NO20051804L - GHRH analoger - Google Patents
GHRH analogerInfo
- Publication number
- NO20051804L NO20051804L NO20051804A NO20051804A NO20051804L NO 20051804 L NO20051804 L NO 20051804L NO 20051804 A NO20051804 A NO 20051804A NO 20051804 A NO20051804 A NO 20051804A NO 20051804 L NO20051804 L NO 20051804L
- Authority
- NO
- Norway
- Prior art keywords
- ghrh
- relates
- present
- analogs
- human
- Prior art date
Links
- 101710142969 Somatoliberin Proteins 0.000 title abstract 5
- 102100022831 Somatoliberin Human genes 0.000 title 1
- 102000038461 Growth Hormone-Releasing Hormone Human genes 0.000 abstract 4
- 239000000095 Growth Hormone-Releasing Hormone Substances 0.000 abstract 4
- 101000997535 Homo sapiens Growth hormone-releasing hormone receptor Proteins 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000000977 initiatory effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000017854 proteolysis Effects 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/25—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Anesthesiology (AREA)
Abstract
Foreliggende oppfinnelse angår veksthormon frigivende hormon (GHRH) analoger. Mer bestemt angår oppfirmelsen syntetiske GHRH analoger med 29 aminosyrer eller mer, som viser samtidig en øket resistens overfor proteolyse og en høy bindingsaffinitet til human GHRH reseptor i in vitro studier, sammenlignet med humant nativt GHRN (1 29)NH2. Foreliggende oppfirmelse angår også anvendelsen av disse analogene for spesifikk stimulering av in vivo GH fiigiving så vel som fremstilling av et medikament for behandling av GH-mangel-relaterte tilstander. Foreliggende oppfirmelse fremskaffer også en fremgangsmåte for initiering av GHRH induserte biologiske virkninger i et pattedyr.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41134002P | 2002-09-18 | 2002-09-18 | |
PCT/CA2003/001418 WO2004027064A2 (en) | 2002-09-18 | 2003-09-17 | Ghrh analogues |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20051804L true NO20051804L (no) | 2005-04-13 |
Family
ID=32030666
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20051804A NO20051804L (no) | 2002-09-18 | 2005-04-13 | GHRH analoger |
Country Status (13)
Country | Link |
---|---|
US (2) | US20060128615A1 (no) |
EP (1) | EP1539959A2 (no) |
JP (1) | JP2006504694A (no) |
KR (1) | KR20050071498A (no) |
CN (1) | CN1688696A (no) |
BR (1) | BR0314619A (no) |
CA (1) | CA2496687A1 (no) |
MX (1) | MXPA05002991A (no) |
NO (1) | NO20051804L (no) |
NZ (1) | NZ539218A (no) |
RU (1) | RU2005111253A (no) |
WO (1) | WO2004027064A2 (no) |
ZA (1) | ZA200502221B (no) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL2118123T3 (pl) | 2007-01-31 | 2016-06-30 | Dana Farber Cancer Inst Inc | Stabilizowane peptydy p53 i ich zastosowania |
CA2682174C (en) | 2007-03-28 | 2021-04-06 | President And Fellows Of Harvard College | Stitched polypeptides |
CA2680329A1 (en) * | 2007-04-04 | 2008-10-16 | Theratechnologies Inc. | Pharmaceutical formulations of ghrh molecules |
US20090088380A1 (en) * | 2007-07-12 | 2009-04-02 | Pierrette Gaudreau | Ghrh analogs and therapeutic uses thereof |
WO2010121351A1 (en) * | 2009-04-20 | 2010-10-28 | Theratechnologies Inc. | Use of (hexenoyl trans-3)hgrf(1-44)nh2 and ritonavir in combination therapy |
US20100267636A1 (en) * | 2009-04-20 | 2010-10-21 | Theratechnologies Inc. | Use of cytochrome p450-metabolized drugs and grf molecules in combination therapy |
WO2011153491A2 (en) | 2010-06-03 | 2011-12-08 | University Of Miami | Agonists of growth hormone releasing hormone as effectors for survival and proliferation of pancreatic islets |
KR20130099938A (ko) | 2010-08-13 | 2013-09-06 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티도미메틱 거대고리 |
WO2012037519A2 (en) * | 2010-09-16 | 2012-03-22 | University Of Miami | Acceleration of wound healing by growth hormone releasing hormone and its agonists |
CN103547591A (zh) | 2011-04-21 | 2014-01-29 | 瑟瑞技术公司 | 生长激素释放因子(grf)类似物及其用途 |
CN108929375A (zh) | 2011-10-18 | 2018-12-04 | 爱勒让治疗公司 | 拟肽大环化合物 |
US9079974B2 (en) | 2011-12-21 | 2015-07-14 | The University Of Miami | GH-RH analogs with potent agonistic effects |
CA2864120A1 (en) | 2012-02-15 | 2013-08-22 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
ES2817877T3 (es) | 2012-02-15 | 2021-04-08 | Aileron Therapeutics Inc | Macrociclos peptidomiméticos |
WO2013190520A2 (en) | 2012-06-22 | 2013-12-27 | The General Hospital Corporation | Gh-releasing agents in the treatment of vascular stenosis and associated conditions |
AU2013337388B2 (en) | 2012-11-01 | 2018-08-02 | Aileron Therapeutics, Inc. | Disubstituted amino acids and methods of preparation and use thereof |
WO2014100816A2 (en) | 2012-12-21 | 2014-06-26 | University Of Miami | Ghrh agonists for islet cell transplantation and function and the treatment of diabetes |
WO2014100809A2 (en) | 2012-12-21 | 2014-06-26 | University Of Miami | Ghrh agonists for the treatment of ischemic disorders |
US20150174207A1 (en) * | 2013-12-24 | 2015-06-25 | University Of Miami | Methods for treating cancer with ghrh agonists |
CN105198966B (zh) * | 2014-06-26 | 2019-06-21 | 中国人民解放军军事医学科学院毒物药物研究所 | GnRH类似物-细胞毒分子缀合物、其制备方法及用途 |
JP2017533889A (ja) | 2014-09-24 | 2017-11-16 | エルロン・セラピューティクス・インコーポレイテッドAileron Therapeutics,Inc. | ペプチド模倣大環状分子およびその使用 |
CN104558150B (zh) * | 2014-11-04 | 2017-12-15 | 广东药学院 | 一类生长激素释放激素类似肽及其在制备治疗不孕不育药物中的应用 |
WO2016154058A1 (en) | 2015-03-20 | 2016-09-29 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
CA3021231A1 (en) | 2016-04-19 | 2017-10-26 | Griffon Pharmaceuticals Inc. | Pegylated bioactive peptides and uses thereof |
CN111407884B (zh) * | 2019-06-24 | 2021-12-07 | 浙江大学 | 促生长激素释放激素激动剂ghrh-a在制备抗衰老药物中的用途 |
CN111533800B (zh) * | 2020-03-18 | 2021-08-31 | 浙江湖州纳福生物医药有限公司 | 新型生长激素释放激素类似肽改构和二聚体化制备及其应用 |
Family Cites Families (115)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US652047A (en) * | 1899-09-23 | 1900-06-19 | Nelson T Shields | Artificial tooth. |
US4411890A (en) * | 1981-04-14 | 1983-10-25 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
US3862925A (en) * | 1973-07-05 | 1975-01-28 | American Home Prod | Preparation of somatotropin release inhibiting factor and intermediates therefor |
US3842067A (en) * | 1973-07-27 | 1974-10-15 | American Home Prod | Synthesis of(des-asn5)-srif and intermediates |
US4301066A (en) * | 1980-05-08 | 1981-11-17 | American Home Products Corp. | Preparation of (D-Trp 6)-LH-RH via the heptapeptide H-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2 |
US4439356A (en) * | 1981-03-03 | 1984-03-27 | Syva Company | Unsymmetrical fluorescein derivatives |
US4517181A (en) * | 1982-09-15 | 1985-05-14 | The Salk Institute For Biological Studies | Mammalian PGRF |
US4563352A (en) * | 1982-10-04 | 1986-01-07 | The Salk Institute For Biological Studies | Human pancreatic GRF |
US4529595A (en) * | 1983-01-13 | 1985-07-16 | The Salk Institute For Biological Studies | GRF Analogs |
US4595676A (en) * | 1983-04-26 | 1986-06-17 | The Salk Institute For Biological Studies | Rat hypothalamic GRF |
US4518586A (en) * | 1983-01-13 | 1985-05-21 | The Salk Institute For Biological Studies | GRF Analogs III |
US4628043A (en) * | 1983-04-26 | 1986-12-09 | The Salk Institute For Biological Studies | Hypothalamic GRF agonists |
US4585756A (en) * | 1983-10-12 | 1986-04-29 | The Salk Institute For Biological Studies | Bovine GRF |
US4610976A (en) * | 1983-08-29 | 1986-09-09 | The Salk Institute For Biological Studies | Porcine GRF |
US4605643A (en) * | 1984-03-02 | 1986-08-12 | The Salk Institute For Biological Studies | Ovine GRF |
US4626523A (en) * | 1983-09-13 | 1986-12-02 | The Salk Institute For Biological Studies | GRF analogs II |
US4528190A (en) * | 1983-10-25 | 1985-07-09 | The Salk Institute For Biological Studies | GRF Analogs IV |
US4622312A (en) * | 1984-09-24 | 1986-11-11 | Hoffmann-La Roche Inc. | Growth hormone releasing factor analogs |
EP0189673B1 (en) * | 1984-12-24 | 1990-09-26 | Sumitomo Pharmaceuticals Company, Limited | Stable growth hormone releasing factor preparation |
US4734399A (en) * | 1985-08-06 | 1988-03-29 | Hoffmann-La Roche Inc. | Growth hormone releasing factor analogs |
US4689318A (en) * | 1985-08-29 | 1987-08-25 | The Salk Institute For Biological Studies | GRF analogs |
US4843064A (en) * | 1987-01-13 | 1989-06-27 | The Salk Institute For Biological Studies | GRF analogs V |
US4784987A (en) * | 1987-01-13 | 1988-11-15 | The Salk Institute For Biological Studies | GRF analogs VI |
US5877277A (en) * | 1987-09-24 | 1999-03-02 | Biomeasure, Inc. | Octapeptide bombesin analogs |
US5756458A (en) * | 1989-06-16 | 1998-05-26 | Pharmacia & Upjohn Company | Stabilized potent GRF analogs |
US5137872A (en) * | 1989-09-18 | 1992-08-11 | Pitman-Moore, Inc. | Growth hormone-releasing factor analogs |
CA2084061A1 (en) * | 1991-04-09 | 1992-10-10 | Arthur M. Felix | Growth hormone releasing factor analogs |
US5262519A (en) * | 1991-05-15 | 1993-11-16 | The Salk Institute For Biological Studies | GRF analogs XI |
US6916489B2 (en) * | 1992-06-15 | 2005-07-12 | Emisphere Technologies, Inc. | Active agent transport systems |
US20010003001A1 (en) * | 1993-04-22 | 2001-06-07 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US6610329B2 (en) * | 1993-04-22 | 2003-08-26 | Emisphere Technologies Inc. | Compositions for the delivery of antigens |
SE9301667D0 (sv) * | 1993-05-14 | 1993-05-14 | Kabi Pharmacia Ab | New use |
US6297212B1 (en) * | 1994-05-31 | 2001-10-02 | Gregory M. Fahy | Growth hormone therapy and related methods and pharmaceutical compositions |
US5837276A (en) * | 1994-09-02 | 1998-11-17 | Delab | Apparatus for the delivery of elongate solid drug compositions |
CA2158782C (en) * | 1994-09-23 | 2010-01-12 | Pierrette Gaudreau | Marker for growth hormone-releasing factor receptors |
US20020111461A1 (en) * | 1999-05-21 | 2002-08-15 | Todd C. Somers | Low molecular weight peptidomimetic growth hormone secretagogues |
US6458764B1 (en) * | 1995-05-26 | 2002-10-01 | Theratechnologies Inc. | GRF analogs with increased biological potency |
IT1285405B1 (it) * | 1995-06-06 | 1998-06-03 | Alza Corp | Modificazione di farmaci polipeptidici per accrescere il flusso per elettrotrasporto. |
TW432073B (en) * | 1995-12-28 | 2001-05-01 | Pfizer | Pyrazolopyridine compounds |
ATE238063T1 (de) * | 1996-01-11 | 2003-05-15 | Upjohn Co | Wässrige zusammensetzung mit verzögerter freisetzung, enthaltend rinderwachstumshormon- freisetzungsfaktor |
EP0914094A4 (en) * | 1996-03-28 | 2000-03-01 | Univ Illinois | MATERIALS AND METHOD FOR PRODUCING IMPROVED LIPOSOMAL AGENTS |
JP2000511892A (ja) * | 1996-05-24 | 2000-09-12 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | 可溶性ベーターシート形成性ペプチドの合成 |
DK1007080T3 (da) * | 1996-08-30 | 2007-07-30 | Peptech Ltd | Formulering til vedvarende frigivelse af peptidagonister og analoger af GnRH |
US6420518B1 (en) * | 1997-04-04 | 2002-07-16 | Genetech, Inc. | Insulin-like growth factor agonist molecules |
US6121416A (en) * | 1997-04-04 | 2000-09-19 | Genentech, Inc. | Insulin-like growth factor agonist molecules |
TW577759B (en) * | 1997-04-18 | 2004-03-01 | Ipsen Pharma Biotech | Sustained release compositions in the form of microcapsules or implants and the process for their preparation |
EP1001970B1 (en) * | 1997-06-25 | 2007-03-07 | Pfizer Inc. | Dipeptide derivatives as growth hormone secretagogues |
UA64751C2 (uk) * | 1997-06-25 | 2004-03-15 | Пфайзер Продактс Інк. | Спосіб лікування інсулінової толерантності речовинами, які посилюють секрецію гормону росту (варіанти) та фармацевтична композиція (варіанти) |
AU8589998A (en) * | 1997-07-24 | 1999-02-16 | Valentis, Inc. | Ghrh expression system and methods of use |
AUPO930697A0 (en) * | 1997-09-19 | 1997-10-09 | Walter And Eliza Hall Institute Of Medical Research, The | Catalytic antibodies and a method of producing same |
GB9723955D0 (en) * | 1997-11-14 | 1998-01-07 | Generic Biolog Limited | Improvements in or relating to detection of molecules in samples |
EP0922446A1 (en) * | 1997-12-03 | 1999-06-16 | Applied Research Systems Ars Holding N.V. | Solution-phase site-specific preparation of GRF-PEG conjugates |
US6803357B1 (en) * | 1998-02-02 | 2004-10-12 | New England Medical Center Hospitals, Inc. | Method of regulating glucose metabolism, and reagents related thereto |
US20030167531A1 (en) * | 1998-07-10 | 2003-09-04 | Russell Douglas A. | Expression and purification of bioactive, authentic polypeptides from plants |
US6512162B2 (en) * | 1998-07-10 | 2003-01-28 | Calgene Llc | Expression of eukaryotic peptides in plant plastids |
US6057422A (en) * | 1998-11-25 | 2000-05-02 | The Administrators Of The Tulane Educational Fund | Antagonistic analogs of GH-RH inhibiting IGF-I and -II |
US6696063B1 (en) * | 1998-12-30 | 2004-02-24 | Applied Research Systems Ars Holding N.V. | Treatment of HIV-associated dysmorphia/dysmetabolic syndrome (HADDS) with or without lipodystrophy |
EP1141015B1 (en) * | 1999-01-06 | 2009-07-15 | Genentech, Inc. | Insulin-like growth factor (igf) i mutant variants |
AU2879100A (en) * | 1999-02-12 | 2000-08-29 | Miles A. Libbey Iii | Formulation and system for intra-oral delivery of pharmaceutical agents |
US6759393B1 (en) * | 1999-04-12 | 2004-07-06 | Pfizer Inc. | Growth hormone and growth hormone releasing hormone compositions |
US6437101B1 (en) * | 1999-05-07 | 2002-08-20 | Akzo Nobel N.V. | Methods for protein purification using aqueous two-phase extraction |
US6268178B1 (en) * | 1999-05-25 | 2001-07-31 | Phage Biotechnology Corp. | Phage-dependent super-production of biologically active protein and peptides |
US7078514B1 (en) * | 1999-06-12 | 2006-07-18 | Michael O. Thorner | Chicken growth hormone releasing hormone receptor |
GB9915200D0 (en) * | 1999-06-29 | 1999-09-01 | Janssen Pharmaceutica Nv | Neurotrophic factor receptor |
EP1064934A1 (en) * | 1999-06-30 | 2001-01-03 | Applied Research Systems ARS Holding N.V. | GRF-containing lyophilized pharmaceutical composition |
WO2001007475A1 (fr) * | 1999-07-23 | 2001-02-01 | Kenji Kangawa | Nouveaux peptides |
US20040192593A1 (en) * | 1999-07-26 | 2004-09-30 | Baylor College Of Medicine | Protease resistant ti-growth hormone releasing hormone |
AU772752B2 (en) * | 1999-07-26 | 2004-05-06 | Baylor College Of Medicine | Super-active porcine growth hormone releasing hormone analog |
KR100345214B1 (ko) * | 1999-08-17 | 2002-07-25 | 이강춘 | 생체적합성 고분자가 수식된 펩타이드의 비점막 전달 |
AU1130501A (en) * | 1999-11-03 | 2001-05-14 | Novo Nordisk A/S | Use of a growth hormone or a growth hormone secretagogue for appetite-suppression or induction of satiety |
US6866851B1 (en) * | 1999-12-28 | 2005-03-15 | Washington University | GFRα1-RET specific agonists and methods therefor |
WO2001047558A1 (fr) * | 1999-12-28 | 2001-07-05 | Kaken Pharmaceutical Co., Ltd. | Medicaments protegeant les nerfs |
US20010020012A1 (en) * | 2000-02-01 | 2001-09-06 | Andersen Maibritt Bansholm | Use of compounds for the regulation of food intake |
EP1278858A2 (en) * | 2000-03-24 | 2003-01-29 | Millennium Pharmaceuticals, Inc. | 46743 and 27417, novel human acyltransferase family members and uses therefor |
US7834141B1 (en) * | 2000-03-31 | 2010-11-16 | Theresa Siler-Khodr | Non-mammalian GnRH analogs and uses thereof in tumor cell growth regulation and cancer therapy |
CA2405701A1 (en) * | 2000-04-12 | 2001-10-25 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US20020061838A1 (en) * | 2000-05-17 | 2002-05-23 | Barton Holmquist | Peptide pharmaceutical formulations |
WO2001092292A2 (en) * | 2000-05-30 | 2001-12-06 | Merck & Co., Inc. | Ghrelin analogs |
JP2004509079A (ja) * | 2000-08-02 | 2004-03-25 | セラテクノロジーズ・インコーポレーテッド | 効力が増大した修飾生体ペプチド |
WO2002028437A1 (en) * | 2000-10-05 | 2002-04-11 | Ares Trading S.A. | Regioselective liquid phase pegylation |
US6750194B1 (en) * | 2000-10-23 | 2004-06-15 | The Procter & Gamble Company | Methods of identifying compounds for regulating muscle mass or function using vasoactive intestinal peptide receptors |
US20030083299A1 (en) * | 2000-11-04 | 2003-05-01 | Ferguson Ian A. | Non-invasive delivery of polypeptides through the blood-brain barrier |
WO2003049761A1 (en) * | 2000-12-08 | 2003-06-19 | Neuronz Limited | Use of insuline-like growth factor-i for promoting remyelination of axons |
US20030074679A1 (en) * | 2000-12-12 | 2003-04-17 | Schwartz Robert J. | Administration of nucleic acid sequence to female animal to enhance growth in offspring |
US20020091090A1 (en) * | 2000-12-28 | 2002-07-11 | Cole Bridget M. | Somatostatin antagonists and agonists |
CU23157A1 (es) * | 2001-01-03 | 2006-07-18 | Ct Ingenieria Genetica Biotech | COMPOSICION FARMACéUTICA PARA EL TRATAMIENTO DEL DANO TISULAR DEBIDO A FALTA DE IRRIGACION SANGUINEA ARTERIAL |
US7264810B2 (en) * | 2001-01-19 | 2007-09-04 | Cytos Biotechnology Ag | Molecular antigen array |
CN1491233A (zh) * | 2001-02-02 | 2004-04-21 | 康久化学公司 | 长效生长激素释放因子衍生物 |
FR2821359B1 (fr) * | 2001-02-27 | 2003-05-09 | Sod Conseils Rech Applic | L'heterocarpine, une proteine fixant le ghrh humain |
US6890905B2 (en) * | 2001-04-02 | 2005-05-10 | Prosidion Limited | Methods for improving islet signaling in diabetes mellitus and for its prevention |
WO2002090387A1 (en) * | 2001-05-10 | 2002-11-14 | Queensland University Of Technology | Reproductive cancer diagnosis and therapy |
US20030013637A1 (en) * | 2001-05-18 | 2003-01-16 | Hideto Ikushima | Novel anti-autoimmune composition by inhibition of GRF action |
US6858580B2 (en) * | 2001-06-04 | 2005-02-22 | Nobex Corporation | Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
DK1397155T3 (en) * | 2001-06-21 | 2015-12-07 | Genentech Inc | Prolonged release formulation |
WO2003023000A2 (en) * | 2001-09-07 | 2003-03-20 | Baylor College Of Medicine | Linear dna fragments for gene expression |
CN100417419C (zh) * | 2001-10-26 | 2008-09-10 | 贝勒医学院 | 改变个体的瘦体重和骨特性的组合物和方法 |
PL195917B1 (pl) * | 2001-10-31 | 2007-11-30 | Inst Farmaceutyczny | Nowe peptydy - analogi ludzkiego hormonu uwalniającego hormon wzrostu |
US7297794B2 (en) * | 2001-11-13 | 2007-11-20 | Emisphere Technologies, Inc. | Phenoxy amine compounds and compositions for delivering active agents |
JPWO2003047624A1 (ja) * | 2001-12-07 | 2005-04-14 | 科研製薬株式会社 | 細胞遊走阻害剤 |
CA2475273A1 (en) * | 2002-02-07 | 2003-08-14 | Baylor College Of Medicine | Modified pituitary gland development in offspring from expectant mother animals treated with growth hormone releasing hormone therapy |
WO2003070751A2 (en) * | 2002-02-20 | 2003-08-28 | Regents Of The University Of Minnesota | Partial peptide mimetics and methods |
CN1638732A (zh) * | 2002-03-04 | 2005-07-13 | 研究及应用科学协会股份有限公司 | 含载体肽的缓释药物制剂 |
EP1493747B1 (en) * | 2002-04-11 | 2012-12-19 | Daiichi Sankyo Company, Limited | Process for producing modified peptide |
WO2003086272A2 (en) * | 2002-04-16 | 2003-10-23 | Kamada Ltd. | Ultrapure transferrin for pharmaceutical compositions |
EP1506786B1 (en) * | 2002-05-21 | 2016-11-23 | Daiichi Sankyo Company, Limited | Medicinal compositions containing ghrelin |
DE60331226D1 (de) * | 2002-05-24 | 2010-03-25 | Medtronic Inc | Verfahren und dna-konstrukte zur produktion von polypeptiden mit hoher ausbeute |
US20040014645A1 (en) * | 2002-05-28 | 2004-01-22 | Advisys, Inc. | Increased delivery of a nucleic acid construct in vivo by the poly-L-glutamate ("PLG") system |
EP1517988B1 (de) * | 2002-06-20 | 2013-05-08 | Augustinus Bader | Verwendung von Erythropoietin zur Geweberegeneration in vivo |
EP1543020B1 (en) * | 2002-07-16 | 2011-04-13 | VGX Pharmaceuticals, LLC | Codon optimized synthetic plasmids |
KR20050027168A (ko) * | 2002-07-19 | 2005-03-17 | 사이토스 바이오테크놀로지 아게 | 그렐린-캐리어 컨쥬게이트 |
TWI331922B (en) * | 2002-08-09 | 2010-10-21 | Ipsen Pharma Sas | Growth hormone releasing peptides |
EP1407779A1 (en) * | 2002-10-10 | 2004-04-14 | Gastrotech A/S | Use of ghrelin for treating low body weight and body fat in gastrectomized individuals |
AU2003229222B2 (en) * | 2003-05-29 | 2009-11-12 | Theratechnologies Inc. | GRF analog compositions and their use |
WO2005014033A1 (en) * | 2003-07-29 | 2005-02-17 | Ares Trading S.A. | Use of human growth hormone in multiple system atrophy |
US20050063937A1 (en) * | 2003-09-16 | 2005-03-24 | Cheng Li | Multiple-arm peptide compounds, methods of manufacture and use in therapy |
-
2003
- 2003-09-17 EP EP03750194A patent/EP1539959A2/en not_active Withdrawn
- 2003-09-17 CN CNA038222914A patent/CN1688696A/zh active Pending
- 2003-09-17 MX MXPA05002991A patent/MXPA05002991A/es unknown
- 2003-09-17 BR BR0314619-7A patent/BR0314619A/pt not_active IP Right Cessation
- 2003-09-17 WO PCT/CA2003/001418 patent/WO2004027064A2/en active Application Filing
- 2003-09-17 JP JP2004536729A patent/JP2006504694A/ja active Pending
- 2003-09-17 NZ NZ539218A patent/NZ539218A/en unknown
- 2003-09-17 RU RU2005111253/13A patent/RU2005111253A/ru not_active Application Discontinuation
- 2003-09-17 CA CA002496687A patent/CA2496687A1/en not_active Abandoned
- 2003-09-17 US US10/527,598 patent/US20060128615A1/en not_active Abandoned
- 2003-09-17 KR KR1020057004781A patent/KR20050071498A/ko not_active Application Discontinuation
-
2005
- 2005-03-16 ZA ZA200502221A patent/ZA200502221B/en unknown
- 2005-04-13 NO NO20051804A patent/NO20051804L/no not_active Application Discontinuation
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2007
- 2007-06-01 US US11/809,596 patent/US20090023646A1/en not_active Abandoned
Also Published As
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ZA200502221B (en) | 2006-08-30 |
AU2003269631A1 (en) | 2004-04-08 |
BR0314619A (pt) | 2005-08-02 |
CN1688696A (zh) | 2005-10-26 |
WO2004027064A3 (en) | 2004-11-18 |
JP2006504694A (ja) | 2006-02-09 |
US20090023646A1 (en) | 2009-01-22 |
NZ539218A (en) | 2008-03-28 |
RU2005111253A (ru) | 2005-11-20 |
KR20050071498A (ko) | 2005-07-07 |
CA2496687A1 (en) | 2004-04-01 |
MXPA05002991A (es) | 2005-10-05 |
US20060128615A1 (en) | 2006-06-15 |
EP1539959A2 (en) | 2005-06-15 |
WO2004027064A2 (en) | 2004-04-01 |
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