物递送的药用生物可溶凝胶 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3311577A (en) * | 1965-03-29 | 1967-03-28 | Burton Parsons Chemicals Inc | Underwater contact lens solution |
| US4100271A (en) * | 1976-02-26 | 1978-07-11 | Cooper Laboratories, Inc. | Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes |
| US4188373A (en) * | 1976-02-26 | 1980-02-12 | Cooper Laboratories, Inc. | Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes |
| DE2714065A1 (de) * | 1977-03-30 | 1978-10-12 | Boehringer Mannheim Gmbh | Instillationszubereitung |
| US4478822A (en) * | 1983-05-16 | 1984-10-23 | Merck & Co., Inc. | Drug delivery system utilizing thermosetting gels |
| US4474752A (en) * | 1983-05-16 | 1984-10-02 | Merck & Co., Inc. | Drug delivery system utilizing thermosetting gels |
| US4474751A (en) * | 1983-05-16 | 1984-10-02 | Merck & Co., Inc. | Ophthalmic drug delivery system utilizing thermosetting gels |
| US4474753A (en) * | 1983-05-16 | 1984-10-02 | Merck & Co., Inc. | Topical drug delivery system utilizing thermosetting gels |
| FR2588189B1 (fr) * | 1985-10-03 | 1988-12-02 | Merck Sharp & Dohme | Composition pharmaceutique de type a transition de phase liquide-gel |
| GB2203039B (en) * | 1987-03-02 | 1990-10-24 | American Cyanamid Co | Stable ophthalmic preparations containing acetazolamide |
| US5252318A (en) * | 1990-06-15 | 1993-10-12 | Allergan, Inc. | Reversible gelation compositions and methods of use |
| US5077033A (en) * | 1990-08-07 | 1991-12-31 | Mediventures Inc. | Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide |
| MX9200339A (es) * | 1991-01-28 | 1992-08-01 | Hoechst Ag | Preparado para la liberacion controlada de sustancias activas, que son apropiadas como terapeuticos o para mejorar el crecimiento y el aprovechamiento de los piensos en rumiantes |
| AU679937B2 (en) * | 1992-11-18 | 1997-07-17 | Johnson & Johnson Consumer Products, Inc. | Extrudable compositions for topical or transdermal drug delivery |
-
1993
- 1993-11-10 CA CA002153234A patent/CA2153234C/en not_active Expired - Fee Related
- 1993-11-10 KR KR1019950703156A patent/KR0162025B1/ko not_active IP Right Cessation
- 1993-11-10 WO PCT/JP1993/001636 patent/WO1994023750A1/ja active IP Right Grant
- 1993-11-10 US US08/397,064 patent/US5624962A/en not_active Expired - Lifetime
- 1993-11-10 DK DK93924801T patent/DK0694310T3/da active
- 1993-11-10 RU RU95122560A patent/RU2108112C1/ru not_active IP Right Cessation
- 1993-11-10 AU AU54333/94A patent/AU668447B2/en not_active Expired
- 1993-11-10 AT AT93924801T patent/ATE189772T1/de not_active IP Right Cessation
- 1993-11-10 DE DE69327878T patent/DE69327878T2/de not_active Expired - Lifetime
- 1993-11-10 EP EP93924801A patent/EP0694310B1/en not_active Expired - Lifetime
- 1993-11-10 HU HU9502086A patent/HU220864B1/hu not_active IP Right Cessation
- 1993-11-10 ES ES93924801T patent/ES2141775T3/es not_active Expired - Lifetime
- 1993-11-15 CN CN93121431A patent/CN1048393C/zh not_active Expired - Lifetime
- 1993-11-16 IL IL107626A patent/IL107626A/xx not_active IP Right Cessation
-
1995
- 1995-07-26 FI FI953575A patent/FI112778B/fi not_active IP Right Cessation
- 1995-08-14 NO NO19953189A patent/NO311635B1/no not_active IP Right Cessation
-
1998
- 1998-12-08 HK HK98112925A patent/HK1017805A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2153234A1 (en) | 1994-10-27 |
| DE69327878D1 (de) | 2000-03-23 |
| FI112778B (fi) | 2004-01-15 |
| AU5433394A (en) | 1994-11-08 |
| AU668447B2 (en) | 1996-05-02 |
| FI953575A (fi) | 1995-07-26 |
| HK1017805A1 (en) | 1999-11-26 |
| HUT71676A (en) | 1996-01-29 |
| RU2108112C1 (ru) | 1998-04-10 |
| CN1048393C (zh) | 2000-01-19 |
| FI953575A0 (fi) | 1995-07-26 |
| KR960700075A (ko) | 1996-01-19 |
| US5624962A (en) | 1997-04-29 |
| NO953189L (no) | 1995-08-14 |
| DK0694310T3 (da) | 2000-06-05 |
| DE69327878T2 (de) | 2000-06-15 |
| HU9502086D0 (en) | 1995-09-28 |
| EP0694310A4 (en) | 1996-04-24 |
| CA2153234C (en) | 1999-02-16 |
| CN1097593A (zh) | 1995-01-25 |
| ES2141775T3 (es) | 2000-04-01 |
| NO953189D0 (no) | 1995-08-14 |
| WO1994023750A1 (en) | 1994-10-27 |
| IL107626A0 (en) | 1994-02-27 |
| EP0694310A1 (en) | 1996-01-31 |
| HU220864B1 (en) | 2002-06-29 |
| ATE189772T1 (de) | 2000-03-15 |
| EP0694310B1 (en) | 2000-02-16 |
| KR0162025B1 (ko) | 1998-12-01 |
| IL107626A (en) | 1997-09-30 |
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