ATE511859T1 - Apoptoseinduktion in toll-artige rezeptoren exprimierenden tumorzellen - Google Patents
Apoptoseinduktion in toll-artige rezeptoren exprimierenden tumorzellenInfo
- Publication number
- ATE511859T1 ATE511859T1 AT05774637T AT05774637T ATE511859T1 AT E511859 T1 ATE511859 T1 AT E511859T1 AT 05774637 T AT05774637 T AT 05774637T AT 05774637 T AT05774637 T AT 05774637T AT E511859 T1 ATE511859 T1 AT E511859T1
- Authority
- AT
- Austria
- Prior art keywords
- toll
- tumor cells
- expressing tumor
- apoptosis induction
- receptors expressing
- Prior art date
Links
- 102000002689 Toll-like receptor Human genes 0.000 title abstract 7
- 108020000411 Toll-like receptor Proteins 0.000 title abstract 7
- 210000004881 tumor cell Anatomy 0.000 title abstract 4
- 230000006907 apoptotic process Effects 0.000 title 1
- 230000006698 induction Effects 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 101000831496 Homo sapiens Toll-like receptor 3 Proteins 0.000 abstract 2
- 102100024324 Toll-like receptor 3 Human genes 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 239000000556 agonist Substances 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0331—Animal model for proliferative diseases
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58961604P | 2004-07-20 | 2004-07-20 | |
PCT/US2005/025602 WO2006014653A1 (en) | 2004-07-20 | 2005-07-19 | Induction of apoptosis in toll-like receptor expressing tumor cells |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE511859T1 true ATE511859T1 (de) | 2011-06-15 |
Family
ID=35229744
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05774637T ATE511859T1 (de) | 2004-07-20 | 2005-07-19 | Apoptoseinduktion in toll-artige rezeptoren exprimierenden tumorzellen |
Country Status (12)
Country | Link |
---|---|
US (2) | US20060147456A1 (de) |
EP (1) | EP1768699A1 (de) |
JP (1) | JP2008507530A (de) |
KR (1) | KR20070043795A (de) |
CN (1) | CN101018567B (de) |
AT (1) | ATE511859T1 (de) |
AU (2) | AU2005269733B2 (de) |
CA (1) | CA2574176A1 (de) |
MX (1) | MX2007000770A (de) |
NO (1) | NO20070945L (de) |
RU (1) | RU2401661C9 (de) |
WO (1) | WO2006014653A1 (de) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2258712A3 (de) * | 2002-03-15 | 2011-05-04 | Multicell Immunotherapeutics, Inc. | Zusammensetzungen und Verfahren zur Einleitung bzw. Verstärkung von Antikörper- und Haupthistokompatibilität-Klasse-I- oder-Klasse-II-beschränkten T-Zell-Reaktionen unter Anwendung von Immunmodulierenden, nicht-codierenden RNA-Motiven |
AU2004225480A1 (en) * | 2003-03-26 | 2004-10-14 | Multicell Immunotherapeutics, Inc. | Selected RNA motifs to include cell death and/or apoptosis |
WO2006054129A1 (en) * | 2004-11-19 | 2006-05-26 | Institut Gustave Roussy | Improved treatment of cancer by double-stranded rna |
US20120189643A1 (en) * | 2004-11-30 | 2012-07-26 | Carton Jill M | Toll Like Receptor 3 Antagonists, Methods and Uses |
EP2522352B1 (de) | 2006-03-02 | 2017-01-11 | Agency for Science, Technology and Research | Verfahren zur Stammzellenmodulation |
EP2023722A4 (de) * | 2006-05-15 | 2012-01-18 | Univ Kentucky | Toll-like-rezeptor (tlr)-stimulierung für okulare angiogenese und maculadegeneration |
EP1881080A1 (de) * | 2006-07-18 | 2008-01-23 | Institut Gustave Roussy | Funktionsstörung des Toll-ähnliches Rezeptors 4 und biologische Anwendungen davon |
US20080124366A1 (en) * | 2006-08-06 | 2008-05-29 | Ohlfest John R | Methods and Compositions for Treating Tumors |
JP5115921B2 (ja) * | 2007-02-28 | 2013-01-09 | 株式会社ペルセウスプロテオミクス | 腎癌の診断薬および治療薬 |
CA2685557A1 (en) * | 2007-04-24 | 2008-10-30 | John Wayne Cancer Institute | Functional toll-like receptors (tlr) on melanocytes and melanoma cells and uses thereof |
JP2011504462A (ja) * | 2007-11-02 | 2011-02-10 | エージェンシー フォー サイエンス,テクノロジー アンド リサーチ | 腫瘍の予防および治療のための方法および化合物 |
EP2214824A4 (de) * | 2007-11-28 | 2015-08-19 | Smart Tube Inc | Vorrichtungen, systeme und verfahren zur entnahme, stimulation, stabilisierung und analyse einer biologischen probe |
US8481508B2 (en) | 2008-02-21 | 2013-07-09 | University Of Kentucky Research Foundation | Ultra-small RNAs as toll-like receptor-3 antagonists |
US20110076296A1 (en) | 2008-04-25 | 2011-03-31 | Innate Pharma S.A. | TLR3 Agonist Compositions |
EP2316032A1 (de) * | 2008-08-20 | 2011-05-04 | INSERM - Institut National de la Santé et de la Recherche Médicale | Verfahren zur vorhersage des ansprechens auf eine antikrebsbehandlung mit einem agonisten von tlr7 oder einem agonisten von tlr8 |
GB0820698D0 (en) * | 2008-11-12 | 2008-12-17 | Ludwig Inst Cancer Res | Uses of immunomodulators |
US8628762B2 (en) | 2008-12-10 | 2014-01-14 | Icahn School Of Medicine At Mount Sinai | T-helper cell type 17 lineage-specific adjuvants, compositions and methods |
WO2011041582A2 (en) | 2009-09-30 | 2011-04-07 | President And Fellows Of Harvard College | Methods for modulation of autophagy through the modulation of autophagy-inhibiting gene products |
WO2011072871A1 (en) * | 2009-12-18 | 2011-06-23 | Bavarian Nordic A/S | Production of ifn-lambda by conventional dendritic cells and uses thereof |
KR101250419B1 (ko) * | 2010-12-16 | 2013-04-05 | 강원대학교산학협력단 | Tlr 작동제를 포함하는 유방암 방사선 치료 보조제 |
RU2014103159A (ru) * | 2011-07-22 | 2015-08-27 | Павел КАЛИНСКИЙ | Опухолесективная модуляция хемокинов |
CN102652802A (zh) * | 2012-04-18 | 2012-09-05 | 南京中医药大学 | 癌毒方在制备调控肝癌细胞TLRs/NF-κB信号转导药物中的应用 |
US9517993B2 (en) | 2012-07-29 | 2016-12-13 | The Regents Of The University Of Colorado, A Body Corporate | Antagonists of the toll-like receptor 1/2 complex |
US10105305B2 (en) * | 2014-02-19 | 2018-10-23 | The Johns Hopkins University | Compositions and methods for promoting skin regeneration and hair growth |
ES2725948T3 (es) | 2014-06-04 | 2019-09-30 | Exicure Inc | Suministro multivalente de inmunomoduladores mediante ácidos nucleicos esféricos liposomales para aplicaciones profilácticas o terapéuticas |
CN105796594A (zh) * | 2016-03-28 | 2016-07-27 | 南京大学 | 一种组合物在制备治疗肿瘤药物中的应用及该组合物的使用方法 |
CN106191238B (zh) * | 2016-07-08 | 2020-01-10 | 中国医学科学院基础医学研究所 | Tlr3预测肿瘤转移、评估预后和选择防治方案的应用 |
WO2018039629A2 (en) | 2016-08-25 | 2018-03-01 | Northwestern University | Micellar spherical nucleic acids from thermoresponsive, traceless templates |
WO2018209270A1 (en) | 2017-05-11 | 2018-11-15 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (snas) |
CN108295060A (zh) * | 2018-04-08 | 2018-07-20 | 王长国 | 一种tlr7激动剂在增强cik细胞对肿瘤细胞杀伤力方面的应用 |
WO2020232226A1 (en) | 2019-05-16 | 2020-11-19 | The Johns Hopkins University | Compositions and methods for skin rejuvenation |
CN111117966A (zh) * | 2020-03-02 | 2020-05-08 | 南通大学 | 一种利用乳酸的体外细胞培养方法 |
CN111579538B (zh) * | 2020-04-22 | 2022-12-30 | 山东第一医科大学(山东省医学科学院) | 一种利用凋亡试剂盒检测循环肿瘤细胞的方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3040121B2 (ja) * | 1988-01-12 | 2000-05-08 | ジェネンテク,インコーポレイテッド | 増殖因子レセプターの機能を阻害することにより腫瘍細胞を処置する方法 |
CN1040504A (zh) * | 1988-06-22 | 1990-03-21 | Hem研究公司 | 用双链核糖核酸调节淋巴激活素抗性细胞状态 |
US20040006242A1 (en) * | 1999-02-01 | 2004-01-08 | Hawkins Lynn D. | Immunomodulatory compounds and method of use thereof |
WO2003035695A2 (en) * | 2001-07-26 | 2003-05-01 | Tanox, Inc. | Agents that activate or inhibit toll-like receptor 9 |
TW200303759A (en) * | 2001-11-27 | 2003-09-16 | Schering Corp | Methods for treating cancer |
AU2003295649A1 (en) * | 2002-11-22 | 2004-06-18 | Nuvelo,Inc. | Methods of therapy and diagnosis |
JP3810731B2 (ja) * | 2002-11-29 | 2006-08-16 | 独立行政法人科学技術振興機構 | 哺乳動物のToll様受容体3に結合する新規アダプタータンパク質およびその遺伝子 |
-
2005
- 2005-07-19 RU RU2007105987/14A patent/RU2401661C9/ru not_active IP Right Cessation
- 2005-07-19 EP EP05774637A patent/EP1768699A1/de not_active Withdrawn
- 2005-07-19 AT AT05774637T patent/ATE511859T1/de not_active IP Right Cessation
- 2005-07-19 WO PCT/US2005/025602 patent/WO2006014653A1/en active Application Filing
- 2005-07-19 KR KR1020077001407A patent/KR20070043795A/ko not_active Application Discontinuation
- 2005-07-19 CN CN2005800308083A patent/CN101018567B/zh not_active Expired - Fee Related
- 2005-07-19 MX MX2007000770A patent/MX2007000770A/es unknown
- 2005-07-19 US US11/184,191 patent/US20060147456A1/en not_active Abandoned
- 2005-07-19 AU AU2005269733A patent/AU2005269733B2/en not_active Ceased
- 2005-07-19 CA CA002574176A patent/CA2574176A1/en not_active Abandoned
- 2005-07-19 JP JP2007522657A patent/JP2008507530A/ja active Pending
-
2007
- 2007-02-19 NO NO20070945A patent/NO20070945L/no not_active Application Discontinuation
- 2007-12-06 US US11/951,582 patent/US20090285779A1/en not_active Abandoned
-
2008
- 2008-11-24 AU AU2008249173A patent/AU2008249173A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2008249173A1 (en) | 2008-12-11 |
KR20070043795A (ko) | 2007-04-25 |
US20090285779A1 (en) | 2009-11-19 |
NO20070945L (no) | 2007-02-19 |
MX2007000770A (es) | 2007-03-26 |
CN101018567B (zh) | 2011-07-27 |
AU2005269733B2 (en) | 2008-10-30 |
CA2574176A1 (en) | 2006-02-09 |
EP1768699A1 (de) | 2007-04-04 |
RU2007105987A (ru) | 2008-08-27 |
AU2005269733A1 (en) | 2006-02-09 |
JP2008507530A (ja) | 2008-03-13 |
WO2006014653A1 (en) | 2006-02-09 |
RU2401661C2 (ru) | 2010-10-20 |
US20060147456A1 (en) | 2006-07-06 |
CN101018567A (zh) | 2007-08-15 |
RU2401661C9 (ru) | 2011-01-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |