EA200800102A1 - Кристаллическое основание эсциталопрама и диспергируемые во рту таблетки, содержащие основание эсциталопрама - Google Patents

Кристаллическое основание эсциталопрама и диспергируемые во рту таблетки, содержащие основание эсциталопрама

Info

Publication number
EA200800102A1
EA200800102A1 EA200800102A EA200800102A EA200800102A1 EA 200800102 A1 EA200800102 A1 EA 200800102A1 EA 200800102 A EA200800102 A EA 200800102A EA 200800102 A EA200800102 A EA 200800102A EA 200800102 A1 EA200800102 A1 EA 200800102A1
Authority
EA
Eurasian Patent Office
Prior art keywords
salts
escital
prema
basis
escitalopram
Prior art date
Application number
EA200800102A
Other languages
English (en)
Other versions
EA019239B1 (ru
Inventor
Роберт Дансер
Ханс Петерсен
Оле Нильсен
Майкл Харолд Рок
Хелле Элиасен
Кен Лильегрен
Original Assignee
Х. Лундбекк А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37546630&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200800102(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Х. Лундбекк А/С filed Critical Х. Лундбекк А/С
Publication of EA200800102A1 publication Critical patent/EA200800102A1/ru
Publication of EA019239B1 publication Critical patent/EA019239B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B63/00—Purification; Separation; Stabilisation; Use of additives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение относится к кристаллическому основанию хорошо известного лекарственного средства антидепрессанта эсциталопрама, S-1-[3-(диметиламино)пропил]-1-(4-фторфенил)-1,3-дигидро-5-изобензофуранкарбонитрила, к препаратам указанного основания, к способу получения очищенных солей эсциталопрама, таких как оксалат, с использованием основания, к солям, получаемым с помощью указанного способа, и к препаратам, содержащим такие соли, и к способу получения очищенного свободного основания эсциталопрама или солей эсциталопрама, таких как оксалат, с использованием гидробромида, к солям, получаемым с помощью указанного способа, и к препаратам, содержащим такие соли. Наконец, настоящее изобретение относится к диспергируемой во рту таблетке, имеющей твердость по меньшей мере 22 Н, и время дезинтеграции в ротовой полости, меньшее чем 120 с, и содержащей активный фармацевтический ингредиент, адсорбированный на водорастворимом наполнителе, где активный фармацевтический ингредиент имеет температуру плавления в пределах 40-100°С, а также к способу получения такой диспергируемой во рту таблетки.
EA200800102A 2005-06-22 2006-06-22 Кристаллическое свободное основание эсциталопрама и фармацевтическая композиция, содержащая свободное основание эсциталопрама EA019239B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200500912 2005-06-22
PCT/DK2006/000366 WO2006136169A2 (en) 2005-06-22 2006-06-22 Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base

Publications (2)

Publication Number Publication Date
EA200800102A1 true EA200800102A1 (ru) 2008-04-28
EA019239B1 EA019239B1 (ru) 2014-02-28

Family

ID=37546630

Family Applications (2)

Application Number Title Priority Date Filing Date
EA200800102A EA019239B1 (ru) 2005-06-22 2006-06-22 Кристаллическое свободное основание эсциталопрама и фармацевтическая композиция, содержащая свободное основание эсциталопрама
EA201001108A EA201001108A1 (ru) 2005-06-22 2006-06-22 Диспергируемые во рту таблетки, содержащие основание эсциталопрама, и способ их получения

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA201001108A EA201001108A1 (ru) 2005-06-22 2006-06-22 Диспергируемые во рту таблетки, содержащие основание эсциталопрама, и способ их получения

Country Status (39)

Country Link
EP (3) EP1896439B2 (ru)
JP (5) JP4906852B2 (ru)
KR (5) KR101340815B1 (ru)
CN (2) CN101928269A (ru)
AR (2) AR055062A1 (ru)
AT (3) ATE497500T1 (ru)
AU (2) AU2006261452B2 (ru)
BG (1) BG66086B1 (ru)
BR (1) BRPI0612295A2 (ru)
CA (2) CA2646780A1 (ru)
CY (1) CY1112392T1 (ru)
CZ (3) CZ300686B6 (ru)
DE (2) DE602006019961D1 (ru)
DK (3) DK1896439T4 (ru)
EA (2) EA019239B1 (ru)
EE (1) EE00773U1 (ru)
ES (2) ES2356838T5 (ru)
FI (2) FI20077133A (ru)
GB (2) GB2442160B (ru)
HR (1) HRP20110093T4 (ru)
HU (1) HUP0800135A3 (ru)
IL (1) IL187454A0 (ru)
IS (1) IS8705A (ru)
LT (1) LT5550B (ru)
LV (1) LV13677B (ru)
MX (1) MX2007015328A (ru)
MY (2) MY143252A (ru)
NO (2) NO20080359L (ru)
PL (2) PL384185A1 (ru)
PT (1) PT1896439E (ru)
RS (1) RS51575B2 (ru)
SG (1) SG169358A1 (ru)
SI (1) SI1896439T2 (ru)
SK (1) SK500402007A3 (ru)
TR (2) TR200708792T1 (ru)
TW (2) TWI358407B (ru)
UA (1) UA86536C2 (ru)
WO (1) WO2006136169A2 (ru)
ZA (2) ZA200711066B (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0123400D0 (en) 2001-09-28 2001-11-21 Novartis Ag Organic compounds
WO2008059514A2 (en) * 2006-07-31 2008-05-22 Cadila Healthcare Limited Process for preparing escitalopram
WO2008104880A2 (en) * 2007-03-01 2008-09-04 Aurobindo Pharma Limited Stable solid dosage forms of an antidepressant
ME02391B (me) 2010-07-23 2016-09-20 H Lundbeck As Postupak za prečišćavanje farmaceutski prihvatljivih soli escitaloprama
CN103360353A (zh) * 2013-08-07 2013-10-23 中国药科大学 草酸艾司西酞普兰杂质的制备方法
JP2018016569A (ja) * 2016-07-26 2018-02-01 株式会社トクヤマ （１ｓ）−１−［３−（ジメチルアミノ）プロピル］−１−（４−フルオロフェニル）−１，３−ジヒドロイソベンゾフラン−５−カルボニトリル蓚酸塩の製造方法
WO2018190294A1 (ja) * 2017-04-10 2018-10-18 東和薬品株式会社 エスシタロプラム医薬組成物
CN110711198B (zh) * 2018-07-12 2022-03-15 山东大学 D-甘露糖在制备抗抑郁药物中的应用
KR102331187B1 (ko) 2019-04-09 2021-11-26 주식회사 라이트팜텍 에스시탈로프람을 함유하는 안정성이 우수한 경구용 액제 조성물 및 그의 제조방법

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1526331A (en) 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
JPH05222041A (ja) * 1992-02-13 1993-08-31 Mitsubishi Gas Chem Co Inc アデニン誘導体の精製法
EP0743850B1 (en) * 1994-01-27 1999-10-06 The Board Of Regents Of The University Of Oklahoma Rapidly dissolving oral dosage form
US5607697A (en) * 1995-06-07 1997-03-04 Cima Labs, Incorporated Taste masking microparticles for oral dosage forms
CA2325909C (en) 1997-06-30 2006-07-04 Beloit Technologies, Inc. Method and apparatus for the high speed application of coating to a traveling paper web
ES2148120T3 (es) 1997-07-08 2002-01-16 Lundbeck & Co As H Metodo para la preparacion de citalopram.
EA002770B1 (ru) 1997-11-11 2002-08-29 Х.Лундбекк А/С Способ получения циталопрама
FR2785538B1 (fr) * 1998-11-06 2004-04-09 Prographarm Laboratoires Comprime a delitement rapide perfectionne
US20020071864A1 (en) * 1999-03-25 2002-06-13 Yuhan Corporation Rapidly disintegrable tablet for oral administration
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
JP2001226372A (ja) * 1999-12-06 2001-08-21 Sumika Fine Chemicals Co Ltd ロサルタンの結晶性または結晶化された酸付加塩およびロサルタンの精製方法
GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
EP1329217A4 (en) * 2000-10-06 2007-04-04 Takeda Pharmaceutical SOLID PREPARATIONS
US20040014680A1 (en) * 2000-10-16 2004-01-22 Hiroaki Nakagami Medicinal compositions quickly disintegrating in the oral cavity and process for producing the same
US7799342B2 (en) 2000-12-06 2010-09-21 Wyeth Llc Fast dissolving tablet
DK1181713T3 (da) * 2000-12-22 2005-01-31 Lundbeck & Co As H Fremgangsmåde til fremstilling af rent citalopram
EA003459B1 (ru) * 2000-12-28 2003-06-26 Х.Лундбекк А/С Способ получения чистого циталопрама
KR20100012089A (ko) * 2001-05-01 2010-02-05 하. 룬트벡 아크티에 셀스카브 경상이성체성 순수 에스시탈로프람의 용도
US6872405B2 (en) * 2001-05-10 2005-03-29 Yamanouchi Pharmaceutical Co., Ltd. Quick-disintegrating tablet in buccal cavity and manufacturing method thereof
GB0113842D0 (en) * 2001-06-07 2001-08-01 Boots Co Plc Therapeutic agents
AR034612A1 (es) * 2001-06-25 2004-03-03 Lundbeck & Co As H Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram
AR034759A1 (es) 2001-07-13 2004-03-17 Lundbeck & Co As H Metodo para la preparacion de escitalopram
HUP0401946A2 (hu) * 2001-07-31 2005-01-28 H. Lundbeck A/S Escitalopramot tartalmazó kristályos gyógyszerkészítmény
IS7239A (is) * 2001-12-14 2004-04-29 H. Lundbeck A/S Aðferð til framleiðslu á essítalóprami
AU2003222435A1 (en) * 2002-01-07 2003-07-24 Sun Pharmaceutical Industries Limited Process for the preparation of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
FR2834889B1 (fr) * 2002-01-18 2004-04-02 Roquette Freres Forme pharmaceutique solide orodispersible
GB0204607D0 (en) * 2002-02-27 2002-04-10 Matrix Lab Ltd Process
EP2228060A1 (en) * 2002-05-03 2010-09-15 Skyepharma Canada Inc. Oral dosage forms comprising fenofibrate
RS51092B (sr) 2002-12-23 2010-10-31 H. Lundbeck A/S. Escitalopram bromhidrat i postupak za njegovo pripremanje
CN1510024A (zh) * 2002-12-24 2004-07-07 北京德众万全药物技术开发有限公司 可用于制备西酞普兰(s)-对映异构体的新的化合物及其制备方法
DE10305984A1 (de) * 2003-02-13 2004-09-02 Helm Ag Salze organischer Säuren mit Clopidogrel und deren Verwendung zur Herstellung phamazeutischer Formulierungen
NZ544007A (en) * 2003-05-07 2009-05-31 Samyang Corp Highly plastic granules for making fast melting tablets
ES2688193T3 (es) * 2003-10-15 2018-10-31 Fuji Chemical Industry Co., Ltd. Comprimido de disgregación rápida en la cavidad oral
WO2005049596A1 (en) * 2003-11-20 2005-06-02 Natco Pharma Limited A process for the preparation of high purity escitalopram
HU227491B1 (en) * 2003-11-25 2011-07-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Tablet containing citalopram hydrogen bromide
BRPI0508266A (pt) * 2004-03-05 2007-07-31 Lundbeck & Co As H partìculas cristalinas de oxalato de escitalopram, forma de dosagem única sólida, e, métodos para a fabricação de partìculas cristalinas de oxalato de escitalopram e para reduzir a quantidade de hidroxila que contém impurezas no citalopram, escitalopram ou uma mistura não racêmica de r- e s-citalopram
EP1877394A1 (en) * 2005-04-04 2008-01-16 Jubilant Organosys Limited Process for the preparation of escitalopram or its acid addition salts

Also Published As

Publication number Publication date
JP4415056B2 (ja) 2010-02-17
NO20101777L (no) 2008-01-18
EE00773U1 (et) 2008-10-15
WO2006136169A2 (en) 2006-12-28
HUP0800135A3 (en) 2009-01-28
MY143252A (en) 2011-04-15
FI20077133A (fi) 2007-12-20
ES2319073A1 (es) 2009-05-01
ZA200711066B (en) 2009-07-29
CN101928269A (zh) 2010-12-29
ES2356838T3 (es) 2011-04-13
GB0811164D0 (en) 2008-07-23
CZ299906B6 (cs) 2008-12-29
GB2442160B (en) 2010-01-20
PL1896439T5 (pl) 2016-01-29
HUP0800135A2 (en) 2008-06-30
TW200740785A (en) 2007-11-01
JP2012072168A (ja) 2012-04-12
AR055062A1 (es) 2007-08-01
CN101189220A (zh) 2008-05-28
ZA200901698B (en) 2010-04-28
UA86536C2 (ru) 2009-04-27
EP1896439B1 (en) 2011-02-02
HRP20110093T4 (hr) 2015-02-27
TWI358407B (en) 2012-02-21
CZ301286B6 (cs) 2009-12-30
MX2007015328A (es) 2008-02-15
CZ2007898A3 (cs) 2008-01-23
TWI347942B (en) 2011-09-01
SI1896439T2 (sl) 2014-12-31
EP2385044A1 (en) 2011-11-09
LT2008005A (en) 2008-10-27
KR20080018191A (ko) 2008-02-27
GB2442160A (en) 2008-03-26
WO2006136169A3 (en) 2007-10-18
GB0724557D0 (en) 2008-01-23
BG110024A (bg) 2008-05-30
PT1896439E (pt) 2011-02-15
JP2009046506A (ja) 2009-03-05
NO20080359L (no) 2008-01-18
KR20100133023A (ko) 2010-12-20
EP1896439A2 (en) 2008-03-12
GB2448834B (en) 2010-01-20
JP5731957B2 (ja) 2015-06-10
CZ300686B6 (cs) 2009-07-15
DK200800075A (da) 2008-03-15
AR079750A2 (es) 2012-02-15
FI20080548A (fi) 2008-10-07
DE602006019961D1 (de) 2011-03-17
LT5550B (lt) 2009-03-25
ES2356838T5 (es) 2015-01-26
PL1896439T3 (pl) 2011-04-29
HRP20110093T1 (hr) 2011-03-31
EP1896439B2 (en) 2014-10-15
CA2612827A1 (en) 2006-12-28
BG66086B1 (bg) 2011-03-31
AU2006261452B2 (en) 2010-02-04
ATE497500T1 (de) 2011-02-15
AU2010200844A1 (en) 2010-04-01
SG169358A1 (en) 2011-03-30
KR20110084341A (ko) 2011-07-21
PL384185A1 (pl) 2008-06-23
EA201001108A1 (ru) 2011-02-28
DE112006001619T5 (de) 2008-06-12
AT10983U1 (de) 2010-02-15
ES2319073B1 (es) 2010-02-26
BRPI0612295A2 (pt) 2011-01-04
CY1112392T1 (el) 2015-12-09
SK500402007A3 (sk) 2008-05-06
JP2009179635A (ja) 2009-08-13
IS8705A (is) 2008-01-14
CA2646780A1 (en) 2006-12-28
DK1896439T4 (en) 2015-01-12
AT11883U1 (de) 2011-06-15
RS51575B2 (sr) 2018-02-28
KR20110033310A (ko) 2011-03-30
TR200708792T1 (tr) 2008-05-21
KR101340815B1 (ko) 2013-12-11
CA2612827C (en) 2010-11-30
DK200900284A (da) 2009-02-27
EP2325177A1 (en) 2011-05-25
TR201000625T1 (tr) 2010-03-22
GB2448834A (en) 2008-10-29
DK1896439T3 (da) 2011-02-28
TW201130808A (en) 2011-09-16
JP2008546724A (ja) 2008-12-25
KR20120064140A (ko) 2012-06-18
IL187454A0 (en) 2008-02-09
EA019239B1 (ru) 2014-02-28
RS51575B (en) 2011-08-31
AU2006261452A1 (en) 2006-12-28
MY143239A (en) 2011-04-15
SI1896439T1 (sl) 2011-03-31
JP4906852B2 (ja) 2012-03-28
JP2009179634A (ja) 2009-08-13
LV13677B (en) 2008-05-20

Similar Documents

Publication Publication Date Title
EA200800102A1 (ru) Кристаллическое основание эсциталопрама и диспергируемые во рту таблетки, содержащие основание эсциталопрама
HUP0100531A2 (hu) Citalopram kristályos bázisa, eljárás előállítására, és azt tartalmazó gyógyszerkészítmények
HRP20160327T1 (hr) Čvrsti dozirni oblici fentanila s poboljšanom bukalnom apsorpcijom
DE602005007339D1 (de) Nebivolol und dessen pharmazeutisch unbedenkliche salze, herstellungsverfahren und pharmazeutische zusammensetzungen von nebivolol
SE0104341D0 (sv) New use
IL139227A0 (en) N-substituted aminotetralins as ligands for the neuropeptide yy5 receptor useful in the treatment of obesity and other disorders
HUP0300078A2 (en) Method for the preparation of citalopram
EA200801909A1 (ru) Соединения пиридина для лечения заболеваний, опосредованных действием простагландина
TW200505505A (en) Process for modifying drug crystal formation
DK1641438T3 (da) Fremgangsmåde til fremstilling af den amorfe form af et lægemiddel
HUP0401451A2 (hu) Eljárás escitalopram elõállítására
DK1511489T3 (da) Nye farmaceutiske sammensætninger indeholdende flibanserin-polymorf A
UA96575C2 (en) Process for the preparation of olmesartan medoxomil
MX2023008671A (es) Composicion farmaceutica.
HUP0103071A2 (hu) Citalopramot tartalmazó gyógyászati készítmény
HUP0302531A2 (hu) Citalopramot tartalmazó gyógyászati készítmények
TH98476A (th) เบสที่เป็นผลึกของเอสซิทาโลแปรม และยาเม็ดกระจายตัวในปากซึ่งประกอบรวมด้วยเอสซิทาโลแปรมเบส
TH98476B (th) เบสที่เป็นผลึกของเอสซิทาโลแปรม และยาเม็ดกระจายตัวในปากซึ่งประกอบรวมด้วยเอสซิทาโลแปรมเบส
UA88284C2 (ru) Твердая лекарственная форма, которая содержит действующее вещество из группы ингибиторов обратного захвата моноаминовых нейротрансмиттеров с 2,3-двухзамещенным тропановым скелетом, способ ее получения и применения
WO2005049024A3 (de) Feste pharmazeutische zubereitungsform

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU