HUP0302531A2 - Citalopramot tartalmazó gyógyászati készítmények - Google Patents
Citalopramot tartalmazó gyógyászati készítményekInfo
- Publication number
- HUP0302531A2 HUP0302531A2 HU0302531A HUP0302531A HUP0302531A2 HU P0302531 A2 HUP0302531 A2 HU P0302531A2 HU 0302531 A HU0302531 A HU 0302531A HU P0302531 A HUP0302531 A HU P0302531A HU P0302531 A2 HUP0302531 A2 HU P0302531A2
- Authority
- HU
- Hungary
- Prior art keywords
- citalopram
- weight
- active ingredient
- preparations
- pharmaceutical compositions
- Prior art date
Links
- WSEQXVZVJXJVFP-HXUWFJFHSA-N (R)-citalopram Chemical compound C1([C@@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-HXUWFJFHSA-N 0.000 title abstract 5
- 229960001653 citalopram Drugs 0.000 title abstract 5
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000004480 active ingredient Substances 0.000 abstract 2
- WSEQXVZVJXJVFP-UHFFFAOYSA-N 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile Chemical compound O1CC2=CC(C#N)=CC=C2C1(CCCN(C)C)C1=CC=C(F)C=C1 WSEQXVZVJXJVFP-UHFFFAOYSA-N 0.000 abstract 1
- 238000005056 compaction Methods 0.000 abstract 1
- 238000007906 compression Methods 0.000 abstract 1
- 230000006835 compression Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000007909 melt granulation Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 238000005550 wet granulation Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A találmány hatóanyagként citalopramot, azaz 1-[3-(dimetilamino)propil]-1-(4-fluorfenil)-1,3-dihidro-5-izobenzofuránkarbonitrilt tartalmazó, szilárd dózisegység formájúgyógyászati készítményekre vonatkozik, amelyek citaloprambázis vagyennek gyógyászatilag elfogadható sója és adott esetben agyógyszergyártásban szokásosan használt hordozó és/vagy egyébsegédanyag hengeres tömörítését mint műveletet magába foglalóeljárással kerülnek előállításra. Ezek a készítmények -citaloprambázisként számítva - 2-60 tömeg%, előnyösebben 10-40 tömeg%,a leginkább előnyösen 15-25 tömeg% hatóanyagot tartalmaznak. Atalálmány szerinti megoldás előnye, hogy a hengeres tömörítés kevésbéenergiaigényes és jóval kevésbé bonyolult és költséges berendezésekbenvégrehajtható, mint a citalopram-szemcseméret növelésére korábbanhasznosított nedves vagy ömledék granulálás. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200100016 | 2001-01-05 | ||
| PCT/DK2002/000003 WO2002053133A1 (en) | 2001-01-05 | 2002-01-03 | Pharmaceutical composition containing citalopram |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0302531A2 true HUP0302531A2 (hu) | 2003-11-28 |
| HUP0302531A3 HUP0302531A3 (en) | 2007-06-28 |
Family
ID=8159961
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0302531A HUP0302531A3 (en) | 2001-01-05 | 2002-01-03 | Pharmaceutical compositions containing citalopram |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20040058989A1 (hu) |
| EP (1) | EP1351667A1 (hu) |
| JP (1) | JP2004517111A (hu) |
| KR (1) | KR20030070088A (hu) |
| CN (1) | CN1484523A (hu) |
| AU (1) | AU2001100195B4 (hu) |
| BG (1) | BG108034A (hu) |
| BR (1) | BR0206272A (hu) |
| CA (1) | CA2358356A1 (hu) |
| CZ (1) | CZ20032119A3 (hu) |
| EA (1) | EA005596B1 (hu) |
| HR (1) | HRP20030546A2 (hu) |
| HU (1) | HUP0302531A3 (hu) |
| IL (1) | IL156547A0 (hu) |
| IS (1) | IS6857A (hu) |
| MX (1) | MXPA03005965A (hu) |
| NO (1) | NO20033073D0 (hu) |
| PL (1) | PL362358A1 (hu) |
| SK (1) | SK9912003A3 (hu) |
| WO (1) | WO2002053133A1 (hu) |
| YU (1) | YU54503A (hu) |
| ZA (1) | ZA200304860B (hu) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2406592C (en) * | 2002-10-04 | 2003-09-30 | Duchesnay Inc. | Method of preparing pharmaceutical dosage forms containing multiple active ingredients |
| AU2004222339A1 (en) * | 2003-03-14 | 2004-09-30 | Nirmal Mulye | A process for preparing sustained release tablets |
| HU227491B1 (en) * | 2003-11-25 | 2011-07-28 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Tablet containing citalopram hydrogen bromide |
| WO2006123243A2 (en) * | 2005-05-20 | 2006-11-23 | Aurobindo Pharma Limited | Pharmaceutical dosage forms comprising escitalopram in form of granules |
| CN100353939C (zh) * | 2006-01-05 | 2007-12-12 | 昆明积大制药有限公司 | 含西酞普兰和环糊精的抗抑郁口服药用组合物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1358915A (en) * | 1971-09-13 | 1974-07-03 | Merck & Co Inc | Directly compressed tablet and composition therefor |
| GB1526331A (en) * | 1976-01-14 | 1978-09-27 | Kefalas As | Phthalanes |
| GB2357762B (en) * | 2000-03-13 | 2002-01-30 | Lundbeck & Co As H | Crystalline base of citalopram |
| US6977306B2 (en) * | 2000-05-02 | 2005-12-20 | Sumitomo Chemical Company, Limited | Citalopram hydrobromide crystal and method for crystallization thereof |
| CA2353693C (en) * | 2000-08-10 | 2003-07-22 | H. Lundbeck A/S | Pharmaceutical composition containing citalopram |
-
2001
- 2001-07-26 AU AU2001100195A patent/AU2001100195B4/en not_active Ceased
- 2001-10-04 CA CA002358356A patent/CA2358356A1/en not_active Abandoned
-
2002
- 2002-01-03 MX MXPA03005965A patent/MXPA03005965A/es unknown
- 2002-01-03 SK SK991-2003A patent/SK9912003A3/sk unknown
- 2002-01-03 YU YU54503A patent/YU54503A/sh unknown
- 2002-01-03 HU HU0302531A patent/HUP0302531A3/hu unknown
- 2002-01-03 PL PL02362358A patent/PL362358A1/xx not_active Application Discontinuation
- 2002-01-03 KR KR10-2003-7008953A patent/KR20030070088A/ko not_active Application Discontinuation
- 2002-01-03 CN CNA028034686A patent/CN1484523A/zh active Pending
- 2002-01-03 CZ CZ20032119A patent/CZ20032119A3/cs unknown
- 2002-01-03 EA EA200300768A patent/EA005596B1/ru not_active IP Right Cessation
- 2002-01-03 IL IL15654702A patent/IL156547A0/xx unknown
- 2002-01-03 JP JP2002554084A patent/JP2004517111A/ja not_active Withdrawn
- 2002-01-03 WO PCT/DK2002/000003 patent/WO2002053133A1/en not_active Application Discontinuation
- 2002-01-03 BR BR0206272-0A patent/BR0206272A/pt not_active IP Right Cessation
- 2002-01-03 EP EP02726983A patent/EP1351667A1/en not_active Withdrawn
-
2003
- 2003-06-23 IS IS6857A patent/IS6857A/is unknown
- 2003-06-23 ZA ZA200304860A patent/ZA200304860B/en unknown
- 2003-07-01 US US10/619,743 patent/US20040058989A1/en not_active Abandoned
- 2003-07-04 HR HR20030546A patent/HRP20030546A2/xx not_active Application Discontinuation
- 2003-07-04 NO NO20033073A patent/NO20033073D0/no not_active Application Discontinuation
- 2003-07-28 BG BG108034A patent/BG108034A/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO20033073L (no) | 2003-07-04 |
| EA200300768A1 (ru) | 2003-10-30 |
| HUP0302531A3 (en) | 2007-06-28 |
| PL362358A1 (en) | 2004-10-18 |
| IL156547A0 (en) | 2004-01-04 |
| CA2358356A1 (en) | 2002-01-20 |
| BR0206272A (pt) | 2003-12-30 |
| AU2001100195A4 (en) | 2001-08-16 |
| WO2002053133A1 (en) | 2002-07-11 |
| AU2001100195B4 (en) | 2001-12-20 |
| HRP20030546A2 (en) | 2005-06-30 |
| EP1351667A1 (en) | 2003-10-15 |
| US20040058989A1 (en) | 2004-03-25 |
| CN1484523A (zh) | 2004-03-24 |
| ZA200304860B (en) | 2004-06-30 |
| BG108034A (bg) | 2005-02-28 |
| KR20030070088A (ko) | 2003-08-27 |
| SK9912003A3 (en) | 2003-12-02 |
| CZ20032119A3 (en) | 2004-03-17 |
| EA005596B1 (ru) | 2005-04-28 |
| IS6857A (is) | 2003-06-23 |
| YU54503A (sh) | 2006-05-25 |
| NO20033073D0 (no) | 2003-07-04 |
| JP2004517111A (ja) | 2004-06-10 |
| MXPA03005965A (es) | 2003-09-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA9A | Lapse of provisional patent protection due to relinquishment or protection considered relinquished |