GB2448834B - Preparation of salts of escitalopram - Google Patents

Preparation of salts of escitalopram

Info

Publication number
GB2448834B
GB2448834B GB0811164A GB0811164A GB2448834B GB 2448834 B GB2448834 B GB 2448834B GB 0811164 A GB0811164 A GB 0811164A GB 0811164 A GB0811164 A GB 0811164A GB 2448834 B GB2448834 B GB 2448834B
Authority
GB
United Kingdom
Prior art keywords
escitalopram
salts
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB0811164A
Other languages
English (en)
Other versions
GB0811164D0 (en
GB2448834A (en
Inventor
Robert James Dancer
Hans Petersen
Ole Nielsen
Michael Harold Rock
Helle Eliasen
Ken Liljegren
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37546630&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GB2448834(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Publication of GB0811164D0 publication Critical patent/GB0811164D0/en
Publication of GB2448834A publication Critical patent/GB2448834A/en
Application granted granted Critical
Publication of GB2448834B publication Critical patent/GB2448834B/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B63/00—Purification; Separation; Stabilisation; Use of additives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
GB0811164A 2005-06-22 2006-06-22 Preparation of salts of escitalopram Expired - Fee Related GB2448834B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200500912 2005-06-22
GB0724557A GB2442160B (en) 2005-06-22 2006-06-22 Preparation of escitalopram free base and salts

Publications (3)

Publication Number Publication Date
GB0811164D0 GB0811164D0 (en) 2008-07-23
GB2448834A GB2448834A (en) 2008-10-29
GB2448834B true GB2448834B (en) 2010-01-20

Family

ID=37546630

Family Applications (2)

Application Number Title Priority Date Filing Date
GB0811164A Expired - Fee Related GB2448834B (en) 2005-06-22 2006-06-22 Preparation of salts of escitalopram
GB0724557A Expired - Fee Related GB2442160B (en) 2005-06-22 2006-06-22 Preparation of escitalopram free base and salts

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB0724557A Expired - Fee Related GB2442160B (en) 2005-06-22 2006-06-22 Preparation of escitalopram free base and salts

Country Status (39)

Country Link
EP (3) EP1896439B2 (enExample)
JP (5) JP4906852B2 (enExample)
KR (5) KR20080018191A (enExample)
CN (2) CN101928269A (enExample)
AR (2) AR055062A1 (enExample)
AT (3) AT10983U1 (enExample)
AU (2) AU2006261452B2 (enExample)
BG (1) BG66086B1 (enExample)
BR (1) BRPI0612295A2 (enExample)
CA (2) CA2646780A1 (enExample)
CY (1) CY1112392T1 (enExample)
CZ (3) CZ300686B6 (enExample)
DE (2) DE602006019961D1 (enExample)
DK (3) DK1896439T4 (enExample)
EA (2) EA019239B1 (enExample)
EE (1) EE00773U1 (enExample)
ES (2) ES2319073B1 (enExample)
FI (2) FI20077133A7 (enExample)
GB (2) GB2448834B (enExample)
HR (1) HRP20110093T4 (enExample)
HU (1) HUP0800135A3 (enExample)
IL (1) IL187454A0 (enExample)
IS (1) IS8705A (enExample)
LT (1) LT5550B (enExample)
LV (1) LV13677B (enExample)
MX (1) MX2007015328A (enExample)
MY (2) MY143252A (enExample)
NO (2) NO20080359L (enExample)
PL (2) PL1896439T5 (enExample)
PT (1) PT1896439E (enExample)
RS (1) RS51575B2 (enExample)
SG (1) SG169358A1 (enExample)
SI (1) SI1896439T2 (enExample)
SK (1) SK500402007A3 (enExample)
TR (2) TR200708792T1 (enExample)
TW (2) TWI358407B (enExample)
UA (1) UA86536C2 (enExample)
WO (1) WO2006136169A2 (enExample)
ZA (2) ZA200711066B (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0123400D0 (en) 2001-09-28 2001-11-21 Novartis Ag Organic compounds
WO2008059514A2 (en) * 2006-07-31 2008-05-22 Cadila Healthcare Limited Process for preparing escitalopram
WO2008104880A2 (en) * 2007-03-01 2008-09-04 Aurobindo Pharma Limited Stable solid dosage forms of an antidepressant
EP2595979B1 (en) 2010-07-23 2016-04-06 H. Lundbeck A/S Process for the purification of pharmaceutically acceptable salts of escitalopram
CN103360353A (zh) * 2013-08-07 2013-10-23 中国药科大学 草酸艾司西酞普兰杂质的制备方法
JP2018016569A (ja) * 2016-07-26 2018-02-01 株式会社トクヤマ （１ｓ）−１−［３−（ジメチルアミノ）プロピル］−１−（４−フルオロフェニル）−１，３−ジヒドロイソベンゾフラン−５−カルボニトリル蓚酸塩の製造方法
WO2018190294A1 (ja) * 2017-04-10 2018-10-18 東和薬品株式会社 エスシタロプラム医薬組成物
CN110711198B (zh) * 2018-07-12 2022-03-15 山东大学 D-甘露糖在制备抗抑郁药物中的应用
KR102331187B1 (ko) 2019-04-09 2021-11-26 주식회사 라이트팜텍 에스시탈로프람을 함유하는 안정성이 우수한 경구용 액제 조성물 및 그의 제조방법
WO2022153262A1 (en) * 2021-01-18 2022-07-21 Anton Frenkel Pharmaceutical dosage form

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003000672A1 (en) * 2001-06-25 2003-01-03 H. Lundbeck A/S Process for the preparation of racemic citalopram and/or s- or r-citalopram by separation of a mixture of r- and s-citalopram
WO2006106531A1 (en) * 2005-04-04 2006-10-12 Jubilant Organosys Ltd Process for the preparation of escitalopram or its acid addition salts

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GB1526331A (en) 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
JPH05222041A (ja) * 1992-02-13 1993-08-31 Mitsubishi Gas Chem Co Inc アデニン誘導体の精製法
BR9506579A (pt) * 1994-01-27 1997-09-16 Univ Oklahoma Matriz de suporte particulado forma de dosagem farmacêutica sólida de rápida dissolução processo para a preparação da matriz de suporte particulado e processo para a preparação da forma de dosagem farmacêutica sólida de rápida dissolução
US5607697A (en) * 1995-06-07 1997-03-04 Cima Labs, Incorporated Taste masking microparticles for oral dosage forms
AU4655597A (en) 1997-06-30 1999-01-19 Beloit Technologies, Inc. Method and apparatus for the high speed application of coating to a traveling paper web
ATE205824T1 (de) 1997-07-08 2001-10-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
WO1998019512A2 (en) 1997-11-11 1998-05-14 H. Lundbeck A/S Method for the preparation of citalopram
FR2785538B1 (fr) * 1998-11-06 2004-04-09 Prographarm Laboratoires Comprime a delitement rapide perfectionne
US20020071864A1 (en) * 1999-03-25 2002-06-13 Yuhan Corporation Rapidly disintegrable tablet for oral administration
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
JP2001226372A (ja) * 1999-12-06 2001-08-21 Sumika Fine Chemicals Co Ltd ロサルタンの結晶性または結晶化された酸付加塩およびロサルタンの精製方法
GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
AU2001294192A1 (en) * 2000-10-06 2002-04-22 Takeda Chemical Industries Ltd. Solid preparations
JP4446463B2 (ja) * 2000-10-16 2010-04-07 第一三共株式会社 口腔内速崩壊性医薬組成物およびその製造方法
US7799342B2 (en) 2000-12-06 2010-09-21 Wyeth Llc Fast dissolving tablet
IL147226A (en) * 2000-12-22 2006-04-10 Lundbeck & Co As H Process for the preparation of pure citalopram
TR200200018T1 (tr) * 2000-12-28 2002-06-21 H. Lundbeck A/S Saf sitalopram hazırlanması için yöntem.
MXPA03008777A (es) * 2001-05-01 2004-02-12 Lundbeck & Co As H El uso de escitalopram enantiomericamente puro.
US6872405B2 (en) * 2001-05-10 2005-03-29 Yamanouchi Pharmaceutical Co., Ltd. Quick-disintegrating tablet in buccal cavity and manufacturing method thereof
GB0113842D0 (en) * 2001-06-07 2001-08-01 Boots Co Plc Therapeutic agents
AR034759A1 (es) 2001-07-13 2004-03-17 Lundbeck & Co As H Metodo para la preparacion de escitalopram
ES2280892T3 (es) * 2001-07-31 2007-09-16 H. Lundbeck A/S Composicion cristalina que contiene escitalopram.
IS7239A (is) * 2001-12-14 2004-04-29 H. Lundbeck A/S Aðferð til framleiðslu á essítalóprami
AU2003222435A1 (en) * 2002-01-07 2003-07-24 Sun Pharmaceutical Industries Limited Process for the preparation of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
FR2834889B1 (fr) * 2002-01-18 2004-04-02 Roquette Freres Forme pharmaceutique solide orodispersible
GB0204607D0 (en) * 2002-02-27 2002-04-10 Matrix Lab Ltd Process
CA2484375C (en) * 2002-05-03 2012-04-10 Skyepharma Canada Inc. Oral dosage forms comprising fenofibrate
PT1578738E (pt) 2002-12-23 2008-04-11 Lundbeck & Co As H Bromidrato de escitalopram e um método para a sua preparação
CN1510024A (zh) * 2002-12-24 2004-07-07 北京德众万全药物技术开发有限公司 可用于制备西酞普兰(s)-对映异构体的新的化合物及其制备方法
DE10305984A1 (de) * 2003-02-13 2004-09-02 Helm Ag Salze organischer Säuren mit Clopidogrel und deren Verwendung zur Herstellung phamazeutischer Formulierungen
EP1620075B1 (en) * 2003-05-07 2020-06-24 Samyang Biopharmaceuticals Corporation Highly plastic granules for making fast melting tablets
JP4726628B2 (ja) * 2003-10-15 2011-07-20 富士化学工業株式会社 口腔内速崩壊性錠剤
WO2005049596A1 (en) * 2003-11-20 2005-06-02 Natco Pharma Limited A process for the preparation of high purity escitalopram
HU227491B1 (en) * 2003-11-25 2011-07-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Tablet containing citalopram hydrogen bromide
CA2558198A1 (en) * 2004-03-05 2005-09-15 H. Lundbeck A/S Crystalline composition containing escitalopram oxalate

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003000672A1 (en) * 2001-06-25 2003-01-03 H. Lundbeck A/S Process for the preparation of racemic citalopram and/or s- or r-citalopram by separation of a mixture of r- and s-citalopram
WO2006106531A1 (en) * 2005-04-04 2006-10-12 Jubilant Organosys Ltd Process for the preparation of escitalopram or its acid addition salts

Also Published As

Publication number Publication date
DK200800075A (da) 2008-03-15
EP2325177A1 (en) 2011-05-25
EP1896439A2 (en) 2008-03-12
AT11883U1 (de) 2011-06-15
ES2319073B1 (es) 2010-02-26
SI1896439T2 (sl) 2014-12-31
ATE497500T1 (de) 2011-02-15
EA019239B1 (ru) 2014-02-28
DK1896439T3 (da) 2011-02-28
FI20080548A7 (fi) 2008-10-07
DK1896439T4 (en) 2015-01-12
DE602006019961D1 (de) 2011-03-17
GB2442160A (en) 2008-03-26
AU2006261452A1 (en) 2006-12-28
GB0724557D0 (en) 2008-01-23
KR101340815B1 (ko) 2013-12-11
IL187454A0 (en) 2008-02-09
CN101928269A (zh) 2010-12-29
ES2356838T3 (es) 2011-04-13
TWI347942B (en) 2011-09-01
ZA200711066B (en) 2009-07-29
NO20080359L (no) 2008-01-18
GB0811164D0 (en) 2008-07-23
RS51575B (sr) 2011-08-31
EA201001108A1 (ru) 2011-02-28
KR20080018191A (ko) 2008-02-27
MY143239A (en) 2011-04-15
TR201000625T1 (tr) 2010-03-22
SG169358A1 (en) 2011-03-30
JP2009179634A (ja) 2009-08-13
BRPI0612295A2 (pt) 2011-01-04
JP2009179635A (ja) 2009-08-13
HUP0800135A3 (en) 2009-01-28
JP4906852B2 (ja) 2012-03-28
AT10983U1 (de) 2010-02-15
KR20100133023A (ko) 2010-12-20
EP1896439B1 (en) 2011-02-02
GB2442160B (en) 2010-01-20
JP4415056B2 (ja) 2010-02-17
SK500402007A3 (sk) 2008-05-06
LT2008005A (en) 2008-10-27
IS8705A (is) 2008-01-14
EP2385044A1 (en) 2011-11-09
EP1896439B2 (en) 2014-10-15
AU2010200844A1 (en) 2010-04-01
ES2356838T5 (es) 2015-01-26
AR079750A2 (es) 2012-02-15
PL1896439T5 (pl) 2016-01-29
CZ301286B6 (cs) 2009-12-30
EA200800102A1 (ru) 2008-04-28
BG110024A (bg) 2008-05-30
JP2009046506A (ja) 2009-03-05
SI1896439T1 (sl) 2011-03-31
CA2646780A1 (en) 2006-12-28
KR20120064140A (ko) 2012-06-18
DE112006001619T5 (de) 2008-06-12
ZA200901698B (en) 2010-04-28
JP5731957B2 (ja) 2015-06-10
RS51575B2 (sr) 2018-02-28
CN101189220A (zh) 2008-05-28
KR20110033310A (ko) 2011-03-30
AR055062A1 (es) 2007-08-01
AU2006261452B2 (en) 2010-02-04
CZ299906B6 (cs) 2008-12-29
KR20110084341A (ko) 2011-07-21
WO2006136169A2 (en) 2006-12-28
TW201130808A (en) 2011-09-16
TR200708792T1 (tr) 2008-05-21
HRP20110093T4 (hr) 2015-02-27
LV13677B (en) 2008-05-20
FI20077133L (fi) 2007-12-20
PT1896439E (pt) 2011-02-15
LT5550B (lt) 2009-03-25
CY1112392T1 (el) 2015-12-09
TW200740785A (en) 2007-11-01
CZ300686B6 (cs) 2009-07-15
TWI358407B (en) 2012-02-21
FI20080548L (fi) 2008-10-07
PL384185A1 (pl) 2008-06-23
MX2007015328A (es) 2008-02-15
JP2008546724A (ja) 2008-12-25
CZ2007898A3 (cs) 2008-01-23
UA86536C2 (ru) 2009-04-27
PL1896439T3 (pl) 2011-04-29
MY143252A (en) 2011-04-15
HUP0800135A2 (en) 2008-06-30
BG66086B1 (bg) 2011-03-31
FI20077133A7 (fi) 2007-12-20
GB2448834A (en) 2008-10-29
ES2319073A1 (es) 2009-05-01
DK200900284A (da) 2009-02-27
JP2012072168A (ja) 2012-04-12
WO2006136169A3 (en) 2007-10-18
EE00773U1 (et) 2008-10-15
CA2612827C (en) 2010-11-30
NO20101777L (no) 2008-01-18
CA2612827A1 (en) 2006-12-28
HRP20110093T1 (hr) 2011-03-31

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20110622