NO300976B1 - 1,3-dihydro-2H-imidazo£4,5-b|kinolin-2-on-derivater, samt mellomprodukter for fremstilling derav - Google Patents

1,3-dihydro-2H-imidazo£4,5-b|kinolin-2-on-derivater, samt mellomprodukter for fremstilling derav Download PDF

Info

Publication number
NO300976B1
NO300976B1 NO941497A NO941497A NO300976B1 NO 300976 B1 NO300976 B1 NO 300976B1 NO 941497 A NO941497 A NO 941497A NO 941497 A NO941497 A NO 941497A NO 300976 B1 NO300976 B1 NO 300976B1
Authority
NO
Norway
Prior art keywords
formula
alkyl
mixture
compounds
acid
Prior art date
Application number
NO941497A
Other languages
English (en)
Norwegian (no)
Other versions
NO941497D0 (OSRAM
NO941497L (no
Inventor
Eddy Jean Edgard Freyne
Alfons Herman Marg Raeymaekers
Didier Robert Guy G Courcelles
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO941497D0 publication Critical patent/NO941497D0/no
Publication of NO941497L publication Critical patent/NO941497L/no
Publication of NO300976B1 publication Critical patent/NO300976B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/96—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
NO941497A 1991-10-30 1994-04-25 1,3-dihydro-2H-imidazo£4,5-b|kinolin-2-on-derivater, samt mellomprodukter for fremstilling derav NO300976B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78495591A 1991-10-30 1991-10-30
PCT/EP1992/002496 WO1993009118A1 (en) 1991-10-30 1992-10-27 1,3-dihydro-2h-imidazo(4,5-b)quinolin-2-one derivatives as phosphodiesterase inhibitors

Publications (3)

Publication Number Publication Date
NO941497D0 NO941497D0 (OSRAM) 1994-04-25
NO941497L NO941497L (no) 1994-04-25
NO300976B1 true NO300976B1 (no) 1997-08-25

Family

ID=25134048

Family Applications (1)

Application Number Title Priority Date Filing Date
NO941497A NO300976B1 (no) 1991-10-30 1994-04-25 1,3-dihydro-2H-imidazo£4,5-b|kinolin-2-on-derivater, samt mellomprodukter for fremstilling derav

Country Status (24)

Country Link
US (3) US5521187A (OSRAM)
EP (2) EP0610372B1 (OSRAM)
JP (1) JP3488922B2 (OSRAM)
KR (1) KR100251895B1 (OSRAM)
CN (1) CN1041726C (OSRAM)
AT (1) ATE131479T1 (OSRAM)
AU (1) AU660337B2 (OSRAM)
CA (1) CA2121230C (OSRAM)
DE (1) DE69206820T2 (OSRAM)
DK (1) DK0610372T3 (OSRAM)
ES (1) ES2083773T3 (OSRAM)
FI (1) FI105548B (OSRAM)
GR (1) GR3018909T3 (OSRAM)
HU (1) HU220608B1 (OSRAM)
IL (1) IL103570A (OSRAM)
MX (1) MX9206258A (OSRAM)
NO (1) NO300976B1 (OSRAM)
NZ (1) NZ244779A (OSRAM)
PH (1) PH31245A (OSRAM)
PL (1) PL170749B1 (OSRAM)
RU (1) RU2127273C1 (OSRAM)
TW (1) TW249234B (OSRAM)
WO (1) WO1993009118A1 (OSRAM)
ZA (1) ZA928373B (OSRAM)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH31245A (en) * 1991-10-30 1998-06-18 Janssen Pharmaceutica Nv 1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives.
US5502177A (en) * 1993-09-17 1996-03-26 Gilead Sciences, Inc. Pyrimidine derivatives for labeled binding partners
US5703827A (en) * 1996-02-29 1997-12-30 Monolithic System Technology, Inc. Method and structure for generating a boosted word line voltage and a back bias voltage for a memory array
US6028183A (en) * 1997-11-07 2000-02-22 Gilead Sciences, Inc. Pyrimidine derivatives and oligonucleotides containing same
US6007992A (en) * 1997-11-10 1999-12-28 Gilead Sciences, Inc. Pyrimidine derivatives for labeled binding partners
US6541485B1 (en) * 1999-06-10 2003-04-01 3M Innovative Properties Company Urea substituted imidazoquinolines
US6331539B1 (en) * 1999-06-10 2001-12-18 3M Innovative Properties Company Sulfonamide and sulfamide substituted imidazoquinolines
UA72611C2 (uk) * 2000-05-17 2005-03-15 Орто-Макнейл Фармацевтикал, Інк. Похідні заміщеного піролопіридинону, корисні як інгібітори фосфодіестерази
US7115630B2 (en) * 2000-10-02 2006-10-03 Janssen Pharmaceutica N.V. Metabotropic glutamate receptor antagonists
UA75622C2 (en) * 2000-12-08 2006-05-15 3M Innovative Properties Co Aryl ether substituted imidazoquinolines, pharmaceutical composition based thereon
SE0100902D0 (sv) * 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
SE0100903D0 (sv) * 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
WO2002094321A1 (en) 2001-05-23 2002-11-28 Tanabe Seiyaku Co., Ltd. Compositions for promoting healing of bone fracture
EP1389467B1 (en) 2001-05-23 2013-07-03 Mitsubishi Tanabe Pharma Corporation Therapeutic composition for the regenerative treatment of cartilage diseases
DE10135815A1 (de) * 2001-07-23 2003-02-06 Bayer Ag Verwendung von 2-Alkoxyphenyl-substituierten Imidazotriazinonen
SE0103710D0 (sv) * 2001-11-07 2001-11-07 Astrazeneca Ab Compounds
EP1492571A2 (en) * 2002-03-29 2005-01-05 Janssen Pharmaceutica N.V. Radiolabelled quinoline and quinolinone derivatives and their use as metabotropic glutamate receptor ligands
SE0202539D0 (sv) * 2002-08-27 2002-08-27 Astrazeneca Ab Compounds
GB0221246D0 (en) * 2002-09-13 2002-10-23 Astrazeneca Ab Compounds
MY157827A (en) * 2003-06-27 2016-07-29 3M Innovative Properties Co Sulfonamide substituted imidazoquinolines
WO2005018556A2 (en) 2003-08-12 2005-03-03 3M Innovative Properties Company Hydroxylamine substituted imidazo-containing compounds
PH12006500401A1 (en) 2003-08-27 2005-03-10 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted imidazoquinolines
EP1660026A4 (en) 2003-09-05 2008-07-16 3M Innovative Properties Co TREATMENT FOR CD5 + B CELL LYMPHOMA
US7544697B2 (en) 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
EP1673087B1 (en) 2003-10-03 2015-05-13 3M Innovative Properties Company Alkoxy substituted imidazoquinolines
WO2005048945A2 (en) 2003-11-14 2005-06-02 3M Innovative Properties Company Hydroxylamine substituted imidazo ring compounds
EP1685129A4 (en) 2003-11-14 2008-10-22 3M Innovative Properties Co OXIMSUBSTITUTED IMIDAZORING CONNECTIONS
CA2547020C (en) 2003-11-25 2014-03-25 3M Innovative Properties Company 1h-imidazo[4,5-c]pyridine-4-amine derivatives as immune response modifier
US8802853B2 (en) 2003-12-29 2014-08-12 3M Innovative Properties Company Arylalkenyl and arylalkynyl substituted imidazoquinolines
WO2005066169A2 (en) 2003-12-30 2005-07-21 3M Innovative Properties Company Imidazoquinolinyl, imidazopyridinyl, and imidazonaphthyridinyl sulfonamides
US20050203156A1 (en) * 2004-03-12 2005-09-15 Wyeth Hydantoins having RNase modulatory activity
AU2005228150A1 (en) 2004-03-24 2005-10-13 3M Innovative Properties Company Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
US8017779B2 (en) 2004-06-15 2011-09-13 3M Innovative Properties Company Nitrogen containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
US8026366B2 (en) 2004-06-18 2011-09-27 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
WO2006038923A2 (en) 2004-06-18 2006-04-13 3M Innovative Properties Company Aryl substituted imidazonaphthyridines
WO2006065280A2 (en) 2004-06-18 2006-06-22 3M Innovative Properties Company Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and methods
US7648992B2 (en) 2004-07-05 2010-01-19 Astrazeneca Ab Hydantoin derivatives for the treatment of obstructive airway diseases
SE0401762D0 (sv) * 2004-07-05 2004-07-05 Astrazeneca Ab Novel compounds
AU2005284835A1 (en) * 2004-09-14 2006-03-23 Novartis Vaccines And Diagnostics Inc. Imidazoquinoline compounds
SE0403085D0 (sv) 2004-12-17 2004-12-17 Astrazeneca Ab Novel componds
SE0403086D0 (sv) * 2004-12-17 2004-12-17 Astrazeneca Ab Compounds
AU2005322898B2 (en) 2004-12-30 2011-11-24 3M Innovative Properties Company Chiral fused (1,2)imidazo(4,5-c) ring compounds
JP5313502B2 (ja) 2004-12-30 2013-10-09 スリーエム イノベイティブ プロパティズ カンパニー 置換キラル縮合［１，２］イミダゾ［４，５−ｃ］環状化合物
CA2597092A1 (en) 2005-02-04 2006-08-10 Coley Pharmaceutical Group, Inc. Aqueous gel formulations containing immune reponse modifiers
CA2597587A1 (en) 2005-02-11 2006-08-17 Coley Pharmaceutical Group, Inc. Oxime and hydroxylamine substituted imidazo[4,5-c] ring compounds and methods
EP1863814A1 (en) 2005-04-01 2007-12-12 Coley Pharmaceutical Group, Inc. 1-substituted pyrazolo (3,4-c) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases
EP1869043A2 (en) 2005-04-01 2007-12-26 Coley Pharmaceutical Group, Inc. Pyrazolopyridine-1,4-diamines and analogs thereof
EP2258357A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
WO2007047978A2 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by pde inhibition
JP2009513672A (ja) 2005-10-31 2009-04-02 ブレインセルス，インコーポレイティド 神経発生のｇａｂａ受容体媒介調節
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP2377531A2 (en) 2006-05-09 2011-10-19 Braincells, Inc. Neurogenesis by modulating angiotensin
MX2008014320A (es) 2006-05-09 2009-03-25 Braincells Inc Neurogenesis mediada por el receptor de 5-hidroxitriptamina.
WO2008008432A2 (en) 2006-07-12 2008-01-17 Coley Pharmaceutical Group, Inc. Substituted chiral fused( 1,2) imidazo (4,5-c) ring compounds and methods
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
TW200831488A (en) * 2006-11-29 2008-08-01 Astrazeneca Ab Novel compounds
EP1969929A1 (de) 2007-03-12 2008-09-17 Bayer CropScience AG Substituierte Phenylamidine und deren Verwendung als Fungizide
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
WO2014055586A1 (en) 2012-10-02 2014-04-10 California Institute Of Technology Transition-metal free reductive cleavage of aromatic c-o, c-n, and c-s bonds by activated silanes
CN107253967B (zh) * 2012-10-02 2021-03-30 加州理工学院 芳族化合物的无过渡金属的甲硅烷基化
WO2016022624A1 (en) 2014-08-06 2016-02-11 California Institute Of Technology Silylation of aromatic heterocycles by earth abundant transition-metal-free catalysts
WO2016036685A1 (en) 2014-09-02 2016-03-10 California Institute Of Technology Base-catalyzed silylation of terminial alkyne c-h bonds
WO2016100606A1 (en) 2014-12-19 2016-06-23 California Institute Of Technology Silylation of aromatic heterocycles by disilanes using potassium alkoxide catalysts
CN110441434A (zh) * 2019-08-29 2019-11-12 重庆华邦胜凯制药有限公司 Gc-ms分离测定对氨基水杨酸中相关杂质的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1602188A (en) * 1977-12-01 1981-11-11 Wellcome Found Hydantoin derivatives
JPS6021941B2 (ja) * 1981-01-28 1985-05-30 株式会社村田製作所 圧電性磁器組成物
US4668686A (en) * 1985-04-25 1987-05-26 Bristol-Myers Company Imidazoquinoline antithrombrogenic cardiotonic agents
US4775674A (en) * 1986-05-23 1988-10-04 Bristol-Myers Company Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors
US4701459A (en) * 1986-07-08 1987-10-20 Bristol-Myers Company 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation
US5306822A (en) * 1988-05-25 1994-04-26 Warner-Lambert Company Arylmethylenyl derivatives of oxazolidinone
NZ234186A (en) * 1989-07-07 1991-10-25 Janssen Pharmaceutica Nv Imidazo quinazolin-one derivatives and pharmaceutical compositions
CN1030196C (zh) * 1989-07-07 1995-11-01 詹森药业有限公司 增强收缩力和舒张力的-二氢咪唑并喹唑啉酮衍生物的制备方法
US5043327A (en) * 1989-07-18 1991-08-27 Janssen Pharmaceutica N.V. Positive inotropic and lusitropic 3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one derivatives, compositions and use
US4943573A (en) * 1989-11-01 1990-07-24 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
WO1991007177A1 (en) * 1989-11-13 1991-05-30 Pfizer Inc. Pyrimidone derivatives and analogs in the treatment of asthma or certain skin disorders
PH31245A (en) * 1991-10-30 1998-06-18 Janssen Pharmaceutica Nv 1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives.

Also Published As

Publication number Publication date
DE69206820T2 (de) 1996-05-15
FI942010A7 (fi) 1994-04-29
HU220608B1 (hu) 2002-03-28
US5521187A (en) 1996-05-28
DK0610372T3 (da) 1996-01-29
EP0541153A1 (en) 1993-05-12
CN1072681A (zh) 1993-06-02
HU9401245D0 (en) 1994-08-29
ZA928373B (en) 1994-04-29
EP0610372B1 (en) 1995-12-13
AU660337B2 (en) 1995-06-22
US5541325A (en) 1996-07-30
JPH07500599A (ja) 1995-01-19
HUT66453A (en) 1994-11-28
GR3018909T3 (en) 1996-05-31
DE69206820D1 (de) 1996-01-25
NZ244779A (en) 1994-10-26
TW249234B (OSRAM) 1995-06-11
CA2121230A1 (en) 1993-05-13
IL103570A (en) 1996-03-31
FI942010A0 (fi) 1994-04-29
NO941497D0 (OSRAM) 1994-04-25
CN1041726C (zh) 1999-01-20
KR100251895B1 (ko) 2000-09-01
MX9206258A (es) 1993-04-01
NO941497L (no) 1994-04-25
RU2127273C1 (ru) 1999-03-10
US5516908A (en) 1996-05-14
WO1993009118A1 (en) 1993-05-13
PL170749B1 (pl) 1997-01-31
IL103570A0 (en) 1993-03-15
JP3488922B2 (ja) 2004-01-19
CA2121230C (en) 2003-03-11
AU2908392A (en) 1993-06-07
PH31245A (en) 1998-06-18
ATE131479T1 (de) 1995-12-15
FI105548B (fi) 2000-09-15
EP0610372A1 (en) 1994-08-17
ES2083773T3 (es) 1996-04-16

Similar Documents

Publication Publication Date Title
NO300976B1 (no) 1,3-dihydro-2H-imidazo£4,5-b|kinolin-2-on-derivater, samt mellomprodukter for fremstilling derav
DE69115134T2 (de) Pyranderivate zur Verwendung als 5-Lipoxygenasehemmer.
EP0248523B1 (en) Pyrazoles
EP1194144B1 (en) Antibacterial compounds
US5925769A (en) Acetylenic 1,5-diarylpyrazoles as antiinflammatory agents
JP5014315B2 (ja) ４−ニトロイミダゾール化合物の製造法
US5234928A (en) Quinazoline-3-alkanoic acid derivatives, their salts and their preparation processes
CZ291576B6 (cs) Derivát imidazolu afinitní k alfa2 receptorům, farmaceuticky přijatelný přípravek jej obsahující a jeho použití
JPH0363277A (ja) ３，５―ジヒドロイミダゾ［２，１―ｂ］キナゾリン―２（１□ＤＨ）―オン誘導体
US5698567A (en) Heterocyclic spiro compounds
US20040198980A1 (en) Selective rxr ligands
US5182289A (en) Heterobicyclic compounds having antiinflammatory activity
DE69104481T2 (de) Imidazo[4,5-c]pyridine als paf antagonisten.
US5043327A (en) Positive inotropic and lusitropic 3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one derivatives, compositions and use
JPH11130761A (ja) ベンゾチアゾール誘導体
JPH05194436A (ja) ４−〔４−〔４−（４−ヒドロキシフエニル）−１−ピペラジニル〕フエニル〕−５−メチル−３ｈ−１，２−４−トリアゾロ−３−ン誘導体類
US5843958A (en) Arylpyrazoles as leukotriene inhibitors
JPH02191257A (ja) ベンゾヘテロ環化合物
US5220023A (en) Glycine derivatives
HUT54125A (en) Process for producing triazine derivatives and pharmaceutical compositions comprising same
US5120845A (en) Positive inotropic and lusitropic 3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one derivatives
DK164322B (da) Analogifremgangsmaade til fremstilling af 2-(imidazolylmethyl)- eller 2-(triazolylmethyl)benzooebaathiophener
JPH04247090A (ja) ピリミドベンゾチアジン誘導体を含む抗炎症剤
HU193633B (en) Process for production of new benzo /b/ tiofenes and tiocromates

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees