SG11201405276PA - Xten conjugate compositions and methods of making same - Google Patents
Xten conjugate compositions and methods of making sameInfo
- Publication number
- SG11201405276PA SG11201405276PA SG11201405276PA SG11201405276PA SG11201405276PA SG 11201405276P A SG11201405276P A SG 11201405276PA SG 11201405276P A SG11201405276P A SG 11201405276PA SG 11201405276P A SG11201405276P A SG 11201405276PA SG 11201405276P A SG11201405276P A SG 11201405276PA
- Authority
- SG
- Singapore
- Prior art keywords
- methods
- making same
- conjugate compositions
- xten conjugate
- xten
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0052—Small organic molecules
-
- A—HUMAN NECESSITIES
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- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0056—Peptides, proteins, polyamino acids
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261634312P | 2012-02-27 | 2012-02-27 | |
US201261690187P | 2012-06-18 | 2012-06-18 | |
US201261709942P | 2012-10-04 | 2012-10-04 | |
PCT/US2013/028116 WO2013130683A2 (en) | 2012-02-27 | 2013-02-27 | Xten conjugate compositions and methods of making same |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201405276PA true SG11201405276PA (en) | 2014-10-30 |
Family
ID=49083255
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201405276PA SG11201405276PA (en) | 2012-02-27 | 2013-02-27 | Xten conjugate compositions and methods of making same |
SG10201700340WA SG10201700340WA (en) | 2012-02-27 | 2013-02-27 | Xten conjugate compositions and methods of making same |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201700340WA SG10201700340WA (en) | 2012-02-27 | 2013-02-27 | Xten conjugate compositions and methods of making same |
Country Status (17)
Country | Link |
---|---|
US (4) | US10172953B2 (en) |
EP (2) | EP2819788B1 (en) |
JP (5) | JP6355563B2 (en) |
KR (1) | KR102057356B1 (en) |
CN (3) | CN107496932A (en) |
AU (2) | AU2013226090B2 (en) |
CA (2) | CA3179537A1 (en) |
CL (1) | CL2014002277A1 (en) |
EA (2) | EA030911B1 (en) |
HK (1) | HK1200139A1 (en) |
IL (2) | IL234309B (en) |
MX (2) | MX366864B (en) |
PE (1) | PE20142451A1 (en) |
PH (1) | PH12014501924A1 (en) |
SG (2) | SG11201405276PA (en) |
WO (2) | WO2013130684A1 (en) |
ZA (2) | ZA201406339B (en) |
Families Citing this family (99)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ593833A (en) * | 2009-02-03 | 2013-10-25 | Amunix Operating Inc | Extended recombinant polypeptides and compositions comprising same |
MX366864B (en) * | 2012-02-27 | 2019-07-26 | Amunix Operating Inc | Xten conjugate compositions and methods of making same. |
WO2014100913A1 (en) * | 2012-12-24 | 2014-07-03 | Beijing Anxinhuaide Biotech. Co., Ltd | Improving the half life of a therapeutic polypeptide by fusing with a trimeric scaffold protein via a spacer |
US9289502B2 (en) * | 2013-03-08 | 2016-03-22 | Emerald Therapeutics, Inc. | Preparation of oligo conjugates |
EP2979702A4 (en) * | 2013-03-25 | 2016-11-16 | Zeria Pharm Co Ltd | Postprandial gastrokinetic agent |
JP6822839B2 (en) | 2013-09-13 | 2021-01-27 | ザ・スクリップス・リサーチ・インスティテュート | Modified therapeutic agents and their compositions |
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EP3089745A4 (en) | 2013-12-31 | 2017-05-17 | Placon Therapeutics, Inc. | Compounds, compositions, and methods for the treatment of cancers |
US9119832B2 (en) | 2014-02-05 | 2015-09-01 | The Regents Of The University Of California | Methods of treating mild brain injury |
US10588980B2 (en) | 2014-06-23 | 2020-03-17 | Novartis Ag | Fatty acids and their use in conjugation to biomolecules |
EP3797768A1 (en) | 2014-06-23 | 2021-03-31 | Placon Therapeutics, Inc. | Maleimide-functionalised platinum for use in the treatment of cancer |
CN106573077B (en) * | 2014-06-30 | 2019-07-30 | 塔弗达治疗有限公司 | Target conjugate and its particle and preparation |
US20170281732A1 (en) * | 2014-08-19 | 2017-10-05 | Oxeia Biopharmaceuticals, Inc. | Methods of treating mild brain injury |
SG11201702122RA (en) * | 2014-09-16 | 2017-04-27 | Univ Western Australia | Treatment of tumours using peptide-protein conjugates |
US20170266257A1 (en) * | 2014-09-25 | 2017-09-21 | Oxeia Biopharmaceuticals, Inc. | Methods of treating traumatic brain injury |
EP3218390A4 (en) * | 2014-11-11 | 2018-11-21 | Amunix Operating Inc. | Targeted xten conjugate compositions and methods of making same |
US11304976B2 (en) | 2015-02-18 | 2022-04-19 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
US11000548B2 (en) | 2015-02-18 | 2021-05-11 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
WO2016132366A1 (en) | 2015-02-18 | 2016-08-25 | Enlivex Therapeutics Ltd. | Combination immune therapy and cytokine control therapy for cancer treatment |
US11318163B2 (en) | 2015-02-18 | 2022-05-03 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
US11596652B2 (en) | 2015-02-18 | 2023-03-07 | Enlivex Therapeutics R&D Ltd | Early apoptotic cells for use in treating sepsis |
US11497767B2 (en) | 2015-02-18 | 2022-11-15 | Enlivex Therapeutics R&D Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
LT3283508T (en) | 2015-04-17 | 2021-07-12 | Alpine Immune Sciences, Inc. | Immunomodulatory proteins with tunable affinities |
US10857181B2 (en) | 2015-04-21 | 2020-12-08 | Enlivex Therapeutics Ltd | Therapeutic pooled blood apoptotic cell preparations and uses thereof |
EP3613756B1 (en) * | 2015-04-28 | 2024-02-21 | Hybio Pharmaceutical Co., Ltd. | High performance liquid chromatography method for polypeptide mixtures |
WO2016193380A1 (en) | 2015-06-02 | 2016-12-08 | Novo Nordisk A/S | Insulins with polar recombinant extensions |
EP3328998A1 (en) * | 2015-07-27 | 2018-06-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Mutated factor x polypeptides and uses thereof for the treatment of haemophilia |
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MA43348A (en) * | 2015-10-01 | 2018-08-08 | Novo Nordisk As | PROTEIN CONJUGATES |
WO2017075535A1 (en) | 2015-10-28 | 2017-05-04 | Oxeia Biopharmaceuticals, Inc. | Methods of treating neurodegenerative conditions |
EP3368546A4 (en) | 2015-10-28 | 2019-06-26 | Tarveda Therapeutics, Inc. | Sstr-targeted conjugates and particles and formulations thereof |
US20170145394A1 (en) | 2015-11-23 | 2017-05-25 | The Regents Of The University Of California | Tracking and manipulating cellular rna via nuclear delivery of crispr/cas9 |
HRP20211466T1 (en) * | 2015-12-09 | 2021-12-24 | Medizinische Universität Wien | Monomaleimide-functionalized platinum compounds for cancer therapy |
CA3009880A1 (en) * | 2015-12-28 | 2017-07-06 | Idemitsu Kosan Co., Ltd. | Peptide tag and tagged protein including same |
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AR107560A1 (en) * | 2016-02-24 | 2018-05-09 | Lilly Co Eli | COMPOUND THAT DECREASES GLUCOSE IN BLOOD |
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CA3019202A1 (en) | 2016-04-15 | 2017-10-19 | Alpine Immune Sciences, Inc. | Cd80 variant immunomodulatory proteins and uses thereof |
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WO2017197048A1 (en) * | 2016-05-11 | 2017-11-16 | Amunix Operating Inc. | Albumin binding conjugate compositions and methods of making and using same |
EP3465221B1 (en) | 2016-05-27 | 2020-07-22 | H. Hoffnabb-La Roche Ag | Bioanalytical method for the characterization of site-specific antibody-drug conjugates |
KR102590454B1 (en) | 2016-07-07 | 2023-10-17 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | Antibody-Adjuvant Conjugate |
US11471488B2 (en) | 2016-07-28 | 2022-10-18 | Alpine Immune Sciences, Inc. | CD155 variant immunomodulatory proteins and uses thereof |
WO2018022945A1 (en) | 2016-07-28 | 2018-02-01 | Alpine Immune Sciences, Inc. | Cd112 variant immunomodulatory proteins and uses thereof |
EP3491013A1 (en) | 2016-07-28 | 2019-06-05 | Alpine Immune Sciences, Inc. | Cd155 variant immunomodulatory proteins and uses thereof |
KR20190099194A (en) | 2016-10-20 | 2019-08-26 | 알파인 이뮨 사이언시즈, 인코포레이티드 | Secretory variant immunomodulatory proteins and engineered cell therapy |
WO2018170026A2 (en) | 2017-03-16 | 2018-09-20 | Alpine Immune Sciences, Inc. | Cd80 variant immunomodulatory proteins and uses thereof |
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HRP20231382T1 (en) | 2017-03-16 | 2024-02-16 | Alpine Immune Sciences, Inc. | Pd-l1 variant immunomodulatory proteins and uses thereof |
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KR20200030065A (en) | 2017-06-21 | 2020-03-19 | 재즈 파마슈티칼즈 아일랜드 리미티드 | Modified L-asparaginase |
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US10889627B2 (en) * | 2017-06-29 | 2021-01-12 | Ureka Sarl | Pro-drug peptide with improved pharmaceutical properties |
JP2019043946A (en) * | 2017-08-31 | 2019-03-22 | 国立大学法人埼玉大学 | Ligand for molecule purification, tag peptide for molecule purification, and molecule purification method using the same |
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AU2018351000B2 (en) | 2017-10-18 | 2023-11-30 | Alpine Immune Sciences, Inc. | Variant ICOS Ligand immunomodulatory proteins and related compositions and methods |
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US20200385469A1 (en) * | 2017-12-21 | 2020-12-10 | Amunix Pharmaceuticals, Inc. | Release segments and binding compositions comprising same |
AU2019205273B2 (en) | 2018-01-03 | 2024-04-04 | Alpine Immune Sciences, Inc. | Multi-domain immunomodulatory proteins and methods of use thereof |
KR102113588B1 (en) * | 2018-03-26 | 2020-05-22 | (주)터틀바이오 | Mass Production System of Oligopeptide with His-Pro Repeats |
US20210363219A1 (en) | 2018-06-15 | 2021-11-25 | Alpine Immune Sciences, Inc. | Pd-1 variant immunomodulatory proteins and uses thereof |
WO2019241609A1 (en) * | 2018-06-15 | 2019-12-19 | Trustees Of Boston University | Polypeptide compositions and methods for site-specific targeting of therapeutic agents |
AU2019345151A1 (en) | 2018-09-19 | 2021-04-29 | Alpine Immune Sciences, Inc. | Methods and uses of variant CD80 fusion proteins and related constructs |
BR112021005907A2 (en) | 2018-09-27 | 2021-08-10 | Xilio Development, Inc. | masked cytokines, nucleic acid, vector, host cell, methods for producing a masked cytokine, for treating or preventing a neoplastic disease and for treating or preventing a neoplastic inflammatory or autoimmune disease, composition, pharmaceutical composition and kit |
EP3864024A4 (en) * | 2018-10-10 | 2022-07-06 | University of Washington | Fusion products and bioconjugates containing mixed charge peptides |
MA54070A (en) | 2018-10-29 | 2021-09-08 | Biogen Ma Inc | HUMANIZED AND STABILIZED FC5 VARIANTS FOR ENHANCED TRANSPORT ACROSS THE BLOOD-BRAIN BARRIER |
CN111153965A (en) * | 2018-11-07 | 2020-05-15 | 浙江道尔生物科技有限公司 | Artificial recombinant protein for improving performance of active protein or polypeptide and application thereof |
JP2022510276A (en) | 2018-11-30 | 2022-01-26 | アルパイン イミューン サイエンシズ インコーポレイテッド | CD86 variant immunomodulatory protein and its use |
CA3130794A1 (en) | 2019-03-15 | 2020-09-24 | Bolt Biotherapeutics, Inc. | Immunoconjugates targeting her2 |
US20220218785A1 (en) | 2019-04-17 | 2022-07-14 | Alpine Immune Sciences, Inc. | Methods and uses of variant icos ligand (icosl) fusion proteins |
EP3757217A1 (en) * | 2019-06-27 | 2020-12-30 | GlaxoSmithKline Biologicals S.A. | Methods for protein purification |
AU2020345138A1 (en) * | 2019-09-13 | 2022-04-21 | Biological E Limited | N-terminal extension sequence for expression of recombinant therapeutic peptides |
CN113597434B (en) | 2019-12-31 | 2022-07-01 | 北京质肽生物医药科技有限公司 | Fusion proteins of GLP-1 and GDF15 and conjugates thereof |
CN115322794A (en) | 2020-01-11 | 2022-11-11 | 北京质肽生物医药科技有限公司 | Conjugates of fusion proteins of GLP-1 and FGF21 |
WO2021226553A2 (en) | 2020-05-08 | 2021-11-11 | Alpine Immune Sciences, Inc. | April and baff inhibitory immunomodulatory proteins with and without a t cell inhibitory protein and methods of use thereof |
AU2021267940A1 (en) | 2020-05-08 | 2022-12-08 | President And Fellows Of Harvard College | Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence |
WO2021262985A1 (en) * | 2020-06-25 | 2021-12-30 | Amunix Pharmaceuticals, Inc. | Cytokine conjugates |
AU2021335509A1 (en) | 2020-09-04 | 2023-03-09 | F. Hoffmann-La Roche Ag | Antibody that binds to VEGF-A and ANG2 and methods of use |
TW202228784A (en) | 2020-09-23 | 2022-08-01 | 奧地利商艾柏力維亞生技有限公司 | Compound for the sequestration of undesirale anti-peg antibodies in a patient |
JP2023545684A (en) | 2020-09-30 | 2023-10-31 | ベイジン キューエル バイオファーマシューティカル カンパニー,リミテッド | Polypeptide conjugates and methods of use |
KR20230087538A (en) * | 2020-10-16 | 2023-06-16 | 엠펙 엘에이, 엘.엘.씨. | Linker compound containing an amide bond |
TWI815194B (en) | 2020-10-22 | 2023-09-11 | 美商基利科學股份有限公司 | INTERLEUKIN-2-Fc FUSION PROTEINS AND METHODS OF USE |
CN112362797B (en) * | 2020-10-26 | 2022-05-27 | 浙江国正检测技术有限公司 | Method for detecting quinolone drugs in feed |
AU2021409801A1 (en) | 2020-12-21 | 2023-06-22 | Allogene Therapeutics, Inc. | Protease-activating cd45-gate car |
EP4267592A1 (en) * | 2020-12-23 | 2023-11-01 | Jazz Pharmaceuticals Ireland Ltd. | Methods of purifying charge-shielded fusion proteins |
EP4333869A1 (en) | 2021-05-07 | 2024-03-13 | Alpine Immune Sciences, Inc. | Methods of dosing and treatment with a taci-fc fusion immunomodulatory protein |
CN113671085B (en) * | 2021-08-30 | 2023-03-03 | 珠海润都制药股份有限公司 | Method for detecting 2-azido-3-methylbutyric acid in valsartan |
CN113845585A (en) * | 2021-11-08 | 2021-12-28 | 浙江毓昌生物技术有限公司 | Method for removing recombinant human growth hormone endotoxin by using metal chelate chromatography |
WO2023172883A1 (en) | 2022-03-07 | 2023-09-14 | Alpine Immune Sciences, Inc. | Immunomodulatory proteins of variant cd80 polypeptides, cell therapies thereof and related methods and uses |
WO2023212294A1 (en) | 2022-04-29 | 2023-11-02 | Broadwing Bio Llc | Angiopoietin-related protein 7-specific antibodies and uses thereof |
WO2023212298A1 (en) | 2022-04-29 | 2023-11-02 | Broadwing Bio Llc | Bispecific antibodies and methods of treating ocular disease |
WO2023212293A1 (en) | 2022-04-29 | 2023-11-02 | Broadwing Bio Llc | Complement factor h related 4-specific antibodies and uses thereof |
CN116063387B (en) * | 2022-07-12 | 2023-11-24 | 东北农业大学 | Proline protection type enzymolysis-resistant antibacterial peptide and preparation method and application thereof |
CN115819513B (en) * | 2022-07-25 | 2023-10-17 | 东北农业大学 | Lauric acid modified enzymolysis-resistant peptide and preparation method and application thereof |
Family Cites Families (114)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA811368B (en) | 1980-03-24 | 1982-04-28 | Genentech Inc | Bacterial polypedtide expression employing tryptophan promoter-operator |
US4398908A (en) | 1980-11-28 | 1983-08-16 | Siposs George G | Insulin delivery system |
US4435173A (en) | 1982-03-05 | 1984-03-06 | Delta Medical Industries | Variable rate syringe pump for insulin delivery |
DK27885A (en) | 1985-01-22 | 1986-07-23 | Novo Industri As | PREPARATION OF PEPTIDES |
US5118666A (en) | 1986-05-05 | 1992-06-02 | The General Hospital Corporation | Insulinotropic hormone |
US4933185A (en) | 1986-09-24 | 1990-06-12 | Massachusetts Institute Of Technology | System for controlled release of biologically active compounds |
US4976696A (en) | 1987-08-10 | 1990-12-11 | Becton, Dickinson And Company | Syringe pump and the like for delivering medication |
US5182375A (en) | 1987-08-28 | 1993-01-26 | The Salk Institute For Biological Studies | DNA encoding follistatin |
US5041538A (en) | 1987-08-28 | 1991-08-20 | The Salk Institute For Biological Studies | Mammalian follistatin |
US5270176A (en) | 1987-11-20 | 1993-12-14 | Hoechst Aktiengesellschaft | Method for the selective cleavage of fusion proteins with lysostaphin |
US4904584A (en) | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
JP2717808B2 (en) | 1988-08-10 | 1998-02-25 | テルモ株式会社 | Syringe pump |
US6225449B1 (en) | 1991-10-04 | 2001-05-01 | Washington University | Hormone analogs with multiple CTP extensions |
US5017378A (en) | 1989-05-01 | 1991-05-21 | The University Of Virginia Alumni Patents Foundation | Intraorgan injection of biologically active compounds contained in slow-release microcapsules or microspheres |
US5599907A (en) | 1989-05-10 | 1997-02-04 | Somatogen, Inc. | Production and use of multimeric hemoglobins |
US5298022A (en) | 1989-05-29 | 1994-03-29 | Amplifon Spa | Wearable artificial pancreas |
US5318540A (en) | 1990-04-02 | 1994-06-07 | Pharmetrix Corporation | Controlled release infusion device |
US5492534A (en) | 1990-04-02 | 1996-02-20 | Pharmetrix Corporation | Controlled release portable pump |
US5176502A (en) | 1990-04-25 | 1993-01-05 | Becton, Dickinson And Company | Syringe pump and the like for delivering medication |
US5622929A (en) | 1992-01-23 | 1997-04-22 | Bristol-Myers Squibb Company | Thioether conjugates |
NZ265452A (en) | 1993-03-29 | 1997-09-22 | Univ Cincinnati | Analogues of peptide yy, dimers and pharmaceutical compositions |
US5545616A (en) | 1994-09-22 | 1996-08-13 | Genentech, Inc. | Method for predicting and/or preventing preterm labor |
US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
US5574010A (en) | 1994-11-14 | 1996-11-12 | The Regents Of The University Of California | Treatment of pancreatic tumors with peptide YY and analogs thereof |
US5521283A (en) | 1995-01-31 | 1996-05-28 | Eli Lilly And Company | Anti-obesity proteins |
US5532336A (en) | 1995-01-31 | 1996-07-02 | Eli Lilly And Company | Anti-obesity proteins |
US6184201B1 (en) | 1995-04-14 | 2001-02-06 | Nps Allelix Corp. | Intestinotrophic glucagon-like peptide-2 analogs |
US5834428A (en) | 1995-04-14 | 1998-11-10 | 1149336 Ontario Inc. | Glucagon-like peptide-2 and its therapeutic use |
US5789379A (en) | 1995-04-14 | 1998-08-04 | Allelix Biopharmaceutical Inc. | Glucagon-like peptide-2 analogs |
US5990077A (en) | 1995-04-14 | 1999-11-23 | 1149336 Ontario Inc. | Glucagon-like peptide-2 and its therapeutic use |
US5830655A (en) | 1995-05-22 | 1998-11-03 | Sri International | Oligonucleotide sizing using cleavable primers |
SE9503380D0 (en) | 1995-09-29 | 1995-09-29 | Pharmacia Ab | Protein derivatives |
CA2237114A1 (en) | 1995-11-07 | 1997-05-15 | Kaneka Corporation | Autoantigens |
US6936439B2 (en) | 1995-11-22 | 2005-08-30 | Amgen Inc. | OB fusion protein compositions and methods |
CN1304058C (en) | 1996-03-12 | 2007-03-14 | Pg-Txl有限公司 | Water soluble paclitaxel prodrugs |
US6441025B2 (en) | 1996-03-12 | 2002-08-27 | Pg-Txl Company, L.P. | Water soluble paclitaxel derivatives |
US5994500A (en) | 1996-07-19 | 1999-11-30 | 1149336 Ontario Inc. | Antagonists of intestinotrophic GLP-2 peptides |
US20020025933A1 (en) | 1996-08-30 | 2002-02-28 | Knudsen Liselotte Bjerre | GLP-2 derivatives |
WO1998026095A1 (en) | 1996-12-10 | 1998-06-18 | Genetrace Systems Inc. | Releasable nonvolatile mass-label molecules |
AT405516B (en) | 1997-02-27 | 1999-09-27 | Immuno Ag | FACTOR X-ANALOG WITH MODIFIED PROTEASE SPLIT |
JP2002512624A (en) | 1997-05-21 | 2002-04-23 | バイオベーション リミテッド | Method for producing non-immunogenic protein |
US6248564B1 (en) | 1997-08-29 | 2001-06-19 | Harvard University | Mutant MHC class I molecules |
IL136349A0 (en) | 1997-11-25 | 2001-05-20 | Gen Hospital Corp | Virulence-associated nucleic acid sequences and uses thereof |
DE69838526T2 (en) | 1998-02-05 | 2008-07-03 | Biosense Webster, Inc., Diamond Bar | Device for releasing a drug in the heart |
US6406632B1 (en) | 1998-04-03 | 2002-06-18 | Symyx Technologies, Inc. | Rapid characterization of polymers |
PL196533B1 (en) | 1998-04-28 | 2008-01-31 | Applied Research Systems | Method for the stepwise attachment of polyethylene glycol (peg) in series to polypeptide |
US7090976B2 (en) | 1999-11-10 | 2006-08-15 | Rigel Pharmaceuticals, Inc. | Methods and compositions comprising Renilla GFP |
GB9815157D0 (en) | 1998-07-13 | 1998-09-09 | Metron Designs Ltd | High resolution pulse width setting from relatively low frequency clocks |
US20030190740A1 (en) | 1998-10-13 | 2003-10-09 | The University Of Georgia Research Foundation, Inc | Stabilized bioactive peptides and methods of identification, synthesis, and use |
WO2000034317A2 (en) | 1998-12-08 | 2000-06-15 | Biovation Limited | Method for reducing immunogenicity of proteins |
US7666400B2 (en) | 2005-04-06 | 2010-02-23 | Ibc Pharmaceuticals, Inc. | PEGylation by the dock and lock (DNL) technique |
CA2696819C (en) | 1999-07-23 | 2015-07-07 | Kenji Kangawa | Ghrelin related peptides |
US20030109428A1 (en) | 1999-12-01 | 2003-06-12 | John Bertin | Novel molecules of the card-related protein family and uses thereof |
US20050287153A1 (en) | 2002-06-28 | 2005-12-29 | Genentech, Inc. | Serum albumin binding peptides for tumor targeting |
WO2001092292A2 (en) | 2000-05-30 | 2001-12-06 | Merck & Co., Inc. | Ghrelin analogs |
US7186683B2 (en) | 2000-09-18 | 2007-03-06 | Sanos Bioscience A/S | Use of GLP for the treatment, prevention, diagnosis, and prognosis of bone-related and nutrition-related disorders |
US20030228309A1 (en) | 2000-11-08 | 2003-12-11 | Theodora Salcedo | Antibodies that immunospecifically bind to TRAIL receptors |
US20030049689A1 (en) | 2000-12-14 | 2003-03-13 | Cynthia Edwards | Multifunctional polypeptides |
PE20020908A1 (en) | 2001-03-21 | 2002-10-26 | Cell Therapeutics Inc | RECOMBINANT PRODUCTION OF POLYANIONIC POLYMERS AND USE OF THE SAME |
WO2002079415A2 (en) | 2001-03-30 | 2002-10-10 | Lexigen Pharmaceuticals Corp. | Reducing the immunogenicity of fusion proteins |
KR100407467B1 (en) | 2001-07-12 | 2003-11-28 | 최수봉 | Insulin pump operated by remote-controller |
WO2003011213A2 (en) | 2001-07-30 | 2003-02-13 | Eli Lilly And Company | Method for treating diabetes and obesity |
US7125843B2 (en) | 2001-10-19 | 2006-10-24 | Neose Technologies, Inc. | Glycoconjugates including more than one peptide |
US20080167238A1 (en) | 2001-12-21 | 2008-07-10 | Human Genome Sciences, Inc. | Albumin Fusion Proteins |
US7524821B2 (en) | 2002-06-20 | 2009-04-28 | University Of Maryland Biotechnology Institute | Scaffolded maleimide clusters for multivalent peptide assembly |
US7294513B2 (en) | 2002-07-24 | 2007-11-13 | Wyatt Technology Corporation | Method and apparatus for characterizing solutions of small particles |
US20050032081A1 (en) | 2002-12-13 | 2005-02-10 | Jingyue Ju | Biomolecular coupling methods using 1,3-dipolar cycloaddition chemistry |
US7166575B2 (en) | 2002-12-17 | 2007-01-23 | Nastech Pharmaceutical Company Inc. | Compositions and methods for enhanced mucosal delivery of peptide YY and methods for treating and preventing obesity |
WO2004104020A2 (en) | 2003-05-14 | 2004-12-02 | Dow Corning Corporation | Repeat sequence protein polymer active agent conjugates, methods and uses |
US20070161087A1 (en) | 2003-05-29 | 2007-07-12 | Wolfgang Glaesner | Glp-1 fusion proteins |
US7498024B2 (en) | 2003-06-03 | 2009-03-03 | Cell Genesys, Inc. | Compositions and methods for enhanced expression of immunoglobulins from a single vector using a peptide cleavage site |
US20050152979A1 (en) | 2003-09-05 | 2005-07-14 | Cell Therapeutics, Inc. | Hydrophobic drug compositions containing reconstitution enhancer |
US20070203058A1 (en) | 2003-09-19 | 2007-08-30 | Novo Nordisk A/S | Novel Glp-1 Derivatives |
WO2005046583A2 (en) | 2003-10-30 | 2005-05-26 | Emory University | Modified fviii having reduced immunogenicity through mutagenesis of a2 and c2 epitopes |
US20060148680A1 (en) | 2004-01-14 | 2006-07-06 | Kieliszewski Marcia J | Glycoproteins produced in plants and methods of their use |
PL1729795T3 (en) | 2004-02-09 | 2016-08-31 | Human Genome Sciences Inc | Albumin fusion proteins |
US8076288B2 (en) | 2004-02-11 | 2011-12-13 | Amylin Pharmaceuticals, Inc. | Hybrid polypeptides having glucose lowering activity |
EP3059245B1 (en) | 2004-07-23 | 2018-11-07 | Acceleron Pharma Inc. | Actrii receptor antagonistic antibodies |
EP1797127B1 (en) | 2004-09-24 | 2017-06-14 | Amgen Inc. | Modified fc molecules |
US20060099710A1 (en) * | 2004-11-10 | 2006-05-11 | Donnelly Mark I | Vector for improved in vivo production of proteins |
JP5735194B2 (en) | 2005-01-25 | 2015-06-17 | セル セラピューティクス インコーポレーテッド | Biologically active protein with improved in vivo half-life |
US8263545B2 (en) | 2005-02-11 | 2012-09-11 | Amylin Pharmaceuticals, Inc. | GIP analog and hybrid polypeptides with selectable properties |
ATE498631T1 (en) | 2005-05-04 | 2011-03-15 | Zealand Pharma As | GLUCAGON LIKE PEPTIDE 2 (GLP-2) ANALOGUE |
US7855279B2 (en) | 2005-09-27 | 2010-12-21 | Amunix Operating, Inc. | Unstructured recombinant polymers and uses thereof |
US7846445B2 (en) | 2005-09-27 | 2010-12-07 | Amunix Operating, Inc. | Methods for production of unstructured recombinant polymers and uses thereof |
WO2007073486A2 (en) | 2005-12-20 | 2007-06-28 | Duke University | Methods and compositions for delivering active agents with enhanced pharmacological properties |
DK2402754T4 (en) | 2006-03-06 | 2023-08-28 | Amunix Operating Inc | Unstructured recombinant polymers and uses thereof |
EP2010222A1 (en) | 2006-03-31 | 2009-01-07 | Baxter International Inc. | Pegylated factor viii |
WO2007130535A2 (en) | 2006-05-04 | 2007-11-15 | Molecular Innovations | Novel protein fusion/tag technology |
KR101454508B1 (en) * | 2006-05-30 | 2014-11-04 | 제넨테크, 인크. | Antibodies and immunoconjugates and uses therefor |
WO2008052187A2 (en) | 2006-10-27 | 2008-05-02 | Genentech. Inc. | Antibodies and immunoconjugates and uses therefor |
WO2008049711A1 (en) | 2006-10-27 | 2008-05-02 | Novo Nordisk A/S | Peptide extended insulins |
US8563521B2 (en) | 2007-06-21 | 2013-10-22 | Technische Universitat Munchen | Biological active proteins having increased in vivo and/or in vitro stability |
JP2010536341A (en) | 2007-08-15 | 2010-12-02 | アムニクス, インコーポレイテッド | Compositions and methods for altering properties of biologically active polypeptides |
CN102131516B (en) | 2008-06-27 | 2016-03-16 | 杜克大学 | Comprise the therapeutic agent of elastin-like peptides |
US8957021B2 (en) | 2009-02-03 | 2015-02-17 | Amunix Operating Inc. | Glucose-regulating polypeptides and methods of making and using same |
US8680050B2 (en) * | 2009-02-03 | 2014-03-25 | Amunix Operating Inc. | Growth hormone polypeptides fused to extended recombinant polypeptides and methods of making and using same |
NZ593833A (en) | 2009-02-03 | 2013-10-25 | Amunix Operating Inc | Extended recombinant polypeptides and compositions comprising same |
US8703717B2 (en) * | 2009-02-03 | 2014-04-22 | Amunix Operating Inc. | Growth hormone polypeptides and methods of making and using same |
CN106916229A (en) | 2009-06-08 | 2017-07-04 | 阿穆尼克斯运营公司 | Growth hormone polypeptides and its preparation and application |
US9849188B2 (en) | 2009-06-08 | 2017-12-26 | Amunix Operating Inc. | Growth hormone polypeptides and methods of making and using same |
EP3222287A1 (en) | 2009-08-24 | 2017-09-27 | Amunix Operating Inc. | Coagulation factor ix compositions and methods of making and using same |
WO2011028344A2 (en) | 2009-08-25 | 2011-03-10 | Amunix Operating Inc. | Interleukin-1 receptor antagonist compositions and methods of making and using same |
CA2779099C (en) | 2009-10-30 | 2021-08-10 | Northwestern University | Templated nanoconjugates |
US20110312881A1 (en) | 2009-12-21 | 2011-12-22 | Amunix, Inc. | Bifunctional polypeptide compositions and methods for treatment of metabolic and cardiovascular diseases |
US8557961B2 (en) | 2010-04-02 | 2013-10-15 | Amunix Operating Inc. | Alpha 1-antitrypsin compositions and methods of making and using same |
WO2011123813A2 (en) * | 2010-04-02 | 2011-10-06 | Amunix Operating Inc. | Binding fusion proteins, binding fusion protein-drug conjugates, xten-drug conjugates and methods of making and using same |
US8859629B2 (en) | 2010-04-27 | 2014-10-14 | Synaffix B.V. | Fused cyclooctyne compounds and their use in metal-free click reactions |
SI2571510T1 (en) * | 2010-05-21 | 2019-02-28 | Xl-Protein Gmbh | Biosynthetic proline/alanine random coil polypeptides and their uses |
US20130017997A1 (en) | 2010-08-19 | 2013-01-17 | Amunix Operating Inc. | Factor VIII Compositions and Methods of Making and Using Same |
PT2755675T (en) | 2011-09-12 | 2018-10-11 | Amunix Operating Inc | Glucagon-like peptide-2 compositions and methods of making and using same |
ES2771208T3 (en) | 2012-02-15 | 2020-07-06 | Bioverativ Therapeutics Inc | Factor VIII compositions and methods of preparation and use thereof |
MX366864B (en) | 2012-02-27 | 2019-07-26 | Amunix Operating Inc | Xten conjugate compositions and methods of making same. |
US9601471B2 (en) | 2015-04-23 | 2017-03-21 | Apple Inc. | Three layer stack structure |
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