NO20090854L - Serin-treonin protein kinase og parp modulatorer - Google Patents
Serin-treonin protein kinase og parp modulatorerInfo
- Publication number
- NO20090854L NO20090854L NO20090854A NO20090854A NO20090854L NO 20090854 L NO20090854 L NO 20090854L NO 20090854 A NO20090854 A NO 20090854A NO 20090854 A NO20090854 A NO 20090854A NO 20090854 L NO20090854 L NO 20090854L
- Authority
- NO
- Norway
- Prior art keywords
- protein kinase
- serine
- activity
- threonine protein
- molecules
- Prior art date
Links
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
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- C07D221/06—Ring systems of three rings
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- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Abstract
Oppfinnelsen vedrører delvis molekyler som har visse biologiske aktiviteter som omfatter, men er ikke begrenset til, hemme celleproliferasjon, modulerende proteinkinase aktivitet og modulerende polymerase aktivitet. Molekyler ifølge oppfinnelsen kan modulere kasein kinase (CK) aktivitet og/eller poly(ADP-ribose)polymerase (PARP) aktivitet. Oppfinnelsen vedrører også delvis metoder for anvendelse av slike molekyler.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84206106P | 2006-09-01 | 2006-09-01 | |
US84454206P | 2006-09-13 | 2006-09-13 | |
US84668306P | 2006-09-22 | 2006-09-22 | |
US87393606P | 2006-12-07 | 2006-12-07 | |
US89571607P | 2007-03-19 | 2007-03-19 | |
PCT/US2007/077464 WO2008028168A2 (en) | 2006-09-01 | 2007-08-31 | Serine-threonine protein kinase and parp modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20090854L true NO20090854L (no) | 2009-04-29 |
Family
ID=39136972
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20090854A NO20090854L (no) | 2006-09-01 | 2009-02-25 | Serin-treonin protein kinase og parp modulatorer |
Country Status (17)
Country | Link |
---|---|
US (2) | US7956064B2 (no) |
EP (1) | EP2061765B1 (no) |
JP (1) | JP5399905B2 (no) |
KR (1) | KR20090050094A (no) |
AU (1) | AU2007289065B2 (no) |
BR (1) | BRPI0719123A2 (no) |
CA (2) | CA2974246C (no) |
DK (1) | DK2061765T3 (no) |
ES (1) | ES2528316T3 (no) |
HK (1) | HK1137448A1 (no) |
IL (1) | IL197088A0 (no) |
MX (1) | MX2009002298A (no) |
NO (1) | NO20090854L (no) |
PL (1) | PL2061765T3 (no) |
PT (1) | PT2061765E (no) |
RU (1) | RU2681209C2 (no) |
WO (1) | WO2008028168A2 (no) |
Families Citing this family (98)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2008520744A (ja) * | 2004-11-19 | 2008-06-19 | ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア | 抗炎症性ピラゾロピリミジン |
EP2004654B1 (en) | 2006-04-04 | 2013-05-22 | The Regents of the University of California | Pyrazolopyrimidine derivatives for use as kinase antagonists |
EP2061765B1 (en) | 2006-09-01 | 2014-10-22 | Senhwa Biosciences, Inc. | Serine-threonine protein kinase and PARP modulators |
US20110160232A1 (en) * | 2007-10-04 | 2011-06-30 | Pingda Ren | Certain chemical entities and therapeutic uses thereof |
US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
KR101653842B1 (ko) | 2008-01-04 | 2016-09-02 | 인텔리카인, 엘엘씨 | 특정 화학 물질, 조성물 및 방법 |
CN102036561A (zh) * | 2008-02-29 | 2011-04-27 | 赛林药物股份有限公司 | 蛋白激酶调节剂 |
US8637542B2 (en) * | 2008-03-14 | 2014-01-28 | Intellikine, Inc. | Kinase inhibitors and methods of use |
US8993580B2 (en) | 2008-03-14 | 2015-03-31 | Intellikine Llc | Benzothiazole kinase inhibitors and methods of use |
US20110212053A1 (en) * | 2008-06-19 | 2011-09-01 | Dapeng Qian | Phosphatidylinositol 3 kinase inhibitors |
US20110224223A1 (en) * | 2008-07-08 | 2011-09-15 | The Regents Of The University Of California, A California Corporation | MTOR Modulators and Uses Thereof |
CA2730106A1 (en) | 2008-07-08 | 2010-01-14 | Intellikine, Inc. | Kinase inhibitors and methods of use |
BRPI0918846A2 (pt) | 2008-09-02 | 2019-09-24 | Novartis Ag | inibidores de cinase heterocíclica |
US8703778B2 (en) | 2008-09-26 | 2014-04-22 | Intellikine Llc | Heterocyclic kinase inhibitors |
US8697709B2 (en) | 2008-10-16 | 2014-04-15 | The Regents Of The University Of California | Fused ring heteroaryl kinase inhibitors |
US8476431B2 (en) * | 2008-11-03 | 2013-07-02 | Itellikine LLC | Benzoxazole kinase inhibitors and methods of use |
DK2364983T3 (da) | 2008-11-11 | 2013-12-09 | Jeil Pharmaceutical Co Ltd | Nyt tricyklisk derivat eller farmaceutisk acceptable salte deraf, fremgangsmåde til fremstilling deraf og farmaceutisk sammensætning indeholdende disse |
ES2550101T3 (es) | 2008-12-17 | 2015-11-04 | Merck Patent Gmbh | Inhibidores de proteína quinasa de benzonaftiridinona tricíclica modificada con anillo C y su uso |
AU2009336141A1 (en) * | 2009-01-08 | 2011-08-11 | Cylene Pharmaceuticals, Inc. | Combination therapies for neoplastic disorders |
US20100173013A1 (en) * | 2009-01-08 | 2010-07-08 | Denis Drygin | Treatment of neoplastic disorders using combination therapies |
KR20120044281A (ko) * | 2009-04-17 | 2012-05-07 | 사일린 파마슈티칼스, 인크 | 단백질 키나제 ck2 활성과 관련된 장애의 치료 방법 |
WO2010129816A2 (en) | 2009-05-07 | 2010-11-11 | Intellikine, Inc. | Heterocyclic compounds and uses thereof |
JP5715625B2 (ja) * | 2009-07-30 | 2015-05-07 | 武田薬品工業株式会社 | ポリ(adp−リボース)ポリメラーゼ(parp)阻害剤 |
CA2771890A1 (en) * | 2009-08-26 | 2011-03-03 | Fabrice Pierre | Condensed quinolines as protein kinase modulators |
CN102647904A (zh) * | 2009-09-16 | 2012-08-22 | 赛林药物股份有限公司 | 新型三环蛋白激酶调节剂 |
WO2011041785A1 (en) | 2009-10-02 | 2011-04-07 | Cylene Pharmaceuticals, Inc. | Biomarkers for predicting the sensitivity and response of protein kinase ck2-mediated diseases to ck2 inhibitors |
WO2011047384A2 (en) | 2009-10-16 | 2011-04-21 | The Regents Of The University Of California | Methods of inhibiting ire1 |
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CA2974246A1 (en) | 2008-03-06 |
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CA2661842C (en) | 2017-08-22 |
CA2661842A1 (en) | 2008-03-06 |
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IL197088A0 (en) | 2009-11-18 |
DK2061765T3 (en) | 2015-01-26 |
US20090105233A1 (en) | 2009-04-23 |
KR20090050094A (ko) | 2009-05-19 |
US7956064B2 (en) | 2011-06-07 |
PT2061765E (pt) | 2015-02-06 |
PL2061765T3 (pl) | 2015-04-30 |
EP2061765A2 (en) | 2009-05-27 |
BRPI0719123A2 (pt) | 2013-12-17 |
RU2013130739A (ru) | 2015-01-10 |
AU2007289065A2 (en) | 2009-06-25 |
EP2061765A4 (en) | 2012-03-21 |
US9062043B2 (en) | 2015-06-23 |
WO2008028168A2 (en) | 2008-03-06 |
US20090264423A2 (en) | 2009-10-22 |
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WO2008028168A3 (en) | 2008-11-13 |
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