GB2448834B - Preparation of salts of escitalopram - Google Patents

Preparation of salts of escitalopram

Info

Publication number
GB2448834B
GB2448834B GB0811164A GB0811164A GB2448834B GB 2448834 B GB2448834 B GB 2448834B GB 0811164 A GB0811164 A GB 0811164A GB 0811164 A GB0811164 A GB 0811164A GB 2448834 B GB2448834 B GB 2448834B
Authority
GB
United Kingdom
Prior art keywords
escitalopram
salts
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB0811164A
Other languages
English (en)
Other versions
GB2448834A (en
GB0811164D0 (en
Inventor
Robert James Dancer
Hans Petersen
Ole Nielsen
Michael Harold Rock
Helle Eliasen
Ken Liljegren
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37546630&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GB2448834(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Publication of GB0811164D0 publication Critical patent/GB0811164D0/en
Publication of GB2448834A publication Critical patent/GB2448834A/en
Application granted granted Critical
Publication of GB2448834B publication Critical patent/GB2448834B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B63/00—Purification; Separation; Stabilisation; Use of additives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
GB0811164A 2005-06-22 2006-06-22 Preparation of salts of escitalopram Expired - Fee Related GB2448834B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200500912 2005-06-22
GB0724557A GB2442160B (en) 2005-06-22 2006-06-22 Preparation of escitalopram free base and salts

Publications (3)

Publication Number Publication Date
GB0811164D0 GB0811164D0 (en) 2008-07-23
GB2448834A GB2448834A (en) 2008-10-29
GB2448834B true GB2448834B (en) 2010-01-20

Family

ID=37546630

Family Applications (2)

Application Number Title Priority Date Filing Date
GB0811164A Expired - Fee Related GB2448834B (en) 2005-06-22 2006-06-22 Preparation of salts of escitalopram
GB0724557A Expired - Fee Related GB2442160B (en) 2005-06-22 2006-06-22 Preparation of escitalopram free base and salts

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB0724557A Expired - Fee Related GB2442160B (en) 2005-06-22 2006-06-22 Preparation of escitalopram free base and salts

Country Status (39)

Country Link
EP (3) EP2325177A1 (enExample)
JP (5) JP4906852B2 (enExample)
KR (5) KR101340815B1 (enExample)
CN (2) CN101928269A (enExample)
AR (2) AR055062A1 (enExample)
AT (3) AT10983U1 (enExample)
AU (2) AU2006261452B2 (enExample)
BG (1) BG66086B1 (enExample)
BR (1) BRPI0612295A2 (enExample)
CA (2) CA2612827C (enExample)
CY (1) CY1112392T1 (enExample)
CZ (3) CZ301286B6 (enExample)
DE (2) DE112006001619T5 (enExample)
DK (3) DK1896439T4 (enExample)
EA (2) EA201001108A1 (enExample)
EE (1) EE00773U1 (enExample)
ES (2) ES2356838T5 (enExample)
FI (2) FI20080548L (enExample)
GB (2) GB2448834B (enExample)
HR (1) HRP20110093T4 (enExample)
HU (1) HUP0800135A3 (enExample)
IL (1) IL187454A0 (enExample)
IS (1) IS8705A (enExample)
LT (1) LT5550B (enExample)
LV (1) LV13677B (enExample)
MX (1) MX2007015328A (enExample)
MY (2) MY143239A (enExample)
NO (2) NO20080359L (enExample)
PL (2) PL1896439T5 (enExample)
PT (1) PT1896439E (enExample)
RS (1) RS51575B2 (enExample)
SG (1) SG169358A1 (enExample)
SI (1) SI1896439T2 (enExample)
SK (1) SK500402007A3 (enExample)
TR (2) TR200708792T1 (enExample)
TW (2) TWI358407B (enExample)
UA (1) UA86536C2 (enExample)
WO (1) WO2006136169A2 (enExample)
ZA (2) ZA200711066B (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0123400D0 (en) 2001-09-28 2001-11-21 Novartis Ag Organic compounds
WO2008059514A2 (en) * 2006-07-31 2008-05-22 Cadila Healthcare Limited Process for preparing escitalopram
WO2008104880A2 (en) * 2007-03-01 2008-09-04 Aurobindo Pharma Limited Stable solid dosage forms of an antidepressant
SI2595979T1 (sl) 2010-07-23 2016-09-30 H. Lundbeck A/S Proces za čiščenje farmacevtsko sprejemljivih soli Escitaloprama
CN103360353A (zh) * 2013-08-07 2013-10-23 中国药科大学 草酸艾司西酞普兰杂质的制备方法
JP2018016569A (ja) * 2016-07-26 2018-02-01 株式会社トクヤマ （１ｓ）−１−［３−（ジメチルアミノ）プロピル］−１−（４−フルオロフェニル）−１，３−ジヒドロイソベンゾフラン−５−カルボニトリル蓚酸塩の製造方法
WO2018190294A1 (ja) * 2017-04-10 2018-10-18 東和薬品株式会社 エスシタロプラム医薬組成物
CN110711198B (zh) * 2018-07-12 2022-03-15 山东大学 D-甘露糖在制备抗抑郁药物中的应用
KR102331187B1 (ko) 2019-04-09 2021-11-26 주식회사 라이트팜텍 에스시탈로프람을 함유하는 안정성이 우수한 경구용 액제 조성물 및 그의 제조방법
US20240100012A1 (en) * 2021-01-18 2024-03-28 Mark Hasleton Pharmaceutical dosage form

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003000672A1 (en) * 2001-06-25 2003-01-03 H. Lundbeck A/S Process for the preparation of racemic citalopram and/or s- or r-citalopram by separation of a mixture of r- and s-citalopram
WO2006106531A1 (en) * 2005-04-04 2006-10-12 Jubilant Organosys Ltd Process for the preparation of escitalopram or its acid addition salts

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1526331A (en) 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
JPH05222041A (ja) * 1992-02-13 1993-08-31 Mitsubishi Gas Chem Co Inc アデニン誘導体の精製法
HUT74514A (en) * 1994-01-27 1997-01-28 Janssen Pharmaceutica Nv Rapidly dissolving oral dosage form
US5607697A (en) * 1995-06-07 1997-03-04 Cima Labs, Incorporated Taste masking microparticles for oral dosage forms
EP0993524B1 (en) 1997-06-30 2002-11-20 Beloit Technologies, Inc. Method and apparatus for the high speed application of coating to a traveling paper web
JP3526581B2 (ja) 1997-07-08 2004-05-17 ハー・ルンドベック・アクティーゼルスカブ シタロプラムの製造方法
CN1286687A (zh) 1997-11-11 2001-03-07 H·隆德贝克有限公司 制备西酞普兰的方法
FR2785538B1 (fr) * 1998-11-06 2004-04-09 Prographarm Laboratoires Comprime a delitement rapide perfectionne
US20020071864A1 (en) * 1999-03-25 2002-06-13 Yuhan Corporation Rapidly disintegrable tablet for oral administration
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
JP2001226372A (ja) * 1999-12-06 2001-08-21 Sumika Fine Chemicals Co Ltd ロサルタンの結晶性または結晶化された酸付加塩およびロサルタンの精製方法
GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
US7510728B2 (en) * 2000-10-06 2009-03-31 Takeda Pharmaceutical Company Limited Solid preparations
CN1469737A (zh) * 2000-10-16 2004-01-21 ��һ��������ҩ��ʽ���� 口腔内快速崩解的药用组合物及其制备方法
US7799342B2 (en) * 2000-12-06 2010-09-21 Wyeth Llc Fast dissolving tablet
TR200201166T1 (tr) * 2000-12-22 2002-10-21 H.Lundbecks A/S Saf sitalopram hazırlanması için yöntem
JP2003519121A (ja) * 2000-12-28 2003-06-17 ハー・ルンドベック・アクチエゼルスカベット 純粋なシタロプラムの製造方法
CA2445843A1 (en) * 2001-05-01 2002-11-07 H. Lundbeck A/S The use of enantiomeric pure escitalopram
US6872405B2 (en) * 2001-05-10 2005-03-29 Yamanouchi Pharmaceutical Co., Ltd. Quick-disintegrating tablet in buccal cavity and manufacturing method thereof
GB0113842D0 (en) * 2001-06-07 2001-08-01 Boots Co Plc Therapeutic agents
AR034759A1 (es) 2001-07-13 2004-03-17 Lundbeck & Co As H Metodo para la preparacion de escitalopram
ATE352546T1 (de) * 2001-07-31 2007-02-15 Lundbeck & Co As H Kristalline zusammensetzung enthaltend escitalopram
IS7239A (is) 2001-12-14 2004-04-29 H. Lundbeck A/S Aðferð til framleiðslu á essítalóprami
WO2003057132A2 (en) * 2002-01-07 2003-07-17 Sun Pharmaceutical Industries Limited Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
FR2834889B1 (fr) * 2002-01-18 2004-04-02 Roquette Freres Forme pharmaceutique solide orodispersible
GB0204607D0 (en) * 2002-02-27 2002-04-10 Matrix Lab Ltd Process
WO2003092659A1 (en) * 2002-05-03 2003-11-13 Skyepharma Canada Inc. Oral dosage forms comprising fenofibrate
NZ540281A (en) 2002-12-23 2008-07-31 Lundbeck & Co As H Escitalopram hydrobromide and a method for the preparation thereof
CN1510024A (zh) * 2002-12-24 2004-07-07 北京德众万全药物技术开发有限公司 可用于制备西酞普兰(s)-对映异构体的新的化合物及其制备方法
DE10305984A1 (de) * 2003-02-13 2004-09-02 Helm Ag Salze organischer Säuren mit Clopidogrel und deren Verwendung zur Herstellung phamazeutischer Formulierungen
JP4739217B2 (ja) * 2003-05-07 2011-08-03 サムヤン コーポレイション 速く溶ける錠剤を製造するための高可塑性顆粒
IN234086B (enExample) * 2003-10-15 2009-05-29 Fuji Chem Ind Co Ltd
AU2003282383A1 (en) * 2003-11-20 2005-06-08 Natco Pharma Limited A process for the preparation of high purity escitalopram
HU227491B1 (en) * 2003-11-25 2011-07-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Tablet containing citalopram hydrogen bromide
NZ549100A (en) * 2004-03-05 2010-02-26 Lundbeck & Co As H Crystalline composition containing escitalopram oxalate

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003000672A1 (en) * 2001-06-25 2003-01-03 H. Lundbeck A/S Process for the preparation of racemic citalopram and/or s- or r-citalopram by separation of a mixture of r- and s-citalopram
WO2006106531A1 (en) * 2005-04-04 2006-10-12 Jubilant Organosys Ltd Process for the preparation of escitalopram or its acid addition salts

Also Published As

Publication number Publication date
PT1896439E (pt) 2011-02-15
HRP20110093T1 (hr) 2011-03-31
AU2010200844A1 (en) 2010-04-01
JP4415056B2 (ja) 2010-02-17
LV13677B (en) 2008-05-20
EP1896439B1 (en) 2011-02-02
JP5731957B2 (ja) 2015-06-10
MX2007015328A (es) 2008-02-15
SI1896439T2 (sl) 2014-12-31
TR201000625T1 (tr) 2010-03-22
EA019239B1 (ru) 2014-02-28
CN101189220A (zh) 2008-05-28
DE602006019961D1 (de) 2011-03-17
FI20080548A7 (fi) 2008-10-07
AU2006261452B2 (en) 2010-02-04
TR200708792T1 (tr) 2008-05-21
AR079750A2 (es) 2012-02-15
CN101928269A (zh) 2010-12-29
ES2356838T3 (es) 2011-04-13
EP2325177A1 (en) 2011-05-25
MY143239A (en) 2011-04-15
KR20110084341A (ko) 2011-07-21
AU2006261452A1 (en) 2006-12-28
CA2612827C (en) 2010-11-30
BG66086B1 (bg) 2011-03-31
JP2008546724A (ja) 2008-12-25
ES2319073B1 (es) 2010-02-26
CA2612827A1 (en) 2006-12-28
UA86536C2 (ru) 2009-04-27
ZA200901698B (en) 2010-04-28
GB2448834A (en) 2008-10-29
SG169358A1 (en) 2011-03-30
CZ299906B6 (cs) 2008-12-29
DK200800075A (da) 2008-03-15
KR20120064140A (ko) 2012-06-18
PL1896439T3 (pl) 2011-04-29
EP1896439A2 (en) 2008-03-12
JP2012072168A (ja) 2012-04-12
AT10983U1 (de) 2010-02-15
EA201001108A1 (ru) 2011-02-28
GB2442160A (en) 2008-03-26
TWI358407B (en) 2012-02-21
SK500402007A3 (sk) 2008-05-06
DK200900284A (da) 2009-02-27
CZ2007898A3 (cs) 2008-01-23
AR055062A1 (es) 2007-08-01
NO20101777L (no) 2008-01-18
EA200800102A1 (ru) 2008-04-28
SI1896439T1 (sl) 2011-03-31
FI20077133A7 (fi) 2007-12-20
WO2006136169A2 (en) 2006-12-28
RS51575B (sr) 2011-08-31
KR20100133023A (ko) 2010-12-20
RS51575B2 (sr) 2018-02-28
GB0724557D0 (en) 2008-01-23
AT11883U1 (de) 2011-06-15
CA2646780A1 (en) 2006-12-28
TW200740785A (en) 2007-11-01
FI20077133L (fi) 2007-12-20
DK1896439T4 (en) 2015-01-12
TW201130808A (en) 2011-09-16
FI20080548L (fi) 2008-10-07
KR20080018191A (ko) 2008-02-27
HUP0800135A2 (en) 2008-06-30
CY1112392T1 (el) 2015-12-09
EE00773U1 (et) 2008-10-15
ES2319073A1 (es) 2009-05-01
TWI347942B (en) 2011-09-01
MY143252A (en) 2011-04-15
LT2008005A (en) 2008-10-27
HRP20110093T4 (hr) 2015-02-27
BG110024A (bg) 2008-05-30
LT5550B (lt) 2009-03-25
GB0811164D0 (en) 2008-07-23
CZ300686B6 (cs) 2009-07-15
GB2442160B (en) 2010-01-20
EP1896439B2 (en) 2014-10-15
PL1896439T5 (pl) 2016-01-29
IS8705A (is) 2008-01-14
JP2009046506A (ja) 2009-03-05
DK1896439T3 (da) 2011-02-28
ZA200711066B (en) 2009-07-29
NO20080359L (no) 2008-01-18
IL187454A0 (en) 2008-02-09
CZ301286B6 (cs) 2009-12-30
DE112006001619T5 (de) 2008-06-12
WO2006136169A3 (en) 2007-10-18
KR20110033310A (ko) 2011-03-30
JP2009179635A (ja) 2009-08-13
PL384185A1 (pl) 2008-06-23
ES2356838T5 (es) 2015-01-26
EP2385044A1 (en) 2011-11-09
HUP0800135A3 (en) 2009-01-28
JP4906852B2 (ja) 2012-03-28
KR101340815B1 (ko) 2013-12-11
BRPI0612295A2 (pt) 2011-01-04
JP2009179634A (ja) 2009-08-13
ATE497500T1 (de) 2011-02-15

Similar Documents

Publication Publication Date Title
IL184036A0 (en) Preparation of rosuvastatin
ZA200710877B (en) Preparation of syngas
IL191774A0 (en) Solid preparation
IL186871A0 (en) External preparation for skin
IL184405A0 (en) Novel processes for the preparation of a benzofuran
EP1942734A4 (en) PREPARATION OF THE APREPITANT
EP1906944A4 (en) SKI ANDRIN-B-PREPARATION
NO20055643D0 (no) Preparation of lodixanol
ZA200800522B (en) New salt II
AP2007004282A0 (en) Derivatives of A 1-phenyltriazole as antiparasiticagents
EP1893625A4 (en) PROCESS FOR THE PREPARATION OF 9-DEAZAPURINE DERIVATIVES
DK2392335T3 (en) Use of 24-norUDCA
GB2442160B (en) Preparation of escitalopram free base and salts
ZA200705107B (en) Selected benzofuran derivatives
EP1961415A4 (en) ADHESIVE PREPARATION
EP1964538A4 (en) PROCESS FOR THE PREPARATION OF PHARMACEUTICAL SUBSTANCES
ZA200801708B (en) Synthesis of 1±-fluoro-25-hydroxy-16-23E-diene-26,27-bishomo-20-EPI-cholecalciferol
IL187948A0 (en) Preparation of rosuvastatin
ZA200800515B (en) New Salt I
ZA200706292B (en) Novel salts of 6-heterocyclyl substituted hexahydrophenanthridine derivatives
EP1951694A4 (en) FORMS OF SALTS
GB0505952D0 (en) Preparation of 11c methyl iodide
GB0503758D0 (en) Improvements to cookware
PL381715A1 (pl) Nowe pochodne piperazynowe dialkilooksindoli
GB0510203D0 (en) Detachable fish-hook

Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20110622