NO20005539L - Infraröd matriksassistert laserdesorpsjon/ionisering massespektrometrisk analyse av makromolekyler - Google Patents

Infraröd matriksassistert laserdesorpsjon/ionisering massespektrometrisk analyse av makromolekyler

Info

Publication number
NO20005539L
NO20005539L NO20005539A NO20005539A NO20005539L NO 20005539 L NO20005539 L NO 20005539L NO 20005539 A NO20005539 A NO 20005539A NO 20005539 A NO20005539 A NO 20005539A NO 20005539 L NO20005539 L NO 20005539L
Authority
NO
Norway
Prior art keywords
macromolecules
mass spectrometric
laser desorption
assisted laser
ionization mass
Prior art date
Application number
NO20005539A
Other languages
English (en)
Norwegian (no)
Other versions
NO20005539D0 (no
Inventor
Franz Hillenkamp
Hubert Koester
Original Assignee
Sequenom Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sequenom Inc filed Critical Sequenom Inc
Publication of NO20005539D0 publication Critical patent/NO20005539D0/no
Publication of NO20005539L publication Critical patent/NO20005539L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/161—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission using photoionisation, e.g. by laser
    • H01J49/164—Laser desorption/ionisation, e.g. matrix-assisted laser desorption/ionisation [MALDI]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
    • B82B3/00—Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6872—Methods for sequencing involving mass spectrometry
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25875—Gaseous sample or with change of physical state

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Plasma & Fusion (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Nanotechnology (AREA)
  • Manufacturing & Machinery (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
NO20005539A 1998-05-07 2000-11-02 Infraröd matriksassistert laserdesorpsjon/ionisering massespektrometrisk analyse av makromolekyler NO20005539L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/074,936 US6723564B2 (en) 1998-05-07 1998-05-07 IR MALDI mass spectrometry of nucleic acids using liquid matrices
PCT/US1999/010251 WO1999057318A2 (fr) 1998-05-07 1999-05-07 Analyse de molecules par spectrometrie de masse a desorption/ionisation par laser, assistee par matrice absorbant l'infrarouge

Publications (2)

Publication Number Publication Date
NO20005539D0 NO20005539D0 (no) 2000-11-02
NO20005539L true NO20005539L (no) 2001-01-05

Family

ID=22122547

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20005539A NO20005539L (no) 1998-05-07 2000-11-02 Infraröd matriksassistert laserdesorpsjon/ionisering massespektrometrisk analyse av makromolekyler

Country Status (9)

Country Link
US (3) US6723564B2 (fr)
EP (1) EP1075545A2 (fr)
JP (1) JP2002513917A (fr)
KR (1) KR20010043409A (fr)
AU (1) AU3896799A (fr)
CA (1) CA2328110A1 (fr)
DE (1) DE19983215T1 (fr)
NO (1) NO20005539L (fr)
WO (1) WO1999057318A2 (fr)

Families Citing this family (232)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5605798A (en) * 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
US5777324A (en) 1996-09-19 1998-07-07 Sequenom, Inc. Method and apparatus for maldi analysis
US7285422B1 (en) 1997-01-23 2007-10-23 Sequenom, Inc. Systems and methods for preparing and analyzing low volume analyte array elements
ATE319855T1 (de) 1996-12-10 2006-03-15 Sequenom Inc Abspaltbare, nicht-flüchtige moleküle zur massenmarkierung
US20110166040A1 (en) * 1997-09-05 2011-07-07 Ibis Biosciences, Inc. Compositions for use in identification of strains of e. coli o157:h7
US20020009394A1 (en) 1999-04-02 2002-01-24 Hubert Koster Automated process line
US6869572B1 (en) * 1999-09-13 2005-03-22 Millipore Corporation High density cast-in-place sample preparation card
US7917301B1 (en) 2000-09-19 2011-03-29 Sequenom, Inc. Method and device for identifying a biological sample
US7668658B2 (en) * 1999-10-13 2010-02-23 Sequenom, Inc. Methods for generating databases and databases for identifying polymorphic genetic markers
ATE444532T1 (de) 1999-10-13 2009-10-15 Sequenom Inc Verfahren zur identifizierung von polymorphen genetischen markern
EP1679381A1 (fr) * 2000-06-08 2006-07-12 Xiao Bing Wang Procédé d'extension d'amorce isomère et trousse pour la détection et la quantification des acides nucléiques spécifiques
US6824980B2 (en) * 2000-06-08 2004-11-30 Xiao Bing Wang Isometric primer extension method and kit for detection and quantification of specific nucleic acid
DE10029914A1 (de) * 2000-06-19 2002-01-03 Epigenomics Ag Verfahren zur hochparallelen Analyse von Polymorphismen
DE60135549D1 (de) 2000-06-19 2008-10-09 Correlogic Systems Inc Heuristisches klassifikationsverfahren
US6680203B2 (en) 2000-07-10 2004-01-20 Esperion Therapeutics, Inc. Fourier transform mass spectrometry of complex biological samples
AU2001280581A1 (en) 2000-07-18 2002-01-30 Correlogic Systems, Inc. A process for discriminating between biological states based on hidden patterns from biological data
WO2002014849A1 (fr) 2000-08-16 2002-02-21 Vanderbilt University Systeme et procede de spectrometrie de masse a desorption-ionisation par impact laser assistee par matrice dans des gels de polyacrylamide
US20020195555A1 (en) * 2000-10-11 2002-12-26 Weinberger Scot R. Apparatus and methods for affinity capture tandem mass spectrometry
CA2425434A1 (fr) * 2000-10-11 2002-04-18 Tina Morris Procedes de caracterisation d'interactions moleculaires au moyen de la spectrometrie de masse en tandem pour capture par affinite
JP4015946B2 (ja) * 2000-10-30 2007-11-28 シークエノム・インコーポレーテツド 基板上にサブマイクロリットルの体積を供給する方法及び装置
AU4153502A (en) * 2000-11-16 2002-06-03 Ciphergen Biosystems Inc Method for analyzing mass spectra
WO2002048399A2 (fr) * 2000-12-13 2002-06-20 Institut für Physikalische Hochtechnologie e.V. Procede de coupes simultanees a position specifique de chaines moleculaires organiques filiformes, en particulier d'adn
AU2002245345A1 (en) 2001-01-30 2002-08-12 Board Of Trustees Operating Michigan State University Control system and apparatus for use with laser excitation or ionization
US7609731B2 (en) 2001-01-30 2009-10-27 Board Of Trustees Operating Michigan State University Laser system using ultra-short laser pulses
US7450618B2 (en) 2001-01-30 2008-11-11 Board Of Trustees Operating Michigan State University Laser system using ultrashort laser pulses
US7567596B2 (en) 2001-01-30 2009-07-28 Board Of Trustees Of Michigan State University Control system and apparatus for use with ultra-fast laser
GB0103516D0 (en) * 2001-02-13 2001-03-28 Cole Polytechnique Federale De Apparatus for dispensing a sample
AU2002240423B2 (en) 2001-02-14 2006-03-09 Picoliter Inc. Acoustic sample introduction for analysis and/or processing
US6707038B2 (en) * 2001-02-14 2004-03-16 Picoliter Inc. Method and system using acoustic ejection for selective fluid deposition on a nonuniform sample surface
US7026163B1 (en) 2001-02-23 2006-04-11 Mayo Foundation For Medical Education And Research Sulfotransferase sequence variants
US7718354B2 (en) 2001-03-02 2010-05-18 Ibis Biosciences, Inc. Methods for rapid identification of pathogens in humans and animals
US7226739B2 (en) 2001-03-02 2007-06-05 Isis Pharmaceuticals, Inc Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations
US20040121309A1 (en) 2002-12-06 2004-06-24 Ecker David J. Methods for rapid detection and identification of bioagents in blood, bodily fluids, and bodily tissues
US20030027135A1 (en) 2001-03-02 2003-02-06 Ecker David J. Method for rapid detection and identification of bioagents
WO2004060278A2 (fr) 2002-12-06 2004-07-22 Isis Pharmaceuticals, Inc. Procedes d'identification rapide de pathogenes chez l'homme et les betes
US20040121314A1 (en) * 2002-12-06 2004-06-24 Ecker David J. Methods for rapid detection and identification of bioagents in containers
US7666588B2 (en) 2001-03-02 2010-02-23 Ibis Biosciences, Inc. Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy
US20030036057A1 (en) * 2001-03-09 2003-02-20 Andreas Braun Genes and polymorphisms associated with cardiovascular disease and their use
EP1386343B1 (fr) * 2001-03-19 2012-10-24 Gyros Patent Ab Systeme microfluide pour spectrometrie de masse avec desorption / ionisation energetique
KR20030031911A (ko) * 2001-04-19 2003-04-23 싸이퍼젠 바이오시스템즈, 인코포레이티드 질량 분석법과 친화성 태그를 이용한 생물분자 특성화
US20020155587A1 (en) 2001-04-20 2002-10-24 Sequenom, Inc. System and method for testing a biological sample
GB0110030D0 (en) * 2001-04-24 2001-06-13 Grosveld Frank RNA genomics
US7056731B1 (en) 2001-06-22 2006-06-06 Mayo Foundation For Medical Education And Research Sulfotransferase SULT2A1 sequence variants
US7217510B2 (en) 2001-06-26 2007-05-15 Isis Pharmaceuticals, Inc. Methods for providing bacterial bioagent characterizing information
US8073627B2 (en) 2001-06-26 2011-12-06 Ibis Biosciences, Inc. System for indentification of pathogens
WO2004050830A2 (fr) * 2001-08-30 2004-06-17 Science And Technology Corporation @ University Of New Mexico Methodes destinees a la fixation covalente de proteines a des substrats
EP1451674A4 (fr) * 2001-10-26 2008-08-20 Sequenom Inc Procede et appareil de distribution parallele de volumes precis de particules solides
US7186551B1 (en) 2001-11-14 2007-03-06 Mayo Foundation For Medical Education And Research 3′-phosphoadenosine -5′-phosphosulfate synthetase 2 (PAPSS2) sequence variants
US7067311B1 (en) 2001-11-14 2006-06-27 Mayo Foundation For Medical Education And Research 3′-phosphoadenosine-5′-phosphosulfate synthetase 1 (PAPSS1) sequence variants
EP1465720A4 (fr) * 2001-12-19 2010-05-12 Biogen Idec Inc Procedes pour detecter des demi-anticorps par mise en oeuvre d'une electrophorese sur gel sur circuits integres
US7288641B1 (en) 2002-01-30 2007-10-30 Mayo Foundation For Medical Education And Research Sulfotransferase 1E1 sequence variants
US20020193950A1 (en) * 2002-02-25 2002-12-19 Gavin Edward J. Method for analyzing mass spectra
US6881950B2 (en) * 2002-04-12 2005-04-19 University Of South Florida Method for producing a three-dimensional macro-molecular structure
EP1501863A4 (fr) * 2002-05-03 2007-01-24 Sequenom Inc Muteines de proteines d'ancrage de kinase, leurs peptides, et procedes associes
US20040224329A1 (en) * 2003-05-08 2004-11-11 Gjerde Douglas T. Three-dimensional solid phase extraction surfaces
TW200403434A (en) * 2002-07-29 2004-03-01 Correlogic Systems Inc Quality assurance/quality control for electrospray ionization processes
CN102344960B (zh) 2002-09-06 2014-06-18 波士顿大学信托人 基因表达的定量
US7833802B2 (en) * 2002-11-21 2010-11-16 Ada Technologies, Inc. Stroboscopic liberation and methods of use
US7597936B2 (en) * 2002-11-26 2009-10-06 University Of Utah Research Foundation Method of producing a pigmented composite microporous material
AU2003298733B2 (en) 2002-11-27 2009-06-18 Agena Bioscience, Inc. Fragmentation-based methods and systems for sequence variation detection and discovery
JP3928043B2 (ja) * 2002-11-29 2007-06-13 独立行政法人産業技術総合研究所 生体高分子光切断装置および生体高分子光切断方法
GB0229337D0 (en) * 2002-12-17 2003-01-22 Amersham Biosciences Ab Method and system for mass spectrometry
US7371523B1 (en) 2003-01-09 2008-05-13 Mayo Foundation For Medical Education And Research Phenylethanolamine-N-methyltransferase sequence variants
SG153699A1 (en) 2003-01-16 2009-07-29 Caprotec Bioanalytics Gmbh Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
US7425624B1 (en) 2003-01-21 2008-09-16 Mayo Foundation For Medical Education And Research Sulfotransferase 1A3 sequence variants
WO2004072268A2 (fr) 2003-02-12 2004-08-26 Mayo Foundation For Medical Education And Research Pkhdl1, homologue du gene de la maladie renale autosomique recessive
US6956208B2 (en) * 2003-03-17 2005-10-18 Indiana University Research And Technology Corporation Method and apparatus for controlling position of a laser of a MALDI mass spectrometer
EP1604381A2 (fr) * 2003-03-17 2005-12-14 Indiana University Research and Technology Corporation Spectrometre de masse de desorption-ionisation par impact laser assistee par matrice (maldi) comportant un ensemble d'orientation et son procede de fonctionnement
US20040183009A1 (en) * 2003-03-17 2004-09-23 Reilly James P. MALDI mass spectrometer having a laser steering assembly and method of operating the same
US6977370B1 (en) * 2003-04-07 2005-12-20 Ciphergen Biosystems, Inc. Off-resonance mid-IR laser desorption ionization
US7250290B1 (en) 2003-04-15 2007-07-31 Mayo Foundation For Medical Education And Research Arsenic methyltransferase sequence variants
US8046171B2 (en) 2003-04-18 2011-10-25 Ibis Biosciences, Inc. Methods and apparatus for genetic evaluation
US8057993B2 (en) 2003-04-26 2011-11-15 Ibis Biosciences, Inc. Methods for identification of coronaviruses
WO2004097395A1 (fr) * 2003-04-30 2004-11-11 Sumitomo Chemical Company, Limited Matrice pour l'analyse de masse par ionisation par desorption laser assistee par matrice (maldi)
US8158354B2 (en) 2003-05-13 2012-04-17 Ibis Biosciences, Inc. Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US7964343B2 (en) 2003-05-13 2011-06-21 Ibis Biosciences, Inc. Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
WO2004109254A2 (fr) * 2003-06-06 2004-12-16 Ionwerks Matrices maldi a base de fullerene pour peptides et proteines
DK1660680T3 (da) 2003-07-31 2009-06-22 Sequenom Inc Fremgangsmåde til multipleks-polymerasekædereaktioner på höjt niveau og homogene masseforlængelsesreaktioner til genotypebestemmelse af polymorfismer
EA200600346A1 (ru) * 2003-08-01 2006-08-25 Коррелоджик Системз, Инк. Множественные протеомные свойства сыворотки, полученные с помощью спектрометрии с высоким разрешением, для выявления рака яичников
WO2005024068A2 (fr) * 2003-09-05 2005-03-17 Sequenom, Inc. Analyse de variations de sequences alleles specifiques
US20120122102A1 (en) 2003-09-11 2012-05-17 Rangarajan Sampath Compositions for use in identification of bacteria
US20060240412A1 (en) * 2003-09-11 2006-10-26 Hall Thomas A Compositions for use in identification of adenoviruses
US8097416B2 (en) 2003-09-11 2012-01-17 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US20080138808A1 (en) * 2003-09-11 2008-06-12 Hall Thomas A Methods for identification of sepsis-causing bacteria
US20100129811A1 (en) * 2003-09-11 2010-05-27 Ibis Biosciences, Inc. Compositions for use in identification of pseudomonas aeruginosa
US8546082B2 (en) 2003-09-11 2013-10-01 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
WO2005052567A1 (fr) * 2003-11-24 2005-06-09 Biogen Idec Ma Inc. Procedes de detection de demi-anticorps par electrophorese sur gel sur puce
JP4774534B2 (ja) * 2003-12-11 2011-09-14 アングーク ファーマシューティカル カンパニー，リミティド 集中化適応モデル及び遠隔操作サンプルプロセッシングの使用を介した生物学的状態の診断方法
WO2005069934A2 (fr) * 2004-01-20 2005-08-04 Mcw Research Foundation, Inc. Identification de peptides
US7666592B2 (en) * 2004-02-18 2010-02-23 Ibis Biosciences, Inc. Methods for concurrent identification and quantification of an unknown bioagent
US7588906B2 (en) * 2004-02-24 2009-09-15 Wisconsin Alumni Research Foundation Hydrogels for biomolecule analysis and corresponding method to analyze biomolecules
US8119336B2 (en) 2004-03-03 2012-02-21 Ibis Biosciences, Inc. Compositions for use in identification of alphaviruses
EP1727911B1 (fr) 2004-03-26 2013-01-23 Sequenom, Inc. Clivage specifique de base de produits d'amplification specifique a la methylation en combinaison avec une analyse de masse
WO2005117270A2 (fr) 2004-05-24 2005-12-08 Isis Pharmaceuticals, Inc. Spectrometrie de masse a filtration ionique selective par seuillage numerique
US20050266411A1 (en) 2004-05-25 2005-12-01 Hofstadler Steven A Methods for rapid forensic analysis of mitochondrial DNA
US7785843B2 (en) 2004-06-23 2010-08-31 Sequenom, Inc. Target-specific compomers and methods of use
US7811753B2 (en) 2004-07-14 2010-10-12 Ibis Biosciences, Inc. Methods for repairing degraded DNA
NZ582466A (en) 2004-07-30 2011-09-30 Adeza Biomedical Corp Oncofetal fibronectin as a marker for disease and other conditions and methods for detection of oncofetal fibronectin
US7309589B2 (en) * 2004-08-20 2007-12-18 Vironix Llc Sensitive detection of bacteria by improved nested polymerase chain reaction targeting the 16S ribosomal RNA gene and identification of bacterial species by amplicon sequencing
WO2006135400A2 (fr) 2004-08-24 2006-12-21 Isis Pharmaceuticals, Inc. Procedes pour l'identification rapide d'organismes recombinants
JP2008512129A (ja) * 2004-09-10 2008-04-24 セクエノム，インコーポレイティド 核酸の広範囲配列分析法
WO2006037059A2 (fr) * 2004-09-27 2006-04-06 The Johns Hopkins Universtiy Systeme de spectrometrie de masse de point d'intervention
JP2008517608A (ja) 2004-10-22 2008-05-29 レビビコア， インコーポレイテッド 遺伝子改変された免疫系を有する有蹄動物
US20070003996A1 (en) * 2005-02-09 2007-01-04 Hitt Ben A Identification of bacteria and spores
US8084207B2 (en) 2005-03-03 2011-12-27 Ibis Bioscience, Inc. Compositions for use in identification of papillomavirus
WO2006094238A2 (fr) 2005-03-03 2006-09-08 Isis Pharmaceuticals, Inc. Compositions utilisees pour identifier des virus secondaires
ATE508208T1 (de) 2005-03-08 2011-05-15 Postech Foundation Verfahren zur de-novo-peptidsequenzierung mittels maldi-massenspektrometrie
US8377711B2 (en) * 2005-04-04 2013-02-19 Ada Technologies, Inc. Stroboscopic liberation and methods of use
US7709204B2 (en) 2005-04-29 2010-05-04 Mayo Foundation For Medical Education And Research Assessing brain aneurysms
US20060252081A1 (en) * 2005-05-06 2006-11-09 Applera Corporation PNA probes, mixtures, methods and kits pertaining to the determination of Mycoplasma and related Mollicutes
US20080312514A1 (en) * 2005-05-12 2008-12-18 Mansfield Brian C Serum Patterns Predictive of Breast Cancer
US7390894B2 (en) 2005-07-07 2008-06-24 Mayo Foundation For Medical Education And Research Glutathione S-transferase sequence variants
US7858306B2 (en) 2005-07-07 2010-12-28 Mayo Foundation For Medical Education And Research HSD3B1 sequence variants
JP2009502137A (ja) 2005-07-21 2009-01-29 アイシス ファーマシューティカルズ インコーポレイティッド 核酸変種の迅速な同定および定量のための方法
WO2007041067A2 (fr) * 2005-09-29 2007-04-12 Children's Hospital & Research Center At Oakland Procedes et compositions utiles pour le genotypage kir
US7572586B2 (en) 2005-11-01 2009-08-11 Mayo Foundation For Medical Education And Research Identifying susceptibility to cardiac hypertrophy
US20080023630A1 (en) * 2005-11-22 2008-01-31 Ciphergen Biosystems Inc. Polymer probe doped with conductive material for mass spectrometry
US20080026386A1 (en) 2006-03-31 2008-01-31 Behrens Timothy W Irf-5 haplotypes in systemic lupus erythematosus
EP2010679A2 (fr) 2006-04-06 2009-01-07 Ibis Biosciences, Inc. Compositions pour l'identification de champignons
US9018562B2 (en) 2006-04-10 2015-04-28 Board Of Trustees Of Michigan State University Laser material processing system
US8084734B2 (en) 2006-05-26 2011-12-27 The George Washington University Laser desorption ionization and peptide sequencing on laser induced silicon microcolumn arrays
CA2653974A1 (fr) 2006-05-30 2008-02-14 Mayo Foundation For Medical Education And Research Detection et traitement de la demence
DK2037948T3 (en) 2006-05-30 2016-08-01 Mayo Foundation Detection and treatment of dementia
AU2007268369A1 (en) * 2006-05-30 2007-12-06 Synergenz Bioscience Limited Methods and compositions for assessment of pulmonary function and disorders
CA2663029C (fr) 2006-09-14 2016-07-19 Ibis Biosciences, Inc. Procede d'amplification ciblee de genome entier pour l'identification d'agents pathogenes
US8758682B2 (en) 2006-09-29 2014-06-24 Ge Healthcare Bio-Sciences Ab Method and device for small scale reactions
JP2010508024A (ja) * 2006-10-26 2010-03-18 インテグレイテッド ディーエヌエイ テクノロジーズ インコーポレイテッド 複数のオリゴヌクレオチド用のフィンガープリント分析
EP1930444A1 (fr) * 2006-12-08 2008-06-11 BioSpring Gesellschaft für Biotechnologie mbH Procédé spectrométrique de masse sur des échantillons contenant des acides nucléiques
WO2008074769A1 (fr) * 2006-12-18 2008-06-26 Covalx Ag Analyse directe d'agrégats de protéines thérapeutiques par spectrométrie de masse
GB0700475D0 (en) * 2007-01-10 2007-02-21 Cole Polytechnique Federale De Ionization device
US8363215B2 (en) 2007-01-25 2013-01-29 Ada Technologies, Inc. Methods for employing stroboscopic signal amplification and surface enhanced raman spectroscopy for enhanced trace chemical detection
JP5680304B2 (ja) 2007-02-23 2015-03-04 アイビス バイオサイエンシズ インコーポレイティッド 迅速な法医学的ｄｎａ分析法
WO2008118809A1 (fr) * 2007-03-23 2008-10-02 Ibis Biosciences, Inc. Compositions utilisées pour identifier des populations mixtes d'agents biologiques
US20100291544A1 (en) * 2007-05-25 2010-11-18 Ibis Biosciences, Inc. Compositions for use in identification of strains of hepatitis c virus
US9598724B2 (en) 2007-06-01 2017-03-21 Ibis Biosciences, Inc. Methods and compositions for multiple displacement amplification of nucleic acids
EP2152897B1 (fr) 2007-06-05 2015-02-18 Melica HB Procédés et matériaux liés à la pigmentation des poils et au cancer
US20110045456A1 (en) * 2007-06-14 2011-02-24 Ibis Biosciences, Inc. Compositions for use in identification of adventitious contaminant viruses
KR101262202B1 (ko) 2007-06-29 2013-05-16 안국약품 주식회사 난소암의 예측 마커
US20090180931A1 (en) 2007-09-17 2009-07-16 Sequenom, Inc. Integrated robotic sample transfer device
US7888127B2 (en) * 2008-01-15 2011-02-15 Sequenom, Inc. Methods for reducing adduct formation for mass spectrometry analysis
US8986253B2 (en) 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
US20110097704A1 (en) * 2008-01-29 2011-04-28 Ibis Biosciences, Inc. Compositions for use in identification of picornaviruses
DE102008007112B3 (de) * 2008-01-31 2009-08-06 Johann Wolfgang Goethe-Universität Frankfurt am Main Verfahren zur Sequenzierung eines RNA-Moleküls mittels Massenspektrometrie
WO2009094784A1 (fr) * 2008-01-31 2009-08-06 Mds Analytical Technologies, A Business Unit Of Mds Inc., Doing Business Through Its Sciex Division Dépistage à haut débit de perturbation du métabolisme à l'aide d'une source d'ions à désorption laser couplée à un analyseur de masse
US20110177515A1 (en) * 2008-05-30 2011-07-21 Ibis Biosciences, Inc. Compositions for use in identification of francisella
WO2009155103A2 (fr) * 2008-05-30 2009-12-23 Ibis Biosciences, Inc. Compositions destinées à être utilisées dans l’identification de pathogènes transmis par les tiques
US20110151437A1 (en) * 2008-06-02 2011-06-23 Ibis Biosciences, Inc. Compositions for use in identification of adventitious viruses
WO2010033599A2 (fr) 2008-09-16 2010-03-25 Ibis Biosciences, Inc. Cartouches de mélange, postes de mélange et kits, systèmes et procédés associés
US8476013B2 (en) 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
EP2347254A2 (fr) 2008-09-16 2011-07-27 Ibis Biosciences, Inc. Unités de traitement d'échantillons, systèmes et procédés associés
US8408421B2 (en) 2008-09-16 2013-04-02 Tandem Diabetes Care, Inc. Flow regulating stopcocks and related methods
EP2344893B1 (fr) 2008-09-16 2014-10-15 Ibis Biosciences, Inc. Systèmes et procédés de manipulation de microplaques
US8962247B2 (en) 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
WO2010033878A2 (fr) 2008-09-19 2010-03-25 David Brown Dispositif de mesure de la concentration d’un soluté et procédés associés
WO2010036965A2 (fr) 2008-09-25 2010-04-01 Suregene Llc Marqueurs génétiques d'endophénotypes de la schizophrénie
US20110189687A1 (en) * 2008-10-02 2011-08-04 Ibis Bioscience, Inc. Compositions for use in identification of members of the bacterial genus mycoplasma
US20110200985A1 (en) * 2008-10-02 2011-08-18 Rangarajan Sampath Compositions for use in identification of herpesviruses
US20110183346A1 (en) * 2008-10-03 2011-07-28 Ibis Biosciences, Inc. Compositions for use in identification of neisseria, chlamydia, and/or chlamydophila bacteria
WO2010039787A1 (fr) * 2008-10-03 2010-04-08 Ibis Biosciences, Inc. Compositions destinées à identifier clostridium difficile
WO2010039848A2 (fr) * 2008-10-03 2010-04-08 Ibis Biosciences, Inc. Compositions pour utilisation dans l’identification de streptococcus pneumoniae
WO2010039763A2 (fr) * 2008-10-03 2010-04-08 Ibis Biosciences, Inc. Compositions à utiliser pour l'identification de bactéries résistant aux antibiotiques
WO2010039775A1 (fr) * 2008-10-03 2010-04-08 Ibis Biosciences, Inc. Compositions destinées à identifier des membres de la classe bactérienne des alphaproteobacter
WO2010051288A1 (fr) 2008-10-27 2010-05-06 Revivicor, Inc. Ongulés immunodéprimés
US9202678B2 (en) 2008-11-14 2015-12-01 Board Of Trustees Of Michigan State University Ultrafast laser system for biological mass spectrometry
US8110796B2 (en) 2009-01-17 2012-02-07 The George Washington University Nanophotonic production, modulation and switching of ions by silicon microcolumn arrays
US8268264B2 (en) * 2009-02-09 2012-09-18 Caprotec Bioanalytics Gmbh Devices, systems and methods for separating magnetic particles
EP2396803A4 (fr) 2009-02-12 2016-10-26 Ibis Biosciences Inc Ensembles sonde d'ionisation
DE102009011653B4 (de) * 2009-03-04 2011-12-15 Bruker Daltonik Gmbh Lasersystem für MALDI-Massenspektrometrie
GB2468394B (en) * 2009-03-04 2015-05-13 Bruker Daltonik Gmbh Laser system for maldi mass spectrometry
WO2010141128A2 (fr) 2009-03-05 2010-12-09 Board Of Trustees Of Michigan State University Système d'amplification laser
US9719083B2 (en) 2009-03-08 2017-08-01 Ibis Biosciences, Inc. Bioagent detection methods
DE102009013914B4 (de) * 2009-03-19 2011-05-05 Bruker Daltonik Gmbh Kalibriersubstanzen für Atmosphärendruck-Ionenquellen
US9393564B2 (en) 2009-03-30 2016-07-19 Ibis Biosciences, Inc. Bioagent detection systems, devices, and methods
US9490113B2 (en) 2009-04-07 2016-11-08 The George Washington University Tailored nanopost arrays (NAPA) for laser desorption ionization in mass spectrometry
WO2010141763A1 (fr) * 2009-06-03 2010-12-09 Wayne State University Spectrométrie de masse utilisant une technique d'ionisation par pulvérisation laser
US20120108514A1 (en) 2009-07-09 2012-05-03 University Of Iowa Research Foundation Long acting atrial natriuretic peptide (la-anp) and methods for use thereof
EP2454000A4 (fr) 2009-07-17 2016-08-10 Ibis Biosciences Inc Systèmes pour l'identification d'un bioagent
WO2011008971A1 (fr) 2009-07-17 2011-01-20 Ibis Biosciences, Inc. Appareil de levage et de montage
EP2932994B1 (fr) 2009-07-30 2017-11-08 Tandem Diabetes Care, Inc. Nouveau joint torique, mécanisme de distribution et système de pompe de perfusion portable qui lui sont associés
WO2011014811A1 (fr) 2009-07-31 2011-02-03 Ibis Biosciences, Inc. Amorces de capture et supports solides liés à une séquence de capture pour tests diagnostiques moléculaires
WO2011017656A2 (fr) 2009-08-06 2011-02-10 Ibis Biosciences, Inc. Compositions de base déterminées non massiques pour détection d'acide nucléique
US20110065111A1 (en) * 2009-08-31 2011-03-17 Ibis Biosciences, Inc. Compositions For Use In Genotyping Of Klebsiella Pneumoniae
US20110091882A1 (en) * 2009-10-02 2011-04-21 Ibis Biosciences, Inc. Determination of methylation status of polynucleotides
EP3225695A1 (fr) 2009-10-15 2017-10-04 Ibis Biosciences, Inc. Amplification de déplacement multiple
CN101710097B (zh) * 2009-12-02 2012-11-07 中国科学院长春应用化学研究所 用基质辅助激光解吸质谱检测乌头碱体外代谢产物的方法
DK2516680T3 (en) 2009-12-22 2016-05-02 Sequenom Inc Method and kits to identify aneuploidy
US10273544B2 (en) 2010-02-11 2019-04-30 Dana-Farber Cancer Institute, Inc. Methods for predicting likelihood of responding to treatment
WO2011115840A2 (fr) * 2010-03-14 2011-09-22 Ibis Biosciences, Inc. Recherche de parasites par le biais de la recherche d'endosymbiotes
US8563705B2 (en) 2010-05-12 2013-10-22 Mayo Foundation For Medical Education And Research Ribonucleic acid binding motif protein 20 sequence variants
US20120021928A1 (en) 2010-06-18 2012-01-26 Kerstin Lindblad-Toh Genetic risk assessment for shar-pei fever
US10041948B2 (en) 2010-10-12 2018-08-07 Mayo Foundation For Medical Education And Research Materials and methods for determining cancer risk
JP5995956B2 (ja) 2011-03-26 2016-09-21 フォルム ファーマシューティカルズ、インコーポレイテッド 前頭側頭葉変性症の標的治療の方法
US8642951B2 (en) 2011-05-04 2014-02-04 Agilent Technologies, Inc. Device, system, and method for reflecting ions
HUE042817T2 (hu) 2011-06-28 2019-07-29 Codexis Inc Fehérjevariánsok elõállítása régiókeveréssel
WO2013032784A1 (fr) 2011-08-30 2013-03-07 Mayo Foundation For Medical Education And Research Polypeptides natriurétiques
CN103827303B (zh) 2011-09-26 2021-10-22 普瑞阿那利提克斯有限公司 细胞外核酸的稳定化和分离
CN103827322B (zh) 2011-09-26 2017-05-31 凯杰有限公司 细胞外核酸的稳定化和分离
US11021733B2 (en) 2011-09-26 2021-06-01 Qiagen Gmbh Stabilization and isolation of extracellular nucleic acids
WO2013103896A1 (fr) 2012-01-06 2013-07-11 Mayo Foundation For Medical Education And Research Traitement de maladies cardiovasculaires ou rénales
ES2930180T3 (es) 2012-03-02 2022-12-07 Sequenom Inc Métodos para enriquecer ácido nucleico canceroso a partir de una muestra biológica
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
US8735091B2 (en) * 2012-05-17 2014-05-27 Biomerieux, Inc. Methods for inactivation and extraction of acid-fast bacteria for characterization and/or identification using mass spectrometry
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
US10504613B2 (en) 2012-12-20 2019-12-10 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9238100B2 (en) 2012-06-07 2016-01-19 Tandem Diabetes Care, Inc. Device and method for training users of ambulatory medical devices
JP2015521862A (ja) 2012-07-13 2015-08-03 セクエノム， インコーポレイテッド 非侵襲性の出生前診断に有用な母体サンプル由来の胎児核酸のメチル化に基づく富化のためのプロセスおよび組成物
AU2013322643C1 (en) 2012-09-25 2018-11-08 Qiagen Gmbh Stabilisation of biological samples
JP5999699B2 (ja) * 2012-11-16 2016-09-28 国立研究開発法人理化学研究所 タンパク質定量方法
US9305756B2 (en) 2013-03-13 2016-04-05 Agena Bioscience, Inc. Preparation enhancements and methods of use for MALDI mass spectrometry
EP3597774A1 (fr) 2013-03-13 2020-01-22 Sequenom, Inc. Amorces pour analyse de la méthylation de l'adn
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
CN105283550A (zh) 2013-03-18 2016-01-27 凯杰有限公司 生物样品的稳定化
US20160281133A1 (en) * 2013-03-18 2016-09-29 Qiagen Gmbh Stabilization and isolation of extracellular nucleic acids
JP5949644B2 (ja) * 2013-04-09 2016-07-13 株式会社島津製作所 Ｍａｌｄｉ質量分析方法
CN103760184A (zh) * 2014-01-16 2014-04-30 江南大学 一种测定铅离子的磁共振成像传感器的构建方法
EP3117011B1 (fr) 2014-03-13 2020-05-06 Sequenom, Inc. Méthodes et procédés d'évaluation non invasive de variations génétiques
WO2015175846A2 (fr) 2014-05-16 2015-11-19 University Of Massachusetts Traitement de la leucémie myéloïde chronique (lmc)
RS59158B9 (sr) 2015-08-17 2020-09-30 Kura Oncology Inc Postupci lečenja pacijenata obolelih od kancera pomoću inhibitora farneziltransferaze
AU2016312197B2 (en) 2015-08-24 2022-08-18 Biomerieux, Inc. Methods for inactivation and extraction of acid-fast bacteria from liquid media for characterization and/or identification using mass spectrometry
CA3005694A1 (fr) 2015-11-20 2017-05-26 Qiagen Gmbh Procede de preparation de compositions sterilisees d'acides nucleiques extracellulaires
CN105548340B (zh) * 2016-02-23 2018-01-23 武汉大学 黑磷在基质辅助激光解吸电离飞行时间质谱中的应用
GB201609952D0 (en) * 2016-06-07 2016-07-20 Micromass Ltd Combined optical and mass spectral tissue ID probes
CA2937046A1 (fr) 2016-07-25 2018-01-25 Kresimir Franjic Methode de preparation de couches d'echantillons minces
WO2019169163A1 (fr) * 2018-02-28 2019-09-06 Northeastern University Jettison-ms pour espèce d'acide nucléique
AU2019237541A1 (en) 2018-03-23 2020-10-08 Editas Medicine, Inc. CRISPR/Cas9-mediated exon-skipping approach for USH2A-associated Usher syndrome
JP7386174B2 (ja) 2018-03-27 2023-11-24 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム Ｈｅｒ２エクソン１９変異を有するがん細胞に対する抗腫瘍活性を有する化合物
JP7556502B2 (ja) 2019-05-09 2024-09-26 フジフィルム セルラー ダイナミクス，インコーポレイテッド ヘパトサイトの作製方法
CN112337414A (zh) 2019-08-09 2021-02-09 胡桃钳医疗公司 微流体设备及其使用方法
US20220380765A1 (en) 2019-11-02 2022-12-01 Board Of Regents, The University Of Texas System Targeting nonsense-mediated decay to activate p53 pathway for the treatment of cancer
JP7384358B2 (ja) * 2020-04-27 2023-11-21 株式会社島津製作所 有機化合物の構造解析方法
CN112649489A (zh) * 2020-09-27 2021-04-13 浙江迪谱诊断技术有限公司 一种核酸质谱离子净化方法
JPWO2023234373A1 (fr) * 2022-05-31 2023-12-07

Family Cites Families (161)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3568735A (en) 1968-06-26 1971-03-09 Cooke Eng Co Laboratory microtitration dispensing apparatus
CH543306A (de) 1971-10-13 1973-10-31 Hoffmann La Roche Mikropipettiergerät
US3776700A (en) 1971-12-08 1973-12-04 Linbro Chem Co Inc Serial dilution apparatus
US3843443A (en) 1973-03-30 1974-10-22 J Fishman Polypeptide materials bound to fluorocarbon polymers
US5283342A (en) 1992-06-09 1994-02-01 Neorx Corporation Biotinylated small molecules
US3999689A (en) 1976-01-07 1976-12-28 Ciantro Steven V Device for simultaneously delivering equal amounts of liquid
DE2739829C2 (de) 1977-09-03 1986-04-10 Gesellschaft für Strahlen- und Umweltforschung mbH, 8000 München Anordnung zur Analyse einer Probenschicht durch Beschuß mit elektromagnetischer Strahlung
US4356270A (en) 1977-11-08 1982-10-26 Genentech, Inc. Recombinant DNA cloning vehicle
US4139346A (en) 1977-11-28 1979-02-13 Enzo Bio Chem Incorporated Nucleic acid and protein binding paper
US4218539A (en) 1978-03-24 1980-08-19 Weltman Joel K Enzyme conjugates and method of preparation and use
US4179402A (en) 1978-05-15 1979-12-18 Shell Oil Company Resin-metal-ligand composition
US4282287A (en) 1980-01-24 1981-08-04 Giese Roger W Biochemical avidin-biotin multiple-layer system
US4442354A (en) 1982-01-22 1984-04-10 Atom Sciences, Inc. Sputter initiated resonance ionization spectrometry
US4461328A (en) 1982-06-04 1984-07-24 Drummond Scientific Company Pipette device
DE3221681A1 (de) 1982-06-08 1983-12-08 Bayer Ag, 5090 Leverkusen Massenspektrometer mit externer probenhalterung
US4994373A (en) 1983-01-27 1991-02-19 Enzo Biochem, Inc. Method and structures employing chemically-labelled polynucleotide probes
US4948882A (en) 1983-02-22 1990-08-14 Syngene, Inc. Single-stranded labelled oligonucleotides, reactive monomers and methods of synthesis
US4548245A (en) 1983-03-04 1985-10-22 Dynatech Laboratories Incorporated Disposable/reusable dispenser for dispensing contaminatable and noncontaminatable liquids
GB8314523D0 (en) 1983-05-25 1983-06-29 Lowe C R Diagnostic device
US4542102A (en) 1983-07-05 1985-09-17 Molecular Diagnostics, Inc. Coupling of nucleic acids to solid support by photochemical methods
DE3329892A1 (de) 1983-08-18 1985-03-07 Köster, Hubert, Prof. Dr., 2000 Hamburg Verfahren zur herstellung von oligonucleotiden
US4554839A (en) 1983-10-14 1985-11-26 Cetus Corporation Multiple trough vessel for automated liquid handling apparatus
US4983521A (en) 1983-10-26 1991-01-08 The Regents Of The University Of California Transmembrane integrator sequences
US4582789A (en) 1984-03-21 1986-04-15 Cetus Corporation Process for labeling nucleic acids using psoralen derivatives
US4729947A (en) 1984-03-29 1988-03-08 The Board Of Regents Of The University Of Nebraska DNA sequencing
US4683194A (en) 1984-05-29 1987-07-28 Cetus Corporation Method for detection of polymorphic restriction sites and nucleic acid sequences
US4849077A (en) 1984-08-06 1989-07-18 Akademie Der Wissenschaften Der Ddr Process for solid phase-sequencing of nucleic acid fragments
US4952518A (en) 1984-10-01 1990-08-28 Cetus Corporation Automated assay machine and assay tray
US5118605A (en) 1984-10-16 1992-06-02 Chiron Corporation Polynucleotide determination with selectable cleavage sites
US5430136A (en) 1984-10-16 1995-07-04 Chiron Corporation Oligonucleotides having selectably cleavable and/or abasic sites
US5221518A (en) 1984-12-14 1993-06-22 Mills Randell L DNA sequencing apparatus
US5064754A (en) 1984-12-14 1991-11-12 Mills Randell L Genomic sequencing method
US4681870A (en) 1985-01-11 1987-07-21 Imre Corporation Protein A-silica immunoadsorbent and process for its production
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4797355A (en) 1985-06-13 1989-01-10 Amgen Inc. Methods for attaching polynucleotides to supports
US5047215A (en) 1985-06-18 1991-09-10 Polyfiltronics, Inc. Multiwell test plate
US4948442A (en) 1985-06-18 1990-08-14 Polyfiltronics, Inc. Method of making a multiwell test plate
US4757141A (en) 1985-08-26 1988-07-12 Applied Biosystems, Incorporated Amino-derivatized phosphite and phosphate linking agents, phosphoramidite precursors, and useful conjugates thereof
US5023187A (en) 1985-09-13 1991-06-11 Fisher Scientific Company Method and device for accelerated treatment of thin sample on surface
US4731335A (en) 1985-09-13 1988-03-15 Fisher Scientific Company Method for treating thin samples on a surface employing capillary flow
US4806546A (en) 1985-09-30 1989-02-21 Miles Inc. Immobilization of nucleic acids on derivatized nylon supports
US4855225A (en) 1986-02-07 1989-08-08 Applied Biosystems, Inc. Method of detecting electrophoretically separated oligonucleotides
US5604099A (en) 1986-03-13 1997-02-18 Hoffmann-La Roche Inc. Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids
US5108703A (en) 1986-03-26 1992-04-28 Beckman Instruments, Inc. Automated multi-purpose analytical chemistry processing center and laboratory work station
FR2597260B1 (fr) 1986-04-10 1988-07-15 Univ Pasteur Procede d'introduction directe automatique d'echantillons dans un spectrometre de masse, et dispositif pour la mise en oeuvre de ce procede
GB8610665D0 (en) 1986-05-01 1986-06-04 Oxley Dev Co Ltd Filtered electrical connectors
US5000921A (en) 1986-10-24 1991-03-19 Hanaway Richard W Multiple pipette samples
GB8626075D0 (en) 1986-10-31 1986-12-03 Vg Instr Group Time-of-flight mass spectrometer
US4877745A (en) 1986-11-17 1989-10-31 Abbott Laboratories Apparatus and process for reagent fluid dispensing and printing
AU603617B2 (en) 1986-11-17 1990-11-22 Abbott Laboratories Apparatus and process for reagent fluid dispensing and printing
EP0269520A3 (fr) 1986-11-21 1988-08-24 Institut Pasteur Rétrovirus du type HIV-2 susceptible de provoquer le sida, et ses constituants antigéniques et nucléiques
US4762881A (en) 1987-01-09 1988-08-09 E. I. Du Pont De Nemours And Company Photoreactive benzoylphenylalanines and related peptides
US4779467A (en) 1987-01-28 1988-10-25 Rainin Instrument Co., Inc. Liquid-end assembly for multichannel air-displacement pipette
US4954444A (en) 1987-03-02 1990-09-04 E. I. Du Pont De Nemours And Company Enzyme immobilization and bioaffinity separations with perfluorocarbon polymer-based supports
US4885250A (en) 1987-03-02 1989-12-05 E. I. Du Pont De Nemours And Company Enzyme immobilization and bioaffinity separations with perfluorocarbon polymer-based supports
CA1285536C (fr) 1987-03-11 1991-07-02 Akihiro Ohoka Dispositif debiteur
US5149625A (en) 1987-08-11 1992-09-22 President And Fellows Of Harvard College Multiplex analysis of DNA
JPS6433070U (fr) 1987-08-22 1989-03-01
US4902481A (en) 1987-12-11 1990-02-20 Millipore Corporation Multi-well filtration test apparatus
US5670381A (en) 1988-01-29 1997-09-23 Abbott Laboratories Devices for performing ion-capture binding assays
DE3809504C1 (fr) 1988-03-22 1989-09-21 Bruker - Franzen Analytik Gmbh, 2800 Bremen, De
EP0339781A3 (fr) 1988-04-29 1991-09-25 Beckman Instruments, Inc. Injecteur capillaire automatique
ATE141946T1 (de) 1988-06-14 1996-09-15 Qiagen Gmbh Hiv-2-virusvarianten
US5003059A (en) 1988-06-20 1991-03-26 Genomyx, Inc. Determining DNA sequences by mass spectrometry
US4925629A (en) 1988-07-28 1990-05-15 Bioquant, Inc. Diagnostic device
FR2636739B1 (fr) 1988-09-20 1993-02-12 Commissariat Energie Atomique Procede et installation d'identification des bases d'un adn
GB8822228D0 (en) 1988-09-21 1988-10-26 Southern E M Support-bound oligonucleotides
DE3930312A1 (de) 1988-10-24 1990-04-26 Max Planck Gesellschaft Verfahren zur direkten sequenzierung von nukleinsaeureketten
US5512439A (en) 1988-11-21 1996-04-30 Dynal As Oligonucleotide-linked magnetic particles and uses thereof
US5082935A (en) 1988-12-15 1992-01-21 Amoco Corporation Diagnostic reagents made by attaching cytidine containing nucleic acid probes to amino functionalized solid supports by bisulfite mediated transamination
US5237016A (en) 1989-01-05 1993-08-17 Siska Diagnostics, Inc. End-attachment of oligonucleotides to polyacrylamide solid supports for capture and detection of nucleic acids
US5077210A (en) 1989-01-13 1991-12-31 Eigler Frances S Immobilization of active agents on substrates with a silane and heterobifunctional crosslinking agent
US4920264A (en) 1989-01-17 1990-04-24 Sri International Method for preparing samples for mass analysis by desorption from a frozen solution
JP2901004B2 (ja) 1989-04-12 1999-06-02 株式会社日立製作所 Ｄｎａの塩基配列決定法
EP0396116B1 (fr) 1989-05-02 1997-02-05 Abbott Laboratories Fixation covalente des membres de liaison spécifiques aux phases solides
US5242974A (en) 1991-11-22 1993-09-07 Affymax Technologies N.V. Polymer reversal on solid surfaces
US5443816A (en) 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
FR2650840B1 (fr) 1989-08-11 1991-11-29 Bertin & Cie Procede rapide de detection et/ou d'identification d'une seule base sur une sequence d'acide nucleique, et ses applications
US5118937A (en) 1989-08-22 1992-06-02 Finnigan Mat Gmbh Process and device for the laser desorption of an analyte molecular ions, especially of biomolecules
US5045694A (en) 1989-09-27 1991-09-03 The Rockefeller University Instrument and method for the laser desorption of ions in mass spectrometry
US5262128A (en) 1989-10-23 1993-11-16 The United States Of America As Represented By The Department Of Health And Human Services Array-type multiple cell injector
US5410068A (en) 1989-10-23 1995-04-25 Perseptive Biosystems, Inc. Succinimidyl trityl compounds and a process for preparing same
US5252743A (en) 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
WO1991011533A1 (fr) 1990-01-26 1991-08-08 E.I. Du Pont De Nemours And Company Procede d'isolement de produits d'extension a partir de reactions de polymerase d'amorces d'adn orientees a l'aide d'un brin complementaire
US5288644A (en) 1990-04-04 1994-02-22 The Rockefeller University Instrument and method for the sequencing of genome
US5195657A (en) 1990-04-30 1993-03-23 Source Scientific Systems Manifold liquid handling device with backsip function
US5387505A (en) 1990-05-04 1995-02-07 Eastman Kodak Company Preparation and isolation of single-stranded biotinylated nucleic acids by heat avidin-biotin cleavage
DE69032425T2 (de) 1990-05-11 1998-11-26 Microprobe Corp., Bothell, Wash. Teststreifen zum Eintauchen für Nukleinsäure-Hybridisierungsassays und Verfahren zur kovalenten Immobilisierung von Oligonucleotiden
US5135870A (en) 1990-06-01 1992-08-04 Arizona Board Of Regents Laser ablation/ionizaton and mass spectrometric analysis of massive polymers
DE4019005C2 (de) 1990-06-13 2000-03-09 Finnigan Mat Gmbh Vorrichtungen zur Analyse von Ionen hoher Masse
DE4024545A1 (de) 1990-08-02 1992-02-06 Boehringer Mannheim Gmbh Verfahren und vorrichtung zum dosierten zufuehren einer biochemischen analysefluessigkeit auf ein target
US5234824A (en) 1990-11-13 1993-08-10 Specialty Laboratories, Inc. Rapid purification of DNA
US5474895A (en) 1990-11-14 1995-12-12 Siska Diagnostics Inc. Non-isotopic detection of nucleic acids using a polystyrene support-based sandwich hybridization assay and compositions useful therefor
US5210412A (en) 1991-01-31 1993-05-11 Wayne State University Method for analyzing an organic sample
WO1992013629A1 (fr) 1991-01-31 1992-08-20 Wayne State University Procede d'analyse d'un echantillon organique
IT1246676B (it) 1991-02-21 1994-11-24 Seac Srl Apparecchiatura per analisi immunologiche.
US5627066A (en) 1991-05-14 1997-05-06 Mount Sinai School Of Medicine Of The City University Of New York Method and apparatus for in vitro fertilization
US5198531A (en) 1991-06-14 1993-03-30 Research Diagnostic Antibodies Polymeric resin for peptide synthesis
JP2904583B2 (ja) 1991-10-11 1999-06-14 プロメガ・コーポレーション 真核無細胞抽出物中での転写と翻訳の共役
US5492817A (en) 1993-11-09 1996-02-20 Promega Corporation Coupled transcription and translation in eukaryotic cell-free extract
US5160840A (en) 1991-10-25 1992-11-03 Vestal Marvin L Time-of-flight analyzer and method
US5605662A (en) 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
IL103674A0 (en) 1991-11-19 1993-04-04 Houston Advanced Res Center Method and apparatus for molecule detection
JP3939338B2 (ja) 1991-11-22 2007-07-04 アフィメトリックス， インコーポレイテッド ポリマー合成に対する組合わせの戦略
US5171989A (en) 1992-01-24 1992-12-15 Board Of Trustees Of Leland Stanford Jr. University Method and apparatus for continuous sample ice matrix production for laser desorption in mass spectrometry
DE4202123C2 (de) 1992-01-27 1995-04-06 Bruker Franzen Analytik Gmbh Vorrichtung für die massenspektrometrische Untersuchung schneller organischer Ionen
US5312233A (en) 1992-02-25 1994-05-17 Ivek Corporation Linear liquid dispensing pump for dispensing liquid in nanoliter volumes
US5382793A (en) 1992-03-06 1995-01-17 Hewlett-Packard Company Laser desorption ionization mass monitor (LDIM)
US5792664A (en) 1992-05-29 1998-08-11 The Rockefeller University Methods for producing and analyzing biopolymer ladders
US5757392A (en) 1992-09-11 1998-05-26 Brother Kogyo Kabushiki Kaisha Piezoelectric type liquid droplet ejecting device which compensates for residual pressure fluctuations
US5795714A (en) 1992-11-06 1998-08-18 Trustees Of Boston University Method for replicating an array of nucleic acid probes
US5503980A (en) 1992-11-06 1996-04-02 Trustees Of Boston University Positional sequencing by hybridization
ATE267877T1 (de) 1993-01-07 2004-06-15 Sequenom Inc Dns - sequenzierung durch massenspektronomie
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
CA2115811A1 (fr) 1993-02-17 1994-08-18 Claus Krebber Methode de selection in vivo de proteines fixatrices de ligands
EP0612994A3 (fr) 1993-02-26 1996-03-06 Ciba Geigy Ag Matrice pour la spectrométrie de masse avec désorption par laser assistée par matrice.
WO1994021822A1 (fr) 1993-03-19 1994-09-29 Sequenom, Inc. Sequençage de l'adn au moyen de la spectrometrie de masse par degradation a l'exonuclease
US5416193A (en) 1993-04-30 1995-05-16 Pfizer Inc. Coupling reagent and method
US5381008A (en) 1993-05-11 1995-01-10 Mds Health Group Ltd. Method of plasma mass analysis with reduced space charge effects
US5376788A (en) 1993-05-26 1994-12-27 University Of Manitoba Apparatus and method for matrix-assisted laser desorption mass spectrometry
WO1995002190A1 (fr) 1993-07-09 1995-01-19 Baxter Diagnostics Inc. Dispositif et procede de distribution de fluide
RU2041263C1 (ru) 1993-08-11 1995-08-09 Геннадий Моисеевич Ершов Способ микродозирования водных растворов веществ на носитель и устройство для его осуществления
US5527675A (en) 1993-08-20 1996-06-18 Millipore Corporation Method for degradation and sequencing of polymers which sequentially eliminate terminal residues
US5439649A (en) 1993-09-29 1995-08-08 Biogenex Laboratories Automated staining apparatus
EP0764264A2 (fr) * 1993-11-12 1997-03-26 Waters Corporation Sm par tdv a desorption laser assistee par matrice a resolution amelioree
US5622829A (en) 1993-12-08 1997-04-22 The Regents Of The University Of California Genetic markers for breast, ovarian, and prostatic cancer
US5457041A (en) 1994-03-25 1995-10-10 Science Applications International Corporation Needle array and method of introducing biological substances into living cells using the needle array
US5643722A (en) 1994-05-11 1997-07-01 Trustees Of Boston University Methods for the detection and isolation of proteins
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5612474A (en) 1994-06-30 1997-03-18 Eli Lilly And Company Acid labile immunoconjugate intermediates
US5498545A (en) 1994-07-21 1996-03-12 Vestal; Marvin L. Mass spectrometer system and method for matrix-assisted laser desorption measurements
JP3612092B2 (ja) 1994-09-07 2005-01-19 株式会社日立製作所 Ｄｎａの分離・分取法及びその解析法
US5545539A (en) 1994-10-18 1996-08-13 Genzyme Corporation Method for nucleotide sequence amplification
US5504326A (en) 1994-10-24 1996-04-02 Indiana University Foundation Spatial-velocity correlation focusing in time-of-flight mass spectrometry
US5512295A (en) 1994-11-10 1996-04-30 The Board Of Trustees Of The Leland Stanford Junior University Synthetic liposomes for enhanced uptake and delivery
US5601982A (en) 1995-02-07 1997-02-11 Sargent; Jeannine P. Method and apparatus for determining the sequence of polynucleotides
JP3592780B2 (ja) 1995-02-22 2004-11-24 富士写真フイルム株式会社 液体噴射装置
WO1996032504A2 (fr) * 1995-04-11 1996-10-17 Trustees Of Boston University Sequençage de biopolymeres en phase solide
US5624711A (en) 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
US5827659A (en) 1995-05-19 1998-10-27 Perseptive Biosystems, Inc. Methods and apparatus for sequencing polymers using mass spectrometry
US5869240A (en) 1995-05-19 1999-02-09 Perseptive Biosystems, Inc. Methods and apparatus for sequencing polymers with a statistical certainty using mass spectrometry
US5625184A (en) 1995-05-19 1997-04-29 Perseptive Biosystems, Inc. Time-of-flight mass spectrometry analysis of biomolecules
US5700642A (en) 1995-05-22 1997-12-23 Sri International Oligonucleotide sizing using immobilized cleavable primers
US5830655A (en) * 1995-05-22 1998-11-03 Sri International Oligonucleotide sizing using cleavable primers
US5589136A (en) 1995-06-20 1996-12-31 Regents Of The University Of California Silicon-based sleeve devices for chemical reactions
US5869242A (en) 1995-09-18 1999-02-09 Myriad Genetics, Inc. Mass spectrometry to assess DNA sequence polymorphisms
US5654545A (en) 1995-09-19 1997-08-05 Bruker-Franzen Analytik Gmbh Mass resolution in time-of-flight mass spectrometers with reflectors
US5705813A (en) 1995-11-01 1998-01-06 Hewlett-Packard Company Integrated planar liquid handling system for maldi-TOF MS
US5716825A (en) 1995-11-01 1998-02-10 Hewlett Packard Company Integrated nucleic acid analysis system for MALDI-TOF MS
US5641959A (en) 1995-12-21 1997-06-24 Bruker-Franzen Analytik Gmbh Method for improved mass resolution with a TOF-LD source
US5742049A (en) 1995-12-21 1998-04-21 Bruker-Franzen Analytik Gmbh Method of improving mass resolution in time-of-flight mass spectrometry
EP0886681A1 (fr) * 1996-03-04 1998-12-30 Genetrace Systems, Inc. Methodes de criblage des acides nucleiques par spectrometrie de masse
US5777325A (en) 1996-05-06 1998-07-07 Hewlett-Packard Company Device for time lag focusing time-of-flight mass spectrometry
AU4042597A (en) * 1996-07-19 1998-02-10 Hybridon, Inc. Method for sequencing nucleic acids using matrix-assisted laser desorption ionization time-of-flight mass spectrometry
US5743960A (en) 1996-07-26 1998-04-28 Bio-Dot, Inc. Precision metered solenoid valve dispenser
CA2301875A1 (fr) * 1996-09-19 1998-03-26 Genetrace Systems Procedes de preparation d'acides nucleiques pour des analyses de spectrometrie de masse
US5777324A (en) 1996-09-19 1998-07-07 Sequenom, Inc. Method and apparatus for maldi analysis
US5826214A (en) 1996-09-26 1998-10-20 The United States Of America As Represented By The Secretary Of The Army Hand-held probe for real-time analysis of trace pollutants in atmosphere and on surfaces
US5864137A (en) 1996-10-01 1999-01-26 Genetrace Systems, Inc. Mass spectrometer
US5885775A (en) 1996-10-04 1999-03-23 Perseptive Biosystems, Inc. Methods for determining sequences information in polynucleotides using mass spectrometry
AU735416B2 (en) * 1996-11-06 2001-07-05 Sequenom, Inc. Dna diagnostics based on mass spectrometry

Also Published As

Publication number Publication date
DE19983215T1 (de) 2001-05-17
EP1075545A2 (fr) 2001-02-14
US20030148528A1 (en) 2003-08-07
US20010055811A1 (en) 2001-12-27
US6558902B1 (en) 2003-05-06
US6723564B2 (en) 2004-04-20
JP2002513917A (ja) 2002-05-14
WO1999057318A2 (fr) 1999-11-11
US6706530B2 (en) 2004-03-16
CA2328110A1 (fr) 1999-11-11
AU3896799A (en) 1999-11-23
KR20010043409A (ko) 2001-05-25
NO20005539D0 (no) 2000-11-02
WO1999057318A3 (fr) 2000-03-23

Similar Documents

Publication Publication Date Title
NO20005539D0 (no) Infrarød matriksassistert laserdesorpsjon/ionisering massespektrometrisk analyse av makromolekyler
DE69909683D1 (de) Flugzeitmassenspektrometer und detektor dafür und spektrometrieverfahren
DE60044892D1 (de) Ionenquelle, Massenspektrometer, Massenspektrometrie und Überwachungssystem
DE69631556D1 (de) Biomolekülenanalyse mittels Flugzeitmassenspektrometrie
DE69740125D1 (de) Plasmamassenspektrometer
GB0126525D0 (en) A quadrupole ion trap device, methods of operating a quadrupole ion trap device and a mass spectrometer including the quadrupole ion trap device
DE69402569D1 (de) Ionenfalle Massenspektrometer
GB2289161B (en) Device and method for mass spectrometric analysis of substance mixtures by coupling capillary electrophoretic separation(ce)with electrospray ionization(esi)
GB2308227B (en) Electrospray and atmospheric pressure chemical ionization mass spectrometer and ion source
DE69943192D1 (de) Matrixunterstützte Atmosphärendrucklaserdesorptions- und Ionisationsvorrichtung und Analyseverfahren (MALDI)
WO2003102537A3 (fr) Source d'ionisation presentant plusieurs modes combines a haute vitesse pour des spectrometres de masse
DE69729360D1 (de) Analyse spectrometrischer Daten
DE69906935D1 (de) Flugzeitmassenspektrometer
GB2370686B (en) Mass spectrometers and methods of mass spectrometry
AU3668599A (en) Ion trap mass spectrometer with electrospray ionization
IL137065A0 (en) Electrospray device for mass spectrometer
CA2391140A1 (fr) Spectrometre de masse
GB0108187D0 (en) Mass spectrometer and methods of mass spectrometry
DE69634270D1 (de) On-line qualitative analyse chemischer zusammensetzungen mittels ramanspektrometrie
AU7804098A (en) Volatile matrices for matrix-assisted laser desorption/ionization mass spectrometry
NO995974D0 (no) Analyse av datanett
AU3718597A (en) End cap reflectron for time-of-flight mass spectrometer
AU2065199A (en) Time-of-flight mass spectrometer
DE10084700T1 (de) Externer Verschluss für Elektrosprühionisierungsmassenspektrometrie
DE69936800D1 (de) Massenspektrometer

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application