NO20013381L - 2-oksybenzoksazinonderivater for behandling av fedme - Google Patents
2-oksybenzoksazinonderivater for behandling av fedmeInfo
- Publication number
- NO20013381L NO20013381L NO20013381A NO20013381A NO20013381L NO 20013381 L NO20013381 L NO 20013381L NO 20013381 A NO20013381 A NO 20013381A NO 20013381 A NO20013381 A NO 20013381A NO 20013381 L NO20013381 L NO 20013381L
- Authority
- NO
- Norway
- Prior art keywords
- reduced
- aryl
- formula
- compounds
- obesity
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
- C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
- C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
Anvendelse av en forbindelse som. har formel (I). eller et salt, en ester, et amid eller et. forløperlegemiddel derav ved inhibering. av et enzym hvis foretrukne virkningsmåte. er å katalysere hydrolysen av en ester-. gruppe, f.eks. ved kontroll og inhibering. av uønskede enzymer i produkter og frem-. gangsmåter. Forbindelsene er også anvend-. bare innen medisinen, f.eks. ved behand-. ling av fedme og beslektede tilstander.ppfinnelsen vedrører også nye forbind-. elser innenfor formel (I), fremgangsmåter. for fremstilling av dem, og farmasøytiske. preparater som inneholder dem. I formel. (I) er A en aromatisk eller heteroaro-. matisk 6-ring, og Rer forgrenet eller. uforgrenet alkyl (eventuelt avbrutt av. ett eller flere oksygenatomer), alkenyl,. alkynyl, sykloalkyl, sykloalkenyl, aryl,. arylalkyl, redusert arylalkyl, aryl-. alkenyl, heteroaryl, heteroarylalkyl,. heteroarylalkenyl, redusert aryl, redus-. ert heteroaryl, redusert heteroarylalkyl. eller et substituert derivat av hvilken. som helst av gruppene ovenfor.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9900413.7A GB9900413D0 (en) | 1999-01-08 | 1999-01-08 | Inhibitors |
GBGB9917294.2A GB9917294D0 (en) | 1999-07-22 | 1999-07-22 | Inhibitors |
PCT/GB2000/000032 WO2000040247A1 (en) | 1999-01-08 | 2000-01-06 | 2-oxy-benzoxazinone derivatives for the treatment of obesity |
Publications (3)
Publication Number | Publication Date |
---|---|
NO20013381D0 NO20013381D0 (no) | 2001-07-06 |
NO20013381L true NO20013381L (no) | 2001-09-07 |
NO333922B1 NO333922B1 (no) | 2013-10-21 |
Family
ID=26314965
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20013381A NO333922B1 (no) | 1999-01-08 | 2001-07-06 | 2-oksybenzoksazinonderivater, fremgangsmåte for fremstilling, anvendelse derav for fremstilling av et medikament for behandling av fedme samt farmasøytisk preparat og matprodukt omfattende forbindelsen |
Country Status (24)
Country | Link |
---|---|
US (4) | US6624161B2 (no) |
EP (1) | EP1143977B3 (no) |
JP (1) | JP3822439B2 (no) |
KR (1) | KR100678998B1 (no) |
CN (2) | CN1315813C (no) |
AR (1) | AR022204A1 (no) |
AT (1) | ATE293447T1 (no) |
AU (1) | AU765147C (no) |
CA (1) | CA2359819C (no) |
CH (1) | CH1143977H1 (no) |
DE (1) | DE60019555C5 (no) |
DK (1) | DK1143977T3 (no) |
ES (1) | ES2240052T7 (no) |
HK (2) | HK1047588B (no) |
HU (1) | HUP0105003A3 (no) |
MX (1) | MXPA01006921A (no) |
MY (1) | MY122578A (no) |
NO (1) | NO333922B1 (no) |
NZ (1) | NZ512740A (no) |
PL (1) | PL207383B1 (no) |
PT (1) | PT1143977E (no) |
RU (1) | RU2245331C2 (no) |
SI (1) | SI1143977T1 (no) |
WO (1) | WO2000040247A1 (no) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR022204A1 (es) * | 1999-01-08 | 2002-09-04 | Norgine Bv | Compuesto, proceso para su preparacion, composicion farmaceutica y producto comestible que lo comprende. |
GB0001572D0 (en) * | 2000-01-24 | 2000-03-15 | Alizyme Therapeutics Ltd | Inhibitors |
US6504028B2 (en) * | 2000-07-11 | 2003-01-07 | The Procter & Gamble Co. | Process for preparing benzoxazin-4-one polymer conjugates |
AU2002331064B2 (en) | 2001-08-10 | 2007-08-23 | Palatin Technologies, Inc. | Peptidomimetics of biologically active metallopeptides |
KR100934256B1 (ko) | 2001-08-30 | 2009-12-28 | 알리자임 테라퓨틱스 리미티드 | 리파제 억제 활성을 갖는 티에노(1,3)옥사진-4-온 |
CN1620439A (zh) * | 2001-12-20 | 2005-05-25 | Osi药物公司 | 胰脂肪酶抑制剂化合物、其合成方法和应用 |
US8372430B2 (en) | 2002-12-17 | 2013-02-12 | The Procter & Gamble Company | Compositions, methods, and kits useful for the alleviation of gastrointestinal effects |
WO2004110338A2 (en) * | 2003-06-12 | 2004-12-23 | Biomas Ltd. | Methods of treating obesity and related disorders using tellurium and selenium compounds |
GB0319124D0 (en) * | 2003-08-14 | 2003-09-17 | Smithkline Beecham Corp | Chemical compounds |
US20050239859A2 (en) * | 2003-09-03 | 2005-10-27 | Solvay Pharmaceuticals Gmbh | Novel medical uses of 4,5-dihydro-1h-pyrazole derivatives having cb1- antagonistic activity |
US20050124660A1 (en) * | 2003-10-27 | 2005-06-09 | Jochen Antel | Novel medical uses of compounds showing CB1-antagonistic activity and combination treatment involving said compounds |
US20050143441A1 (en) * | 2003-10-27 | 2005-06-30 | Jochen Antel | Novel medical combination treatment of obesity involving 4,5-dihydro-1H-pyrazole derivatives having CB1-antagonistic activity |
US20050244367A1 (en) * | 2004-05-03 | 2005-11-03 | Ilypsa, Inc. | Phospholipase inhibitors localized in the gastrointestinal lumen |
RU2007119315A (ru) | 2004-10-25 | 2008-11-27 | Зольвай Фармасьютиклз Гмбх (De) | Фармацевтические композиции, содержащие антагонисты каннабиноидного рецептора св1 и открыватели калиевых каналов, предназначенные для лечения сахарного диабета типа i, ожирения и связанных с ними состояний |
US20090082435A1 (en) * | 2005-04-28 | 2009-03-26 | The Regents Of The University Of California | Methods, Compositions, And Compounds For Modulation Of Monoacylglycerol Lipase, Pain, And Stress-Related Disorders |
WO2006132440A1 (ja) | 2005-06-09 | 2006-12-14 | Takeda Pharmaceutical Company Limited | 固形製剤 |
JP2010254623A (ja) * | 2009-04-24 | 2010-11-11 | Takeda Chem Ind Ltd | ベンゾオキサジノン化合物の結晶 |
US9237762B2 (en) | 2010-05-24 | 2016-01-19 | Swedish Oat Fiber Ab | Aqueous dispersion comprising galactolipids and method for production thereof |
AU2012101841A4 (en) * | 2011-12-23 | 2013-01-17 | Norgine Bv | Compositions comprising cetilistat |
WO2013092786A1 (en) | 2011-12-23 | 2013-06-27 | Norgine B.V. | Compositions comprising cetilistat |
DE202012104963U1 (de) | 2012-12-19 | 2013-01-14 | Norgine B.V. | Cetilistat aufweisende Zusammensetzungen |
CN103936687B (zh) * | 2014-03-24 | 2016-03-30 | 重庆东得医药科技有限公司 | 一种制备西替利司他的方法 |
CN104374836A (zh) * | 2014-09-19 | 2015-02-25 | 安徽安科生物工程(集团)股份有限公司 | 西替利司他及有关杂质的hplc测定方法 |
CN105622538B (zh) * | 2014-10-27 | 2019-02-01 | 中国医学科学院药物研究所 | 一锅法高收率制备新利司他 |
CN104341370B (zh) * | 2014-11-11 | 2017-02-22 | 山东创新药物研发有限公司 | 一种西替利司他的制备方法 |
CN105669585A (zh) * | 2016-01-06 | 2016-06-15 | 北京修正创新药物研究院有限公司 | 一种新利司他的制备方法 |
CN105566164A (zh) * | 2016-01-06 | 2016-05-11 | 北京修正创新药物研究院有限公司 | 一种新利司他杂质的制备方法 |
WO2018011676A1 (en) * | 2016-07-11 | 2018-01-18 | Symed Labs Limited | Novel processes for the preparation of 2-oxy-benzoxazinone derivatives |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE246996C (no) | ||||
US4657893A (en) | 1984-05-09 | 1987-04-14 | Syntex (U.S.A.) Inc. | 4H-3,1-benzoxazin-4-ones and related compounds and use as enzyme inhibitors |
US4745116A (en) | 1985-06-25 | 1988-05-17 | Syntex (U.S.A.) Inc. | 2-oxy-4H-3,1-benzoxazin-4-ones and related compounds and pharmaceutical use |
US4665070A (en) * | 1985-06-25 | 1987-05-12 | Syntex (U.S.A.) Inc. | 2-oxy-4H-3,1-benzoxazin-4-ones and pharmaceutical use |
DD246996A1 (de) * | 1986-02-26 | 1987-06-24 | Univ Leipzig | Verfahren zur herstellung von gegebenenfalls substituierten 2-alkoxy- bzw. 2-aroxy-3,1-benzoxazin-4-onen |
CA1309556C (en) * | 1987-06-09 | 1992-10-27 | Masayuki Kokubo | 4h-3,1-benzoxazin-4-one compounds and pharmaceutical composition thereoffor the inhibition of serine proteases |
US5652237A (en) | 1994-09-09 | 1997-07-29 | Warner-Lambert Company | 2-substituted-4H-3, 1-benzoxazin-4-ones and benzthiazin-4-ones as inhibitors of complement C1r protease for the treatment of inflammatory processes |
US5985872A (en) * | 1995-05-24 | 1999-11-16 | G.D. Searle & Co. | 2-amino-benzoxazinones for the treatment of viral infections |
US5776756A (en) * | 1995-08-31 | 1998-07-07 | Toyo Hakko Co., Ltd. | Fermentation compositions having superoxide dismutating activity and an antihypertensive agent for treatment of constipation each having the superoxide dismutating activity |
US6139833A (en) * | 1997-08-08 | 2000-10-31 | Lexicon Genetics Incorporated | Targeted gene discovery |
US6207371B1 (en) * | 1996-10-04 | 2001-03-27 | Lexicon Genetics Incorporated | Indexed library of cells containing genomic modifications and methods of making and utilizing the same |
US6136566A (en) * | 1996-10-04 | 2000-10-24 | Lexicon Graphics Incorporated | Indexed library of cells containing genomic modifications and methods of making and utilizing the same |
EP1124807A1 (en) * | 1997-10-27 | 2001-08-22 | Dr. Reddy's Research Foundation | Novel heterocyclic compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them |
US6080576A (en) * | 1998-03-27 | 2000-06-27 | Lexicon Genetics Incorporated | Vectors for gene trapping and gene activation |
AR022204A1 (es) * | 1999-01-08 | 2002-09-04 | Norgine Bv | Compuesto, proceso para su preparacion, composicion farmaceutica y producto comestible que lo comprende. |
-
2000
- 2000-01-05 AR ARP000100030A patent/AR022204A1/es not_active Application Discontinuation
- 2000-01-06 DE DE60019555T patent/DE60019555C5/de not_active Expired - Lifetime
- 2000-01-06 AT AT00900082T patent/ATE293447T1/de active IP Right Maintenance
- 2000-01-06 CA CA002359819A patent/CA2359819C/en not_active Expired - Fee Related
- 2000-01-06 PT PT00900082T patent/PT1143977E/pt unknown
- 2000-01-06 CN CNB008036225A patent/CN1315813C/zh not_active Expired - Lifetime
- 2000-01-06 CN CN2005101250838A patent/CN1915981B/zh not_active Expired - Lifetime
- 2000-01-06 AU AU18846/00A patent/AU765147C/en not_active Expired
- 2000-01-06 ES ES00900082T patent/ES2240052T7/es active Active
- 2000-01-06 SI SI200030683T patent/SI1143977T1/xx unknown
- 2000-01-06 NZ NZ512740A patent/NZ512740A/en not_active IP Right Cessation
- 2000-01-06 HU HU0105003A patent/HUP0105003A3/hu unknown
- 2000-01-06 MY MYPI20000057A patent/MY122578A/en unknown
- 2000-01-06 DK DK00900082T patent/DK1143977T3/da active
- 2000-01-06 JP JP2000592004A patent/JP3822439B2/ja not_active Expired - Fee Related
- 2000-01-06 RU RU2001123171/04A patent/RU2245331C2/ru not_active IP Right Cessation
- 2000-01-06 MX MXPA01006921A patent/MXPA01006921A/es active IP Right Grant
- 2000-01-06 WO PCT/GB2000/000032 patent/WO2000040247A1/en active IP Right Grant
- 2000-01-06 PL PL385853A patent/PL207383B1/pl unknown
- 2000-01-06 CH CH00900082T patent/CH1143977H1/fr unknown
- 2000-01-06 EP EP00900082A patent/EP1143977B3/en not_active Expired - Lifetime
- 2000-01-06 KR KR1020017008576A patent/KR100678998B1/ko active IP Right Review Request
-
2001
- 2001-07-06 US US09/901,887 patent/US6624161B2/en not_active Expired - Lifetime
- 2001-07-06 NO NO20013381A patent/NO333922B1/no not_active IP Right Cessation
-
2002
- 2002-11-27 US US10/306,377 patent/US7825113B2/en not_active Expired - Fee Related
- 2002-12-13 HK HK02109053.3A patent/HK1047588B/zh not_active IP Right Cessation
-
2007
- 2007-07-27 HK HK07108198.6A patent/HK1103928A1/xx not_active IP Right Cessation
-
2008
- 2008-03-07 US US12/044,318 patent/US7858617B2/en not_active Expired - Fee Related
-
2010
- 2010-11-23 US US12/952,972 patent/US8877750B2/en not_active Expired - Fee Related
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