NO20080359L - Krystallinsk base av escitalopram og orodispergerbare tabletter omfattende escitalopram base - Google Patents
Krystallinsk base av escitalopram og orodispergerbare tabletter omfattende escitalopram baseInfo
- Publication number
- NO20080359L NO20080359L NO20080359A NO20080359A NO20080359L NO 20080359 L NO20080359 L NO 20080359L NO 20080359 A NO20080359 A NO 20080359A NO 20080359 A NO20080359 A NO 20080359A NO 20080359 L NO20080359 L NO 20080359L
- Authority
- NO
- Norway
- Prior art keywords
- escitalopram
- base
- salts
- crystalline
- oxalate
- Prior art date
Links
- 229960004341 escitalopram Drugs 0.000 title abstract 6
- WSEQXVZVJXJVFP-FQEVSTJZSA-N escitalopram Chemical compound C1([C@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-FQEVSTJZSA-N 0.000 title abstract 6
- 150000003839 salts Chemical class 0.000 abstract 6
- 239000002585 base Substances 0.000 abstract 3
- 238000009472 formulation Methods 0.000 abstract 3
- 238000004519 manufacturing process Methods 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 abstract 2
- 239000008186 active pharmaceutical agent Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 abstract 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 abstract 1
- 239000000945 filler Substances 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B63/00—Purification; Separation; Stabilisation; Use of additives
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200500912 | 2005-06-22 | ||
| PCT/DK2006/000366 WO2006136169A2 (en) | 2005-06-22 | 2006-06-22 | Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20080359L true NO20080359L (no) | 2008-01-18 |
Family
ID=37546630
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20080359A NO20080359L (no) | 2005-06-22 | 2008-01-18 | Krystallinsk base av escitalopram og orodispergerbare tabletter omfattende escitalopram base |
| NO20101777A NO20101777L (no) | 2005-06-22 | 2010-12-20 | Orodispergerbare tabletter |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20101777A NO20101777L (no) | 2005-06-22 | 2010-12-20 | Orodispergerbare tabletter |
Country Status (39)
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0123400D0 (en) | 2001-09-28 | 2001-11-21 | Novartis Ag | Organic compounds |
| WO2008059514A2 (en) * | 2006-07-31 | 2008-05-22 | Cadila Healthcare Limited | Process for preparing escitalopram |
| EP2134325A2 (en) * | 2007-03-01 | 2009-12-23 | Aurobindo Pharma Limited | Stable solid dosage forms of an antidepressant |
| HUE028897T2 (en) | 2010-07-23 | 2017-01-30 | H Lundbeck As | A method of purifying pharmaceutically acceptable salts of escitalopram |
| CN103360353A (zh) * | 2013-08-07 | 2013-10-23 | 中国药科大学 | 草酸艾司西酞普兰杂质的制备方法 |
| JP2018016569A (ja) * | 2016-07-26 | 2018-02-01 | 株式会社トクヤマ | （１ｓ）−１−［３−（ジメチルアミノ）プロピル］−１−（４−フルオロフェニル）−１，３−ジヒドロイソベンゾフラン−５−カルボニトリル蓚酸塩の製造方法 |
| JP6423133B1 (ja) * | 2017-04-10 | 2018-11-14 | 東和薬品株式会社 | エスシタロプラム医薬組成物 |
| CN110711198B (zh) * | 2018-07-12 | 2022-03-15 | 山东大学 | D-甘露糖在制备抗抑郁药物中的应用 |
| KR102331187B1 (ko) | 2019-04-09 | 2021-11-26 | 주식회사 라이트팜텍 | 에스시탈로프람을 함유하는 안정성이 우수한 경구용 액제 조성물 및 그의 제조방법 |
| EP4277661A1 (en) * | 2021-01-18 | 2023-11-22 | Anton Frenkel | Pharmaceutical dosage form |
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| GB1526331A (en) | 1976-01-14 | 1978-09-27 | Kefalas As | Phthalanes |
| GB8814057D0 (en) | 1988-06-14 | 1988-07-20 | Lundbeck & Co As H | New enantiomers & their isolation |
| JPH05222041A (ja) * | 1992-02-13 | 1993-08-31 | Mitsubishi Gas Chem Co Inc | アデニン誘導体の精製法 |
| NZ279674A (en) * | 1994-01-27 | 1997-02-24 | Univ Oklahoma | Rapidly dissolving oral dosage form containing a particulate support matrix |
| US5607697A (en) * | 1995-06-07 | 1997-03-04 | Cima Labs, Incorporated | Taste masking microparticles for oral dosage forms |
| WO1999000548A1 (en) | 1997-06-30 | 1999-01-07 | Beloit Technologies, Inc. | Method and apparatus for the high speed application of coating to a traveling paper web |
| SK283309B6 (sk) | 1997-07-08 | 2003-05-02 | H. Lundbeck A/S | Spôsob výroby citalopramu a medziprodukty |
| UA62984C2 (en) | 1997-11-11 | 2004-01-15 | Lunnbeck As H | A method for the preparation of citalopram |
| FR2785538B1 (fr) * | 1998-11-06 | 2004-04-09 | Prographarm Laboratoires | Comprime a delitement rapide perfectionne |
| US20020071864A1 (en) * | 1999-03-25 | 2002-06-13 | Yuhan Corporation | Rapidly disintegrable tablet for oral administration |
| ITMI991581A1 (it) | 1999-06-25 | 2001-01-15 | Lundbeck & Co As H | Metodo per la preparazione di citalopram |
| ITMI991579A1 (it) | 1999-06-25 | 2001-01-15 | Lundbeck & Co As H | Metodo per la preparazione di citalopram |
| JP2001226372A (ja) * | 1999-12-06 | 2001-08-21 | Sumika Fine Chemicals Co Ltd | ロサルタンの結晶性または結晶化された酸付加塩およびロサルタンの精製方法 |
| GB2357762B (en) * | 2000-03-13 | 2002-01-30 | Lundbeck & Co As H | Crystalline base of citalopram |
| CA2424770A1 (en) * | 2000-10-06 | 2003-04-03 | Takeda Chemical Industries, Ltd. | Solid pharmaceutical preparation |
| CN1469737A (zh) * | 2000-10-16 | 2004-01-21 | ��һ��������ҩ��ʽ���� | 口腔内快速崩解的药用组合物及其制备方法 |
| US7799342B2 (en) * | 2000-12-06 | 2010-09-21 | Wyeth Llc | Fast dissolving tablet |
| DK1181713T3 (da) * | 2000-12-22 | 2005-01-31 | Lundbeck & Co As H | Fremgangsmåde til fremstilling af rent citalopram |
| TR200200018T1 (tr) * | 2000-12-28 | 2002-06-21 | H. Lundbeck A/S | Saf sitalopram hazırlanması için yöntem. |
| CN1509169A (zh) * | 2001-05-01 | 2004-06-30 | H��¡�±�������˾ | 对映体纯艾司西酞普兰的用途 |
| US6872405B2 (en) * | 2001-05-10 | 2005-03-29 | Yamanouchi Pharmaceutical Co., Ltd. | Quick-disintegrating tablet in buccal cavity and manufacturing method thereof |
| GB0113842D0 (en) * | 2001-06-07 | 2001-08-01 | Boots Co Plc | Therapeutic agents |
| AR034612A1 (es) * | 2001-06-25 | 2004-03-03 | Lundbeck & Co As H | Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram |
| AR034759A1 (es) | 2001-07-13 | 2004-03-17 | Lundbeck & Co As H | Metodo para la preparacion de escitalopram |
| ES2233842T3 (es) * | 2001-07-31 | 2005-06-16 | H. Lundbeck A/S | Composicion cristalina que contiene escitalopram. |
| IS7239A (is) * | 2001-12-14 | 2004-04-29 | H. Lundbeck A/S | Aðferð til framleiðslu á essítalóprami |
| US7148364B2 (en) * | 2002-01-07 | 2006-12-12 | Sun Pharmaceutical Industries | Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran carbonitrile |
| FR2834889B1 (fr) * | 2002-01-18 | 2004-04-02 | Roquette Freres | Forme pharmaceutique solide orodispersible |
| GB0204607D0 (en) * | 2002-02-27 | 2002-04-10 | Matrix Lab Ltd | Process |
| AU2003225285A1 (en) * | 2002-05-03 | 2003-11-17 | Skyepharma Canada Inc. | Oral dosage forms comprising fenofibrate |
| MXPA05005772A (es) | 2002-12-23 | 2005-08-16 | Lundbeck & Co As H | Bromhidrato de escitalopram y un metodo para su preparacion. |
| CN1510024A (zh) * | 2002-12-24 | 2004-07-07 | 北京德众万全药物技术开发有限公司 | 可用于制备西酞普兰(s)-对映异构体的新的化合物及其制备方法 |
| DE10305984A1 (de) * | 2003-02-13 | 2004-09-02 | Helm Ag | Salze organischer Säuren mit Clopidogrel und deren Verwendung zur Herstellung phamazeutischer Formulierungen |
| NZ544007A (en) * | 2003-05-07 | 2009-05-31 | Samyang Corp | Highly plastic granules for making fast melting tablets |
| EP1674083B1 (en) * | 2003-10-15 | 2018-08-01 | Fuji Chemical Industry Co., Ltd. | Tablet quickly disintegrating in oral cavity |
| WO2005049596A1 (en) * | 2003-11-20 | 2005-06-02 | Natco Pharma Limited | A process for the preparation of high purity escitalopram |
| HU227491B1 (en) * | 2003-11-25 | 2011-07-28 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Tablet containing citalopram hydrogen bromide |
| EA200601641A1 (ru) * | 2004-03-05 | 2006-12-29 | Х. Лундбекк А/С | Кристаллическая композиция, содержащая оксалат эсциталопрама |
| WO2006106531A1 (en) * | 2005-04-04 | 2006-10-12 | Jubilant Organosys Ltd | Process for the preparation of escitalopram or its acid addition salts |
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2006
- 2006-06-15 TW TW100102601A patent/TWI358407B/zh not_active IP Right Cessation
- 2006-06-15 TW TW095121358A patent/TWI347942B/zh not_active IP Right Cessation
- 2006-06-21 MY MYPI2010000618A patent/MY143239A/en unknown
- 2006-06-21 AR ARP060102654A patent/AR055062A1/es not_active Application Discontinuation
- 2006-06-21 MY MYPI20062933A patent/MY143252A/en unknown
- 2006-06-22 PT PT06742481T patent/PT1896439E/pt unknown
- 2006-06-22 KR KR1020117005777A patent/KR101340815B1/ko active Active
- 2006-06-22 ES ES06742481.2T patent/ES2356838T5/es active Active
- 2006-06-22 SI SI200630923T patent/SI1896439T2/sl unknown
- 2006-06-22 HU HU0800135A patent/HUP0800135A3/hu unknown
- 2006-06-22 CA CA002646780A patent/CA2646780A1/en not_active Abandoned
- 2006-06-22 CZ CZ20080429A patent/CZ301286B6/cs not_active IP Right Cessation
- 2006-06-22 DE DE602006019961T patent/DE602006019961D1/de active Active
- 2006-06-22 RS RS20110057A patent/RS51575B2/sr unknown
- 2006-06-22 AU AU2006261452A patent/AU2006261452B2/en not_active Withdrawn - After Issue
- 2006-06-22 PL PL06742481T patent/PL1896439T5/pl unknown
- 2006-06-22 EP EP06742481.2A patent/EP1896439B2/en active Active
- 2006-06-22 SK SK50040-2007A patent/SK500402007A3/sk unknown
- 2006-06-22 CZ CZ20080430A patent/CZ300686B6/cs not_active IP Right Cessation
- 2006-06-22 JP JP2008517323A patent/JP4906852B2/ja active Active
- 2006-06-22 SG SG201100648-3A patent/SG169358A1/en unknown
- 2006-06-22 CN CNA2006800200393A patent/CN101189220A/zh active Pending
- 2006-06-22 GB GB0811164A patent/GB2448834B/en not_active Expired - Fee Related
- 2006-06-22 CA CA2612827A patent/CA2612827C/en not_active Expired - Fee Related
- 2006-06-22 KR KR1020077028918A patent/KR20080018191A/ko not_active Ceased
- 2006-06-22 DK DK06742481.2T patent/DK1896439T4/en active
- 2006-06-22 EA EA200800102A patent/EA019239B1/ru not_active IP Right Cessation
- 2006-06-22 GB GB0724557A patent/GB2442160B/en not_active Expired - Fee Related
- 2006-06-22 HR HRP20110093TT patent/HRP20110093T4/hr unknown
- 2006-06-22 CZ CZ20070898A patent/CZ299906B6/cs not_active IP Right Cessation
- 2006-06-22 FI FI20077133A patent/FI20077133L/fi unknown
- 2006-06-22 PL PL384185A patent/PL384185A1/pl unknown
- 2006-06-22 ES ES200750085A patent/ES2319073B1/es not_active Expired - Fee Related
- 2006-06-22 EA EA201001108A patent/EA201001108A1/ru unknown
- 2006-06-22 KR KR1020127014205A patent/KR20120064140A/ko not_active Ceased
- 2006-06-22 BR BRPI0612295-7A patent/BRPI0612295A2/pt not_active IP Right Cessation
- 2006-06-22 KR KR1020117015711A patent/KR20110084341A/ko not_active Ceased
- 2006-06-22 KR KR1020107026804A patent/KR20100133023A/ko not_active Ceased
- 2006-06-22 MX MX2007015328A patent/MX2007015328A/es active IP Right Grant
- 2006-06-22 TR TR2007/08792T patent/TR200708792T1/xx unknown
- 2006-06-22 CN CN201010286088XA patent/CN101928269A/zh active Pending
- 2006-06-22 AT AT0900506U patent/AT10983U1/de not_active IP Right Cessation
- 2006-06-22 ZA ZA200711066A patent/ZA200711066B/xx unknown
- 2006-06-22 EP EP10179395A patent/EP2325177A1/en not_active Withdrawn
- 2006-06-22 WO PCT/DK2006/000366 patent/WO2006136169A2/en not_active Ceased
- 2006-06-22 UA UAA200800362A patent/UA86536C2/ru unknown
- 2006-06-22 EE EEU200800003U patent/EE00773U1/xx not_active IP Right Cessation
- 2006-06-22 AT AT06742481T patent/ATE497500T1/de active
- 2006-06-22 TR TR2010/00625T patent/TR201000625T1/xx unknown
- 2006-06-22 FI FI20080548A patent/FI20080548A7/fi unknown
- 2006-06-22 EP EP10179318A patent/EP2385044A1/en not_active Withdrawn
- 2006-06-22 DE DE112006001619T patent/DE112006001619T5/de not_active Withdrawn
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2007
- 2007-11-18 IL IL187454A patent/IL187454A0/en unknown
- 2007-12-19 BG BG10110024A patent/BG66086B1/bg unknown
- 2007-12-21 LV LVP-07-157A patent/LV13677B/lv unknown
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2008
- 2008-01-14 IS IS8705A patent/IS8705A/is unknown
- 2008-01-18 NO NO20080359A patent/NO20080359L/no unknown
- 2008-01-21 DK DK200800075A patent/DK200800075A/da not_active Application Discontinuation
- 2008-01-21 LT LT2008005A patent/LT5550B/lt not_active IP Right Cessation
- 2008-10-07 JP JP2008260742A patent/JP4415056B2/ja active Active
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2009
- 2009-02-27 DK DKPA200900284A patent/DK200900284A/da not_active Application Discontinuation
- 2009-03-10 ZA ZA200901698A patent/ZA200901698B/en unknown
- 2009-05-12 JP JP2009115280A patent/JP2009179635A/ja active Pending
- 2009-05-12 JP JP2009115279A patent/JP2009179634A/ja active Pending
- 2009-07-07 AT AT0041709U patent/AT11883U1/de not_active IP Right Cessation
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2010
- 2010-03-05 AU AU2010200844A patent/AU2010200844A1/en not_active Withdrawn
- 2010-12-20 NO NO20101777A patent/NO20101777L/no not_active Application Discontinuation
- 2010-12-27 AR ARP100104958A patent/AR079750A2/es not_active Application Discontinuation
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2011
- 2011-02-03 CY CY20111100116T patent/CY1112392T1/el unknown
- 2011-11-24 JP JP2011255804A patent/JP5731957B2/ja active Active
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