FI920992A - Foerfarande foer framstaellning av i industriell skala av ett standardiserat koncentrat av human von willebrand-faktor, vilket har synnerligen hoeg renhet och aer laempligt foer terapeutisk anvaendning - Google Patents

Foerfarande foer framstaellning av i industriell skala av ett standardiserat koncentrat av human von willebrand-faktor, vilket har synnerligen hoeg renhet och aer laempligt foer terapeutisk anvaendning Download PDF

Info

Publication number
FI920992A
FI920992A FI920992A FI920992A FI920992A FI 920992 A FI920992 A FI 920992A FI 920992 A FI920992 A FI 920992A FI 920992 A FI920992 A FI 920992A FI 920992 A FI920992 A FI 920992A
Authority
FI
Finland
Prior art keywords
foer
synnerligen
standardiserat
renhet
laempligt
Prior art date
Application number
FI920992A
Other languages
English (en)
Other versions
FI106721B (fi
FI920992A0 (fi
Inventor
Miryana Burnouf-Radosevich
Thierry Burnouf
Original Assignee
Centre Regional De Transfusion
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Regional De Transfusion filed Critical Centre Regional De Transfusion
Publication of FI920992A0 publication Critical patent/FI920992A0/fi
Publication of FI920992A publication Critical patent/FI920992A/fi
Application granted granted Critical
Publication of FI106721B publication Critical patent/FI106721B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
FI920992A 1991-03-08 1992-03-06 Menetelmä ihmisen standardisoidun, korkean puhtauden omaavan von Willebrand -tekijän konsentraatin valmistamiseksi FI106721B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9102804 1991-03-08
FR9102804A FR2673632A1 (fr) 1991-03-08 1991-03-08 Procede de preparation de concentre de facteur von willebrand humain de tres haute purete, approprie a un usage therapeutique.

Publications (3)

Publication Number Publication Date
FI920992A0 FI920992A0 (fi) 1992-03-06
FI920992A true FI920992A (fi) 1992-09-09
FI106721B FI106721B (fi) 2001-03-30

Family

ID=9410505

Family Applications (1)

Application Number Title Priority Date Filing Date
FI920992A FI106721B (fi) 1991-03-08 1992-03-06 Menetelmä ihmisen standardisoidun, korkean puhtauden omaavan von Willebrand -tekijän konsentraatin valmistamiseksi

Country Status (29)

Country Link
US (1) US5408039A (fi)
EP (1) EP0503991B1 (fi)
JP (1) JP3435668B2 (fi)
AT (1) AT407115B (fi)
AU (1) AU645172B2 (fi)
BE (1) BE1004178A3 (fi)
BR (1) BR9200770A (fi)
CA (1) CA2062340C (fi)
CZ (1) CZ283633B6 (fi)
DE (2) DE69227055T2 (fi)
DK (1) DK0503991T3 (fi)
EE (1) EE03057B1 (fi)
EG (1) EG20300A (fi)
ES (1) ES2121830T3 (fi)
FI (1) FI106721B (fi)
FR (1) FR2673632A1 (fi)
HU (1) HU215098B (fi)
IL (1) IL101043A (fi)
IT (1) IT1256692B (fi)
LT (1) LT3175B (fi)
NL (1) NL300394I1 (fi)
NO (1) NO301278B1 (fi)
NZ (1) NZ241701A (fi)
PL (1) PL168353B1 (fi)
RU (1) RU2088590C1 (fi)
SA (1) SA92120446B1 (fi)
SK (1) SK279533B6 (fi)
UA (1) UA27732C2 (fi)
ZA (1) ZA921430B (fi)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4435392B4 (de) * 1994-10-04 2008-02-07 Immuno Ag Verfahren zur Trennung von vWF in hochmolekularen vWF und niedermolekularen vWF
DE4435485C1 (de) * 1994-10-04 1996-03-21 Immuno Ag Verfahren zur Gewinnung von hochreinem von Willebrand-Faktor
DE4437544A1 (de) * 1994-10-20 1996-04-25 Behringwerke Ag Einsatz von vWF-enthaltenden Konzentraten als Kombinationstherapie bei Therapie mit Antithrombotika und Fibrinolytika
US5659017A (en) * 1995-11-07 1997-08-19 Alpha Therapeutic Corporation Anion exchange process for the purification of Factor VIII
DE19616540A1 (de) * 1995-11-10 1997-05-15 Immuno Ag Verwendung von von Willebrand-Faktor und pharmazeutische Zubereitung
US6005077A (en) * 1995-11-10 1999-12-21 Immuno Aktiengesellschaft Use of von willebrand factor and pharmaceutical formulation
AT403764B (de) 1996-03-15 1998-05-25 Immuno Ag Stabiler faktor viii/vwf-komplex
US6068838A (en) * 1996-04-29 2000-05-30 Baxter Aktiengesellschaft Purified multimerase
AT404358B (de) 1997-02-04 1998-11-25 Immuno Ag Verfahren zur chromatographischen reinigung bzw. fraktionierung von von willebrand-faktor aus einem vwf-hältigen ausgangsmaterial
AT405403B (de) 1997-02-27 1999-08-25 Immuno Ag Reinigung von von willebrand-faktor durch kationenaustauscherchromatographie
AT405485B (de) * 1997-05-28 1999-08-25 Immuno Ag Eine das vwf-propeptid enthaltende pharmazeutische präparation
BR0008405B1 (pt) 1999-02-22 2014-04-22 Baxter Int Composição de fator viii formulada sem a adição de albumina, uso de uma composição de fator viii, e, método de liofilizar uma formulação farmacêutica aquosa
EP1148063A1 (de) * 2000-04-18 2001-10-24 Octapharma AG Haemostatisch aktives vWF enthaltendes Präparat und Verfahren zu seiner Herstellung
EP1593388A1 (en) * 2004-05-05 2005-11-09 ZLB Behring GmbH Therapeutic plasma protein-concentrates containing von willebrand factor as high molecular weight multimers
FR2874216B1 (fr) 2004-08-16 2006-11-03 Lab Francais Du Fractionnement Procede de preparation d'un concentre de facteur von willebrand (fvw) par voie chromatographique et concentre de fvw susceptible d'etre ainsi obtenu
DE102004044419B4 (de) 2004-09-14 2010-04-15 Biotest Ag Verfahren zur Aufreinigung eines von Willebrand Faktors mittels Hydroxylapatit-Durchlaufchromatographie
DE102004044429B4 (de) * 2004-09-14 2009-04-30 Biotest Ag Verfahren zur Herstellung einer Zusammensetzung enthaltend von Willebrand Faktor
ITLU20070007A1 (it) * 2007-05-07 2008-11-08 Kedrion Spa Processo cromatografico per l'ottenimento di un complesso fviii/vwf con differenti rapporti tra le due proteine da utilizzare nella terapia della emofilia a e nella malattia di von willebrand.
DK2167117T3 (da) 2007-06-13 2012-11-19 Csl Behring Gmbh Anvendelse af VWF-stabiliserede FVIII-præparater til ekstravaskulær administration til terapeutisk og profylaktisk behandling af blødningsforstyrrelser
FR2920429B1 (fr) * 2007-08-30 2012-10-05 Lfb Biotechnologies Procede de purification du facteur viii et du facteur von willebrand
EP2073015A1 (en) 2007-12-21 2009-06-24 CSL Behring GmbH Diagnostic in vitro method for assessing Von Willebrand Disease and bleeding risk associated with Von Willebrand Disease and acquired or congenital disorders of platelet function
US20100273206A1 (en) * 2007-12-21 2010-10-28 Manfred Rauh Diagnostic in vitro method for assessing von willebrand disease and increased bleeding risk associated with von willebrand disease and acquired or congenital disorders of platelet function
KR101648734B1 (ko) 2008-06-24 2016-08-18 체에스엘 베링 게엠베하 연장된 생체내 반감기를 갖는 인자 ｖｉｉｉ, 폰 빌레브란트 인자 또는 이들의 복합체
US20100168018A1 (en) * 2008-11-07 2010-07-01 Baxter International Inc. Factor viii formulations
IT1396528B1 (it) 2009-01-19 2012-12-14 Kedrion Spa Nuovo processo di purificazione altamente selettivo di due proteine plasmatiche: von willebrand factor (vwf) e fibronectina (fn).
US20120148557A1 (en) 2009-08-20 2012-06-14 Ulrich Kronthaler Albumin fused coagulation factors for non-intravenous administration in the therapy and prophylactic treatment of bleeding disorders
WO2012082933A1 (en) 2010-12-15 2012-06-21 Baxter International, Inc. Eluate collection using conductivity gradient
US9393289B2 (en) 2011-10-18 2016-07-19 Csl Behring Gmbh Use of sulfated glycosaminoglycans for improving the bioavailability of factor VIII
DK2768521T3 (en) 2011-10-18 2016-10-24 Csl Behring Gmbh Combined use of a sulfated glykosamin glycan and a Hyaluronidase to improve bio-availability of factor VIII
EP2814502B1 (en) 2012-02-15 2017-09-13 CSL Behring GmbH Von willebrand factor variants having improved factor viii binding affinity
EP2796145B1 (en) 2013-04-22 2017-11-01 CSL Ltd. A covalent complex of von willebrand factor and faktor viii linked by a disulphide bridge
AU2014346343B2 (en) * 2013-11-08 2018-05-10 Csl Ltd. New method to concentrate von Willebrand factor or complexes thereof
DK3164150T3 (da) 2014-07-02 2021-02-08 CSL Behring Lengnau AG Modificeret von willebrand-faktor
US10626164B2 (en) 2014-07-25 2020-04-21 Csl Limited Purification of VWF
FR3034669B1 (fr) 2015-04-07 2020-02-14 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Nouvelle utilisation du facteur von willebrand
WO2017066683A1 (en) * 2015-10-15 2017-04-20 Plasma Technologies, Llc Methods for extracting proteins from blood plasma
SG10201912857XA (en) 2016-01-07 2020-02-27 CSL Behring Lengnau AG Mutated von willebrand factor
SG11201805497QA (en) 2016-01-07 2018-07-30 Csl Behring Recombinant Facility Ag Mutated truncated von willebrand factor
CN105622747A (zh) * 2016-02-04 2016-06-01 江西博雅生物制药股份有限公司 一种vWF活性保护液
CN105622746A (zh) * 2016-02-04 2016-06-01 江西博雅生物制药股份有限公司 一种从冷沉淀提取凝血因子ⅷ的废料中提取人血管性血友病因子的制备工艺
CN105541997A (zh) * 2016-02-04 2016-05-04 江西博雅生物制药股份有限公司 一种高纯度和高活性血管性血友病因子的制备工艺
EP3488858A1 (en) 2017-11-27 2019-05-29 Laboratoire Français du Fractionnement et des Biotechnologies A von willebrand factor composition for use in treating a pathology mediated by angiogenesis
CN114249812B (zh) * 2020-09-22 2023-09-15 四川远大蜀阳药业有限责任公司 一种降低vWF制品中IgM含量的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61166542A (ja) * 1985-01-18 1986-07-28 Hitachi Chem Co Ltd 感光性組成物
US4970300A (en) * 1985-02-01 1990-11-13 New York University Modified factor VIII
US5006642A (en) * 1987-06-29 1991-04-09 Rhone-Poulenc Rorer Pharmaceuticals Inc. Purification of von Willebrand Factor by affinity chromatography
FR2632309B1 (fr) * 1988-06-07 1990-08-24 Lille Transfusion Sanguine Procede de purification par voie chromatographique de proteines, notamment de facteur viii, et les produits obtenus

Also Published As

Publication number Publication date
EP0503991A1 (fr) 1992-09-16
JPH0597696A (ja) 1993-04-20
IT1256692B (it) 1995-12-12
ATA43692A (de) 2000-05-15
FI106721B (fi) 2001-03-30
EE03057B1 (et) 1997-12-15
PL293738A1 (en) 1992-09-21
AU645172B2 (en) 1994-01-06
SK279533B6 (sk) 1998-12-02
HUT63176A (en) 1993-07-28
IL101043A0 (en) 1992-11-15
BE1004178A3 (fr) 1992-10-06
CA2062340A1 (fr) 1992-09-09
EG20300A (fr) 1998-10-31
NO920867L (no) 1992-09-09
ZA921430B (en) 1992-11-25
NO301278B1 (no) 1997-10-06
SA92120446B1 (ar) 2004-05-04
FR2673632A1 (fr) 1992-09-11
ITTO920189A0 (it) 1992-03-06
CZ283633B6 (cs) 1998-05-13
DE122009000034I2 (de) 2011-06-16
CS56892A3 (en) 1992-09-16
DE122009000034I1 (de) 2010-04-08
ITTO920189A1 (it) 1993-09-06
HU215098B (hu) 1998-09-28
PL168353B1 (pl) 1996-02-29
US5408039A (en) 1995-04-18
CA2062340C (fr) 2000-05-09
HU9200767D0 (en) 1992-05-28
BR9200770A (pt) 1992-11-17
IL101043A (en) 1997-02-18
RU2088590C1 (ru) 1997-08-27
NL300394I1 (nl) 2009-09-01
LT3175B (en) 1995-02-27
DE69227055D1 (de) 1998-10-29
NO920867D0 (no) 1992-03-05
FI920992A0 (fi) 1992-03-06
NZ241701A (en) 1994-10-26
DK0503991T3 (da) 1999-06-14
UA27732C2 (uk) 2000-10-16
JP3435668B2 (ja) 2003-08-11
AU1113192A (en) 1992-09-10
EP0503991B1 (fr) 1998-09-23
FR2673632B1 (fi) 1995-05-05
DE69227055T2 (de) 1999-04-22
LTIP266A (en) 1994-07-15
ES2121830T3 (es) 1998-12-16
AT407115B (de) 2000-12-27

Similar Documents

Publication Publication Date Title
FI920992A (fi) Foerfarande foer framstaellning av i industriell skala av ett standardiserat koncentrat av human von willebrand-faktor, vilket har synnerligen hoeg renhet och aer laempligt foer terapeutisk anvaendning
DE69110785T3 (de) Narkosemittelverdampfer.
FI921168A0 (fi) Inhalator.
FI880624A0 (fi) Till intubationsroer kopplad spirometer och provtagningsfoerbindning i gasanalysator.
FI890730A0 (fi) Foerfarande foer framstaellning av en metalliserad polyolefinfilm och den erhaollna filmen.
FI910722A (fi) Foerfarande foer hydrolysering av keratin.
FI923947A (fi) Foerfarande foer pulsbreddsmodulation foer oekad linearitet, minskad kommutationsfoerlust och oekad utspaenning i en vaexelriktare/omriktare
FI884033A (fi) Anordning foer att applicera tecken pao ett identifikationsmedel och ett identifikationsmedelarrangemang foer den samma.
FI922239A (fi) Modifierad amorf kiseloxid, foerfarande foer dess framstaellning och anti-blockmedel, daer den ingaor
FI935036A (fi) 1h-imidazol-1-yl-metyl-bensofuranderivat, daer imidazolylgruppen aer substituerade med cykloalkylgrupp
FI883293A0 (fi) Foerfarande foer indikering av manschettstorleken i en blodtrycksmaetare och ett vid indikeringen behoevligt, stroemningen begraensande organ.
FI875686A (fi) Uv-absorberande foereningar och kompositioner innehaollande dessa.
FI903288A0 (fi) Foerfarande och anlaeggning foer tillvaratagning av spillvaermet i den i pappersmaskinens papperstork avgaoende fuktiga torkluften.
FI896245A0 (fi) Foerfarande foer kontroll av parametrar hos den fasta fasen i en suspension och anordning foer detta.
FI884723A0 (fi) Foerfarande foer framstaellning av ett sammanhaollande elastiskt bandage, anordningar foer utfoerande av foerfarandet och medelst foerfarandet framstaellt bandage.
FI935554A0 (fi) Foerfarande och anordning foer maetning av den totala stroemningshastigheten i ventilinstallationer
FI890824A0 (fi) Foerfarande foer framstaellning av skivor av mineralglas med hoeg genomslaeppning i det synliga spektralomraodet och laog genomslaeppning av solenergi och med detta foerfarande framstaellda skivor.
FI925974A (fi) Humant rotavirus-hcr3, nyorganiserade stammar av detta och vaccinkompositioner innehaollande dessa
FI922980A0 (fi) 2-piperidinylpyrimidin-4- karboxamidderivat, framstaellning av dessa och terapeutisk anvaendning av dessa.
DE59202185D1 (de) 4-tert-Alkyl-2-Methylbenzaldehyddialkylacetale.
FI890777A (fi) Foerfarande och anordning foer oeverdragning av ett glidskyddselement, speciellt en glidskyddskedja pao ett fordonshjul.
FI925639A0 (fi) Isoxazolylimidazolderivat, foerfarande foer deras framstaellning och deras anvaendning i laekemedel
FI933663A (fi) Foliopaose och foerfarande foer att fylla i den
FR2680953B1 (fr) Semelle deodorante, antibacteries, hydrothermique jetable.
FI913181A0 (fi) Straolkaella och excitationsanordning foer den.