NO20062134L - Fremgangsmater for syntetisering av heteromultimere polypeptider i gjaer ved anvendelse av haploid parrings strategi - Google Patents

Fremgangsmater for syntetisering av heteromultimere polypeptider i gjaer ved anvendelse av haploid parrings strategi

Info

Publication number
NO20062134L
NO20062134L NO20062134A NO20062134A NO20062134L NO 20062134 L NO20062134 L NO 20062134L NO 20062134 A NO20062134 A NO 20062134A NO 20062134 A NO20062134 A NO 20062134A NO 20062134 L NO20062134 L NO 20062134L
Authority
NO
Norway
Prior art keywords
methods
yeast
hapioid
transformed
synthesizing
Prior art date
Application number
NO20062134A
Other languages
English (en)
Norwegian (no)
Inventor
John Latham
Randall Schatzman
Ilya I Tolstorukov
Mark Litton
James Cregg
Original Assignee
Alder Biopharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alder Biopharmaceuticals Inc filed Critical Alder Biopharmaceuticals Inc
Publication of NO20062134L publication Critical patent/NO20062134L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
NO20062134A 2003-10-22 2006-05-12 Fremgangsmater for syntetisering av heteromultimere polypeptider i gjaer ved anvendelse av haploid parrings strategi NO20062134L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51387603P 2003-10-22 2003-10-22
PCT/US2004/035302 WO2005040395A1 (en) 2003-10-22 2004-10-22 Methods of synthesizing heteromultimeric polypeptides in yeast using a haploid mating strategy

Publications (1)

Publication Number Publication Date
NO20062134L true NO20062134L (no) 2006-06-26

Family

ID=34520146

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20062134A NO20062134L (no) 2003-10-22 2006-05-12 Fremgangsmater for syntetisering av heteromultimere polypeptider i gjaer ved anvendelse av haploid parrings strategi

Country Status (17)

Country Link
US (7) US8268582B2 (pt)
EP (2) EP2330201B1 (pt)
JP (3) JP4994038B2 (pt)
CN (2) CN1871359B (pt)
AU (2) AU2004283299B2 (pt)
CA (1) CA2541651C (pt)
DK (2) DK1678314T3 (pt)
ES (2) ES2630224T3 (pt)
HK (1) HK1093222A1 (pt)
HU (1) HUE033349T2 (pt)
IL (2) IL174783A (pt)
NO (1) NO20062134L (pt)
NZ (1) NZ547279A (pt)
PL (1) PL1678314T3 (pt)
PT (1) PT1678314E (pt)
SI (1) SI1678314T1 (pt)
WO (1) WO2005040395A1 (pt)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9139825B2 (en) 2009-10-30 2015-09-22 Novartis Ag Universal fibronectin type III bottom-side binding domain libraries

Families Citing this family (158)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG165322A1 (en) 2005-08-31 2010-10-28 Schering Corp Engineered anti-il-23 antibodies
DK2021463T3 (en) * 2006-05-19 2017-01-16 Alder Biopharmaceuticals Inc Culture method to obtain a cloned population of antigen-specific B cells
KR100778219B1 (ko) 2006-08-28 2007-11-29 한국생명공학연구원 교배형 특이적 유전자에 의해 조절되는 반수체 제조용형질전환 효모 균주의 제조
US7795411B2 (en) 2006-10-05 2010-09-14 Fred Hutchinson Cancer Research Center Vectors for expressing in vivo biotinylated recombinant proteins
AU2007334499B2 (en) 2006-12-14 2014-04-24 Merck Sharp & Dohme Corp. Engineered anti-TSLP antibody
US20110076752A1 (en) * 2007-02-09 2011-03-31 Medimmune, Llc Antibody library display by yeast cell plasma membrane
EP2426145B1 (en) 2007-02-23 2017-01-18 Merck Sharp & Dohme Corp. Engineered anti-il-23p19 antibodies
NZ579158A (en) 2007-02-23 2012-01-12 Schering Corp Engineered anti-il-23p19 antibodies
CA2679381A1 (en) 2007-02-28 2008-09-04 Schering Corporation Engineered anti-il-23r antibodies
EP2162469A4 (en) * 2007-05-21 2012-08-01 Alderbio Holdings Llc NEW METHODS OF HUMANIZING RABBIT ANTIBODIES AND HUMANIZED RABBIT ANTIBODIES
US9056905B2 (en) * 2007-05-21 2015-06-16 Alderbio Holdings Llc Antibodies to TNF-α and use thereof
US8062864B2 (en) 2007-05-21 2011-11-22 Alderbio Holdings Llc Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies
US7906117B2 (en) * 2007-05-21 2011-03-15 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever
TWI561530B (en) 2007-05-21 2016-12-11 Alderbio Holdings Llc Antibodies to il-6 and use thereof
US9701747B2 (en) 2007-05-21 2017-07-11 Alderbio Holdings Llc Method of improving patient survivability and quality of life by anti-IL-6 antibody administration
US8252286B2 (en) * 2007-05-21 2012-08-28 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat thrombosis
US8178101B2 (en) 2007-05-21 2012-05-15 Alderbio Holdings Inc. Use of anti-IL-6 antibodies having specific binding properties to treat cachexia
US8404235B2 (en) 2007-05-21 2013-03-26 Alderbio Holdings Llc Antagonists of IL-6 to raise albumin and/or lower CRP
US8323649B2 (en) 2008-11-25 2012-12-04 Alderbio Holdings Llc Antibodies to IL-6 and use thereof
CA2744400C (en) 2008-11-25 2019-01-15 Alder Biopharmaceuticals, Inc. Antibodies to il-6 and use thereof
US8337847B2 (en) 2008-11-25 2012-12-25 Alderbio Holdings Llc Methods of treating anemia using anti-IL-6 antibodies
US8420089B2 (en) 2008-11-25 2013-04-16 Alderbio Holdings Llc Antagonists of IL-6 to raise albumin and/or lower CRP
US9452227B2 (en) * 2008-11-25 2016-09-27 Alderbio Holdings Llc Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments
US8992920B2 (en) 2008-11-25 2015-03-31 Alderbio Holdings Llc Anti-IL-6 antibodies for the treatment of arthritis
US9212223B2 (en) 2008-11-25 2015-12-15 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat thrombosis
PL3023438T3 (pl) 2009-09-03 2020-07-27 Merck Sharp & Dohme Corp. Przeciwciała anty-gitr
AU2010315304B2 (en) 2009-11-04 2014-03-27 Merck Sharp & Dohme Llc Engineered anti-TSLP antibody
US9775921B2 (en) 2009-11-24 2017-10-03 Alderbio Holdings Llc Subcutaneously administrable composition containing anti-IL-6 antibody
WO2011066378A2 (en) 2009-11-24 2011-06-03 Alder Biopharmaceuticals, Inc. Antagonists of il-6 to prevent or treat thrombosis
GB201003701D0 (en) * 2010-03-05 2010-04-21 Cilian Ag System for the expression of a protein
TWI542361B (zh) 2010-05-04 2016-07-21 戊瑞治療有限公司 與集落刺激因子1受體(csf1r)結合之抗體類
CA2818814A1 (en) 2010-11-23 2012-05-31 Alder Biopharmaceuticals, Inc. Anti-il-6 antibodies for the treatment of anemia
WO2012075340A2 (en) 2010-12-01 2012-06-07 Alderbio Holdings Llc Anti-ngf compositions and use thereof
US11214610B2 (en) 2010-12-01 2022-01-04 H. Lundbeck A/S High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris
AU2012205384B2 (en) 2011-01-14 2015-09-10 Five Prime Therapeutics, Inc. IL-27 antagonists for treating inflammatory diseases
EP3875115A1 (en) * 2011-05-20 2021-09-08 H. Lundbeck A/S Anti-cgrp compositions and use thereof
JP6189832B2 (ja) 2011-05-20 2017-08-30 アルダーバイオ・ホールディングズ・エルエルシー 慢性および急性の下痢を治療または予防するための抗cgrp若しくは抗cgrp−rの抗体または抗体断片の使用
KR101981662B1 (ko) * 2011-05-20 2019-05-23 앨더바이오 홀딩스 엘엘씨 형질전환된 미생물 예컨대 피치아 패스토리스에서 다중-서브유닛 단백질 예컨대 항체의 고순도 생산
JP6374789B2 (ja) 2011-05-20 2018-08-15 アルダーバイオ・ホールディングズ・エルエルシー 羞明または光嫌悪症を予防または抑制する抗cgrp抗体および抗体断片のそれを必要とする対象、特に片頭痛患者における使用
EP2744903B1 (en) * 2011-08-19 2018-10-10 AlderBio Holdings LLC Multi-copy strategy for high-titer and high-purity production of multi-subunit proteins such as a antibodies in transformed microbes such as pichia pastoris
US10150968B2 (en) 2011-08-19 2018-12-11 Alderbio Holdings Llc Multi-copy strategy for high-titer and high-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris
RU2670743C9 (ru) 2012-05-11 2018-12-19 Файв Прайм Терапьютикс, Инк. Способы лечения состояний антителами, которые связывают рецептор колониестимулирующего фактора 1 (csf1r)
US9803010B2 (en) 2012-06-27 2017-10-31 Merck Sharp & Dohme Corp. Crystalline anti-human IL-23p19 antibodies
CN104684582A (zh) 2012-08-31 2015-06-03 戊瑞治疗有限公司 用结合群落刺激因子1受体(csf1r)的抗体治疗病状的方法
CN103911371B (zh) * 2013-01-05 2016-05-04 中国科学院微生物研究所 一种酿酒酵母整合型表达载体
US20150366890A1 (en) 2013-02-25 2015-12-24 Trustees Of Boston University Compositions and methods for treating fungal infections
US10202630B2 (en) 2013-03-15 2019-02-12 Alderbio Holdings Llc Temperature shift for high yield expression of polypeptides in yeast and other transformed cells
US10138294B2 (en) 2013-03-15 2018-11-27 Alderbio Holdings Llc Temperature shift for high yield expression of polypeptides in yeast and other transformed cells
WO2014145744A1 (en) 2013-03-15 2014-09-18 Alder Biopharmaceuticals, Inc. Antibody purification and purity monitoring
JP6502337B2 (ja) 2013-07-03 2019-04-17 アルダー・バイオファーマシューティカルズ・インコーポレーテッド 抗cgrp抗体を使用したグルコース代謝の調整
US20170114122A1 (en) 2015-10-23 2017-04-27 Alderbio Holdings Llc Regulation of glucose metabolism using anti-cgrp antibodies
EP3016683B1 (en) 2013-07-05 2020-06-24 University of Washington through its Center for Commercialization Soluble mic neutralizing monoclonal antibody for treating cancer
US20150050273A1 (en) 2013-08-01 2015-02-19 Five Prime Therapeutics, Inc. Afucosylated anti-fgfr2iiib antibodies
CN103468595B (zh) * 2013-09-24 2016-01-13 浙江海正药业股份有限公司 表达重组人血白蛋白的酵母菌、其构建方法及应用和表达重组人血白蛋白的方法
CN103710278A (zh) * 2013-12-25 2014-04-09 江南大学 一种低产尿素的工业黄酒酵母代谢工程菌及其构建方法
EP3116957B1 (en) 2014-03-11 2019-06-12 The Chemours Company FC, LLC Tailored dispersion and formation of integrated particle systems via ph responsive groups
AU2015280362B2 (en) 2014-06-23 2021-03-04 Five Prime Therapeutics, Inc. Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (CSF1R)
TWI805109B (zh) 2014-08-28 2023-06-11 美商奇諾治療有限公司 對cd19具專一性之抗體及嵌合抗原受體
CA2963147A1 (en) 2014-10-29 2016-05-06 Five Prime Therapeutics, Inc. Combination therapy for cancer
WO2016070001A1 (en) 2014-10-31 2016-05-06 Jounce Therapeutics, Inc. Methods of treating conditions with antibodies that bind b7-h4
WO2016100838A2 (en) 2014-12-19 2016-06-23 Alder Biopharmaceuticals, Inc. Humanized anti-acth antibodies and use thereof
SG11201704792UA (en) 2014-12-22 2017-07-28 Five Prime Therapeutics Inc Anti-csf1r antibodies for treating pvns
WO2016111947A2 (en) 2015-01-05 2016-07-14 Jounce Therapeutics, Inc. Antibodies that inhibit tim-3:lilrb2 interactions and uses thereof
CN107428833B (zh) 2015-01-16 2021-11-02 朱诺治疗学股份有限公司 Ror1特异性抗体和嵌合抗原受体
SG11201707769VA (en) 2015-03-23 2017-10-30 Jounce Therapeutics Inc Antibodies to icos
DK3283527T3 (da) 2015-04-13 2021-03-08 Five Prime Therapeutics Inc Kombinationsterapi mod cancer
WO2016179194A1 (en) 2015-05-04 2016-11-10 Jounce Therapeutics, Inc. Lilra3 and method of using the same
WO2017019777A1 (en) * 2015-07-27 2017-02-02 Washington University Toolkit for the production of post-translationally modified proteins
US10865394B2 (en) 2015-07-27 2020-12-15 Washington University Toolkit for the production of post-translationally modified proteins
EP3365372A1 (en) 2015-10-22 2018-08-29 Jounce Therapeutics, Inc. Gene signatures for determining icos expression
TW202304515A (zh) 2015-11-23 2023-02-01 美商戊瑞治療有限公司 用於癌症治療之單獨fgfr2抑制劑或與免疫刺激劑組合
WO2017181039A1 (en) 2016-04-15 2017-10-19 Alder Biopharmaceuticals, Inc. Humanized anti-pacap antibodies and uses thereof
CN110088133B (zh) 2016-07-29 2023-12-08 朱诺治疗学股份有限公司 抗独特型抗体及相关方法
AU2017355401A1 (en) 2016-11-02 2019-05-02 Jounce Therapeutics, Inc. Antibodies to PD-1 and uses thereof
MX2019007848A (es) 2017-01-20 2019-09-09 Tayu Huaxia Biotech Medical Group Co Ltd Anticuerpos anti-pd-1 y usos de los mismos.
WO2018187191A1 (en) 2017-04-03 2018-10-11 Jounce Therapeutics, Inc Compositions and methods for the treatment of cancer
SG10202112636SA (en) 2017-05-16 2021-12-30 Five Prime Therapeutics Inc Anti-fgfr2 antibodies in combination with chemotherapy agents in cancer treatment
WO2019000223A1 (en) 2017-06-27 2019-01-03 Nanjing Legend Biotech Co., Ltd. ENABLERS OF IMMUNE EFFECTOR CELLS OF CHIMERIC ANTIBODIES AND METHODS OF USE THEREOF
EP3703750A1 (en) 2017-11-01 2020-09-09 Juno Therapeutics, Inc. Chimeric antigen receptors specific for b-cell maturation antigen and encoding polynucleotides
AU2018358067A1 (en) 2017-11-01 2020-05-07 Juno Therapeutics, Inc. Antibodies and chimeric antigen receptors specific for B-cell maturation antigen
MX2020005662A (es) 2017-12-01 2020-08-20 Pfizer Anticuerpos anti-cxcr5 y composiciones y usos de los mismos.
JP2021506260A (ja) 2017-12-15 2021-02-22 ジュノー セラピューティクス インコーポレイテッド 抗cct5結合分子およびその使用方法
MX2020006668A (es) 2017-12-22 2020-10-07 Jounce Therapeutics Inc Anticuerpos para lilrb2.
WO2019190984A1 (en) 2018-03-29 2019-10-03 Pfizer Inc. Lfa3 variants and compositions and uses thereof
MX2020012613A (es) 2018-06-01 2021-04-13 Tayu Huaxia Biotech Medical Group Co Ltd Composiciones y usos de las mismas para el tratamiento de enfermedades o afecciones.
TW202428604A (zh) 2018-07-09 2024-07-16 美商戊瑞治療有限公司 結合至ilt4的抗體
CN112601761A (zh) 2018-08-13 2021-04-02 印希比股份有限公司 结合ox40的多肽及其用途
PE20211605A1 (es) 2018-09-07 2021-08-23 Pfizer ANTICUERPOS ANTI-avß8 Y COMPOSICIONES Y USOS DE LOS MISMOS
EP3850011A4 (en) 2018-09-10 2022-10-19 Nanjing Legend Biotech Co., Ltd. SINGLE DOMAIN ANTIBODIES AGAINST CD33 AND USES THEREOF
JP2022512684A (ja) 2018-10-11 2022-02-07 インヒブルクス インコーポレイテッド B7h3シングルドメイン抗体およびその治療用組成物
AU2019356573A1 (en) 2018-10-11 2021-05-27 Inhibrx Biosciences, Inc. PD-1 single domain antibodies and therapeutic compositions thereof
CN113518647A (zh) 2018-10-11 2021-10-19 印希比股份有限公司 5t4单域抗体及其治疗性组合物
EP3864045A2 (en) 2018-10-11 2021-08-18 Inhibrx, Inc. Dll3 single domain antibodies and therapeutic compositions thereof
MX2021005024A (es) 2018-11-01 2021-07-21 Juno Therapeutics Inc Metodos de tratamiento que utilizan receptores de antigenos quimericos especificos para antigeno de maduracion de celulas b.
TW202021981A (zh) 2018-11-01 2020-06-16 美商奇諾治療有限公司 G蛋白偶合受體c類第5群成員d(gprc5d)特異性嵌合抗原受體
CN113924311A (zh) 2019-01-07 2022-01-11 印希比股份有限公司 包含修饰的il-2多肽的多肽及其用途
CR20210373A (es) 2019-01-08 2021-08-19 H Lundbeck As Tratamiento agudo y tratamiento rápido de la cefalea usando anticuerpos anti-cgrp
US20220096651A1 (en) 2019-01-29 2022-03-31 Juno Therapeutics, Inc. Antibodies and chimeric antigen receptors specific for receptor tyrosine kinase like orphan receptor 1 (ror1)
EP3938396A1 (en) 2019-03-11 2022-01-19 Jounce Therapeutics, Inc. Anti-icos antibodies for the treatment of cancer
BR112021020999A2 (pt) 2019-05-04 2021-12-14 Inhibrx Inc Polipeptídeos de ligação à clec12a e usos dos mesmos
MX2021013416A (es) 2019-05-04 2021-12-10 Inhibrx Inc Polipeptidos de union al antigeno cd33 y sus usos.
EP3966242A1 (en) 2019-05-04 2022-03-16 Inhibrx, Inc. Cd123-binding polypeptides and uses thereof
US20220378909A1 (en) 2019-11-05 2022-12-01 Jounce Therapeutics, Inc. Methods of Treating Cancer with Anti-PD-1 Antibodies
JP2023504736A (ja) 2019-12-06 2023-02-06 ジュノー セラピューティクス インコーポレイテッド Gprc5d標的結合ドメインに対する抗イディオタイプ抗体ならびに関連する組成物および方法
KR20220122653A (ko) 2019-12-06 2022-09-02 주노 쎄러퓨티크스 인코퍼레이티드 Bcma-표적 결합 도메인에 대한 항-이디오타입 항체 및 관련 조성물 및 방법
WO2021141907A1 (en) 2020-01-06 2021-07-15 Hifibio (Hong Kong) Limited Anti-tnfr2 antibody and uses thereof
IL294466A (en) 2020-01-07 2022-09-01 Hifibio Hk Ltd Anti-galectin-9 antibody and uses thereof
EP4097129A1 (en) 2020-01-29 2022-12-07 Inhibrx, Inc. Cd28 single domain antibodies and multivalent and multispecific constructs thereof
CR20220396A (es) 2020-02-14 2022-11-14 Jounce Therapeutics Inc Anticuerpos y proteínas de fusión que se unen a ccr8 y usos de estos
CA3169910A1 (en) 2020-02-28 2021-09-02 Shanghai Henlius Biotech, Inc. Anti-cd137 constructs, multispecific antibody and uses thereof
AU2021225920A1 (en) 2020-02-28 2022-09-15 Shanghai Henlius Biotech, Inc. Anti-CD137 construct and use thereof
CN115916223A (zh) 2020-04-10 2023-04-04 朱诺治疗学股份有限公司 与用靶向b细胞成熟抗原的嵌合抗原受体工程化的细胞疗法相关的方法和用途
EP4139358A1 (en) 2020-04-20 2023-03-01 Jounce Therapeutics, Inc. Compositions and methods for vaccination and the treatment of infectious diseases
CA3177921A1 (en) 2020-05-04 2021-11-11 Inhibrx, Inc. Canine pd-1-binding polypeptides and uses thereof
CN116529260A (zh) 2020-06-02 2023-08-01 当康生物技术有限责任公司 抗cd93构建体及其用途
TW202210515A (zh) 2020-06-02 2022-03-16 美商當康生物科技有限公司 抗cd39之構築體及其用途
EP4175979A2 (en) 2020-07-02 2023-05-10 Inhibrx, Inc. Polypeptides comprising modified il-2 polypeptides and uses thereof
JP2023532852A (ja) 2020-07-07 2023-08-01 キャンキュア, エルエルシー Mic抗体及び結合剤ならびにそれらの使用方法
TW202221029A (zh) 2020-07-29 2022-06-01 美商當康生物科技有限公司 抗cd93之構築體及其用途
US20230324408A1 (en) 2020-08-05 2023-10-12 Juno Therapeutics, Inc. Anti-idiotypic antibodies to ror1-targeted binding domains and related compositions and methods
IL300537A (en) 2020-08-10 2023-04-01 Gv20 Therapeutics Llc Compositions and methods for treating autoimmune diseases and cancer by targeting IGSF8
CN111944708B (zh) * 2020-08-27 2022-04-01 宜宾五粮液股份有限公司 高产乙酸异戊酯的酵母及其应用
WO2022109084A1 (en) * 2020-11-23 2022-05-27 Merck Sharp & Dohme Corp. Full-length human immunoglobulin g antibody libraries for surface display and secretion in saccharomyces cerevisiae
US11720540B2 (en) 2020-12-30 2023-08-08 Itron, Inc. Secure blockchain data recovery
AU2022218137A1 (en) 2021-02-03 2023-08-24 Mozart Therapeutics, Inc. Binding agents and methods of using the same
KR20230147662A (ko) 2021-02-19 2023-10-23 인히브릭스, 인크. Dr5 결합 폴리펩타이드의 제제
WO2022187863A1 (en) 2021-03-05 2022-09-09 Dynamicure Biotechnology Llc Anti-vista constructs and uses thereof
WO2022204724A1 (en) 2021-03-25 2022-09-29 Dynamicure Biotechnology Llc Anti-igfbp7 constructs and uses thereof
AU2022253902A1 (en) 2021-04-10 2023-11-02 Profoundbio Us Co. Folr1 binding agents, conjugates thereof and methods of using the same
AU2022262644A1 (en) 2021-04-23 2023-11-09 Profoundbio Us Co. Anti-cd70 antibodies, conjugates thereof and methods of using the same
EP4337689A1 (en) 2021-05-12 2024-03-20 Applied Biomedical Science Institute Binding polypeptides against sars cov-2 and uses thereof
EP4355785A1 (en) 2021-06-17 2024-04-24 Amberstone Biosciences, Inc. Anti-cd3 constructs and uses thereof
TW202320857A (zh) 2021-07-06 2023-06-01 美商普方生物製藥美國公司 連接子、藥物連接子及其結合物及其使用方法
CA3225141A1 (en) 2021-07-13 2023-01-19 Keystone Bio, Inc. Diagnostics for porphyromonas gingivalis
CA3225092A1 (en) 2021-07-20 2023-01-26 John C. Timmer Cd8-binding polypeptides and uses thereof
TW202309102A (zh) 2021-07-20 2023-03-01 美商英伊布里克斯公司 靶向cd8之經修飾il-2多肽及其用途
WO2023076876A1 (en) 2021-10-26 2023-05-04 Mozart Therapeutics, Inc. Modulation of immune responses to viral vectors
WO2023092099A1 (en) 2021-11-19 2023-05-25 Ardeagen Corporation Gpc3 binding agents, conjugates thereof and methods of using the same
WO2023133394A1 (en) 2022-01-05 2023-07-13 Inhibrx, Inc. Gamma delta t-cell-binding polypeptides and uses thereof
WO2023133393A1 (en) 2022-01-05 2023-07-13 Inhibrx, Inc. Gamma delta t-cell-targeted modified il-2 polypeptides and uses thereof
TW202342520A (zh) 2022-02-18 2023-11-01 美商樂天醫藥生技股份有限公司 抗計畫性死亡配體1(pd—l1)抗體分子、編碼多核苷酸及使用方法
TW202404636A (zh) 2022-04-08 2024-02-01 美商英伊布里克斯公司 Dr5促效劑及plk1抑制劑或cdk抑制劑之組合療法
WO2023215810A1 (en) 2022-05-05 2023-11-09 Inhibrx, Inc. Albumin-binding polypeptides and uses thereof
TW202410919A (zh) 2022-05-23 2024-03-16 美商英伊布里克斯公司 Dr5促效劑與iap拮抗劑之組合療法
WO2023230488A1 (en) 2022-05-23 2023-11-30 Cereius, Inc. Her2-binding agents and uses thereof
WO2023235699A1 (en) 2022-05-31 2023-12-07 Jounce Therapeutics, Inc. Antibodies to lilrb4 and uses thereof
TW202409086A (zh) 2022-06-11 2024-03-01 美商英伊布里克斯公司 FcRn-結合多肽及其用途
WO2024006975A1 (en) 2022-07-01 2024-01-04 Bristol-Myers Squibb Company Methods for antibody humanization
WO2024015993A1 (en) 2022-07-15 2024-01-18 Fibrogen, Inc. Modified anti-galectin-9 antibody and uses thereof
WO2024020579A1 (en) 2022-07-22 2024-01-25 Bristol-Myers Squibb Company Antibodies binding to human pad4 and uses thereof
WO2024030956A2 (en) 2022-08-03 2024-02-08 Mozart Therapeutics, Inc. Cd39-specific binding agents and methods of using the same
US20240041929A1 (en) 2022-08-05 2024-02-08 Juno Therapeutics, Inc. Chimeric antigen receptors specific for gprc5d and bcma
WO2024040216A2 (en) 2022-08-19 2024-02-22 Fibrogen, Inc. Anti-ccr8 antibodies and uses thereof
WO2024044779A2 (en) 2022-08-26 2024-02-29 Juno Therapeutics, Inc. Antibodies and chimeric antigen receptors specific for delta-like ligand 3 (dll3)
WO2024054929A1 (en) 2022-09-07 2024-03-14 Dynamicure Biotechnology Llc Anti-vista constructs and uses thereof
WO2024102948A1 (en) 2022-11-11 2024-05-16 Celgene Corporation Fc receptor-homolog 5 (fcrh5) specific binding molecules and bispecific t-cell engaging antibodies including same and related methods
WO2024129778A2 (en) 2022-12-13 2024-06-20 Juno Therapeutics, Inc. Chimeric antigen receptors specific for baff-r and cd19 and methods and uses thereof
WO2024216064A1 (en) 2023-04-14 2024-10-17 Twist Bioscience Corporation Compositions and methods related to dkk1 binders

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4775622A (en) * 1982-03-08 1988-10-04 Genentech, Inc. Expression, processing and secretion of heterologous protein by yeast
US5618920A (en) * 1985-11-01 1997-04-08 Xoma Corporation Modular assembly of antibody genes, antibodies prepared thereby and use
DE3689123T2 (de) * 1985-11-01 1994-03-03 Xoma Corp Modulare einheit von antikörpergenen, daraus hergestellte antikörper und verwendung.
US6306625B1 (en) * 1988-12-30 2001-10-23 Smithkline Beecham Biologicals, Sa Method for obtaining expression of mixed polypeptide particles in yeast
US5545727A (en) * 1989-05-10 1996-08-13 Somatogen, Inc. DNA encoding fused di-alpha globins and production of pseudotetrameric hemoglobin
GB8927480D0 (en) 1989-12-05 1990-02-07 Delta Biotechnology Ltd Mutant fungal strain detection and new promoter
AU6275690A (en) 1989-08-09 1991-03-11 Delta Biotechnology Limited Polypeptide production in fungi
US5202422A (en) 1989-10-27 1993-04-13 The Scripps Research Institute Compositions containing plant-produced glycopolypeptide multimers, multimeric proteins and method of their use
US5959177A (en) 1989-10-27 1999-09-28 The Scripps Research Institute Transgenic plants expressing assembled secretory antibodies
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
CA2105064A1 (en) * 1991-04-01 1992-10-02 Martin Anthony Gleeson Genes which influence pichia proteolytic activity, and uses therefor
US5330901A (en) * 1991-04-26 1994-07-19 Research Corporation Technologies, Inc. Expression of human serum albumin in Pichia pastoris
US5440018A (en) * 1992-05-20 1995-08-08 The Green Cross Corporation Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same
ATE253118T1 (de) 1993-02-10 2003-11-15 Unilever Nv Isolierungsverfahren verwendend immobilisierte proteine mit spezifischen bindungskapazitäten
AU6445894A (en) 1993-03-19 1994-10-11 Duke University Method of treatment of tumors with an antibody binding to tenascin
EP0771208B1 (en) 1994-08-12 2005-10-19 Immunomedics, Inc. Immunoconjugates and humanized antibodies specific for b-cell lymphoma and leukemia cells
GB9526733D0 (en) 1995-12-30 1996-02-28 Delta Biotechnology Ltd Fusion proteins
US6232111B1 (en) * 1996-04-10 2001-05-15 Merck & Co., Inc. Method for improving culture medium for recombinant yeast
WO2000023579A1 (en) 1998-10-22 2000-04-27 The Regents Of The University Of California Functionally assembled antigen-specific intact recombinant antibody and a method for production thereof
US6258559B1 (en) * 1999-03-22 2001-07-10 Zymogenetics, Inc. Method for producing proteins in transformed Pichia
WO2003016525A1 (fr) 2001-08-16 2003-02-27 Kansai Chemical Engineering Co., Ltd. Procede de production d'alcool a partir d'amidon
WO2003018749A2 (en) * 2001-08-22 2003-03-06 Shengfeng Li Compositions and methods for generating antigen-binding units
EP2093286B1 (en) 2001-10-01 2013-02-27 Dyax Corporation Multi-chain eukaryotic display vectors and uses thereof
AU2003263163A1 (en) * 2002-09-20 2004-04-08 Cym1P A/S Methods for increasing the production of a recombinant polypeptide from a host cell

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9139825B2 (en) 2009-10-30 2015-09-22 Novartis Ag Universal fibronectin type III bottom-side binding domain libraries
US10253313B2 (en) 2009-10-30 2019-04-09 Novartis Ag Universal fibronectin type III bottom-side binding domain libraries

Also Published As

Publication number Publication date
US10259883B2 (en) 2019-04-16
US20200031949A1 (en) 2020-01-30
US20060270045A1 (en) 2006-11-30
WO2005040395A1 (en) 2005-05-06
NZ547279A (en) 2008-04-30
US20160068849A1 (en) 2016-03-10
AU2004283299B2 (en) 2009-06-18
EP2330201B1 (en) 2017-04-05
ES2630224T3 (es) 2017-08-18
US8709756B2 (en) 2014-04-29
IL211402A (en) 2015-08-31
PT1678314E (pt) 2012-11-27
JP2007508847A (ja) 2007-04-12
JP2015062433A (ja) 2015-04-09
AU2009213095B2 (en) 2012-01-19
US20130029880A1 (en) 2013-01-31
HUE033349T2 (en) 2017-11-28
EP1678314B1 (en) 2012-09-05
ES2393555T3 (es) 2012-12-26
HK1093222A1 (en) 2007-02-23
CA2541651A1 (en) 2005-05-06
JP5982504B2 (ja) 2016-08-31
PL1678314T3 (pl) 2013-02-28
US20110183402A1 (en) 2011-07-28
US8268582B2 (en) 2012-09-18
EP2330201A1 (en) 2011-06-08
IL174783A0 (en) 2006-08-20
US10155819B2 (en) 2018-12-18
SI1678314T1 (sl) 2013-01-31
US20160297887A9 (en) 2016-10-13
IL211402A0 (en) 2011-04-28
DK2330201T3 (en) 2017-07-24
US9873746B2 (en) 2018-01-23
US20080003643A1 (en) 2008-01-03
JP4994038B2 (ja) 2012-08-08
CA2541651C (en) 2011-05-24
IL174783A (en) 2012-10-31
DK1678314T3 (da) 2012-12-03
CN1871359B (zh) 2010-11-17
US7927863B2 (en) 2011-04-19
AU2004283299A1 (en) 2005-05-06
CN101979650B (zh) 2015-09-16
JP2012095669A (ja) 2012-05-24
EP1678314A4 (en) 2007-03-07
EP1678314A1 (en) 2006-07-12
CN101979650A (zh) 2011-02-23
US11447560B2 (en) 2022-09-20
CN1871359A (zh) 2006-11-29
AU2009213095A1 (en) 2009-10-08
US20140206039A1 (en) 2014-07-24

Similar Documents

Publication Publication Date Title
NO20062134L (no) Fremgangsmater for syntetisering av heteromultimere polypeptider i gjaer ved anvendelse av haploid parrings strategi
NO973848L (no) Fremgangsmåte til fremstilling av hemoglobinliknende protein
IL184112A0 (en) A method for producing polypeptides or proteins in a disulfide-bridged two-chain form
NO2012001I1 (no) Ipilimumab (INN) - krav i basispatent
IL190705A0 (en) A method for the production of a permanent human cell line
WO2006012451A3 (en) Compositions and methods of use for mgd-csf in disease treatment
ATE175446T1 (de) Immunogene peptide, antikörper sowie deren verwendungen im zusammenhang mit der cd4- rezeptorbindung
DE68918867D1 (de) Mutanten des hiv-1 Hüllproteins mit fehlenden hypervariabelen domänen.
WO2005086667A3 (en) High efficiency peptide production in plant cells
WO2006069403A3 (en) Methods for producing soluble multi-membrane-spanning proteins
WO2021194826A3 (en) Recombinant sars-cov-2 spike protein and uses thereof
DK1137808T3 (da) Fremgangsmåde til fremstilling af rekombinante celler
WO2004111194A3 (en) Method to increase protein production in culture
JPWO2020072821A5 (pt)
WO2004033627A3 (en) Methods for efficient production of mammalian recombinant proteins
AU1093597A (en) Vector for expression of n-terminally extended proteins in yeast cell
CY1113769T1 (el) Μεθοδοι συνθεσης ετεροπολυμερικων πολυπεπτιδιων σε ζυμομυκητα χρησιμοποιωντας στρατηγικη ζευγαρωματος απλοειδους
WO2023141478A3 (en) Cytokine-immunoreceptor fusion proteins and uses thereof
ATE413452T1 (de) Polypeptid
MX2023011898A (es) Composición de hidrolizado celular a partir de células cultivadas y aplicaciones de la misma.
EP4421180A3 (en) Compositions comprising nkg2d, cxcr2, and dap10/dap12 fusion polypeptides and methods of use thereof
WO2020232017A3 (en) Expression of modified proteins in a peroxisome
WO2022208554A3 (en) Constructs and methods for increased expression of polypeptides
WO2023002061A3 (en) Recombinant host cells and methods for producing casein proteins
WO2023215221A3 (en) Engineered microorganisms with enhanced protein expression and secretion

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application