NO20070945L - Induksjon av apoptose i tumorceller som uttrykker toll-lignende reseptor - Google Patents

Induksjon av apoptose i tumorceller som uttrykker toll-lignende reseptor

Info

Publication number
NO20070945L
NO20070945L NO20070945A NO20070945A NO20070945L NO 20070945 L NO20070945 L NO 20070945L NO 20070945 A NO20070945 A NO 20070945A NO 20070945 A NO20070945 A NO 20070945A NO 20070945 L NO20070945 L NO 20070945L
Authority
NO
Norway
Prior art keywords
tumor cells
receptor
toll
apoptosis
induction
Prior art date
Application number
NO20070945A
Other languages
English (en)
Inventor
Serge Lebecque
Toufic Renno
Bruno Salaun
Isabelle Coste-Invernizzi
Marie-Clotilde Rissoan
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of NO20070945L publication Critical patent/NO20070945L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Noen typer kreftceller uttrykker én eller flere toll-lignende reseptorer (TLR'er). Disse TLR'ene er terapeutiske mål. Oppfinnelsen vedrører fremgangsmåter for å behandle toll-lignende reseptoruttrykkende kreftformer og tumorceller ved å velge en TLR-uttrykkende tumorcelle og kontakte cellen med en terapeutisk effektiv mengde av en TLR-ligand. Oppfinnelsen vedrører spesielt fremgangsmåter for å behandle TLR3-uttrykkende kreftformer og tumorceller ved å benytte TLR3-agonister.
NO20070945A 2004-07-20 2007-02-19 Induksjon av apoptose i tumorceller som uttrykker toll-lignende reseptor NO20070945L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58961604P 2004-07-20 2004-07-20
PCT/US2005/025602 WO2006014653A1 (en) 2004-07-20 2005-07-19 Induction of apoptosis in toll-like receptor expressing tumor cells

Publications (1)

Publication Number Publication Date
NO20070945L true NO20070945L (no) 2007-02-19

Family

ID=35229744

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20070945A NO20070945L (no) 2004-07-20 2007-02-19 Induksjon av apoptose i tumorceller som uttrykker toll-lignende reseptor

Country Status (12)

Country Link
US (2) US20060147456A1 (no)
EP (1) EP1768699A1 (no)
JP (1) JP2008507530A (no)
KR (1) KR20070043795A (no)
CN (1) CN101018567B (no)
AT (1) ATE511859T1 (no)
AU (2) AU2005269733B2 (no)
CA (1) CA2574176A1 (no)
MX (1) MX2007000770A (no)
NO (1) NO20070945L (no)
RU (1) RU2401661C9 (no)
WO (1) WO2006014653A1 (no)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2258712A3 (en) 2002-03-15 2011-05-04 Multicell Immunotherapeutics, Inc. Compositions and Methods to Initiate or Enhance Antibody and Major-histocompatibility Class I or Class II-restricted T Cell Responses by Using Immunomodulatory, Non-coding RNA Motifs
WO2004087877A2 (en) * 2003-03-26 2004-10-14 Astral Inc. Selected rna motifs to include cell death and/or apoptosis
WO2006054129A1 (en) 2004-11-19 2006-05-26 Institut Gustave Roussy Improved treatment of cancer by double-stranded rna
US20120189643A1 (en) * 2004-11-30 2012-07-26 Carton Jill M Toll Like Receptor 3 Antagonists, Methods and Uses
US8058258B2 (en) * 2006-03-02 2011-11-15 Agency For Science, Technology And Research Methods for cancer therapy and stem cell modulation
WO2007133800A2 (en) * 2006-05-15 2007-11-22 University Of Kentucky Toll-like receptor (tlr) stimulation for ocular angiogenesis and macular degeneration
EP1881080A1 (en) * 2006-07-18 2008-01-23 Institut Gustave Roussy Toll like receptor 4 dysfunction and the biological applications thereof
US20080124366A1 (en) * 2006-08-06 2008-05-29 Ohlfest John R Methods and Compositions for Treating Tumors
JP5115921B2 (ja) * 2007-02-28 2013-01-09 株式会社ペルセウスプロテオミクス 腎癌の診断薬および治療薬
CA2685557A1 (en) * 2007-04-24 2008-10-30 John Wayne Cancer Institute Functional toll-like receptors (tlr) on melanocytes and melanoma cells and uses thereof
US8969313B2 (en) * 2007-11-02 2015-03-03 Agency For Science, Technology And Research Methods and compounds for preventing and treating a tumour
JP2011505011A (ja) * 2007-11-28 2011-02-17 スマート チューブ，インコーポレイテッド 生体試料の採取、刺激、安定化及び分析のためのデバイス、システム及び方法
US8481508B2 (en) 2008-02-21 2013-07-09 University Of Kentucky Research Foundation Ultra-small RNAs as toll-like receptor-3 antagonists
WO2009130616A2 (en) 2008-04-25 2009-10-29 Innate Pharma Improved tlr3 agonist compositions
WO2010020590A1 (en) * 2008-08-20 2010-02-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the response to anti-cancer treatment with an agonist of tlr7 or an agonist of tlr8
GB0820698D0 (en) * 2008-11-12 2008-12-17 Ludwig Inst Cancer Res Uses of immunomodulators
US8628762B2 (en) 2008-12-10 2014-01-14 Icahn School Of Medicine At Mount Sinai T-helper cell type 17 lineage-specific adjuvants, compositions and methods
CN102869775A (zh) 2009-09-30 2013-01-09 哈佛大学校长及研究员协会 通过调节自噬抑制基因产物调节自噬的方法
ES2626595T5 (es) * 2009-12-18 2021-11-24 Bavarian Nordic As Producción de IFN-lambda por células dendríticas convencionales y usos de las mismas
KR101250419B1 (ko) * 2010-12-16 2013-04-05 강원대학교산학협력단 Ｔｌｒ 작동제를 포함하는 유방암 방사선 치료 보조제
MX2014000872A (es) * 2011-07-22 2014-07-28 Pawel Kalinski Modulacion de quimiocina selectiva de tumor.
CN102652802A (zh) * 2012-04-18 2012-09-05 南京中医药大学 癌毒方在制备调控肝癌细胞TLRs／NF-κB信号转导药物中的应用
EP2879669A4 (en) 2012-07-29 2016-04-13 Univ Colorado Regents ANTAGONISTS OF THE TOLL-TYPE 1/2 RECEIVER COMPLEX
WO2015127002A1 (en) * 2014-02-19 2015-08-27 The Johns Hopkins University Compositions and methods for promoting skin regeneration and hair growth
TR201908550T4 (tr) 2014-06-04 2019-07-22 Exicure Inc Profilaktik veya terapötik uygulamalar için lipozomal sferik nükleik asitler tarafından immün modülatörlerin çok değerlikli teslimi.
CN105796594A (zh) * 2016-03-28 2016-07-27 南京大学 一种组合物在制备治疗肿瘤药物中的应用及该组合物的使用方法
CN106191238B (zh) * 2016-07-08 2020-01-10 中国医学科学院基础医学研究所 Tlr3预测肿瘤转移、评估预后和选择防治方案的应用
WO2018039629A2 (en) 2016-08-25 2018-03-01 Northwestern University Micellar spherical nucleic acids from thermoresponsive, traceless templates
US11433131B2 (en) 2017-05-11 2022-09-06 Northwestern University Adoptive cell therapy using spherical nucleic acids (SNAs)
CN108295060A (zh) * 2018-04-08 2018-07-20 王长国 一种tlr7激动剂在增强cik细胞对肿瘤细胞杀伤力方面的应用
US11969402B2 (en) 2019-05-16 2024-04-30 The Johns Hopkins University Compositions and methods for skin rejuvenation
CN111117966A (zh) * 2020-03-02 2020-05-08 南通大学 一种利用乳酸的体外细胞培养方法
CN111579538B (zh) * 2020-04-22 2022-12-30 山东第一医科大学(山东省医学科学院) 一种利用凋亡试剂盒检测循环肿瘤细胞的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3040121B2 (ja) * 1988-01-12 2000-05-08 ジェネンテク，インコーポレイテッド 増殖因子レセプターの機能を阻害することにより腫瘍細胞を処置する方法
CN1040504A (zh) * 1988-06-22 1990-03-21 Hem研究公司 用双链核糖核酸调节淋巴激活素抗性细胞状态
US20040006242A1 (en) * 1999-02-01 2004-01-08 Hawkins Lynn D. Immunomodulatory compounds and method of use thereof
EP1412390A2 (en) * 2001-07-26 2004-04-28 Tanox, Inc. Agents that activate or inhibit toll-like receptor 9
TW200303759A (en) * 2001-11-27 2003-09-16 Schering Corp Methods for treating cancer
WO2004047612A2 (en) * 2002-11-22 2004-06-10 Nuvelo, Inc. Methods of therapy and diagnosis
JP3810731B2 (ja) * 2002-11-29 2006-08-16 独立行政法人科学技術振興機構 哺乳動物のＴｏｌｌ様受容体３に結合する新規アダプタータンパク質およびその遺伝子

Also Published As

Publication number Publication date
AU2008249173A1 (en) 2008-12-11
AU2005269733A1 (en) 2006-02-09
JP2008507530A (ja) 2008-03-13
CN101018567B (zh) 2011-07-27
WO2006014653A1 (en) 2006-02-09
US20090285779A1 (en) 2009-11-19
RU2007105987A (ru) 2008-08-27
CN101018567A (zh) 2007-08-15
MX2007000770A (es) 2007-03-26
RU2401661C9 (ru) 2011-01-27
AU2005269733B2 (en) 2008-10-30
EP1768699A1 (en) 2007-04-04
US20060147456A1 (en) 2006-07-06
ATE511859T1 (de) 2011-06-15
CA2574176A1 (en) 2006-02-09
RU2401661C2 (ru) 2010-10-20
KR20070043795A (ko) 2007-04-25

Similar Documents

Publication Publication Date Title
NO20070945L (no) Induksjon av apoptose i tumorceller som uttrykker toll-lignende reseptor
TR201905909T4 (tr) Kanser tedavisi için anti-4-1bb antikorlarının ve adcc indükleyici antikorların kombinasyonları.
MX2019004193A (es) Combinacion de anticuerpos anti-kir y anticuerpos anti-pd-1 para tratar cancer.
MX346973B (es) Anticuerpos especificos de tumores y usos para los mismos.
CY1117604T1 (el) Μια νεα ομαδα αναστολεων του μονοπατιου stat3 και αναστολεων του μονοπατιου καρκινικων βλαστοκυτταρων
AR057941A1 (es) Agentes terapeuticos para el cancer de prostata
MX2013008375A (es) Anticuerpos anti proteina accesoria del receptor de interleucina-1 y su uso para tratamiento en humanos.
MX2013011098A (es) Metodos para aumentar la eficacia de la terapia contra el cancer con receptor 1 de folato (folr1).
BR112015009752A2 (pt) conjugados de anticorpo/fármaco e métodos de uso
MX2010004164A (es) Terapia de combinacion de un anticuerpo anti-cd20 de tipo ii con un inhibidor de proteasoma.
BRPI0606360A2 (pt) método para melhorar a apoptose, método para tratar uma desordem proliferativa e método para tratar células cancerosas
MX336675B (es) Cribado para compuestos anticancerigenos utilizando actividad de netrina-1.
DK1755659T3 (da) Anvendelse af anti-alfa5beta1-antistoffer til inhibering af kræftcelleproliferation
MY158691A (en) Amino pyrozole compound
ATE543834T1 (de) Mit pancreaskrebs assoziierte genfamilie (lbfl313)
EA201492004A1 (ru) Органические композиции для лечения kras-ассоциированных заболеваний
EP2504363A4 (en) ANTICLUSTERIN ANTIBODIES AND ANTIGEN-BINDING FRAGMENTS AND THEIR USE FOR REDUCING TUMOR VOLUME
WO2009108931A3 (en) Method of treating cancer
CR20110479A (es) Combinaciones farmaceuticas que comprenden rdea 119/bay 869766 para el tratamiento de canceres especificos
MX2015011386A (es) Metodo para tratar cancer pancreatico.
EA200970884A1 (ru) Способы лечения рака путем введения комбинаций человеческого интерлейкина ил-18
WO2008132500A3 (en) Chkl inhibitors with b cell depleting antibodies for the treatment of hematologic malignancies
EA201992513A1 (ru) Способ лечения рака груди
CY1116492T1 (el) Δραστηριοτητα του τεμσιρολιμου κατα των ογκων στον καρκινο θηλοειδων νεφρικων κυτταρων
EA201170681A1 (ru) Комбинированная терапия ингибитором киназы p70 s6 и ингибитором mtor

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application