NO301278B1 - Fremgangsmåte for fremstilling av et konsentrat av human von Willebrand faktor - Google Patents
Fremgangsmåte for fremstilling av et konsentrat av human von Willebrand faktor Download PDFInfo
- Publication number
- NO301278B1 NO301278B1 NO920867A NO920867A NO301278B1 NO 301278 B1 NO301278 B1 NO 301278B1 NO 920867 A NO920867 A NO 920867A NO 920867 A NO920867 A NO 920867A NO 301278 B1 NO301278 B1 NO 301278B1
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- NO
- Norway
- Prior art keywords
- von willebrand
- vwf
- willebrand factor
- concentrate
- chromatography
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
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- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9102804A FR2673632A1 (fr) | 1991-03-08 | 1991-03-08 | Procede de preparation de concentre de facteur von willebrand humain de tres haute purete, approprie a un usage therapeutique. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO920867D0 NO920867D0 (no) | 1992-03-05 |
| NO920867L NO920867L (no) | 1992-09-09 |
| NO301278B1 true NO301278B1 (no) | 1997-10-06 |
Family
ID=9410505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO920867A NO301278B1 (no) | 1991-03-08 | 1992-03-05 | Fremgangsmåte for fremstilling av et konsentrat av human von Willebrand faktor |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US5408039A (et) |
| EP (1) | EP0503991B1 (et) |
| JP (1) | JP3435668B2 (et) |
| AT (1) | AT407115B (et) |
| AU (1) | AU645172B2 (et) |
| BE (1) | BE1004178A3 (et) |
| BR (1) | BR9200770A (et) |
| CA (1) | CA2062340C (et) |
| CZ (1) | CZ283633B6 (et) |
| DE (2) | DE69227055T2 (et) |
| DK (1) | DK0503991T3 (et) |
| EE (1) | EE03057B1 (et) |
| EG (1) | EG20300A (et) |
| ES (1) | ES2121830T3 (et) |
| FI (1) | FI106721B (et) |
| FR (1) | FR2673632A1 (et) |
| HU (1) | HU215098B (et) |
| IL (1) | IL101043A (et) |
| IT (1) | IT1256692B (et) |
| LT (1) | LT3175B (et) |
| NL (1) | NL300394I1 (et) |
| NO (1) | NO301278B1 (et) |
| NZ (1) | NZ241701A (et) |
| PL (1) | PL168353B1 (et) |
| RU (1) | RU2088590C1 (et) |
| SA (1) | SA92120446B1 (et) |
| SK (1) | SK279533B6 (et) |
| UA (1) | UA27732C2 (et) |
| ZA (1) | ZA921430B (et) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4435392B4 (de) * | 1994-10-04 | 2008-02-07 | Immuno Ag | Verfahren zur Trennung von vWF in hochmolekularen vWF und niedermolekularen vWF |
| DE4435485C1 (de) * | 1994-10-04 | 1996-03-21 | Immuno Ag | Verfahren zur Gewinnung von hochreinem von Willebrand-Faktor |
| DE4437544A1 (de) * | 1994-10-20 | 1996-04-25 | Behringwerke Ag | Einsatz von vWF-enthaltenden Konzentraten als Kombinationstherapie bei Therapie mit Antithrombotika und Fibrinolytika |
| US5659017A (en) * | 1995-11-07 | 1997-08-19 | Alpha Therapeutic Corporation | Anion exchange process for the purification of Factor VIII |
| DE19616540A1 (de) * | 1995-11-10 | 1997-05-15 | Immuno Ag | Verwendung von von Willebrand-Faktor und pharmazeutische Zubereitung |
| US6005077A (en) * | 1995-11-10 | 1999-12-21 | Immuno Aktiengesellschaft | Use of von willebrand factor and pharmaceutical formulation |
| AT403764B (de) | 1996-03-15 | 1998-05-25 | Immuno Ag | Stabiler faktor viii/vwf-komplex |
| US6068838A (en) * | 1996-04-29 | 2000-05-30 | Baxter Aktiengesellschaft | Purified multimerase |
| AT404358B (de) | 1997-02-04 | 1998-11-25 | Immuno Ag | Verfahren zur chromatographischen reinigung bzw. fraktionierung von von willebrand-faktor aus einem vwf-hältigen ausgangsmaterial |
| AT405403B (de) | 1997-02-27 | 1999-08-25 | Immuno Ag | Reinigung von von willebrand-faktor durch kationenaustauscherchromatographie |
| AT405485B (de) * | 1997-05-28 | 1999-08-25 | Immuno Ag | Eine das vwf-propeptid enthaltende pharmazeutische präparation |
| DE60035260T2 (de) | 1999-02-22 | 2007-10-18 | The University Of Connecticut, Farmington | Neue albuminfreie faktor viii formulierungen |
| EP1148063A1 (de) * | 2000-04-18 | 2001-10-24 | Octapharma AG | Haemostatisch aktives vWF enthaltendes Präparat und Verfahren zu seiner Herstellung |
| EP1593388A1 (en) * | 2004-05-05 | 2005-11-09 | ZLB Behring GmbH | Therapeutic plasma protein-concentrates containing von willebrand factor as high molecular weight multimers |
| FR2874216B1 (fr) | 2004-08-16 | 2006-11-03 | Lab Francais Du Fractionnement | Procede de preparation d'un concentre de facteur von willebrand (fvw) par voie chromatographique et concentre de fvw susceptible d'etre ainsi obtenu |
| DE102004044429B4 (de) * | 2004-09-14 | 2009-04-30 | Biotest Ag | Verfahren zur Herstellung einer Zusammensetzung enthaltend von Willebrand Faktor |
| DE102004044419B4 (de) | 2004-09-14 | 2010-04-15 | Biotest Ag | Verfahren zur Aufreinigung eines von Willebrand Faktors mittels Hydroxylapatit-Durchlaufchromatographie |
| ITLU20070007A1 (it) * | 2007-05-07 | 2008-11-08 | Kedrion Spa | Processo cromatografico per l'ottenimento di un complesso fviii/vwf con differenti rapporti tra le due proteine da utilizzare nella terapia della emofilia a e nella malattia di von willebrand. |
| WO2008151817A1 (en) | 2007-06-13 | 2008-12-18 | Csl Behring Gmbh | Use of vwf stabilized fviii preparations and of vwf preparations without fviii for extravascular administration in the therapy and prophylactic treatment of bleeding disorders |
| FR2920429B1 (fr) * | 2007-08-30 | 2012-10-05 | Lfb Biotechnologies | Procede de purification du facteur viii et du facteur von willebrand |
| EP2073015A1 (en) | 2007-12-21 | 2009-06-24 | CSL Behring GmbH | Diagnostic in vitro method for assessing Von Willebrand Disease and bleeding risk associated with Von Willebrand Disease and acquired or congenital disorders of platelet function |
| US20100273206A1 (en) * | 2007-12-21 | 2010-10-28 | Manfred Rauh | Diagnostic in vitro method for assessing von willebrand disease and increased bleeding risk associated with von willebrand disease and acquired or congenital disorders of platelet function |
| PL2291523T3 (pl) | 2008-06-24 | 2015-05-29 | Csl Behring Gmbh | Czynnik VIII, czynnik von Willebranda lub ich kompleksy o wydłużonym okresie półtrwania in vivo |
| NZ593190A (en) | 2008-11-07 | 2013-01-25 | Baxter Int | Factor viii formulations |
| IT1396528B1 (it) | 2009-01-19 | 2012-12-14 | Kedrion Spa | Nuovo processo di purificazione altamente selettivo di due proteine plasmatiche: von willebrand factor (vwf) e fibronectina (fn). |
| CA2770609A1 (en) | 2009-08-20 | 2011-02-24 | Csl Behring Gmbh | Albumin fused coagulation factors for non-intravenous administration in the therapy and prophylactic treatment of bleeding disorders |
| SG191186A1 (en) | 2010-12-15 | 2013-07-31 | Baxter Int | Eluate collection using conductivity gradient |
| JP6072810B2 (ja) | 2011-10-18 | 2017-02-01 | ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー | 第ｖｉｉｉ因子の生物学的利用能を改善するための硫酸化グリコサミノグリカンの使用 |
| WO2013057171A1 (en) | 2011-10-18 | 2013-04-25 | Csl Behring Gmbh | Combined use of a sulfated glycosaminoglycan and a hyaluronidase for improving the bioavailability of factor viii |
| EP2814502B1 (en) | 2012-02-15 | 2017-09-13 | CSL Behring GmbH | Von willebrand factor variants having improved factor viii binding affinity |
| ES2657291T3 (es) | 2013-04-22 | 2018-03-02 | Csl Ltd. | Un complejo covalente de factor de von Willebrand y factor VIII asociado por un puente disulfuro |
| ES2693380T3 (es) * | 2013-11-08 | 2018-12-11 | Csl Limited | Nuevo método para concentrar el factor de von Willebrand o complejos de este |
| DK3164150T3 (da) | 2014-07-02 | 2021-02-08 | CSL Behring Lengnau AG | Modificeret von willebrand-faktor |
| US10626164B2 (en) | 2014-07-25 | 2020-04-21 | Csl Limited | Purification of VWF |
| FR3034669B1 (fr) | 2015-04-07 | 2020-02-14 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Nouvelle utilisation du facteur von willebrand |
| CN115925781A (zh) * | 2015-10-15 | 2023-04-07 | 普莱泽玛科技有限公司 | 从血浆中提取蛋白质的方法 |
| EP3400238B1 (en) | 2016-01-07 | 2021-05-19 | CSL Behring Lengnau AG | Mutated von willebrand factor |
| DK3400002T3 (da) | 2016-01-07 | 2022-04-11 | CSL Behring Lengnau AG | Muteret, trunkeret von willebrand faktor |
| CN105541997A (zh) * | 2016-02-04 | 2016-05-04 | 江西博雅生物制药股份有限公司 | 一种高纯度和高活性血管性血友病因子的制备工艺 |
| CN105622747A (zh) * | 2016-02-04 | 2016-06-01 | 江西博雅生物制药股份有限公司 | 一种vWF活性保护液 |
| CN105622746A (zh) * | 2016-02-04 | 2016-06-01 | 江西博雅生物制药股份有限公司 | 一种从冷沉淀提取凝血因子ⅷ的废料中提取人血管性血友病因子的制备工艺 |
| EP3488858A1 (en) | 2017-11-27 | 2019-05-29 | Laboratoire Français du Fractionnement et des Biotechnologies | A von willebrand factor composition for use in treating a pathology mediated by angiogenesis |
| CN114249812B (zh) * | 2020-09-22 | 2023-09-15 | 四川远大蜀阳药业有限责任公司 | 一种降低vWF制品中IgM含量的方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61166542A (ja) * | 1985-01-18 | 1986-07-28 | Hitachi Chem Co Ltd | 感光性組成物 |
| US4970300A (en) * | 1985-02-01 | 1990-11-13 | New York University | Modified factor VIII |
| US5006642A (en) * | 1987-06-29 | 1991-04-09 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Purification of von Willebrand Factor by affinity chromatography |
| FR2632309B1 (fr) * | 1988-06-07 | 1990-08-24 | Lille Transfusion Sanguine | Procede de purification par voie chromatographique de proteines, notamment de facteur viii, et les produits obtenus |
-
1991
- 1991-03-08 FR FR9102804A patent/FR2673632A1/fr active Granted
-
1992
- 1992-02-19 AU AU11131/92A patent/AU645172B2/en not_active Expired
- 1992-02-24 NZ NZ241701A patent/NZ241701A/en not_active IP Right Cessation
- 1992-02-24 IL IL10104392A patent/IL101043A/xx not_active IP Right Cessation
- 1992-02-26 ZA ZA921430A patent/ZA921430B/xx unknown
- 1992-02-26 CZ CS92568A patent/CZ283633B6/cs not_active IP Right Cessation
- 1992-02-26 SK SK568-92A patent/SK279533B6/sk not_active IP Right Cessation
- 1992-02-27 DE DE69227055T patent/DE69227055T2/de not_active Expired - Lifetime
- 1992-02-27 DE DE122009000034C patent/DE122009000034I2/de active Active
- 1992-02-27 EP EP92400505A patent/EP0503991B1/fr not_active Expired - Lifetime
- 1992-02-27 DK DK92400505T patent/DK0503991T3/da active
- 1992-02-27 ES ES92400505T patent/ES2121830T3/es not_active Expired - Lifetime
- 1992-03-03 JP JP08030592A patent/JP3435668B2/ja not_active Expired - Lifetime
- 1992-03-04 BE BE9200215A patent/BE1004178A3/fr not_active IP Right Cessation
- 1992-03-05 NO NO920867A patent/NO301278B1/no not_active IP Right Cessation
- 1992-03-05 CA CA002062340A patent/CA2062340C/fr not_active Expired - Lifetime
- 1992-03-06 IT ITTO920189A patent/IT1256692B/it active IP Right Grant
- 1992-03-06 PL PL92293738A patent/PL168353B1/pl unknown
- 1992-03-06 AT AT0043692A patent/AT407115B/de not_active IP Right Cessation
- 1992-03-06 BR BR929200770A patent/BR9200770A/pt not_active Application Discontinuation
- 1992-03-06 FI FI920992A patent/FI106721B/fi active
- 1992-03-06 US US07/846,852 patent/US5408039A/en not_active Expired - Lifetime
- 1992-03-06 HU HU9200767A patent/HU215098B/hu not_active IP Right Cessation
- 1992-03-06 RU SU925011041A patent/RU2088590C1/ru active
- 1992-03-07 EG EG13192A patent/EG20300A/xx active
- 1992-04-18 SA SA92120446A patent/SA92120446B1/ar unknown
- 1992-12-30 LT LTIP266A patent/LT3175B/lt not_active IP Right Cessation
-
1993
- 1993-05-21 UA UA93002713A patent/UA27732C2/uk unknown
-
1994
- 1994-05-23 EE EE9400004A patent/EE03057B1/et not_active IP Right Cessation
-
2009
- 2009-07-07 NL NL300394C patent/NL300394I1/nl unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |