IL101043A - Industrial-scale preparation of a standardized human von willebrand factor concentrate of very high purity and suitable for therapeutic use - Google Patents

Industrial-scale preparation of a standardized human von willebrand factor concentrate of very high purity and suitable for therapeutic use

Info

Publication number
IL101043A
IL101043A IL10104392A IL10104392A IL101043A IL 101043 A IL101043 A IL 101043A IL 10104392 A IL10104392 A IL 10104392A IL 10104392 A IL10104392 A IL 10104392A IL 101043 A IL101043 A IL 101043A
Authority
IL
Israel
Prior art keywords
industrial
high purity
therapeutic use
von willebrand
willebrand factor
Prior art date
Application number
IL10104392A
Other languages
English (en)
Other versions
IL101043A0 (en
Inventor
Miryana Burnouf-Radosevich
Thierry Burnouf
Original Assignee
Centre Regional De Transfusion
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Regional De Transfusion filed Critical Centre Regional De Transfusion
Publication of IL101043A0 publication Critical patent/IL101043A0/xx
Publication of IL101043A publication Critical patent/IL101043A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IL10104392A 1991-03-08 1992-02-24 Industrial-scale preparation of a standardized human von willebrand factor concentrate of very high purity and suitable for therapeutic use IL101043A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9102804A FR2673632A1 (fr) 1991-03-08 1991-03-08 Procede de preparation de concentre de facteur von willebrand humain de tres haute purete, approprie a un usage therapeutique.

Publications (2)

Publication Number Publication Date
IL101043A0 IL101043A0 (en) 1992-11-15
IL101043A true IL101043A (en) 1997-02-18

Family

ID=9410505

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10104392A IL101043A (en) 1991-03-08 1992-02-24 Industrial-scale preparation of a standardized human von willebrand factor concentrate of very high purity and suitable for therapeutic use

Country Status (29)

Country Link
US (1) US5408039A (et)
EP (1) EP0503991B1 (et)
JP (1) JP3435668B2 (et)
AT (1) AT407115B (et)
AU (1) AU645172B2 (et)
BE (1) BE1004178A3 (et)
BR (1) BR9200770A (et)
CA (1) CA2062340C (et)
CZ (1) CZ283633B6 (et)
DE (2) DE69227055T2 (et)
DK (1) DK0503991T3 (et)
EE (1) EE03057B1 (et)
EG (1) EG20300A (et)
ES (1) ES2121830T3 (et)
FI (1) FI106721B (et)
FR (1) FR2673632A1 (et)
HU (1) HU215098B (et)
IL (1) IL101043A (et)
IT (1) IT1256692B (et)
LT (1) LT3175B (et)
NL (1) NL300394I1 (et)
NO (1) NO301278B1 (et)
NZ (1) NZ241701A (et)
PL (1) PL168353B1 (et)
RU (1) RU2088590C1 (et)
SA (1) SA92120446B1 (et)
SK (1) SK279533B6 (et)
UA (1) UA27732C2 (et)
ZA (1) ZA921430B (et)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4435392B4 (de) * 1994-10-04 2008-02-07 Immuno Ag Verfahren zur Trennung von vWF in hochmolekularen vWF und niedermolekularen vWF
DE4435485C1 (de) * 1994-10-04 1996-03-21 Immuno Ag Verfahren zur Gewinnung von hochreinem von Willebrand-Faktor
DE4437544A1 (de) * 1994-10-20 1996-04-25 Behringwerke Ag Einsatz von vWF-enthaltenden Konzentraten als Kombinationstherapie bei Therapie mit Antithrombotika und Fibrinolytika
US5659017A (en) * 1995-11-07 1997-08-19 Alpha Therapeutic Corporation Anion exchange process for the purification of Factor VIII
DE19616540A1 (de) * 1995-11-10 1997-05-15 Immuno Ag Verwendung von von Willebrand-Faktor und pharmazeutische Zubereitung
US6005077A (en) * 1995-11-10 1999-12-21 Immuno Aktiengesellschaft Use of von willebrand factor and pharmaceutical formulation
AT403764B (de) 1996-03-15 1998-05-25 Immuno Ag Stabiler faktor viii/vwf-komplex
US6068838A (en) * 1996-04-29 2000-05-30 Baxter Aktiengesellschaft Purified multimerase
AT404358B (de) * 1997-02-04 1998-11-25 Immuno Ag Verfahren zur chromatographischen reinigung bzw. fraktionierung von von willebrand-faktor aus einem vwf-hältigen ausgangsmaterial
AT405403B (de) 1997-02-27 1999-08-25 Immuno Ag Reinigung von von willebrand-faktor durch kationenaustauscherchromatographie
AT405485B (de) * 1997-05-28 1999-08-25 Immuno Ag Eine das vwf-propeptid enthaltende pharmazeutische präparation
JP5149470B2 (ja) 1999-02-22 2013-02-20 バクスター・インターナショナル・インコーポレイテッド 新規のアルブミンを含有していない第ｖｉｉｉ因子処方物
EP1148063A1 (de) * 2000-04-18 2001-10-24 Octapharma AG Haemostatisch aktives vWF enthaltendes Präparat und Verfahren zu seiner Herstellung
EP1593388A1 (en) * 2004-05-05 2005-11-09 ZLB Behring GmbH Therapeutic plasma protein-concentrates containing von willebrand factor as high molecular weight multimers
FR2874216B1 (fr) 2004-08-16 2006-11-03 Lab Francais Du Fractionnement Procede de preparation d'un concentre de facteur von willebrand (fvw) par voie chromatographique et concentre de fvw susceptible d'etre ainsi obtenu
DE102004044419B4 (de) 2004-09-14 2010-04-15 Biotest Ag Verfahren zur Aufreinigung eines von Willebrand Faktors mittels Hydroxylapatit-Durchlaufchromatographie
DE102004044429B4 (de) * 2004-09-14 2009-04-30 Biotest Ag Verfahren zur Herstellung einer Zusammensetzung enthaltend von Willebrand Faktor
ITLU20070007A1 (it) * 2007-05-07 2008-11-08 Kedrion Spa Processo cromatografico per l'ottenimento di un complesso fviii/vwf con differenti rapporti tra le due proteine da utilizzare nella terapia della emofilia a e nella malattia di von willebrand.
AU2008261261B2 (en) 2007-06-13 2013-06-27 Csl Behring Gmbh Use of VWF stabilized FVIII preparations and of VWF preparations without FVIII for extravascular administration in the therapy and prophylactic treatment of bleeding disorders
FR2920429B1 (fr) * 2007-08-30 2012-10-05 Lfb Biotechnologies Procede de purification du facteur viii et du facteur von willebrand
EP2073015A1 (en) 2007-12-21 2009-06-24 CSL Behring GmbH Diagnostic in vitro method for assessing Von Willebrand Disease and bleeding risk associated with Von Willebrand Disease and acquired or congenital disorders of platelet function
US20100273206A1 (en) * 2007-12-21 2010-10-28 Manfred Rauh Diagnostic in vitro method for assessing von willebrand disease and increased bleeding risk associated with von willebrand disease and acquired or congenital disorders of platelet function
KR101507718B1 (ko) 2008-06-24 2015-04-10 체에스엘 베링 게엠베하 연장된 생체내 반감기를 갖는 인자 ｖｉｉｉ, 폰 빌레브란트 인자 또는 이들의 복합체
NZ593190A (en) 2008-11-07 2013-01-25 Baxter Int Factor viii formulations
IT1396528B1 (it) 2009-01-19 2012-12-14 Kedrion Spa Nuovo processo di purificazione altamente selettivo di due proteine plasmatiche: von willebrand factor (vwf) e fibronectina (fn).
AU2010284977A1 (en) 2009-08-20 2012-03-29 Csl Behring Gmbh Albumin fused coagulation factors for non-intravenous administration in the therapy and prophylactic treatment of bleeding disorders
AU2011343813B2 (en) 2010-12-15 2015-05-21 Takeda Pharmaceutical Company Limited Eluate collection using conductivity gradient
EP2768521B1 (en) 2011-10-18 2016-07-13 CSL Behring GmbH Combined use of a sulfated glycosaminoglycan and a hyaluronidase for improving the bioavailability of factor viii
KR20140083036A (ko) 2011-10-18 2014-07-03 체에스엘 베링 게엠베하 인자 ｖｉｉｉ의 생체이용률을 향상시키기 위한 황산화 글리코사미노글리칸의 용도
PL2814502T3 (pl) 2012-02-15 2018-02-28 Csl Behring Gmbh Warianty czynnika von Willebranda mające ulepszone powinowactwo do wiązania czynnika VIII
EP2796145B1 (en) 2013-04-22 2017-11-01 CSL Ltd. A covalent complex of von willebrand factor and faktor viii linked by a disulphide bridge
WO2015066769A1 (en) 2013-11-08 2015-05-14 Csl Ltd. New method to concentrate von willebrand factor or complexes thereof
BR112016030950A2 (pt) 2014-07-02 2018-03-27 Csl Ltd polipeptídeo modificado que se liga ao fator viii, complexo, composição farmacêutica, métodos para tratar uma coagulopatia, para produzir um polipeptídeo que compreende um vwf modificado e para aumentar a afinidade de ligação ao fator viii do vwf e a meia-vida do fator viii, uso de um polipeptídeo modificado ou de um complexo, polinucleotídeo, plasmídeo ou vetor, e, célula hospedeira.
US10626164B2 (en) 2014-07-25 2020-04-21 Csl Limited Purification of VWF
FR3034669B1 (fr) 2015-04-07 2020-02-14 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Nouvelle utilisation du facteur von willebrand
CN108473530B (zh) * 2015-10-15 2022-12-23 普莱泽玛科技有限公司 从血浆中提取蛋白质的方法
RU2018128582A (ru) 2016-01-07 2020-02-11 Цсл Беринг Ленгнау Аг Мутированный укороченный фактор фон виллебранда
CN108779165B (zh) 2016-01-07 2022-12-02 康诺贝林伦瑙有限公司 突变的冯·维勒布兰德因子
CN105622746A (zh) * 2016-02-04 2016-06-01 江西博雅生物制药股份有限公司 一种从冷沉淀提取凝血因子ⅷ的废料中提取人血管性血友病因子的制备工艺
CN105541997A (zh) * 2016-02-04 2016-05-04 江西博雅生物制药股份有限公司 一种高纯度和高活性血管性血友病因子的制备工艺
CN105622747A (zh) * 2016-02-04 2016-06-01 江西博雅生物制药股份有限公司 一种vWF活性保护液
EP3488858A1 (en) 2017-11-27 2019-05-29 Laboratoire Français du Fractionnement et des Biotechnologies A von willebrand factor composition for use in treating a pathology mediated by angiogenesis
CN114249812B (zh) * 2020-09-22 2023-09-15 四川远大蜀阳药业有限责任公司 一种降低vWF制品中IgM含量的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61166542A (ja) * 1985-01-18 1986-07-28 Hitachi Chem Co Ltd 感光性組成物
US4970300A (en) * 1985-02-01 1990-11-13 New York University Modified factor VIII
US5006642A (en) * 1987-06-29 1991-04-09 Rhone-Poulenc Rorer Pharmaceuticals Inc. Purification of von Willebrand Factor by affinity chromatography
FR2632309B1 (fr) * 1988-06-07 1990-08-24 Lille Transfusion Sanguine Procede de purification par voie chromatographique de proteines, notamment de facteur viii, et les produits obtenus

Also Published As

Publication number Publication date
BR9200770A (pt) 1992-11-17
UA27732C2 (uk) 2000-10-16
JPH0597696A (ja) 1993-04-20
EG20300A (fr) 1998-10-31
IT1256692B (it) 1995-12-12
CA2062340C (fr) 2000-05-09
JP3435668B2 (ja) 2003-08-11
SK279533B6 (sk) 1998-12-02
NO301278B1 (no) 1997-10-06
FI920992A (fi) 1992-09-09
FI106721B (fi) 2001-03-30
BE1004178A3 (fr) 1992-10-06
EP0503991A1 (fr) 1992-09-16
PL168353B1 (pl) 1996-02-29
CA2062340A1 (fr) 1992-09-09
HU215098B (hu) 1998-09-28
AT407115B (de) 2000-12-27
EE03057B1 (et) 1997-12-15
PL293738A1 (en) 1992-09-21
DE122009000034I1 (de) 2010-04-08
FR2673632A1 (fr) 1992-09-11
NO920867D0 (no) 1992-03-05
RU2088590C1 (ru) 1997-08-27
DK0503991T3 (da) 1999-06-14
LTIP266A (en) 1994-07-15
NZ241701A (en) 1994-10-26
DE122009000034I2 (de) 2011-06-16
ES2121830T3 (es) 1998-12-16
CS56892A3 (en) 1992-09-16
AU645172B2 (en) 1994-01-06
SA92120446B1 (ar) 2004-05-04
DE69227055D1 (de) 1998-10-29
NL300394I1 (nl) 2009-09-01
US5408039A (en) 1995-04-18
ITTO920189A0 (it) 1992-03-06
IL101043A0 (en) 1992-11-15
NO920867L (no) 1992-09-09
LT3175B (en) 1995-02-27
ATA43692A (de) 2000-05-15
HUT63176A (en) 1993-07-28
EP0503991B1 (fr) 1998-09-23
CZ283633B6 (cs) 1998-05-13
FI920992A0 (fi) 1992-03-06
AU1113192A (en) 1992-09-10
ITTO920189A1 (it) 1993-09-06
DE69227055T2 (de) 1999-04-22
HU9200767D0 (en) 1992-05-28
FR2673632B1 (et) 1995-05-05
ZA921430B (en) 1992-11-25

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