NO20084608L - Pegylert faktor VIII - Google Patents
Pegylert faktor VIIIInfo
- Publication number
- NO20084608L NO20084608L NO20084608A NO20084608A NO20084608L NO 20084608 L NO20084608 L NO 20084608L NO 20084608 A NO20084608 A NO 20084608A NO 20084608 A NO20084608 A NO 20084608A NO 20084608 L NO20084608 L NO 20084608L
- Authority
- NO
- Norway
- Prior art keywords
- factor viii
- life
- biological activity
- pegylated factor
- vivo half
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78796806P | 2006-03-31 | 2006-03-31 | |
US79023906P | 2006-04-06 | 2006-04-06 | |
PCT/US2007/007560 WO2007126808A1 (fr) | 2006-03-31 | 2007-03-29 | Facteur viii pégylé |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20084608L true NO20084608L (no) | 2008-12-30 |
Family
ID=38330191
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20084608A NO20084608L (no) | 2006-03-31 | 2008-10-30 | Pegylert faktor VIII |
Country Status (11)
Country | Link |
---|---|
US (2) | US7683158B2 (fr) |
EP (1) | EP2010222A1 (fr) |
JP (1) | JP2009532351A (fr) |
KR (1) | KR20080108147A (fr) |
AU (1) | AU2007245190B2 (fr) |
BR (1) | BRPI0708832A2 (fr) |
CA (1) | CA2647314A1 (fr) |
MX (1) | MX2008012600A (fr) |
NO (1) | NO20084608L (fr) |
NZ (1) | NZ572050A (fr) |
WO (1) | WO2007126808A1 (fr) |
Families Citing this family (74)
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US7179617B2 (en) * | 2001-10-10 | 2007-02-20 | Neose Technologies, Inc. | Factor IX: remolding and glycoconjugation of Factor IX |
EP2371856B1 (fr) | 2004-11-12 | 2022-05-18 | Bayer HealthCare LLC | Modification dirigée sur site de FVIII |
US7846445B2 (en) * | 2005-09-27 | 2010-12-07 | Amunix Operating, Inc. | Methods for production of unstructured recombinant polymers and uses thereof |
US7855279B2 (en) * | 2005-09-27 | 2010-12-21 | Amunix Operating, Inc. | Unstructured recombinant polymers and uses thereof |
US7645860B2 (en) * | 2006-03-31 | 2010-01-12 | Baxter Healthcare S.A. | Factor VIII polymer conjugates |
US7985839B2 (en) * | 2006-03-31 | 2011-07-26 | Baxter International Inc. | Factor VIII polymer conjugates |
US7683158B2 (en) | 2006-03-31 | 2010-03-23 | Baxter International Inc. | Pegylated factor VIII |
US7982010B2 (en) * | 2006-03-31 | 2011-07-19 | Baxter International Inc. | Factor VIII polymer conjugates |
EP2101821B1 (fr) | 2006-12-15 | 2014-08-13 | Baxter International Inc. | Conjugué du facteur viia et de l'acide (poly)sialique présentant une demi-vie in vivo prolongée |
WO2008116913A2 (fr) * | 2007-03-28 | 2008-10-02 | Novo Nordisk A/S | Composés peptidiques à pégylation biodégradable transitoire |
WO2008154639A2 (fr) | 2007-06-12 | 2008-12-18 | Neose Technologies, Inc. | Procédé amélioré pour la production de sucres de nucléotide |
WO2009012502A1 (fr) * | 2007-07-19 | 2009-01-22 | The Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University | Électrode neurale intrafasciculaire à mems à auto-ancrage |
JP2010536341A (ja) * | 2007-08-15 | 2010-12-02 | アムニクス, インコーポレイテッド | 生物学的に活性なポリペプチドの特性を改変するための組成物および方法 |
EP2222329A1 (fr) | 2007-11-09 | 2010-09-01 | Baxter International Inc. | Facteur viii et facteur de von willebrand recombinés modifiés et procédé d'utilisation |
WO2009086356A2 (fr) | 2007-12-27 | 2009-07-09 | Baxter International Inc. | Procédé et compositions pour la détection spécifique de macromolécules physiologiquement acceptables |
ES2476690T3 (es) * | 2008-02-27 | 2014-07-15 | Novo Nordisk A/S | Moléculas conjugadas del Factor VIII |
CN102046205A (zh) * | 2008-04-24 | 2011-05-04 | 凯尔特药物Peg有限公司 | 具有延长的半衰期的因子ix缀合物 |
PL2291523T3 (pl) | 2008-06-24 | 2015-05-29 | Csl Behring Gmbh | Czynnik VIII, czynnik von Willebranda lub ich kompleksy o wydłużonym okresie półtrwania in vivo |
AU2014268202B2 (en) * | 2008-08-01 | 2017-08-03 | Takeda Pharmaceutical Company Limited | Factor VIII Polymer Conjugates |
WO2010045321A2 (fr) * | 2008-10-15 | 2010-04-22 | Baxter International Inc. | Pégylation de facteurs de coagulation sanguine recombinants en présence d’anticorps liés |
PT2349342T (pt) | 2008-10-17 | 2018-10-26 | Baxalta Inc | Factores sanguíneos modificados que compreendem um baixo grau de polímero solúvel na água |
CA2748662A1 (fr) * | 2009-01-19 | 2010-07-22 | Bayer Healthcare Llc | Conjugue proteique ayant une fraction bio-protectrice pouvant etre clivee par une endopeptidase |
EP2393828B1 (fr) | 2009-02-03 | 2016-10-12 | Amunix Operating Inc. | Polypeptides recombinants étendus et compositions les comprenant |
US8703717B2 (en) * | 2009-02-03 | 2014-04-22 | Amunix Operating Inc. | Growth hormone polypeptides and methods of making and using same |
US8680050B2 (en) * | 2009-02-03 | 2014-03-25 | Amunix Operating Inc. | Growth hormone polypeptides fused to extended recombinant polypeptides and methods of making and using same |
WO2010102886A1 (fr) * | 2009-02-19 | 2010-09-16 | Novo Nordisk A/S | Modification du facteur viii |
TW201042257A (en) * | 2009-05-26 | 2010-12-01 | Baxter Int | Detection of antibody that binds to water soluble polymer-modified polypeptides |
EP2440228B8 (fr) | 2009-06-08 | 2023-02-22 | Amunix Operating Inc. | Polypeptides de régulation du glucose et leurs procédés de production et d'utilisation |
US9849188B2 (en) | 2009-06-08 | 2017-12-26 | Amunix Operating Inc. | Growth hormone polypeptides and methods of making and using same |
SG10201401194VA (en) | 2009-07-27 | 2014-07-30 | Lipoxen Technologies Ltd | Glycopolysialylation of non-blood coagulation proteins |
EP2459224B1 (fr) * | 2009-07-27 | 2016-06-01 | Baxalta GmbH | Conjugués de protéine de coagulation sanguine |
US8809501B2 (en) | 2009-07-27 | 2014-08-19 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
NZ597600A (en) | 2009-07-27 | 2014-05-30 | Lipoxen Technologies Ltd | Glycopolysialylation of non-blood coagulation proteins |
US8642737B2 (en) | 2010-07-26 | 2014-02-04 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
WO2011028229A1 (fr) | 2009-08-24 | 2011-03-10 | Amunix Operating Inc. | Compositions de facteur ix de coagulation et leurs procédés de fabrication et d'utilisation |
EP4382170A2 (fr) | 2009-12-06 | 2024-06-12 | Bioverativ Therapeutics Inc. | Polypeptides chimériques et hybrides de facteur viii-fc, et leurs procédés d'utilisation |
EP2536753B1 (fr) | 2010-02-16 | 2017-12-20 | Novo Nordisk A/S | Molécules de facteur VIII avec liaison VWF réduite |
US8557961B2 (en) | 2010-04-02 | 2013-10-15 | Amunix Operating Inc. | Alpha 1-antitrypsin compositions and methods of making and using same |
GB201007357D0 (en) * | 2010-04-30 | 2010-06-16 | Leverton Licence Holdings Ltd | Conjugated factor VIII |
GB201007356D0 (en) | 2010-04-30 | 2010-06-16 | Leverton Licence Holdings Ltd | Conjugated factor VIIa |
WO2012007324A2 (fr) * | 2010-07-15 | 2012-01-19 | Novo Nordisk A/S | Variants stabilisés du factor viii |
CA2821945A1 (fr) * | 2010-12-16 | 2012-06-21 | Novo Nordisk A/S | Solution aqueuse de facteur viii |
NZ612320A (en) | 2010-12-22 | 2015-06-26 | Baxter Healthcare Sa | Materials and methods for conjugating a water soluble fatty acid derivative to a protein |
CA3012117A1 (fr) * | 2011-05-27 | 2012-12-06 | Baxalta Incorporated | Fusion de psa avec des serpines et autres proteines therapeutiques |
IN2014CN02448A (fr) | 2011-09-23 | 2015-06-19 | Novo Nordisk As | |
RS63870B1 (sr) | 2012-02-15 | 2023-01-31 | Bioverativ Therapeutics Inc | Sastavi faktora viii i postupci za pravljenje i upotrebu istih |
EP2814502B1 (fr) | 2012-02-15 | 2017-09-13 | CSL Behring GmbH | Variants du facteur de von willebrand ayant une affinité de liaison au facteur viii améliorée |
HUE043537T2 (hu) | 2012-02-15 | 2019-08-28 | Bioverativ Therapeutics Inc | Rekombináns VIII faktor fehérjék |
SG11201405276PA (en) | 2012-02-27 | 2014-10-30 | Amunix Operating Inc | Xten conjugate compositions and methods of making same |
EA033469B1 (ru) * | 2012-04-16 | 2019-10-31 | Cantab Biopharmaceuticals Patents Ltd | Подкожное введение конъюгатов факторов крови с полиэтиленгликолем |
CA2886326C (fr) | 2012-09-28 | 2021-11-02 | Chugai Seiyaku Kabushiki Kaisha | Procede d'evaluation de reaction de coagulation du sang |
US9452138B2 (en) * | 2012-12-28 | 2016-09-27 | Abbott Cardiovascular Systems Inc. | Delivery of biologic therapeutics |
KR20150132449A (ko) * | 2013-03-15 | 2015-11-25 | 바이엘 헬스케어 엘엘씨 | 재조합 인자 viii 제제 |
MX362275B (es) | 2013-04-18 | 2019-01-10 | Novo Nordisk As | Co-agonista de peptido similar a glucagon tipo 1 (glp-1) receptor de glucagon de larga duracion, estables para uso medico. |
ES2657291T3 (es) | 2013-04-22 | 2018-03-02 | Csl Ltd. | Un complejo covalente de factor de von Willebrand y factor VIII asociado por un puente disulfuro |
US10548953B2 (en) | 2013-08-14 | 2020-02-04 | Bioverativ Therapeutics Inc. | Factor VIII-XTEN fusions and uses thereof |
CN106536547A (zh) | 2014-06-04 | 2017-03-22 | 诺和诺德股份有限公司 | 用于医疗用途的glp‑1/胰高血糖素受体共激动剂 |
DK3164150T3 (da) | 2014-07-02 | 2021-02-08 | CSL Behring Lengnau AG | Modificeret von willebrand-faktor |
KR102192494B1 (ko) | 2014-08-04 | 2020-12-18 | 시에스엘 리미티드 | 인자 viii 제형 |
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AU2016266627A1 (en) | 2015-05-22 | 2018-01-18 | CSL Behring Lengnau AG | Truncated von Willebrand Factor polypeptides for treating hemophilia |
KR20180012303A (ko) | 2015-05-22 | 2018-02-05 | 체에스엘 베링 리컴비넌트 퍼실리티 아게 | 변형된 폰 빌레브란트 인자의 제조 방법 |
JP2015155469A (ja) * | 2015-06-01 | 2015-08-27 | バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated | 第fviii因子ポリマー結合体 |
JP6552286B2 (ja) * | 2015-06-05 | 2019-07-31 | 公立大学法人奈良県立医科大学 | 凝固第viii因子の複合体形成能に関する情報の取得方法および試薬キット |
EP3331608A4 (fr) | 2015-08-03 | 2019-05-01 | Bioverativ Therapeutics Inc. | Protéines de fusion du facteur xi et leurs méthodes de production et d'utilisation |
EA038329B1 (ru) | 2015-08-28 | 2021-08-10 | Амьюникс Фармасьютикалз, Инк. | Химерный полипептидный комплекс и способы его получения и применения |
EP3400238B1 (fr) | 2016-01-07 | 2021-05-19 | CSL Behring Lengnau AG | Facteur de von willebrand muté |
DK3400002T3 (da) | 2016-01-07 | 2022-04-11 | CSL Behring Lengnau AG | Muteret, trunkeret von willebrand faktor |
AU2017358865A1 (en) | 2016-11-11 | 2019-05-09 | CSL Behring Lengnau AG | Truncated von willebrand factor polypeptides for extravascular administration in the treatment or prophylaxis of a blood coagulation disorder |
WO2018087267A1 (fr) | 2016-11-11 | 2018-05-17 | Csl Behring Recombinant Facility Ag | Polypeptides du facteur de von willebrand tronqué pour le traitement de l'hémophilie |
CA3071236A1 (fr) * | 2017-09-29 | 2019-04-04 | Chugai Seiyaku Kabushiki Kaisha | Molecule multispecifique de liaison a l'antigene ayant une activite de substitution de la fonction de cofacteur du facteur viii de coagulation sanguine (fviii), et formulation pharmaceutique contenant ladite molecule en tant que principe actif |
JP2018115170A (ja) * | 2018-03-02 | 2018-07-26 | バクスアルタ ゲーエムベーハー | 第fviii因子ポリマー結合体 |
KR20220029733A (ko) | 2019-07-04 | 2022-03-08 | 체에스엘 베링 렝나우 아게 | 응고 인자 viii의 시험관내 안정성을 증가시키기 위한 절단된 폰 빌레브란트 인자 (vwf) |
EP4058049A1 (fr) | 2019-11-11 | 2022-09-21 | CSL Behring Lengnau AG | Polypeptides pour induire une tolérance au facteur viii |
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-
2007
- 2007-03-29 US US11/729,625 patent/US7683158B2/en active Active
- 2007-03-29 WO PCT/US2007/007560 patent/WO2007126808A1/fr active Application Filing
- 2007-03-29 EP EP07754130A patent/EP2010222A1/fr not_active Withdrawn
- 2007-03-29 NZ NZ572050A patent/NZ572050A/en unknown
- 2007-03-29 MX MX2008012600A patent/MX2008012600A/es not_active Application Discontinuation
- 2007-03-29 BR BRPI0708832-9A patent/BRPI0708832A2/pt not_active IP Right Cessation
- 2007-03-29 CA CA002647314A patent/CA2647314A1/fr not_active Abandoned
- 2007-03-29 JP JP2009502944A patent/JP2009532351A/ja not_active Withdrawn
- 2007-03-29 AU AU2007245190A patent/AU2007245190B2/en active Active
- 2007-03-29 KR KR1020087026600A patent/KR20080108147A/ko not_active Application Discontinuation
-
2008
- 2008-10-30 NO NO20084608A patent/NO20084608L/no not_active Application Discontinuation
-
2010
- 2010-03-08 US US12/719,265 patent/US8053561B2/en active Active
Also Published As
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CA2647314A1 (fr) | 2007-11-08 |
KR20080108147A (ko) | 2008-12-11 |
AU2007245190B2 (en) | 2011-07-21 |
AU2007245190A1 (en) | 2007-11-08 |
US20100168391A1 (en) | 2010-07-01 |
US8053561B2 (en) | 2011-11-08 |
EP2010222A1 (fr) | 2009-01-07 |
US7683158B2 (en) | 2010-03-23 |
MX2008012600A (es) | 2008-12-12 |
US20070244301A1 (en) | 2007-10-18 |
BRPI0708832A2 (pt) | 2011-06-14 |
JP2009532351A (ja) | 2009-09-10 |
NZ572050A (en) | 2011-09-30 |
WO2007126808A1 (fr) | 2007-11-08 |
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