NO304829B1 - 3-substituerte oksindolderivater som kaliumkanalmodulatorer - Google Patents

3-substituerte oksindolderivater som kaliumkanalmodulatorer

Info

Publication number
NO304829B1
NO304829B1 NO962232A NO962232A NO304829B1 NO 304829 B1 NO304829 B1 NO 304829B1 NO 962232 A NO962232 A NO 962232A NO 962232 A NO962232 A NO 962232A NO 304829 B1 NO304829 B1 NO 304829B1
Authority
NO
Norway
Prior art keywords
potassium channel
channel modulators
oxindole derivatives
substituted oxindole
substituted
Prior art date
Application number
NO962232A
Other languages
English (en)
Norwegian (no)
Other versions
NO962232L (no
NO962232D0 (no
Inventor
Piyasena Hewawasam
Valentin K Gribkoff
Nicholas A Meanwell
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NO962232D0 publication Critical patent/NO962232D0/no
Publication of NO962232L publication Critical patent/NO962232L/no
Publication of NO304829B1 publication Critical patent/NO304829B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
NO962232A 1995-06-07 1996-05-31 3-substituerte oksindolderivater som kaliumkanalmodulatorer NO304829B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/477,047 US5565483A (en) 1995-06-07 1995-06-07 3-substituted oxindole derivatives as potassium channel modulators

Publications (3)

Publication Number Publication Date
NO962232D0 NO962232D0 (no) 1996-05-31
NO962232L NO962232L (no) 1996-12-09
NO304829B1 true NO304829B1 (no) 1999-02-22

Family

ID=23894292

Family Applications (1)

Application Number Title Priority Date Filing Date
NO962232A NO304829B1 (no) 1995-06-07 1996-05-31 3-substituerte oksindolderivater som kaliumkanalmodulatorer

Country Status (25)

Country Link
US (2) US5565483A (cs)
EP (1) EP0747354B1 (cs)
JP (1) JP4011135B2 (cs)
KR (1) KR100432157B1 (cs)
CN (1) CN1076348C (cs)
AR (1) AR004493A1 (cs)
AT (1) ATE195515T1 (cs)
AU (1) AU707760B2 (cs)
BR (1) BR1100180A (cs)
CA (1) CA2176183C (cs)
CZ (1) CZ289248B6 (cs)
DE (1) DE69609772T2 (cs)
DK (1) DK0747354T3 (cs)
ES (1) ES2148685T3 (cs)
GR (1) GR3034523T3 (cs)
HU (1) HU222046B1 (cs)
IL (1) IL118349A (cs)
NO (1) NO304829B1 (cs)
NZ (1) NZ286748A (cs)
PL (1) PL184660B1 (cs)
PT (1) PT747354E (cs)
RU (1) RU2165925C2 (cs)
SG (1) SG70572A1 (cs)
TW (1) TW384284B (cs)
ZA (1) ZA964327B (cs)

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US6355648B1 (en) * 1999-05-04 2002-03-12 American Home Products Corporation Thio-oxindole derivatives
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US6846813B2 (en) * 2000-06-30 2005-01-25 Pharmacia & Upjohn Company Compounds to treat alzheimer's disease
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US7632866B2 (en) * 2002-10-21 2009-12-15 Ramot At Tel Aviv University Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators
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TW200734334A (en) * 2006-01-13 2007-09-16 Wyeth Corp Treatment of substance abuse
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JP2009531434A (ja) * 2006-03-24 2009-09-03 ワイス 痛みの治療
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US8252559B2 (en) * 2006-08-04 2012-08-28 The California Institute Of Technology Methods and systems for selective fluorination of organic molecules
US8802401B2 (en) * 2007-06-18 2014-08-12 The California Institute Of Technology Methods and compositions for preparation of selectively protected carbohydrates
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CN107835814B (zh) 2015-04-29 2021-07-23 詹森药业有限公司 氮杂苯并咪唑及其作为ampa受体调节剂的用途
KR20170141769A (ko) * 2015-04-29 2017-12-26 얀센 파마슈티카 엔.브이. 인돌론 화합물 및 ampa 수용체 조절제로서의 이의 용도
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AU2018349376A1 (en) 2017-10-09 2020-05-07 Ramot At Tel-Aviv University Ltd. Modulators of potassium ion and TRPV1 channels and uses thereof
WO2020153407A1 (ja) * 2019-01-25 2020-07-30 Ｊｆｅスチール株式会社 高マンガン鋼鋳片の製造方法、および、高マンガン鋼鋼片または鋼板の製造方法
CN110240558B (zh) * 2019-07-10 2022-05-27 上海华理生物医药股份有限公司 一种Flindokalner消旋体的新合成方法
KR102209406B1 (ko) * 2019-11-21 2021-01-29 주식회사 포스코 미세한 주조조직을 갖는 고망간강 및 그 제조방법과 이를 이용한 고망간 강판
EP3912625A1 (en) 2020-05-20 2021-11-24 Kaerus Bioscience Limited Novel maxi-k potassium channel openers for the treatment of fragile x associated disorders
WO2025233532A1 (en) 2024-05-10 2025-11-13 Les Laboratoires Servier Maxi-k potassium channel openers and therapeutic applications thereof

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Also Published As

Publication number Publication date
DE69609772D1 (de) 2000-09-21
HK1003301A1 (en) 1998-10-23
HUP9601547A1 (en) 1997-09-29
TW384284B (en) 2000-03-11
DE69609772T2 (de) 2001-04-12
US5602169A (en) 1997-02-11
PT747354E (pt) 2000-11-30
CZ289248B6 (cs) 2001-12-12
KR100432157B1 (ko) 2004-10-06
KR970001324A (ko) 1997-01-24
CN1144800A (zh) 1997-03-12
AU707760B2 (en) 1999-07-22
JP4011135B2 (ja) 2007-11-21
EP0747354A1 (en) 1996-12-11
PL184660B1 (pl) 2002-11-29
NO962232L (no) 1996-12-09
AR004493A1 (es) 1998-12-16
AU5475796A (en) 1996-12-19
DK0747354T3 (da) 2000-09-18
ZA964327B (en) 1997-11-28
CA2176183C (en) 2010-03-30
GR3034523T3 (en) 2000-12-29
NZ286748A (en) 1998-08-26
CZ161896A3 (en) 1997-03-12
NO962232D0 (no) 1996-05-31
IL118349A (en) 2000-07-26
HU222046B1 (hu) 2003-04-28
SG70572A1 (en) 2000-02-22
ES2148685T3 (es) 2000-10-16
RU2165925C2 (ru) 2001-04-27
JPH08333336A (ja) 1996-12-17
CA2176183A1 (en) 1996-12-08
PL314672A1 (en) 1996-12-09
US5565483A (en) 1996-10-15
IL118349A0 (en) 1996-09-12
EP0747354B1 (en) 2000-08-16
CN1076348C (zh) 2001-12-19
HU9601547D0 (en) 1996-08-28
ATE195515T1 (de) 2000-09-15
BR1100180A (pt) 2000-03-14

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