ATE156492T1 - Bombesinanaloge - Google Patents

Bombesinanaloge

Info

Publication number
ATE156492T1
ATE156492T1 AT92913859T AT92913859T ATE156492T1 AT E156492 T1 ATE156492 T1 AT E156492T1 AT 92913859 T AT92913859 T AT 92913859T AT 92913859 T AT92913859 T AT 92913859T AT E156492 T1 ATE156492 T1 AT E156492T1
Authority
AT
Austria
Prior art keywords
bombesin
derivatives
antagonist
bomb
analogues
Prior art date
Application number
AT92913859T
Other languages
English (en)
Inventor
Judson V Edwards
Bradford O Fanger
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of ATE156492T1 publication Critical patent/ATE156492T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C07K7/086—Bombesin; Related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Immunology (AREA)
  • Nutrition Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Silicon Polymers (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT92913859T 1991-05-23 1992-04-21 Bombesinanaloge ATE156492T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70486391A 1991-05-23 1991-05-23

Publications (1)

Publication Number Publication Date
ATE156492T1 true ATE156492T1 (de) 1997-08-15

Family

ID=24831155

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92913859T ATE156492T1 (de) 1991-05-23 1992-04-21 Bombesinanaloge

Country Status (11)

Country Link
US (1) US5428019A (de)
EP (1) EP0585397B1 (de)
JP (1) JP3350701B2 (de)
AT (1) ATE156492T1 (de)
AU (1) AU659659B2 (de)
CA (1) CA2109322C (de)
DE (1) DE69221486T2 (de)
DK (1) DK0585397T3 (de)
ES (1) ES2106188T3 (de)
GR (1) GR3025003T3 (de)
WO (1) WO1992020707A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5723578A (en) * 1987-09-24 1998-03-03 The Administrators Of Tulane Educational Fund Peptide analogs of bombesin
US5877277A (en) 1987-09-24 1999-03-02 Biomeasure, Inc. Octapeptide bombesin analogs
EP0448677A4 (en) * 1989-09-15 1992-08-26 Biomeasure Inc. Treatment of colon cancer
US5650395A (en) * 1995-03-13 1997-07-22 Hurel; Steven Treatment of pulmonary hypertension
US5786335A (en) * 1995-11-06 1998-07-28 Warner-Lambert Company Sulfhydryl containing peptides for treating vascular disease
US7078413B2 (en) 1996-04-19 2006-07-18 Wisconsin Alumni Research Foundation Compositions and methods of use for a bombesin peptide
US6989371B1 (en) 1996-08-16 2006-01-24 Dabur Research Foundation Bombesin analogs for treatment of cancer
US5861532A (en) * 1997-03-04 1999-01-19 Chiron Corporation Solid-phase synthesis of N-alkyl amides
WO1998047524A1 (en) * 1997-04-22 1998-10-29 Curators Of The University Of Missouri Gastrin receptor-avid peptide conjugates
CA2346154A1 (en) * 2001-05-02 2002-11-02 University Of Missouri Gastrin receptor-avid peptide conjugates
ES2265669T3 (es) * 1997-09-16 2007-02-16 Societe Des Produits Nestle S.A. Uso de una composicion nutritiva especifica para un organo.
US7226577B2 (en) 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
US7922998B2 (en) * 2003-01-13 2011-04-12 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
EP1583564B1 (de) * 2003-01-13 2009-07-01 Bracco Imaging S.p.A Verbesserte linker für radiopharmazeutische verbindungen
US8420050B2 (en) * 2003-01-13 2013-04-16 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7611692B2 (en) 2003-01-13 2009-11-03 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7850947B2 (en) * 2003-01-13 2010-12-14 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US20060239923A1 (en) * 2003-01-13 2006-10-26 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
EP1610805A2 (de) * 2003-03-10 2006-01-04 Biogen Idec Inc. Thiol-vermittelte wirkstoffanbindung an targeting-peptide
CN111500612A (zh) * 2020-03-30 2020-08-07 扬州大学 一种可溶性猪胃泌素释放肽融合蛋白表达载体及其应用
CN116333041A (zh) * 2023-04-10 2023-06-27 湖南中晟全肽生化有限公司 一种激活grp受体的多肽化合物及其用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1592552A (en) * 1976-12-10 1981-07-08 Inst Nat Sante Rech Med Pseudopeptides used as medicaments
US4631270A (en) * 1978-11-20 1986-12-23 Research Corporation Therapeutically useful pseudopeptides, compositions containing the same and methods of preparation and use
EP0076557B1 (de) * 1981-06-22 1985-11-13 Imperial Chemical Industries Plc Peptide und Pseudopeptide, die zwei Substituenten am N-Terminus aufweisen
US4871717A (en) * 1987-01-07 1989-10-03 Administrators Of The Tulane Educational Fund Peptides
JP2795449B2 (ja) * 1987-09-24 1998-09-10 ジ・アドミニストレーターズ・オブ・ザ・ツーレイン・エデュケイショナル・ファンド 治療用ペプチド
US5047502A (en) * 1987-10-23 1991-09-10 Merck And Co., Inc. Gastrin releasing peptide antagonist
EP0313158A3 (de) * 1987-10-23 1990-08-22 Merck & Co. Inc. Antagonisten von Gastrin freisetzenden Peptiden
AU618029B2 (en) * 1987-11-02 1991-12-12 Imperial Chemical Industries Plc Polypeptide compounds
GB8806644D0 (en) * 1988-03-21 1988-04-20 Imp Cancer Res Tech Neuropeptide antagonists
GB8808768D0 (en) * 1988-04-14 1988-05-18 Erba Carlo Spa Peptide ligands for bombesin receptors
GB8813356D0 (en) * 1988-06-06 1988-07-13 Ici Plc Polypeptide compounds
NZ229552A (en) * 1988-06-20 1992-06-25 Merrell Dow Pharma Neurokinin a antagonists
GR1000608B (el) * 1988-07-21 1992-08-31 Erba Carlo Spa Μεθοδος για την παρασκευη ανταγωνιστων bombesin.
AU638423B2 (en) * 1988-10-14 1993-07-01 The Administrators Of The Tulane Eductional Fund Therapeutic peptides
US5028692A (en) * 1989-04-25 1991-07-02 Merck & Co., Inc. Gastrin releasing peptide antagonist
HUT58763A (en) * 1989-11-06 1992-03-30 Erba Carlo Spa Process for producing reduced irreverzible bombezin antagonists and pharmaceutical compositions containing them as active components
NZ236114A (en) * 1989-11-22 1993-04-28 Merrell Dow Pharma Peptide antagonists of bombesin and of gastrin releasing peptide, and pharmaceutical compositions

Also Published As

Publication number Publication date
CA2109322C (en) 2002-11-05
EP0585397B1 (de) 1997-08-06
JP3350701B2 (ja) 2002-11-25
DK0585397T3 (da) 1997-08-25
DE69221486T2 (de) 1998-03-19
AU659659B2 (en) 1995-05-25
ES2106188T3 (es) 1997-11-01
GR3025003T3 (en) 1998-01-30
WO1992020707A1 (en) 1992-11-26
US5428019A (en) 1995-06-27
DE69221486D1 (de) 1997-09-11
CA2109322A1 (en) 1992-11-24
JPH06508126A (ja) 1994-09-14
EP0585397A1 (de) 1994-03-09
AU2184092A (en) 1992-12-30

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Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee