KR101340815B1 - 에스시탈로프람의 결정성 염기 및 에스시탈로프람 염기를 함유한 구강내분산성 정제 - Google Patents

에스시탈로프람의 결정성 염기 및 에스시탈로프람 염기를 함유한 구강내분산성 정제 Download PDF

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Publication number
KR101340815B1
KR101340815B1 KR1020117005777A KR20117005777A KR101340815B1 KR 101340815 B1 KR101340815 B1 KR 101340815B1 KR 1020117005777 A KR1020117005777 A KR 1020117005777A KR 20117005777 A KR20117005777 A KR 20117005777A KR 101340815 B1 KR101340815 B1 KR 101340815B1
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South Korea
Prior art keywords
escitalopram
base
tablets
salts
mixture
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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KR1020117005777A
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English (en)
Korean (ko)
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KR20110033310A (ko
Inventor
로버트 댄서
한스 페테르센
올레 닐센
마이클 해롤드 락
헬레 엘리아센
켄 리리에그렌
Original Assignee
하. 룬트벡 아크티에 셀스카브
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Application filed by 하. 룬트벡 아크티에 셀스카브 filed Critical 하. 룬트벡 아크티에 셀스카브
Publication of KR20110033310A publication Critical patent/KR20110033310A/ko
Application granted granted Critical
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B63/00—Purification; Separation; Stabilisation; Use of additives

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020117005777A 2005-06-22 2006-06-22 에스시탈로프람의 결정성 염기 및 에스시탈로프람 염기를 함유한 구강내분산성 정제 Expired - Lifetime KR101340815B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200500912 2005-06-22
DKPA200500912 2005-06-22
PCT/DK2006/000366 WO2006136169A2 (en) 2005-06-22 2006-06-22 Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020077028918A Division KR20080018191A (ko) 2005-06-22 2006-06-22 에스시탈로프람의 결정성 염기 및 에스시탈로프람 염기를함유한 구강내분산성 정제

Related Child Applications (2)

Application Number Title Priority Date Filing Date
KR1020127014205A Division KR20120064140A (ko) 2005-06-22 2006-06-22 에스시탈로프람의 결정성 염기 및 에스시탈로프람 염기를 함유한 구강내분산성 정제
KR1020117015711A Division KR20110084341A (ko) 2005-06-22 2006-06-22 에스시탈로프람의 결정성 염기 및 에스시탈로프람 염기를 함유한 구강내분산성 정제

Publications (2)

Publication Number Publication Date
KR20110033310A KR20110033310A (ko) 2011-03-30
KR101340815B1 true KR101340815B1 (ko) 2013-12-11

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ID=37546630

Family Applications (5)

Application Number Title Priority Date Filing Date
KR1020117005777A Expired - Lifetime KR101340815B1 (ko) 2005-06-22 2006-06-22 에스시탈로프람의 결정성 염기 및 에스시탈로프람 염기를 함유한 구강내분산성 정제
KR1020127014205A Ceased KR20120064140A (ko) 2005-06-22 2006-06-22 에스시탈로프람의 결정성 염기 및 에스시탈로프람 염기를 함유한 구강내분산성 정제
KR1020077028918A Ceased KR20080018191A (ko) 2005-06-22 2006-06-22 에스시탈로프람의 결정성 염기 및 에스시탈로프람 염기를함유한 구강내분산성 정제
KR1020117015711A Ceased KR20110084341A (ko) 2005-06-22 2006-06-22 에스시탈로프람의 결정성 염기 및 에스시탈로프람 염기를 함유한 구강내분산성 정제
KR1020107026804A Ceased KR20100133023A (ko) 2005-06-22 2006-06-22 에스시탈로프람의 결정성 염기 및 에스시탈로프람 염기를 함유한 구강내분산성 정제

Family Applications After (4)

Application Number Title Priority Date Filing Date
KR1020127014205A Ceased KR20120064140A (ko) 2005-06-22 2006-06-22 에스시탈로프람의 결정성 염기 및 에스시탈로프람 염기를 함유한 구강내분산성 정제
KR1020077028918A Ceased KR20080018191A (ko) 2005-06-22 2006-06-22 에스시탈로프람의 결정성 염기 및 에스시탈로프람 염기를함유한 구강내분산성 정제
KR1020117015711A Ceased KR20110084341A (ko) 2005-06-22 2006-06-22 에스시탈로프람의 결정성 염기 및 에스시탈로프람 염기를 함유한 구강내분산성 정제
KR1020107026804A Ceased KR20100133023A (ko) 2005-06-22 2006-06-22 에스시탈로프람의 결정성 염기 및 에스시탈로프람 염기를 함유한 구강내분산성 정제

Country Status (39)

Country Link
EP (3) EP2325177A1 (enExample)
JP (5) JP4906852B2 (enExample)
KR (5) KR101340815B1 (enExample)
CN (2) CN101928269A (enExample)
AR (2) AR055062A1 (enExample)
AT (3) AT10983U1 (enExample)
AU (2) AU2006261452B2 (enExample)
BG (1) BG66086B1 (enExample)
BR (1) BRPI0612295A2 (enExample)
CA (2) CA2612827C (enExample)
CY (1) CY1112392T1 (enExample)
CZ (3) CZ301286B6 (enExample)
DE (2) DE112006001619T5 (enExample)
DK (3) DK1896439T4 (enExample)
EA (2) EA201001108A1 (enExample)
EE (1) EE00773U1 (enExample)
ES (2) ES2356838T5 (enExample)
FI (2) FI20080548L (enExample)
GB (2) GB2448834B (enExample)
HR (1) HRP20110093T4 (enExample)
HU (1) HUP0800135A3 (enExample)
IL (1) IL187454A0 (enExample)
IS (1) IS8705A (enExample)
LT (1) LT5550B (enExample)
LV (1) LV13677B (enExample)
MX (1) MX2007015328A (enExample)
MY (2) MY143239A (enExample)
NO (2) NO20080359L (enExample)
PL (2) PL1896439T5 (enExample)
PT (1) PT1896439E (enExample)
RS (1) RS51575B2 (enExample)
SG (1) SG169358A1 (enExample)
SI (1) SI1896439T2 (enExample)
SK (1) SK500402007A3 (enExample)
TR (2) TR200708792T1 (enExample)
TW (2) TWI358407B (enExample)
UA (1) UA86536C2 (enExample)
WO (1) WO2006136169A2 (enExample)
ZA (2) ZA200711066B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200119021A (ko) 2019-04-09 2020-10-19 주식회사 라이트팜텍 에스시탈로프람을 함유하는 안정성이 우수한 경구용 액제 조성물 및 그의 제조방법

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WO2008104880A2 (en) * 2007-03-01 2008-09-04 Aurobindo Pharma Limited Stable solid dosage forms of an antidepressant
SI2595979T1 (sl) 2010-07-23 2016-09-30 H. Lundbeck A/S Proces za čiščenje farmacevtsko sprejemljivih soli Escitaloprama
CN103360353A (zh) * 2013-08-07 2013-10-23 中国药科大学 草酸艾司西酞普兰杂质的制备方法
JP2018016569A (ja) * 2016-07-26 2018-02-01 株式会社トクヤマ （１ｓ）−１−［３−（ジメチルアミノ）プロピル］−１−（４−フルオロフェニル）−１，３−ジヒドロイソベンゾフラン−５−カルボニトリル蓚酸塩の製造方法
WO2018190294A1 (ja) * 2017-04-10 2018-10-18 東和薬品株式会社 エスシタロプラム医薬組成物
CN110711198B (zh) * 2018-07-12 2022-03-15 山东大学 D-甘露糖在制备抗抑郁药物中的应用
US20240100012A1 (en) * 2021-01-18 2024-03-28 Mark Hasleton Pharmaceutical dosage form

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200119021A (ko) 2019-04-09 2020-10-19 주식회사 라이트팜텍 에스시탈로프람을 함유하는 안정성이 우수한 경구용 액제 조성물 및 그의 제조방법

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PT1896439E (pt) 2011-02-15
HRP20110093T1 (hr) 2011-03-31
AU2010200844A1 (en) 2010-04-01
JP4415056B2 (ja) 2010-02-17
LV13677B (en) 2008-05-20
EP1896439B1 (en) 2011-02-02
JP5731957B2 (ja) 2015-06-10
MX2007015328A (es) 2008-02-15
SI1896439T2 (sl) 2014-12-31
TR201000625T1 (tr) 2010-03-22
EA019239B1 (ru) 2014-02-28
CN101189220A (zh) 2008-05-28
DE602006019961D1 (de) 2011-03-17
FI20080548A7 (fi) 2008-10-07
AU2006261452B2 (en) 2010-02-04
TR200708792T1 (tr) 2008-05-21
AR079750A2 (es) 2012-02-15
CN101928269A (zh) 2010-12-29
ES2356838T3 (es) 2011-04-13
EP2325177A1 (en) 2011-05-25
MY143239A (en) 2011-04-15
KR20110084341A (ko) 2011-07-21
AU2006261452A1 (en) 2006-12-28
CA2612827C (en) 2010-11-30
BG66086B1 (bg) 2011-03-31
JP2008546724A (ja) 2008-12-25
ES2319073B1 (es) 2010-02-26
CA2612827A1 (en) 2006-12-28
UA86536C2 (ru) 2009-04-27
ZA200901698B (en) 2010-04-28
GB2448834A (en) 2008-10-29
SG169358A1 (en) 2011-03-30
CZ299906B6 (cs) 2008-12-29
DK200800075A (da) 2008-03-15
KR20120064140A (ko) 2012-06-18
PL1896439T3 (pl) 2011-04-29
EP1896439A2 (en) 2008-03-12
JP2012072168A (ja) 2012-04-12
AT10983U1 (de) 2010-02-15
EA201001108A1 (ru) 2011-02-28
GB2442160A (en) 2008-03-26
TWI358407B (en) 2012-02-21
SK500402007A3 (sk) 2008-05-06
DK200900284A (da) 2009-02-27
CZ2007898A3 (cs) 2008-01-23
AR055062A1 (es) 2007-08-01
NO20101777L (no) 2008-01-18
EA200800102A1 (ru) 2008-04-28
SI1896439T1 (sl) 2011-03-31
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