NO20082562L - Heterocyklisk forbindelse med inhiberende aktivitet pa 11- -hydroksysteroid-dehydrogenase type 1 - Google Patents
Heterocyklisk forbindelse med inhiberende aktivitet pa 11- -hydroksysteroid-dehydrogenase type 1Info
- Publication number
- NO20082562L NO20082562L NO20082562A NO20082562A NO20082562L NO 20082562 L NO20082562 L NO 20082562L NO 20082562 A NO20082562 A NO 20082562A NO 20082562 A NO20082562 A NO 20082562A NO 20082562 L NO20082562 L NO 20082562L
- Authority
- NO
- Norway
- Prior art keywords
- substituted
- alkyl
- hydroxysteroid dehydrogenase
- dehydrogenase type
- inhibitory activity
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
- C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D419/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Oppfinnelsen vedrører en forbindelse som er representert ved den etterfølgende formel eller et farmasøytisk aksepterbart salt derav eller et solvat av forbindelsen eller saltet, som er anvendbar som en inhibitor av l ip-hydroksysteroid-dehydrogenase type I, hvori R1 representerer en alkyl som kan være substituert eller lignende; en av R2og R4 representerer en gruppe representert ved formelen: -Y-R5 [hvori Y representerer -O- eller lignende, og R5 representerer en substituert alkyl (hvori substituenten er en cykloalkyl som kan være substituert eller lignende), en forgrenet alkyl som kan være substituert eller lignende], og den andre av R2 og R4 representerer et hydrogen eller en alkyl som kan være substituert; R3 representerer en gruppe representert ved formelen: -C(=O)-Z-R6 (hvori Z representerer en gruppe representert ved -NR7 eller -NR7-W-, R6 representerer cykloalkyl som kan være substituert eller lignende, R7 representerer et hydrogen eller alkyl som kan være substituert, og W representerer en alkylen som kan være substituert; og X representerer =N- eller lignende, med den betingelse at en kombinasjon av 2-(morforino)etoksy som R2, en N-(l-adamantyl)karbamoyl som R3 og en benzyl som R1 er utelukket.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005335995 | 2005-11-21 | ||
PCT/JP2006/323096 WO2007058346A1 (ja) | 2005-11-21 | 2006-11-20 | I型11βヒドロキシステロイド脱水素酵素阻害活性を有するヘテロ環化合物 |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20082562L true NO20082562L (no) | 2008-08-21 |
Family
ID=38048724
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20082562A NO20082562L (no) | 2005-11-21 | 2008-06-09 | Heterocyklisk forbindelse med inhiberende aktivitet pa 11- -hydroksysteroid-dehydrogenase type 1 |
Country Status (12)
Country | Link |
---|---|
US (1) | US8324265B2 (no) |
EP (1) | EP1953145B1 (no) |
JP (1) | JP4276280B2 (no) |
KR (1) | KR101024227B1 (no) |
CN (2) | CN102659659B (no) |
AU (1) | AU2006316087B2 (no) |
BR (1) | BRPI0618885A8 (no) |
CA (1) | CA2630665C (no) |
NO (1) | NO20082562L (no) |
RU (1) | RU2443689C2 (no) |
TW (1) | TWI399367B (no) |
WO (1) | WO2007058346A1 (no) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006132197A1 (ja) | 2005-06-07 | 2006-12-14 | Shionogi & Co., Ltd. | I型11βヒドロキシステロイド脱水素酵素阻害活性を有するヘテロ環化合物 |
CN102659659B (zh) | 2005-11-21 | 2014-07-23 | 盐野义制药株式会社 | 具有I型11β羟基类固醇脱氢酶抑制活性的杂环化合物 |
EP2295411A1 (en) * | 2006-03-22 | 2011-03-16 | F. Hoffmann-La Roche AG | Pyrazoles as 11-beta-hsd-1 |
EP2006286A4 (en) | 2006-03-30 | 2010-04-07 | Shionogi & Co | ISOXAZOLE DERIVATIVE AND ISOTHIAZONE DERIVATIVITY WITH ANTICIPATING EFFECT ON 11 TYPE I BETA HYDROXYSTEROIDDEHYDROGENASE |
AR060901A1 (es) * | 2006-05-12 | 2008-07-23 | Jerini Ag | Compuestos heterociclicos para la inhibicion de integrinas y uso de estos |
JPWO2008053652A1 (ja) * | 2006-11-02 | 2010-02-25 | 塩野義製薬株式会社 | ヒドロキシアダマンタンアミンの製造方法 |
TW200827346A (en) | 2006-11-03 | 2008-07-01 | Astrazeneca Ab | Chemical compounds |
TW200836719A (en) * | 2007-02-12 | 2008-09-16 | Astrazeneca Ab | Chemical compounds |
CN101668524B (zh) * | 2007-02-12 | 2012-10-24 | 阿斯利康(瑞典)有限公司 | 作为11-β-HSD1抑制剂的吡唑衍生物 |
JPWO2008120655A1 (ja) | 2007-03-30 | 2010-07-15 | 株式会社医薬分子設計研究所 | I型11βヒドロキシステロイド脱水素酵素阻害活性を有するオキサゾリジノン誘導体 |
PL2163543T3 (pl) | 2007-05-18 | 2015-06-30 | Shionogi & Co | Heterocykliczna pochodna zawierająca azot o aktywności hamującej dehydrogenazę 11-beta-hydroksysteroidową typu I |
AU2008277783B2 (en) * | 2007-07-17 | 2012-09-20 | F. Hoffmann-La Roche Ag | Inhibitors of 11beta-hydroxysteroid dehydrogenase |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
JP5550041B2 (ja) | 2007-09-27 | 2014-07-16 | 塩野義製薬株式会社 | チトクロームp450を用いたアダマンタン水酸化体の製造方法 |
EP2244705A1 (en) | 2008-02-04 | 2010-11-03 | AstraZeneca AB | Novel crystalline forms of 4- [4- (2-adamantylcarbam0yl) -5-tert-butyl-pyrazol-1-yl]benzoic acid |
FR2942797B1 (fr) * | 2009-03-03 | 2011-04-29 | Pf Medicament | Derives de benzothiazines, leur preparation et leur application a titre de medicaments |
US8507493B2 (en) | 2009-04-20 | 2013-08-13 | Abbvie Inc. | Amide and amidine derivatives and uses thereof |
AU2010310518A1 (en) | 2009-10-22 | 2012-06-07 | Vanderbilt University | mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
JP5686413B2 (ja) * | 2009-12-22 | 2015-03-18 | 塩野義製薬株式会社 | アダマンタンアミン誘導体 |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
WO2011157827A1 (de) | 2010-06-18 | 2011-12-22 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
CN103209957A (zh) * | 2010-08-09 | 2013-07-17 | 盐野义制药株式会社 | 氨基金刚烷氨基甲酸酯衍生物的制备方法 |
RU2606510C2 (ru) | 2010-09-21 | 2017-01-10 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Фармацевтическая композиция |
WO2012120052A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
EP2683700B1 (de) | 2011-03-08 | 2015-02-18 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
EP2683705B1 (de) | 2011-03-08 | 2015-04-22 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2012120055A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
US8828995B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
WO2012124781A1 (ja) | 2011-03-17 | 2012-09-20 | 塩野義製薬株式会社 | ピラゾールカルボン酸誘導体の製造方法 |
KR101332805B1 (ko) * | 2011-03-31 | 2013-11-27 | 한국화학연구원 | 아다만틸기를 갖는 설파마이드 유도체 및 이의 약제학적으로 허용 가능한 염 |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
CA2857438A1 (en) * | 2011-11-30 | 2013-06-06 | Bayer Intellectual Property Gmbh | Fungicidal n-bicycloalkyl and n-tricycloalkyl (thio)carboxamide derivatives |
CN114668761A (zh) | 2015-10-23 | 2022-06-28 | 威佛(国际)股份公司 | 新的膜铁转运蛋白抑制剂 |
WO2017094743A1 (ja) * | 2015-11-30 | 2017-06-08 | 塩野義製薬株式会社 | I型11βヒドロキシステロイド脱水素酵素阻害活性を有する医薬組成物 |
JOP20180036A1 (ar) | 2017-04-18 | 2019-01-30 | Vifor Int Ag | أملاح لمثبطات فروبورتين جديدة |
CN111423396B (zh) * | 2020-04-30 | 2023-01-06 | 沈阳药科大学 | 一种sEH抑制剂及其制备方法和应用 |
Family Cites Families (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4226877A (en) | 1979-05-14 | 1980-10-07 | Abbott Laboratories | Pyrazoles active in the central nervous system |
JPS60214785A (ja) | 1984-03-27 | 1985-10-28 | Nissan Chem Ind Ltd | ピラゾ−ルスルホニルウレア誘導体、および植物生長調節剤または除草剤 |
JPH01207289A (ja) | 1987-10-19 | 1989-08-21 | Mitsui Toatsu Chem Inc | アシルアミノアセトニトリル誘導体の製造法 |
JPH03223256A (ja) | 1989-04-19 | 1991-10-02 | Sumitomo Chem Co Ltd | アミド系化合物およびそれを有効成分とする殺虫、殺ダニ剤 |
AU626402B2 (en) | 1989-04-19 | 1992-07-30 | Sumitomo Chemical Company, Limited | An amide compound and its production and use |
EP0566138B1 (en) | 1992-04-17 | 1998-11-18 | Hodogaya Chemical Co., Ltd. | Amino thiazole derivatives and their use as fungicides |
JPH0625199A (ja) | 1992-04-17 | 1994-02-01 | Hodogaya Chem Co Ltd | チアゾール誘導体 |
IL105939A0 (en) | 1992-06-11 | 1993-10-20 | Rhone Poulenc Agriculture | Herbicidal compounds and compositions |
GB9517622D0 (en) | 1995-08-29 | 1995-11-01 | Univ Edinburgh | Regulation of intracellular glucocorticoid concentrations |
JP3710826B2 (ja) | 1996-10-01 | 2005-10-26 | 日本ゼオン株式会社 | ポリマー分散組成物 |
EP0979228A4 (en) * | 1997-03-18 | 2000-05-03 | Smithkline Beecham Corp | CANNABINOID RECEPTOR AGONISTS |
DE19734664A1 (de) * | 1997-08-11 | 1999-02-18 | Bayer Ag | (Hetero)Aryloxypyrazole |
WO2001023358A1 (fr) | 1999-09-27 | 2001-04-05 | Sagami Chemical Research Center | Derives pyrazole, intermediaires pour la preparation de ces derives, procedes de preparation des derives et intermediaires, et herbicides dont ces derives sont le principe actif |
JP2004502432A (ja) | 2000-07-05 | 2004-01-29 | バイエル アクチェンゲゼルシャフト | ヒト11β−ヒドロキシステロイドデヒドロゲナーゼ1様酵素の調節 |
GB0107383D0 (en) | 2001-03-23 | 2001-05-16 | Univ Edinburgh | Lipid profile modulation |
JP4559690B2 (ja) * | 2001-03-23 | 2010-10-13 | 公益財団法人相模中央化学研究所 | ピラゾール誘導体とその製造中間体及びそれらの製造方法、並びにそれらを有効成分とする除草剤 |
BRPI0209726B1 (pt) | 2001-05-31 | 2015-06-30 | Nihon Nohyaku Co Ltd | Derivado de anilida substituída, produto químico agrícola e hortícola, e, método para aplicar o mesmo |
AR040241A1 (es) * | 2002-06-10 | 2005-03-23 | Merck & Co Inc | Inhibidores de la 11-beta-hidroxiesteroide deshidrogrenasa 1 para el tratamiento de la diabetes obesidad y dislipidemia |
JP2004065194A (ja) | 2002-08-09 | 2004-03-04 | Sumitomo Chem Co Ltd | 脂肪細胞関連因子の分析方法 |
WO2004056744A1 (en) | 2002-12-23 | 2004-07-08 | Janssen Pharmaceutica N.V. | Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors |
EP1599447A1 (en) | 2003-02-28 | 2005-11-30 | Galderma Research & Development, S.N.C. | Ligands that modulate lxr-type receptors |
US7449464B2 (en) | 2003-03-12 | 2008-11-11 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
EP1618090A1 (en) | 2003-04-11 | 2006-01-25 | Novo Nordisk A/S | 11ß-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ACTIVE COMPOUNDS |
US7659408B2 (en) * | 2003-08-07 | 2010-02-09 | Merck Sharp & Dhome Corp. | Pyrazole carboxamides as inhibitors of 11-β-hydroxysteroid dehydrogenase-1 |
WO2005061462A2 (en) * | 2003-12-19 | 2005-07-07 | Neurogen Corporation | Diaryl pyrazole derivatives and their use as neurokinin-3 receptor modulators |
GT200500013A (es) | 2004-01-23 | 2005-08-10 | Amidas herbicidas | |
US7354938B2 (en) | 2004-03-23 | 2008-04-08 | Amgen Inc. | Pyrazole compounds and uses related thereto |
JP2007261945A (ja) | 2004-04-07 | 2007-10-11 | Taisho Pharmaceut Co Ltd | チアゾール誘導体 |
US7880001B2 (en) | 2004-04-29 | 2011-02-01 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme |
US20050245533A1 (en) | 2004-04-29 | 2005-11-03 | Hoff Ethan D | Inhibitors of the 11-beta-hydroxysteroid dehydrogenaseType 1 enzyme and their therapeutic application |
US20050245534A1 (en) | 2004-04-29 | 2005-11-03 | Link James T | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme |
US20050245532A1 (en) | 2004-04-29 | 2005-11-03 | Hoff Ethan D | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their therapeutic application |
US20050261302A1 (en) | 2004-04-29 | 2005-11-24 | Hoff Ethan D | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their therapeutic application |
CA2565843A1 (en) | 2004-05-06 | 2005-11-17 | Pfizer Inc. | Novel compounds of proline and morpholine derivatives |
NZ551076A (en) | 2004-05-07 | 2009-05-31 | Janssen Pharmaceutica Nv | Adamantyl pyrrolidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors |
WO2005112923A2 (en) | 2004-05-20 | 2005-12-01 | Bayer Pharmaceuticals Corporation | 5-anilino-4-heteroarylpyrazole derivatives useful for the treatment of diabetes |
ES2334246T3 (es) | 2004-08-30 | 2010-03-08 | Janssen Pharmaceutica Nv | Derivados triciclos de adamantilamida como inhibidores de la 11-beta-hidroxiesteroide-deshidrogenasa. |
EP1796657B1 (en) | 2004-08-30 | 2009-12-23 | Janssen Pharmaceutica N.V. | N-2 adamantanyl-2-phenoxy-acetamide derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors |
WO2006048750A2 (en) | 2004-11-02 | 2006-05-11 | Pfizer Inc. | Novel compounds of substituted and unsubstituted adamantyl amides |
US20060148871A1 (en) | 2005-01-05 | 2006-07-06 | Rohde Jeffrey J | Metabolic stabilization of substituted adamantane |
MX2007008238A (es) | 2005-01-05 | 2007-08-17 | Abbott Lab | Derivados de adamantilo como inhibidores de la enzima 11-beta-hidroxiesteroide deshidrogenasa tipo 1. |
CA2594116A1 (en) | 2005-01-05 | 2006-07-13 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
GB0506133D0 (en) | 2005-03-24 | 2005-05-04 | Sterix Ltd | Compound |
PT1928840E (pt) | 2005-04-05 | 2011-10-03 | Hoffmann La Roche | 1h-pirazole-4-carboxamidas, a sua preparação e a sua utilização a título de inibidores de 11-betahidroxiesteróide desidrogenase |
WO2006132197A1 (ja) | 2005-06-07 | 2006-12-14 | Shionogi & Co., Ltd. | I型11βヒドロキシステロイド脱水素酵素阻害活性を有するヘテロ環化合物 |
KR100970294B1 (ko) * | 2005-06-08 | 2010-07-15 | 니뽄 다바코 산교 가부시키가이샤 | 복소환 화합물 |
CN102659659B (zh) | 2005-11-21 | 2014-07-23 | 盐野义制药株式会社 | 具有I型11β羟基类固醇脱氢酶抑制活性的杂环化合物 |
EP2295411A1 (en) | 2006-03-22 | 2011-03-16 | F. Hoffmann-La Roche AG | Pyrazoles as 11-beta-hsd-1 |
JP2007262022A (ja) | 2006-03-29 | 2007-10-11 | Mochida Pharmaceut Co Ltd | 新規2−チオフェンカルボキサミド誘導体 |
EP2006286A4 (en) | 2006-03-30 | 2010-04-07 | Shionogi & Co | ISOXAZOLE DERIVATIVE AND ISOTHIAZONE DERIVATIVITY WITH ANTICIPATING EFFECT ON 11 TYPE I BETA HYDROXYSTEROIDDEHYDROGENASE |
WO2007114125A1 (ja) | 2006-03-31 | 2007-10-11 | Shionogi & Co., Ltd. | 微生物によるアダマンタン水酸化体の製造方法 |
WO2007144394A2 (en) | 2006-06-16 | 2007-12-21 | High Point Pharmaceuticals, Llc. | Pharmaceutical use of substituted piperidine carboxamides |
US20100022589A1 (en) | 2006-07-27 | 2010-01-28 | Mccoull William | Pyridine-3-carboxamide compounds and their use for inhibiting 11-beta-hydroxysteroid dehydrogenase |
WO2008044656A1 (fr) | 2006-10-06 | 2008-04-17 | Taisho Pharmaceutical Co., Ltd. | Dérivé d'imidazolidinone |
WO2008051875A2 (en) | 2006-10-20 | 2008-05-02 | Arete Therapeutics, Inc. | Adamantylurea compounds as soluble epoxide hydrolase inhibitors |
JPWO2008053652A1 (ja) | 2006-11-02 | 2010-02-25 | 塩野義製薬株式会社 | ヒドロキシアダマンタンアミンの製造方法 |
TW200827346A (en) | 2006-11-03 | 2008-07-01 | Astrazeneca Ab | Chemical compounds |
TW200836719A (en) | 2007-02-12 | 2008-09-16 | Astrazeneca Ab | Chemical compounds |
JPWO2008120655A1 (ja) | 2007-03-30 | 2010-07-15 | 株式会社医薬分子設計研究所 | I型11βヒドロキシステロイド脱水素酵素阻害活性を有するオキサゾリジノン誘導体 |
PL2163543T3 (pl) | 2007-05-18 | 2015-06-30 | Shionogi & Co | Heterocykliczna pochodna zawierająca azot o aktywności hamującej dehydrogenazę 11-beta-hydroksysteroidową typu I |
US8222417B2 (en) | 2007-06-27 | 2012-07-17 | Taisho Pharmaceutical Co., Ltd | Compound having 11β-HSD1 inhibitory activity |
AU2008277783B2 (en) | 2007-07-17 | 2012-09-20 | F. Hoffmann-La Roche Ag | Inhibitors of 11beta-hydroxysteroid dehydrogenase |
US7977358B2 (en) | 2007-07-26 | 2011-07-12 | Hoffmann-La Roche Inc. | Pyrazol derivatives |
WO2009056881A1 (en) | 2007-10-29 | 2009-05-07 | Astrazeneca Ab | Chemical compounds 313 |
KR20100095439A (ko) | 2007-11-06 | 2010-08-30 | 아스트라제네카 아베 | 4-[4-(2-(아다만틸카르바모일)-5-tert-부틸피라졸-1-일]벤조산 - 465 |
EP2244705A1 (en) | 2008-02-04 | 2010-11-03 | AstraZeneca AB | Novel crystalline forms of 4- [4- (2-adamantylcarbam0yl) -5-tert-butyl-pyrazol-1-yl]benzoic acid |
MX2010011591A (es) | 2008-04-22 | 2010-11-09 | Astrazeneca Ab | Pirimidin-5-carboxamidas sustituidas 281. |
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2006
- 2006-11-20 CN CN201210137039.9A patent/CN102659659B/zh not_active Expired - Fee Related
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- 2006-11-20 CN CNA2006800434381A patent/CN101312951A/zh active Pending
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- 2006-11-20 TW TW095142745A patent/TWI399367B/zh not_active IP Right Cessation
- 2006-11-20 RU RU2008125158/04A patent/RU2443689C2/ru not_active IP Right Cessation
- 2006-11-20 KR KR1020087011881A patent/KR101024227B1/ko not_active IP Right Cessation
- 2006-11-20 BR BRPI0618885A patent/BRPI0618885A8/pt not_active IP Right Cessation
- 2006-11-20 EP EP06832946.5A patent/EP1953145B1/en active Active
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- 2006-11-20 WO PCT/JP2006/323096 patent/WO2007058346A1/ja active Application Filing
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Also Published As
Publication number | Publication date |
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EP1953145B1 (en) | 2015-11-04 |
KR101024227B1 (ko) | 2011-03-29 |
TW200730501A (en) | 2007-08-16 |
CN101312951A (zh) | 2008-11-26 |
TWI399367B (zh) | 2013-06-21 |
CA2630665C (en) | 2011-03-15 |
JP4276280B2 (ja) | 2009-06-10 |
AU2006316087A1 (en) | 2007-05-24 |
CA2630665A1 (en) | 2007-05-24 |
CN102659659A (zh) | 2012-09-12 |
US8324265B2 (en) | 2012-12-04 |
AU2006316087B2 (en) | 2011-03-10 |
CN102659659B (zh) | 2014-07-23 |
EP1953145A1 (en) | 2008-08-06 |
JPWO2007058346A1 (ja) | 2009-05-07 |
EP1953145A4 (en) | 2011-08-24 |
RU2443689C2 (ru) | 2012-02-27 |
BRPI0618885A8 (pt) | 2018-06-26 |
BRPI0618885A2 (pt) | 2012-04-17 |
KR20080067353A (ko) | 2008-07-18 |
WO2007058346A1 (ja) | 2007-05-24 |
RU2008125158A (ru) | 2009-12-27 |
US20090170832A1 (en) | 2009-07-02 |
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