MX336675B - Cribado para compuestos anticancerigenos utilizando actividad de netrina-1. - Google Patents
Cribado para compuestos anticancerigenos utilizando actividad de netrina-1.Info
- Publication number
- MX336675B MX336675B MX2008011067A MX2008011067A MX336675B MX 336675 B MX336675 B MX 336675B MX 2008011067 A MX2008011067 A MX 2008011067A MX 2008011067 A MX2008011067 A MX 2008011067A MX 336675 B MX336675 B MX 336675B
- Authority
- MX
- Mexico
- Prior art keywords
- netrin
- cancer
- screening
- activity
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/18—Testing for antimicrobial activity of a material
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/475—Assays involving growth factors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
La presente invención se refiere a un método in vitro para el cribado de compuestos anticancerígenos en base en la capacidad de estos compuestos de interactuar con el receptor de netrina-1 y/o para inhibir la dimerización del dominio intracelular del receptor de netrina-1 expresado en células tumorales; la invención también se relaciona con un método para predecir la presencia de cáncer metastásico o agresivo o para determinar la eficiencia de un tratamiento anticanceroso en base en la medición del nivel de expresión de netrina-1; la invención comprende adicionalmente equipos y compuestos como un medicamento para el tratamiento de cáncer tal como cáncer de mama metastásico, relacionado con la sobreexpresión de netrina-1 por las células tumorales.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US77692606P | 2006-02-28 | 2006-02-28 | |
PCT/EP2007/051920 WO2007099133A1 (en) | 2006-02-28 | 2007-02-28 | Screening for anti-cancer compounds using netrin-1 activity |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2008011067A MX2008011067A (es) | 2008-11-25 |
MX336675B true MX336675B (es) | 2016-01-27 |
Family
ID=38051332
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2008011067A MX336675B (es) | 2006-02-28 | 2007-02-28 | Cribado para compuestos anticancerigenos utilizando actividad de netrina-1. |
Country Status (21)
Country | Link |
---|---|
US (3) | US20090226458A1 (es) |
EP (1) | EP1989546B1 (es) |
JP (1) | JP5602368B2 (es) |
KR (2) | KR101587932B1 (es) |
CN (1) | CN101389958B (es) |
AU (1) | AU2007220515B2 (es) |
BR (1) | BRPI0707040B8 (es) |
CA (1) | CA2638974C (es) |
CY (1) | CY1118325T1 (es) |
DK (1) | DK1989546T3 (es) |
ES (1) | ES2601352T3 (es) |
HU (1) | HUE030738T2 (es) |
IL (1) | IL193580A (es) |
LT (1) | LT1989546T (es) |
MX (1) | MX336675B (es) |
PL (1) | PL1989546T3 (es) |
PT (1) | PT1989546T (es) |
SG (1) | SG172645A1 (es) |
SI (1) | SI1989546T1 (es) |
WO (1) | WO2007099133A1 (es) |
ZA (1) | ZA200806913B (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009141440A1 (en) * | 2008-05-21 | 2009-11-26 | Centre National De La Recherche Scientifique (Cnrs) | Netrin-1 overexpression as a biological marker and a survival factor for aggressive neuroblastoma |
US20110229485A1 (en) * | 2008-05-21 | 2011-09-22 | Centre National De La Recherche Scientfique (Cnrs) | Inhibition of the nt-3:trkc bound and its application to the treatment of cancer such as neuroblastoma |
EP2208738A1 (en) * | 2009-01-09 | 2010-07-21 | Centre National pour la Recherche Scientifique (CNRS) | Method for the selection of endothelial cells death inducers via netrin-1 and its applications |
WO2010090834A2 (en) * | 2009-01-20 | 2010-08-12 | The Penn State Research Foundation | Netrin-1 as a biomarker of injury and disease |
EP2267153A1 (en) * | 2009-05-26 | 2010-12-29 | Université Claude Bernard Lyon 1 | Identification of netrin-1 receptor unc5c gene mutation in solid cancers |
US9050298B2 (en) | 2010-05-28 | 2015-06-09 | The Regents Of The University Of California | Method of treating ischemia/reperfusion injuries to a heart with netrin-1 |
KR20140004632A (ko) | 2010-08-26 | 2014-01-13 | 에프. 호프만-라 로슈 아게 | DCC의 제 5 피브로넥틴 유형 III 도메인의 재조합 Fc-융합 단백질 |
JP2015504510A (ja) * | 2011-11-04 | 2015-02-12 | インヴィヴィス,エスエーエス | 抗エストロゲン剤の効果予測バイオマーカーのアッセイ |
EP2708241A1 (en) | 2012-09-12 | 2014-03-19 | Netris Pharma | Recombinant Fc-fusion protein of the two Immunoglobulin domains of UNC5 |
EP2708231A1 (en) | 2012-09-12 | 2014-03-19 | Netris Pharma | Combined treatment with netrin-1 interfering drug and chemotherapeutic drug |
EP2893939A1 (en) * | 2014-01-10 | 2015-07-15 | Netris Pharma | Anti-netrin-1 antibody |
CN105031611B (zh) * | 2015-06-18 | 2018-02-09 | 中国医学科学院基础医学研究所 | netrin‑1蛋白在制备用于肿瘤治疗的药物中的用途 |
TW201720459A (zh) | 2015-11-02 | 2017-06-16 | 妮翠斯製藥公司 | Ntn1中和劑與抑制後生控制之藥物之組合治療 |
US10379534B2 (en) * | 2016-01-28 | 2019-08-13 | Qualcomm Incorporated | Drone flight control |
CN107011444B (zh) * | 2016-01-28 | 2021-11-16 | 中国科学院脑科学与智能技术卓越创新中心 | 一种筛选hERG钾离子通道激动剂和毒性检测方法 |
CN105925578A (zh) * | 2016-05-30 | 2016-09-07 | 东北师范大学 | 靶向沉默Neogenin的shRNA |
JP7211952B2 (ja) | 2017-01-05 | 2023-01-24 | ネトリス ファーマ | ネトリン-1干渉薬及び免疫チェックポイント阻害薬による併用治療 |
US20230204565A1 (en) * | 2020-01-02 | 2023-06-29 | The Regents Of The University Of California | Methods for Culturing Cancer Cells and for Inhibiting Invasion of Cancer |
CN112812167B (zh) * | 2021-01-06 | 2023-04-11 | 东北师范大学 | 一种促进细胞存活的Netrin-1模拟肽、Netrin-1截短多肽及其应用 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3611194A1 (de) * | 1986-04-04 | 1987-10-08 | Bayer Ag | Cancerostatisches mittel |
US5565331A (en) | 1993-11-12 | 1996-10-15 | The Regents Of The University Of California | Nucleic acids encoding neural axon outgrowth modulators |
AU704341B2 (en) | 1995-06-30 | 1999-04-22 | Genzyme Corporation | Novel human chromosome 16 genes, compositions, methods of making and using same |
US6030806A (en) | 1995-06-30 | 2000-02-29 | Landes; Gregory M. | Human chromosome 16 genes, compositions, methods of making and using same |
US5824775A (en) | 1996-04-19 | 1998-10-20 | The Regents Of The University Of California | Human netrin-1 |
JPH11335398A (ja) | 1998-05-22 | 1999-12-07 | Hoechst Marion Roussel Kk | 新規な骨誘導活性を有する単量体蛋白質およびそれらからなる軟骨・骨疾患の予防および治療薬 |
US5939271A (en) | 1997-02-19 | 1999-08-17 | The Regents Of The University Of California | Netrin receptor |
US20060025335A1 (en) * | 2004-01-30 | 2006-02-02 | Kinane Thomas B | Netrin compositions and methods of using the same |
AU2005250185A1 (en) * | 2004-06-04 | 2005-12-15 | Laboratoires Serono Sa | Splice variant of UNC5H2 |
WO2006019904A1 (en) * | 2004-07-14 | 2006-02-23 | University Of Utha Research Foundation | Netrin-related compositions and uses |
CA2587921A1 (fr) | 2004-11-22 | 2006-05-26 | Centre National De La Recherche Scientifique | Netrine 4 mutee, ses fragments et leur utilisation comme medicaments |
CA2489780A1 (en) | 2005-01-12 | 2006-07-12 | Inserm | Methods for preventing or treating a condition or a disease associated with angiogenesis |
US20060153840A1 (en) * | 2005-01-12 | 2006-07-13 | Anne Eichmann | Methods for preventing or treating a condition or a disease associated with angiogenesis |
JP4677376B2 (ja) | 2006-07-07 | 2011-04-27 | キヤノン株式会社 | 画像処理装置、画像処理方法、画像処理プログラム及び記憶媒体 |
WO2009141440A1 (en) * | 2008-05-21 | 2009-11-26 | Centre National De La Recherche Scientifique (Cnrs) | Netrin-1 overexpression as a biological marker and a survival factor for aggressive neuroblastoma |
-
2007
- 2007-02-28 DK DK07726556.9T patent/DK1989546T3/en active
- 2007-02-28 JP JP2008556779A patent/JP5602368B2/ja active Active
- 2007-02-28 CN CN200780006936.3A patent/CN101389958B/zh active Active
- 2007-02-28 LT LTEP07726556.9T patent/LT1989546T/lt unknown
- 2007-02-28 BR BRPI0707040A patent/BRPI0707040B8/pt active IP Right Grant
- 2007-02-28 PL PL07726556T patent/PL1989546T3/pl unknown
- 2007-02-28 PT PT77265569T patent/PT1989546T/pt unknown
- 2007-02-28 SI SI200731865A patent/SI1989546T1/sl unknown
- 2007-02-28 CA CA2638974A patent/CA2638974C/en active Active
- 2007-02-28 KR KR1020147029279A patent/KR101587932B1/ko active IP Right Grant
- 2007-02-28 US US12/224,384 patent/US20090226458A1/en not_active Abandoned
- 2007-02-28 EP EP07726556.9A patent/EP1989546B1/en active Active
- 2007-02-28 SG SG2011038783A patent/SG172645A1/en unknown
- 2007-02-28 MX MX2008011067A patent/MX336675B/es unknown
- 2007-02-28 HU HUE07726556A patent/HUE030738T2/en unknown
- 2007-02-28 ES ES07726556.9T patent/ES2601352T3/es active Active
- 2007-02-28 KR KR1020087022051A patent/KR20080113368A/ko not_active Application Discontinuation
- 2007-02-28 WO PCT/EP2007/051920 patent/WO2007099133A1/en active Application Filing
- 2007-02-28 AU AU2007220515A patent/AU2007220515B2/en active Active
-
2008
- 2008-08-12 ZA ZA200806913A patent/ZA200806913B/xx unknown
- 2008-08-20 IL IL193580A patent/IL193580A/en active IP Right Grant
-
2014
- 2014-09-15 US US14/486,124 patent/US20150004159A1/en not_active Abandoned
-
2016
- 2016-10-26 CY CY20161101087T patent/CY1118325T1/el unknown
-
2018
- 2018-06-21 US US16/014,529 patent/US11203641B2/en active Active
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