WO2012093821A3 - 초기유방암의 예후 예측용 유전자 및 이를 이용한 초기유방암의 예후예측 방법 - Google Patents

초기유방암의 예후 예측용 유전자 및 이를 이용한 초기유방암의 예후예측 방법 Download PDF

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Publication number
WO2012093821A3
WO2012093821A3 PCT/KR2012/000021 KR2012000021W WO2012093821A3 WO 2012093821 A3 WO2012093821 A3 WO 2012093821A3 KR 2012000021 W KR2012000021 W KR 2012000021W WO 2012093821 A3 WO2012093821 A3 WO 2012093821A3
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WO
WIPO (PCT)
Prior art keywords
prognosis
predicting
early
breast cancer
stage breast
Prior art date
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PCT/KR2012/000021
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English (en)
French (fr)
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WO2012093821A2 (ko
Inventor
신영기
최윤라
김영덕
오은설
김시은
Original Assignee
주식회사 바이오트라이온
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Application filed by 주식회사 바이오트라이온 filed Critical 주식회사 바이오트라이온
Publication of WO2012093821A2 publication Critical patent/WO2012093821A2/ko
Publication of WO2012093821A3 publication Critical patent/WO2012093821A3/ko
Priority to US13/935,502 priority Critical patent/US20130344482A1/en
Priority to US15/285,194 priority patent/US10428386B2/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57415—Specifically defined cancers of breast
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/723—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor

Abstract

본 발명은 암의 예후(prognosis) 예측을 위한 유전자의 선정방법, 선정된 암의 예후예측용 유전자 및 이를 이용한 유방암 환자의 전이 예측용 키트 및 예측방법에 관한 것이다. 본 발명은 초기 유방암의 유전적 특성을 분석함으로써 환자의 예후를 간단한 방법을 통해 높은 신뢰도로 예측함으로써 불필요한 항암치료를 줄일 수 있는 예후 진단에 유용하게 이용될 수 있다.
PCT/KR2012/000021 2011-01-04 2012-01-02 초기유방암의 예후 예측용 유전자 및 이를 이용한 초기유방암의 예후예측 방법 WO2012093821A2 (ko)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US13/935,502 US20130344482A1 (en) 2011-01-04 2013-07-04 Gene for predicting the prognosis for early-stage breast cancer, and a method for predicting the prognosis for early-stage breast cancer by using the same
US15/285,194 US10428386B2 (en) 2011-01-04 2016-10-04 Gene for predicting the prognosis for early-stage breast cancer, and a method for predicting the prognosis for early-stage breast cancer by using the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020110000521A KR101287600B1 (ko) 2011-01-04 2011-01-04 초기유방암의 예후 예측용 유전자 및 이를 이용한 초기유방암의 예후예측 방법
KR10-2011-0000521 2011-01-04

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US13/935,502 Continuation US20130344482A1 (en) 2011-01-04 2013-07-04 Gene for predicting the prognosis for early-stage breast cancer, and a method for predicting the prognosis for early-stage breast cancer by using the same

Publications (2)

Publication Number Publication Date
WO2012093821A2 WO2012093821A2 (ko) 2012-07-12
WO2012093821A3 true WO2012093821A3 (ko) 2013-01-24

Family

ID=46457820

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2012/000021 WO2012093821A2 (ko) 2011-01-04 2012-01-02 초기유방암의 예후 예측용 유전자 및 이를 이용한 초기유방암의 예후예측 방법

Country Status (3)

Country Link
US (2) US20130344482A1 (ko)
KR (1) KR101287600B1 (ko)
WO (1) WO2012093821A2 (ko)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101672531B1 (ko) * 2013-04-18 2016-11-17 주식회사 젠큐릭스 조기 유방암 예후 예측 진단용 유전자 마커 및 이의 용도
US10655187B2 (en) 2013-04-18 2020-05-19 Gencurix Inc. Genetic marker for early breast cancer prognosis prediction and diagnosis, and use thereof
KR101748867B1 (ko) * 2013-04-19 2017-06-20 주식회사 젠큐릭스 조기 유방암 예후 예측 진단용 자동화 시스템
KR101548830B1 (ko) * 2013-12-30 2015-08-31 가천대학교 산학협력단 줄기세포 배양방법을 이용하여 발굴된 유방암 줄기세포 마커를 이용한 유방암 예후 예측용 조성물
AU2015230677A1 (en) * 2014-03-11 2016-10-27 The Council Of The Queensland Institute Of Medical Research Determining cancer agressiveness, prognosis and responsiveness to treatment
US20170298443A1 (en) * 2014-09-25 2017-10-19 Moffitt Genetics Corporation Prognostic tumor biomarkers
KR101896558B1 (ko) * 2016-11-21 2018-09-07 주식회사 젠큐릭스 유방암 환자의 예후 예측 방법
KR101950717B1 (ko) 2016-11-23 2019-02-21 주식회사 젠큐릭스 유방암 환자의 화학치료 유용성 예측 방법
KR101896545B1 (ko) 2016-11-25 2018-09-07 주식회사 젠큐릭스 유방암 환자의 예후 예측 방법
KR102071491B1 (ko) 2017-11-10 2020-01-30 주식회사 디시젠 차세대 염기서열분석을 이용한 기계학습 기반 유방암 예후 예측 방법 및 예측 시스템
CN109841280B (zh) * 2017-11-29 2023-07-21 郑州大学第一附属医院 食管癌相关特征通路的识别及早期预测模型的构建方法
KR102234904B1 (ko) * 2018-11-30 2021-04-01 주식회사 쓰리빌리언 신규 표적 단백질과 그에 대한 동반진단 바이오마커 발굴 시스템 및 방법
KR102188118B1 (ko) * 2019-04-15 2020-12-07 인천대학교 산학협력단 암에 따른 유전자 간의 상관관계에 기초하여 유전자 분산 표현을 위한 유전자 특징 벡터를 생성하는 전자 장치 및 그 동작 방법
CN110257515B (zh) * 2019-06-14 2023-03-31 清华-伯克利深圳学院筹备办公室 一种用于乳腺癌诊断的分子标志物及其应用
CN112168968A (zh) * 2020-09-25 2021-01-05 中山大学附属第八医院（深圳福田） Fto抑制剂在制备防治乳腺癌产品中的应用
CN114203255B (zh) * 2022-02-17 2022-06-14 北京泽桥医疗科技股份有限公司 一种基于机器学习的中药抗癌关键靶标预测方法
CN116312802B (zh) * 2023-02-01 2023-11-28 中国医学科学院肿瘤医院 一种特征基因trim22用于制备调控乳腺癌相关基因表达的试剂的应用

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KR20030078805A (ko) * 2002-03-29 2003-10-08 오르토-클리니칼 다이아그노스틱스, 인코포레이티드 유방암 예후 포트폴리오
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WO2004065545A2 (en) * 2003-01-15 2004-08-05 Rosetta Inpharmatics Llc. Diagnosis and prognosis of breast cancer patients
WO2005033699A2 (en) * 2003-10-03 2005-04-14 Ncc Technology Ventures Pte Limited Materials and methods relating to breast cancer classification
US20090239214A1 (en) * 2004-07-30 2009-09-24 Hongyue Dai Prognosis of breast cancer patients

Also Published As

Publication number Publication date
WO2012093821A2 (ko) 2012-07-12
US20190017121A9 (en) 2019-01-17
US10428386B2 (en) 2019-10-01
US20170159126A1 (en) 2017-06-08
KR101287600B1 (ko) 2013-07-18
US20130344482A1 (en) 2013-12-26
KR20120079295A (ko) 2012-07-12

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