NO20083501L - Azaindoler som er anvendelige som inhibitorer for Janus-kinaser - Google Patents
Azaindoler som er anvendelige som inhibitorer for Janus-kinaserInfo
- Publication number
- NO20083501L NO20083501L NO20083501A NO20083501A NO20083501L NO 20083501 L NO20083501 L NO 20083501L NO 20083501 A NO20083501 A NO 20083501A NO 20083501 A NO20083501 A NO 20083501A NO 20083501 L NO20083501 L NO 20083501L
- Authority
- NO
- Norway
- Prior art keywords
- inhibitors
- janus kinases
- useful
- azaindoles useful
- azaindoles
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/10—Protein-tyrosine kinases (2.7.10)
- C12Y207/10002—Non-specific protein-tyrosine kinase (2.7.10.2), i.e. spleen tyrosine kinase
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Molecular Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75936706P | 2006-01-17 | 2006-01-17 | |
US84247106P | 2006-09-06 | 2006-09-06 | |
PCT/US2007/001225 WO2007084557A2 (fr) | 2006-01-17 | 2007-01-17 | Azaindoles utiles comme inhibiteurs de janus kinases |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20083501L true NO20083501L (no) | 2008-10-14 |
Family
ID=38197739
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20083501A NO20083501L (no) | 2006-01-17 | 2008-08-13 | Azaindoler som er anvendelige som inhibitorer for Janus-kinaser |
Country Status (19)
Country | Link |
---|---|
US (6) | US7767816B2 (fr) |
EP (3) | EP1973911B1 (fr) |
JP (4) | JP5591471B2 (fr) |
KR (3) | KR101235103B1 (fr) |
CN (3) | CN102532133A (fr) |
AR (1) | AR060316A1 (fr) |
AU (1) | AU2007207533B8 (fr) |
BR (2) | BRPI0706537A2 (fr) |
CA (1) | CA2636189A1 (fr) |
CL (1) | CL2008002140A1 (fr) |
HK (1) | HK1210780A1 (fr) |
IL (1) | IL191902A0 (fr) |
NO (1) | NO20083501L (fr) |
NZ (3) | NZ569899A (fr) |
RU (2) | RU2453548C2 (fr) |
TW (4) | TWI424999B (fr) |
UA (1) | UA95940C2 (fr) |
WO (1) | WO2007084557A2 (fr) |
ZA (2) | ZA200805053B (fr) |
Families Citing this family (97)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2332940B1 (fr) | 2004-03-30 | 2012-10-31 | Vertex Pharmaceuticals Incorporated | Azaindoles utiles comme inhibiteurs de janus kinases et d'autres proteines kinases |
EP2354140A1 (fr) * | 2005-05-20 | 2011-08-10 | Vertex Pharmaceuticals Incorporated | Pyrrolopyridines en tant qu'inhibiteurs de kinase |
CA2621261C (fr) | 2005-09-22 | 2014-05-20 | Incyte Corporation | Inhibiteurs tetracycliques de janus kinases |
UA98449C2 (en) | 2005-12-13 | 2012-05-25 | Инсайт Корпорейшин | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors |
RU2453548C2 (ru) | 2006-01-17 | 2012-06-20 | Вертекс Фармасьютикалз Инкорпорейтед | Азаиндолы, полезные в качестве ингибиторов янус-киназ |
CA2648250A1 (fr) * | 2006-04-05 | 2007-10-18 | Vertex Pharmaceuticals Incorporated | Desazapurines utiles comme inhibiteurs des kinases janus |
US7754838B2 (en) * | 2006-08-08 | 2010-07-13 | E.I. Du Pont De Nemours And Company | Poly(meth)acrylamides and poly(meth)acrylates containing fluorinated amide |
JP5406039B2 (ja) * | 2006-12-21 | 2014-02-05 | バーテックス ファーマシューティカルズ インコーポレイテッド | タンパク質キナーゼ阻害剤として有用な5−シアノ−4−(ピロロ[2,3b]ピリジン−3−イル)−ピリミジン誘導体 |
US8513270B2 (en) | 2006-12-22 | 2013-08-20 | Incyte Corporation | Substituted heterocycles as Janus kinase inhibitors |
WO2008116139A2 (fr) | 2007-03-22 | 2008-09-25 | Vertex Pharmaceuticals Incorporated | Composés utiles en tant qu'inhibiteurs des kinases de janus |
CL2008001709A1 (es) | 2007-06-13 | 2008-11-03 | Incyte Corp | Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras. |
RS53245B2 (sr) | 2007-06-13 | 2022-10-31 | Incyte Holdings Corp | Soli inhibitora janus kinaze (r)-3-(4-(7h-pirolo(2,3-d) pirimidin-4-il)-1h-pirazol-1-il)-3-ciklopentilpropan-nitrila |
JP2011513483A (ja) * | 2008-03-10 | 2011-04-28 | バーテックス ファーマシューティカルズ インコーポレイテッド | タンパク質キナーゼの阻害剤として有用なピリミジンおよびピリジン |
JP5275371B2 (ja) | 2008-03-11 | 2013-08-28 | インサイト・コーポレイション | Jak阻害剤としてのアゼチジン誘導体およびシクロブタン誘導体 |
CA2731451A1 (fr) * | 2008-07-23 | 2010-01-28 | Vertex Pharmaceuticals Incorporated | Inhibiteurs de la pyrazolopyridine kinase |
BRPI1012159B1 (pt) | 2009-05-22 | 2022-01-25 | Incyte Holdings Corporation | Compostos derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo[2,3-d] pirimidinas e pirrol-3-il-pirrolo[2,3-d] pirimidinas como inibidores de janus cinase, composições farmacêuticas compreendendo os referidos compostos e usos dos mesmos |
LT2432472T (lt) | 2009-05-22 | 2020-02-10 | Incyte Holdings Corporation | 3-[4-(7h-pirolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]oktan- arba heptan-nitrilas, kaip jak inhibitoriai |
ES2604667T3 (es) * | 2009-06-17 | 2017-03-08 | Vertex Pharmaceuticals Incorporated | Inhibidores de la replicación de virus de influenza |
AR078012A1 (es) | 2009-09-01 | 2011-10-05 | Incyte Corp | Derivados heterociclicos de las pirazol-4-il- pirrolo (2,3-d) pirimidinas como inhibidores de la quinasa janus |
JP5946768B2 (ja) | 2009-10-09 | 2016-07-06 | インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation | 3−(4−(7H−ピロロ[2,3−d]ピリミジン−4−イル)−1H−ピラゾール−1−イル)−3−シクロペンチルプロパンニトリルのヒドロキシル、ケト及びグルクロニド誘導体 |
PT2516434E (pt) | 2009-12-23 | 2015-10-05 | Takeda Pharmaceutical | Pirrolidinonas heteroaromáticas fundidas como inibidores de syk |
AU2011224484A1 (en) | 2010-03-10 | 2012-09-27 | Incyte Holdings Corporation | Piperidin-4-yl azetidine derivatives as JAK1 inhibitors |
US8481541B2 (en) | 2010-03-22 | 2013-07-09 | Hoffmann-La Roche Inc. | Pyrrolopyrazine kinase inhibitors |
WO2011137022A1 (fr) * | 2010-04-27 | 2011-11-03 | Merck Sharp & Dohme Corp. | Azaindoles comme inhibiteurs de janus kinase |
KR20130083387A (ko) | 2010-05-20 | 2013-07-22 | 에프. 호프만-라 로슈 아게 | Syk 및 jak 억제제로서 피롤로피라진 유도체 |
CN103002875B (zh) | 2010-05-21 | 2016-05-04 | 因塞特控股公司 | Jak抑制剂的局部用制剂 |
US9198911B2 (en) | 2010-11-02 | 2015-12-01 | The Trustees Of Columbia University In The City Of New York | Methods for treating hair loss disorders |
ES2536415T3 (es) | 2010-11-19 | 2015-05-25 | Incyte Corporation | Pirrolopiridinas y pirrolopirimidinas sustituidas heterocíclicas como inhibidores de JAK |
PE20140146A1 (es) | 2010-11-19 | 2014-02-06 | Incyte Corp | Derivados de pirrolopiridina y pirrolopirimidina sustituidos con ciclobutilo como inhibidores de jak |
JP2013545817A (ja) | 2010-12-16 | 2013-12-26 | バーテックス ファーマシューティカルズ インコーポレイテッド | インフルエンザウイルス複製阻害物質 |
CA2822057A1 (fr) | 2010-12-16 | 2012-06-21 | Vertex Pharmaceuticals Incorporated | Inhibiteurs de la replication des virus de la grippe |
CN103562205A (zh) | 2010-12-16 | 2014-02-05 | 沃泰克斯药物股份有限公司 | 流感病毒复制的抑制剂 |
DE102011009961A1 (de) * | 2011-02-01 | 2012-08-02 | Merck Patent Gmbh | 7-Azaindolderivate |
CN103732226B (zh) | 2011-02-18 | 2016-01-06 | 诺瓦提斯药物公司 | mTOR/JAK抑制剂组合疗法 |
AU2012232658B2 (en) | 2011-03-22 | 2016-06-09 | Advinus Therapeutics Limited | Substituted fused tricyclic compounds, compositions and medicinal applications thereof |
EP2714688B1 (fr) | 2011-05-26 | 2016-02-24 | Daiichi Sankyo Company, Limited | Composés hétérocycliques comme inhibiteurs de proteines kinases |
AR086983A1 (es) | 2011-06-20 | 2014-02-05 | Incyte Corp | Derivados de azetidinil fenil, piridil o pirazinil carboxamida como inhibidores de jak |
US9056873B2 (en) | 2011-06-22 | 2015-06-16 | Takeda Pharmaceutical Company Limited | Substituted 6-aza-isoindolin-1-one derivatives |
PL3141548T3 (pl) | 2011-07-05 | 2020-09-07 | Vertex Pharmaceuticals Incorporated | Sposoby i związki pośrednie do wytwarzania azaindoli |
UA118010C2 (uk) * | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
EP2741747A1 (fr) | 2011-08-10 | 2014-06-18 | Novartis Pharma AG | Polythérapie par jak p13k/mtor |
TW201313721A (zh) | 2011-08-18 | 2013-04-01 | Incyte Corp | 作為jak抑制劑之環己基氮雜環丁烷衍生物 |
UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
WO2013070606A1 (fr) | 2011-11-07 | 2013-05-16 | Vertex Pharmaceuticals Incorporated | Méthodes pour le traitement de maladies inflammatoires et combinaisons pharmaceutiques utiles pour celles-ci |
CA3131037A1 (fr) | 2011-11-30 | 2013-06-06 | Emory University | Inhibiteurs de jak antiviraux utiles dans le traitement ou la prevention d'infections retrovirales et autres infections virales |
WO2013117649A1 (fr) * | 2012-02-10 | 2013-08-15 | Galapagos Nv | Dérivés d'imidazo [4, 5-c] pyridine utiles pour le traitement de maladies dégénératives et inflammatoires |
UY34616A (es) * | 2012-02-10 | 2013-09-30 | Galapagos Nv | Nuevo compuesto útil para el tratamiento de enfermedades degenerativas e inflamatorias. |
PL2830662T3 (pl) * | 2012-03-29 | 2019-02-28 | The Trustees Of Columbia University In The City Of New York | Sposoby leczenia zaburzeń utraty włosów |
US20130310340A1 (en) | 2012-05-16 | 2013-11-21 | Rigel Pharmaceuticals, Inc. | Method of treating muscular degradation |
WO2013173720A1 (fr) | 2012-05-18 | 2013-11-21 | Incyte Corporation | Dérivés de pyrrolopyridine et de pyrrolopyrimidine substitués par un pipéridinylcyclobutyle à titre d'inhibiteurs jak |
WO2013184985A1 (fr) | 2012-06-08 | 2013-12-12 | Vertex Pharmaceuticals Incorporated | Inhibiteurs de la réplication de virus de la grippe |
WO2014013014A1 (fr) | 2012-07-18 | 2014-01-23 | Fundació Privada Centre De Regulació Genòmica (Crg) | Inhibiteurs de jak pour l'activation de populations de cellules souches épidermiques |
US9593115B2 (en) | 2012-09-21 | 2017-03-14 | Advinus Therapeutics Ltd. | Substituted fused tricyclic compounds, compositions, and medicinal applications thereof |
WO2014074471A1 (fr) | 2012-11-06 | 2014-05-15 | Vertex Pharmaceuticals Incorporated | Méthodes pour traiter des maladies inflammatoires et combinaisons pharmaceutiques utiles a cette fin |
MY191357A (en) | 2012-11-15 | 2022-06-19 | Incyte Holdings Corp | Sustained-release dosage forms of ruxolitinib |
WO2014089280A1 (fr) * | 2012-12-07 | 2014-06-12 | Calitor Sciences, Llc | Composés alcynyle et leurs procédés d'utilisation |
WO2014110259A1 (fr) | 2013-01-09 | 2014-07-17 | Vertex Pharmaceuticals Incorporated | Formes solides d'un inhibiteur de jak |
WO2014113191A1 (fr) * | 2013-01-15 | 2014-07-24 | Xiaohu Zhang | Inhibiteurs de la voie signalisation hedgehog et leurs applications thérapeutiques |
TW201513861A (zh) * | 2013-01-17 | 2015-04-16 | Galapagos Nv | 用於治療退化性及發炎疾病之新穎化合物 |
UA120162C2 (uk) | 2013-03-06 | 2019-10-25 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки при отриманні інгібітора jak |
KR20150130311A (ko) * | 2013-03-19 | 2015-11-23 | 머크 샤프 앤드 돔 코포레이션 | 야누스 키나제 억제제로서의 n-(2-시아노 헤테로시클릴)피라졸로 피리돈 |
WO2014201332A1 (fr) * | 2013-06-14 | 2014-12-18 | Vertex Pharmaceuticals Incorporated | Combinaisons pharmaceutiques utiles pour traiter la polyarthrite rhumatoïde |
PT3030227T (pt) | 2013-08-07 | 2020-06-25 | Incyte Corp | Formas de dosagem de libertação prolongada para um inibidor de jak1 |
WO2015027005A1 (fr) | 2013-08-22 | 2015-02-26 | Vertex Pharmaceuticals Incorporated | Azaindoles isotopiquement enrichis |
US9296727B2 (en) | 2013-10-07 | 2016-03-29 | Vertex Pharmaceuticals Incorporated | Methods of regioselective synthesis of 2,4-disubstituted pyrimidines |
EP3068776B1 (fr) | 2013-11-13 | 2019-05-29 | Vertex Pharmaceuticals Incorporated | Inhibiteurs de la réplication des virus de la grippe |
MX2016006200A (es) | 2013-11-13 | 2016-08-08 | Vertex Pharma | Metodos para preparar inhibidores de la replicacion de virus de influenza. |
HUE041934T2 (hu) | 2014-02-04 | 2019-06-28 | Taiho Pharmaceutical Co Ltd | Azaindol származék |
US9498467B2 (en) | 2014-05-30 | 2016-11-22 | Incyte Corporation | Treatment of chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) by inhibitors of JAK1 |
US10597390B2 (en) | 2014-08-08 | 2020-03-24 | Janssen Sciences Ireland Uc | Indoles for use in influenza virus infection |
NO2721710T3 (fr) | 2014-08-21 | 2018-03-31 | ||
TWI679205B (zh) | 2014-09-02 | 2019-12-11 | 日商日本新藥股份有限公司 | 吡唑并噻唑化合物及醫藥 |
WO2016075583A1 (fr) * | 2014-11-10 | 2016-05-19 | Glaxosmithkline Intelle Ctual Property (No.2) Limited | Compositions pharmaceutiques à action prolongée contre l'hépatite c |
JP6460382B2 (ja) * | 2014-11-28 | 2019-01-30 | 株式会社豊田自動織機 | 飽和ヘテロ環含有化合物、並びにこれを用いた二次電池用電極及び二次電池、結着剤、蛍光物質 |
EP3294735B8 (fr) | 2015-05-13 | 2022-01-05 | Vertex Pharmaceuticals Incorporated | Inhibiteurs de la réplication des virus de la grippe |
EP3294717B1 (fr) | 2015-05-13 | 2020-07-29 | Vertex Pharmaceuticals Inc. | Procédés de préparation d'inhibiteurs de réplication des virus de la grippe |
TWI712604B (zh) | 2016-03-01 | 2020-12-11 | 日商日本新藥股份有限公司 | 具jak抑制作用之化合物之結晶 |
WO2017198122A1 (fr) * | 2016-05-19 | 2017-11-23 | 四川大学 | Composé anti-grippe à petites molécules, son procédé de préparation et son utilisation |
CN109790158B (zh) * | 2016-07-26 | 2022-06-24 | 苏州隆博泰药业有限公司 | 作为jak抑制剂杂环化合物,该化合物的盐类及其治疗用途 |
WO2018041989A1 (fr) | 2016-09-02 | 2018-03-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Procédés de diagnostic et de traitement de la maladie coeliaque réfractaire de type 2 |
EP3615545B1 (fr) | 2017-04-24 | 2021-09-01 | Cocrystal Pharma, Inc. | Dérivés de pyrrolopyrimidine utiles en tant qu'inhibiteurs de la réplication du virus de la grippe |
WO2019113487A1 (fr) | 2017-12-08 | 2019-06-13 | Incyte Corporation | Polythérapie à faible dose pour le traitement de néoplasmes myéloprolifératifs |
KR20200129099A (ko) | 2018-01-30 | 2020-11-17 | 인사이트 코포레이션 | (1-(3-플루오로-2-(트리플루오로메틸)이소니코티닐)피페리딘-4-온)의 제조 방법 |
US10508113B2 (en) | 2018-03-12 | 2019-12-17 | Abbvie Inc. | Inhibitors of tyrosine kinase 2 mediated signaling |
CN112423759A (zh) | 2018-03-30 | 2021-02-26 | 因赛特公司 | 使用jak抑制剂治疗化脓性汗腺炎 |
CN112638477B (zh) | 2018-07-27 | 2024-01-26 | 共晶制药公司 | 作为流感病毒复制的抑制剂的吡咯并[2,3-b]吡啶衍生物 |
WO2020112716A1 (fr) | 2018-11-26 | 2020-06-04 | Cocrystal Pharma, Inc. | Inhibiteurs de la réplication du virus de la grippe |
CN114364798A (zh) | 2019-03-21 | 2022-04-15 | 欧恩科斯欧公司 | 用于治疗癌症的Dbait分子与激酶抑制剂的组合 |
JP2022527972A (ja) | 2019-04-02 | 2022-06-07 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 前悪性病変を有する患者において癌を予測及び予防する方法 |
US20220202820A1 (en) | 2019-04-16 | 2022-06-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of jak inhibitors for the treatment of painful conditions involving nav1.7 channels |
KR102133595B1 (ko) | 2019-05-31 | 2020-07-13 | 에이치케이이노엔 주식회사 | 단백질 키나제 억제제로서의 헤테로고리 화합물 |
KR102112336B1 (ko) | 2019-08-12 | 2020-05-18 | 에이치케이이노엔 주식회사 | 단백질 키나제 억제제로서의 헤테로고리 화합물 |
WO2021089791A1 (fr) | 2019-11-08 | 2021-05-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Méthodes pour le traitement de cancers qui ont acquis une résistance aux inhibiteurs de kinase |
WO2021148581A1 (fr) | 2020-01-22 | 2021-07-29 | Onxeo | Nouvelle molécule dbait et son utilisation |
WO2021188620A1 (fr) | 2020-03-17 | 2021-09-23 | Cocrystal Pharma Inc. | Dérivés de n5-méthyl-n2-(nonanoyl-l-leucyl)-l-glutaminate peptidomimétiques, dérivés de triazaspiro[4.14]nonadécane et composés similaires utilisés en tant qu'inhibiteurs de réplication de norovirus et de coronavirus |
US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
WO2023222565A1 (fr) | 2022-05-16 | 2023-11-23 | Institut National de la Santé et de la Recherche Médicale | Procédés d'évaluation de l'épuisement de cellules souches hématopoïétiques induites par une inflammation chronique |
Family Cites Families (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ221717A (en) | 1986-09-10 | 1990-08-28 | Sandoz Ltd | Azaindole and indolizine derivatives and pharmaceutical compositions |
US5304121A (en) | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
FR2687402B1 (fr) | 1992-02-14 | 1995-06-30 | Lipha | Nouveaux azaindoles, procedes de preparation et medicaments les contenant. |
US5716981A (en) | 1993-07-19 | 1998-02-10 | Angiogenesis Technologies, Inc. | Anti-angiogenic compositions and methods of use |
WO1995033748A1 (fr) | 1994-06-09 | 1995-12-14 | Smithkline Beecham Corporation | Antagonistes du recepteur de l'endotheline |
US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
GB9721437D0 (en) | 1997-10-10 | 1997-12-10 | Glaxo Group Ltd | Heteroaromatic compounds and their use in medicine |
FR2784375B1 (fr) * | 1998-10-12 | 2000-11-24 | Adir | Nouveaux derives cycliques a chaine cycloalkylenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US6265403B1 (en) | 1999-01-20 | 2001-07-24 | Merck & Co., Inc. | Angiogenesis inhibitors |
US20030153560A1 (en) | 1999-04-23 | 2003-08-14 | Salituro Francesco G. | Inhibitors of c-Jun N-terminal kinases (JNK) |
DE60027431T2 (de) | 1999-07-02 | 2007-07-12 | Stuart A. Rancho Santa Fe Lipton | Verwendung von p38 MAPK Inhibitoren in der Behandlung von Augenkrankheiten |
AU2735201A (en) | 1999-12-28 | 2001-07-09 | Pharmacopeia, Inc. | Pyrimidine and triazine kinase inhibitors |
HUP0301117A3 (en) | 2000-02-17 | 2004-01-28 | Amgen Inc Thousand Oaks | Imidazole derivatives kinase inhibitors, their use, process for their preparation and pharmaceutical compositions containing them |
JP4105948B2 (ja) | 2000-09-15 | 2008-06-25 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼインヒビターとして有用なピラゾール化合物 |
EP1364212B1 (fr) | 2001-03-02 | 2011-02-02 | GPC Biotech AG | Systeme de dosage a trois hybrides |
US7081454B2 (en) | 2001-03-28 | 2006-07-25 | Bristol-Myers Squibb Co. | Tyrosine kinase inhibitors |
ATE432929T1 (de) | 2001-06-15 | 2009-06-15 | Vertex Pharma | 5-(2-aminopyrimidin-4-yl)benzisoxazole als proteinkinasehemmer |
GB0115109D0 (en) | 2001-06-21 | 2001-08-15 | Aventis Pharma Ltd | Chemical compounds |
US20040236110A1 (en) | 2001-09-26 | 2004-11-25 | Ladouceur Gaetan H | Substituted 3-pyridyl indoles and indazoles as c17,20 lyase inhibitors |
TW200306819A (en) | 2002-01-25 | 2003-12-01 | Vertex Pharma | Indazole compounds useful as protein kinase inhibitors |
EP1501833B1 (fr) | 2002-04-26 | 2005-11-02 | Pfizer Products Inc. | Inhibiteurs de la metalloproteinase n-substitues-heteroaryloxy-aryl-spiro-pyrimidine-2,4,6-trione |
US7304061B2 (en) | 2002-04-26 | 2007-12-04 | Vertex Pharmaceuticals Incorporated | Heterocyclic inhibitors of ERK2 and uses thereof |
US7429609B2 (en) | 2002-05-31 | 2008-09-30 | Eisai R & D Management Co., Ltd. | Pyrazole compound and medicinal composition containing the same |
UA78999C2 (en) | 2002-06-04 | 2007-05-10 | Wyeth Corp | 1-(aminoalkyl)-3-sulfonylazaindoles as ligands of 5-hydroxytryptamine-6 |
NZ538426A (en) | 2002-08-02 | 2007-05-31 | Vertex Pharma | Pyrazole compositions useful as inhibitors of glycogen synthase kinase-3 (GSK-3) |
SE0202463D0 (sv) | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | Novel compounds |
WO2004037814A1 (fr) | 2002-10-25 | 2004-05-06 | Vertex Pharmaceuticals Incorporated | Compositions indazolinones utiles en tant qu'inhibiteurs des kinases |
EP1599475A2 (fr) | 2003-03-06 | 2005-11-30 | Eisai Co., Ltd. | Inhibiteurs des jun-kinases (jnk) |
KR20050122210A (ko) | 2003-03-17 | 2005-12-28 | 다케다 샌디에고, 인코포레이티드 | 히스톤 탈아세틸화 효소 억제제 |
GB0308466D0 (en) | 2003-04-11 | 2003-05-21 | Novartis Ag | Organic compounds |
AR045595A1 (es) | 2003-09-04 | 2005-11-02 | Vertex Pharma | Composiciones utiles como inhibidores de proteinas quinasas |
WO2005044181A2 (fr) | 2003-09-09 | 2005-05-19 | Temple University-Of The Commonwealth System Of Higher Education | Protection de tissus et de cellules des effets cytotoxiques d'un rayonnement ionisant par des inhibiteurs abl |
CN1897950A (zh) | 2003-10-14 | 2007-01-17 | 惠氏公司 | 稠合芳基和杂芳基衍生物及其使用方法 |
EP1696920B8 (fr) | 2003-12-19 | 2015-05-06 | Plexxikon Inc. | Composes et methodes de developpement de modulateurs de ret |
EP2332940B1 (fr) * | 2004-03-30 | 2012-10-31 | Vertex Pharmaceuticals Incorporated | Azaindoles utiles comme inhibiteurs de janus kinases et d'autres proteines kinases |
KR20070002081A (ko) | 2004-04-02 | 2007-01-04 | 버텍스 파마슈티칼스 인코포레이티드 | Rock 및 기타 단백질 키나아제의 억제제로서 유용한아자인돌 |
JP2008503473A (ja) | 2004-06-17 | 2008-02-07 | プレキシコン,インコーポレーテッド | C−kit活性を調節する化合物 |
US20060122213A1 (en) | 2004-06-30 | 2006-06-08 | Francoise Pierard | Azaindoles useful as inhibitors of protein kinases |
CA2573362A1 (fr) | 2004-07-27 | 2006-02-09 | Sgx Pharmaceuticals, Inc. | Modulateurs de kinases a base de pyrrolopyridine |
GB0420719D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
WO2006038001A1 (fr) | 2004-10-06 | 2006-04-13 | Celltech R & D Limited | Derives d’aminopyrimidine en tant qu’inhibiteurs de la jnk |
US7855205B2 (en) | 2004-10-29 | 2010-12-21 | Janssen Pharmaceutica Nv | Pyrimidinyl substituted fused-pyrrolyl compounds useful in treating kinase disorders |
EP2316835A1 (fr) | 2004-11-22 | 2011-05-04 | Vertex Pharmceuticals Incorporated | Pyrrolopyrazines et pyrazolopyrazines utilisable comme inhibiteurs de proteines-kinases |
AU2005316540A1 (en) | 2004-12-16 | 2006-06-22 | Vertex Pharmaceuticals Incorporated | Pyrid-2-ones useful as inhibitors of Tec family protein kinases for the treatment of inflammatory, proliferative and immunologically-mediated diseases |
MX2007009429A (es) | 2005-02-03 | 2008-03-18 | Vertex Pharma | Pirrolopirimidinas utiles como inhibidores de proteinas cinasas. |
DE602006014540D1 (en) | 2005-05-16 | 2010-07-08 | Irm Llc | Pyrrolopyridinderivate als proteinkinaseinhibitoren |
EP2354140A1 (fr) * | 2005-05-20 | 2011-08-10 | Vertex Pharmaceuticals Incorporated | Pyrrolopyridines en tant qu'inhibiteurs de kinase |
NZ565255A (en) | 2005-06-22 | 2010-04-30 | Plexxikon Inc | Pyrrolo[2,3-b] pyridine derivatives as protein kinase inhibitors |
SG151327A1 (en) | 2005-09-30 | 2009-04-30 | Vertex Pharmaceuticals Incopor | Deazapurines useful as inhibitors of janus kinases |
RU2453548C2 (ru) * | 2006-01-17 | 2012-06-20 | Вертекс Фармасьютикалз Инкорпорейтед | Азаиндолы, полезные в качестве ингибиторов янус-киназ |
CA2641254A1 (fr) | 2006-02-14 | 2007-08-23 | Vertex Pharmaceuticals Incorporated | Pyrrolo(3,2-c) pyridines utiles en tant qu'inhibiteurs de proteines-kinases |
CA2648250A1 (fr) | 2006-04-05 | 2007-10-18 | Vertex Pharmaceuticals Incorporated | Desazapurines utiles comme inhibiteurs des kinases janus |
EP2102210B1 (fr) | 2006-12-14 | 2011-02-09 | Vertex Pharmceuticals Incorporated | Composés utilisables en tant qu'inhibiteurs de protéines kinases |
EA016234B1 (ru) | 2007-04-05 | 2012-03-30 | Андрей Александрович ИВАЩЕНКО | ЗАМЕЩЕННЫЕ 2,3,4,5-ТЕТРАГИДРО-1Н-ПИРИДО[4,3-b]ИНДОЛЫ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ |
NZ585063A (en) | 2007-11-02 | 2012-05-25 | Vertex Pharma | [1h- pyrazolo [3, 4-b] pyridine-4-yl] -phenyle or -pyridin-2-yle derivatives as protein kinase c-theta |
JP2011513483A (ja) | 2008-03-10 | 2011-04-28 | バーテックス ファーマシューティカルズ インコーポレイテッド | タンパク質キナーゼの阻害剤として有用なピリミジンおよびピリジン |
WO2013070606A1 (fr) | 2011-11-07 | 2013-05-16 | Vertex Pharmaceuticals Incorporated | Méthodes pour le traitement de maladies inflammatoires et combinaisons pharmaceutiques utiles pour celles-ci |
-
2007
- 2007-01-17 RU RU2008133613/04A patent/RU2453548C2/ru not_active IP Right Cessation
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- 2007-01-17 CA CA 2636189 patent/CA2636189A1/fr not_active Abandoned
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- 2007-01-17 EP EP20120176813 patent/EP2537849A3/fr not_active Withdrawn
- 2007-01-17 WO PCT/US2007/001225 patent/WO2007084557A2/fr active Application Filing
- 2007-01-17 KR KR1020127014597A patent/KR101235103B1/ko not_active IP Right Cessation
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- 2007-01-17 CN CN201510004860.7A patent/CN104650077A/zh active Pending
- 2007-01-17 TW TW102147300A patent/TW201412738A/zh unknown
- 2007-01-17 AR ARP070100199 patent/AR060316A1/es unknown
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- 2007-01-17 EP EP20120176810 patent/EP2559694A3/fr not_active Withdrawn
- 2007-01-17 KR KR1020137005929A patent/KR20130041313A/ko not_active Application Discontinuation
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- 2007-01-17 NZ NZ59296807A patent/NZ592968A/xx not_active IP Right Cessation
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2008
- 2008-06-03 IL IL191902A patent/IL191902A0/en unknown
- 2008-06-10 ZA ZA2008/05053A patent/ZA200805053B/en unknown
- 2008-07-21 CL CL2008002140A patent/CL2008002140A1/es unknown
- 2008-08-13 NO NO20083501A patent/NO20083501L/no not_active Application Discontinuation
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2009
- 2009-04-30 HK HK15111605.7A patent/HK1210780A1/xx unknown
- 2009-06-12 ZA ZA2009/04147A patent/ZA200904147B/en unknown
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2010
- 2010-05-07 US US12/775,885 patent/US8163917B2/en not_active Expired - Fee Related
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2011
- 2011-12-14 RU RU2011151085/02A patent/RU2011151085A/ru not_active Application Discontinuation
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2012
- 2012-03-01 US US13/409,702 patent/US8450489B2/en not_active Expired - Fee Related
- 2012-10-11 JP JP2012226368A patent/JP2013010793A/ja not_active Ceased
- 2012-10-11 JP JP2012226367A patent/JP5728454B2/ja not_active Expired - Fee Related
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2013
- 2013-04-25 US US13/870,173 patent/US8822681B2/en not_active Expired - Fee Related
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2014
- 2014-07-24 US US14/339,514 patent/US9120790B2/en not_active Expired - Fee Related
- 2014-08-20 JP JP2014167160A patent/JP2014210823A/ja active Pending
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2015
- 2015-07-29 US US14/812,158 patent/US20160008359A1/en not_active Abandoned
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