ATE444532T1 - Verfahren zur identifizierung von polymorphen genetischen markern - Google Patents

Verfahren zur identifizierung von polymorphen genetischen markern

Info

Publication number
ATE444532T1
ATE444532T1 AT00972148T AT00972148T ATE444532T1 AT E444532 T1 ATE444532 T1 AT E444532T1 AT 00972148 T AT00972148 T AT 00972148T AT 00972148 T AT00972148 T AT 00972148T AT E444532 T1 ATE444532 T1 AT E444532T1
Authority
AT
Austria
Prior art keywords
nucleic acid
obtaining
mass spectrum
detecting
identifying
Prior art date
Application number
AT00972148T
Other languages
English (en)
Inventor
Andreas Braun
Hubert Koester
Den Boom Dirk Van
Yip Ping
Charlie Rodi
Liyan He
Norman Chiu
Christian Jurinke
Original Assignee
Sequenom Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/663,968 external-priority patent/US7917301B1/en
Application filed by Sequenom Inc filed Critical Sequenom Inc
Application granted granted Critical
Publication of ATE444532T1 publication Critical patent/ATE444532T1/de

Links

Classifications

    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00ICT programming tools or database systems specially adapted for bioinformatics
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6827Hybridisation assays for detection of mutation or polymorphism
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/40Population genetics; Linkage disequilibrium
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00ICT programming tools or database systems specially adapted for bioinformatics
    • G16B50/50Compression of genetic data
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/0027Methods for using particle spectrometers
    • H01J49/0036Step by step routines describing the handling of the data generated during a measurement
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Evolutionary Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Medical Informatics (AREA)
  • Theoretical Computer Science (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Databases & Information Systems (AREA)
  • Bioethics (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Ecology (AREA)
  • Physiology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
AT00972148T 1999-10-13 2000-10-13 Verfahren zur identifizierung von polymorphen genetischen markern ATE444532T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US15917699P 1999-10-13 1999-10-13
US21725100P 2000-07-10 2000-07-10
US21765800P 2000-07-10 2000-07-10
US09/663,968 US7917301B1 (en) 2000-09-19 2000-09-19 Method and device for identifying a biological sample
PCT/US2000/028413 WO2001027857A2 (en) 1999-10-13 2000-10-13 Methods for generating databases and databases for identifying polymorphic genetic markers

Publications (1)

Publication Number Publication Date
ATE444532T1 true ATE444532T1 (de) 2009-10-15

Family

ID=27496366

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00972148T ATE444532T1 (de) 1999-10-13 2000-10-13 Verfahren zur identifizierung von polymorphen genetischen markern

Country Status (9)

Country Link
EP (2) EP2088209B1 (de)
JP (2) JP2003519829A (de)
KR (1) KR20020064298A (de)
AT (1) ATE444532T1 (de)
AU (1) AU776811C (de)
CA (1) CA2387035A1 (de)
DE (1) DE60043076D1 (de)
IL (1) IL148930A0 (de)
WO (1) WO2001027857A2 (de)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
US20030129589A1 (en) 1996-11-06 2003-07-10 Hubert Koster Dna diagnostics based on mass spectrometry
US20020009394A1 (en) 1999-04-02 2002-01-24 Hubert Koster Automated process line
US7917301B1 (en) * 2000-09-19 2011-03-29 Sequenom, Inc. Method and device for identifying a biological sample
US7332275B2 (en) 1999-10-13 2008-02-19 Sequenom, Inc. Methods for detecting methylated nucleotides
US6958214B2 (en) 2000-07-10 2005-10-25 Sequenom, Inc. Polymorphic kinase anchor proteins and nucleic acids encoding the same
US7226739B2 (en) 2001-03-02 2007-06-05 Isis Pharmaceuticals, Inc Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations
US20030027135A1 (en) * 2001-03-02 2003-02-06 Ecker David J. Method for rapid detection and identification of bioagents
US7666588B2 (en) 2001-03-02 2010-02-23 Ibis Biosciences, Inc. Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy
US7217510B2 (en) 2001-06-26 2007-05-15 Isis Pharmaceuticals, Inc. Methods for providing bacterial bioagent characterizing information
US7159740B2 (en) 2001-10-26 2007-01-09 Sequenom, Inc. Method and apparatus for parallel dispensing of defined volumes of solid particles
AU2002357871A1 (en) * 2001-12-21 2003-07-15 Smithkline Beecham Corporation High throughput correlation of polymorphic forms with multiple phenotypes within clinical populations
AU2003228809A1 (en) 2002-05-03 2003-11-17 Sequenom, Inc. Kinase anchor protein muteins, peptides thereof, and related methods
CA2508726A1 (en) 2002-12-06 2004-07-22 Isis Pharmaceuticals, Inc. Methods for rapid identification of pathogens in humans and animals
EP1590471A4 (de) 2002-12-31 2009-12-09 Metamorphix Inc Zusammensetzungen, verfahren und systeme zur bestimmung von rindermerkmalen
ATE489629T1 (de) 2003-01-16 2010-12-15 Caprotec Bioanalytics Gmbh Verfahren zur identifizierung von auf arzneimittel nicht-zielgerichteten proteinen
JP4365822B2 (ja) * 2003-02-27 2009-11-18 株式会社日立製作所 塩基配列関連情報を用いた情報処理システム
CA2518238A1 (en) * 2003-03-07 2004-09-23 Sequenom, Inc. Association of polymorphic kinase anchor proteins with cardiac phenotypes and related methods
JP2004287619A (ja) * 2003-03-19 2004-10-14 Ntt Data Corp 疫学情報管理装置、疫学情報管理方法、および、プログラム
ATE425265T1 (de) 2003-07-31 2009-03-15 Sequenom Inc Verfahren für multiplex- polymerasekettenreaktionen auf hohem niveau und homogenen massenverlängerungsreaktionen zur genotypisierung von polymorphismen
US9394565B2 (en) 2003-09-05 2016-07-19 Agena Bioscience, Inc. Allele-specific sequence variation analysis
US7608394B2 (en) 2004-03-26 2009-10-27 Sequenom, Inc. Methods and compositions for phenotype identification based on nucleic acid methylation
EP1727911B1 (de) 2004-03-26 2013-01-23 Sequenom, Inc. Basenspezifische spaltung methylierungsspezifischer amplifikationsprodukte in kombination mit massenanalyse
US20050266411A1 (en) 2004-05-25 2005-12-01 Hofstadler Steven A Methods for rapid forensic analysis of mitochondrial DNA
EP1904655A2 (de) 2005-07-21 2008-04-02 Isis Pharmaceuticals, Inc. Verfahren zur raschen identifizierung und quantifizierung von nukleinsäurevarianten
JP2007102709A (ja) * 2005-10-07 2007-04-19 Toshiba Corp 遺伝子診断用のマーカー選定プログラム、該プログラムを実行する装置及びシステム、並びに遺伝子診断システム
US8871471B2 (en) 2007-02-23 2014-10-28 Ibis Biosciences, Inc. Methods for rapid forensic DNA analysis
US20080228698A1 (en) 2007-03-16 2008-09-18 Expanse Networks, Inc. Creation of Attribute Combination Databases
JP5030166B2 (ja) 2007-05-01 2012-09-19 独立行政法人産業技術総合研究所 レーザー脱離イオン化質量分析に使用される試料支持用基板の試験方法
JP5036042B2 (ja) * 2007-05-28 2012-09-26 株式会社島津製作所 質量分析サンプルの調製方法、リボ核酸のイオン化方法、リボ核酸の質量分析方法、及び細胞由来の低分子リボ核酸の質量分析方法
CN106834481A (zh) * 2007-07-23 2017-06-13 香港中文大学 用于分析遗传变异的方法
US12180549B2 (en) 2007-07-23 2024-12-31 The Chinese University Of Hong Kong Diagnosing fetal chromosomal aneuploidy using genomic sequencing
US20090043752A1 (en) 2007-08-08 2009-02-12 Expanse Networks, Inc. Predicting Side Effect Attributes
US8200509B2 (en) 2008-09-10 2012-06-12 Expanse Networks, Inc. Masked data record access
US7917438B2 (en) 2008-09-10 2011-03-29 Expanse Networks, Inc. System for secure mobile healthcare selection
US8108406B2 (en) 2008-12-30 2012-01-31 Expanse Networks, Inc. Pangenetic web user behavior prediction system
WO2010077336A1 (en) 2008-12-31 2010-07-08 23Andme, Inc. Finding relatives in a database
WO2011048007A2 (de) * 2009-10-21 2011-04-28 Basf Plant Science Company Gmbh Verfahren zur erzeugung von biomarker-referenzpattern
CA2854832C (en) * 2011-11-07 2023-05-23 Ingenuity Systems, Inc. Methods and systems for identification of causal genomic variants
US9892230B2 (en) 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
JP6090201B2 (ja) * 2014-02-19 2017-03-08 株式会社島津製作所 マススペクトルデータ処理装置及びマススペクトルデータ処理方法
EP3129908B1 (de) * 2014-03-25 2021-07-21 Five3 Genomics, LLC Systeme und verfahren zur rna-analyse in der funktionellen bestätigung von krebsmutationen
US10364467B2 (en) 2015-01-13 2019-07-30 The Chinese University Of Hong Kong Using size and number aberrations in plasma DNA for detecting cancer
GB201518391D0 (en) 2015-10-16 2015-12-02 Micromass Ltd Processing mass spectral data
WO2021148593A1 (en) * 2020-01-24 2021-07-29 Evonik Operations Gmbh A method of establishing an epigenetic clock for avian species
US10991185B1 (en) 2020-07-20 2021-04-27 Abbott Laboratories Digital pass verification systems and methods
CN114023379B (zh) * 2021-12-31 2022-05-13 浙江迪谱诊断技术有限公司 一种确定基因型的方法及装置
CN114755289B (zh) * 2022-03-25 2024-08-16 浙江迪谱诊断技术有限公司 一种核酸质谱盐离子干扰评价方法

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
GB2236186B (en) 1989-08-22 1994-01-05 Finnigan Mat Gmbh Process and device for laser desorption of analyte molecular ions, especially of biomolecules
US5846717A (en) 1996-01-24 1998-12-08 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
US5436150A (en) 1992-04-03 1995-07-25 The Johns Hopkins University Functional domains in flavobacterium okeanokoities (foki) restriction endonuclease
US5700672A (en) 1992-07-23 1997-12-23 Stratagene Purified thermostable pyrococcus furiousus DNA ligase
US5503980A (en) 1992-11-06 1996-04-02 Trustees Of Boston University Positional sequencing by hybridization
US5422253A (en) 1992-12-07 1995-06-06 Wisconsin Alumni Research Foundation Method of site specific nucleic acid cleavage
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
ATE267877T1 (de) 1993-01-07 2004-06-15 Sequenom Inc Dns - sequenzierung durch massenspektronomie
JPH08507926A (ja) 1993-03-19 1996-08-27 シーケノム・インコーポレーテツド エキソヌクレアーゼ分解を介した質量分析法によるdna配列決定
US5604098A (en) 1993-03-24 1997-02-18 Molecular Biology Resources, Inc. Methods and materials for restriction endonuclease applications
CA2122203C (en) 1993-05-11 2001-12-18 Melinda S. Fraiser Decontamination of nucleic acid amplification reactions
US5714330A (en) 1994-04-04 1998-02-03 Lynx Therapeutics, Inc. DNA sequencing by stepwise ligation and cleavage
US5858705A (en) 1995-06-05 1999-01-12 Human Genome Sciences, Inc. Polynucleotides encoding human DNA ligase III and methods of using these polynucleotides
US5874283A (en) 1995-05-30 1999-02-23 John Joseph Harrington Mammalian flap-specific endonuclease
CA2226542C (en) 1995-07-11 2006-04-04 Thomas Valentine Mccarthy Glycosylase mediated detection of nucleotide sequences at candidate loci
US6090606A (en) 1996-01-24 2000-07-18 Third Wave Technologies, Inc. Cleavage agents
WO1997037041A2 (en) 1996-03-18 1997-10-09 Sequenom, Inc. Dna sequencing by mass spectrometry
JP2000508912A (ja) * 1996-04-19 2000-07-18 スペクトラ バイオメディカル,インコーポレイテッド 多型形態と複数の表現型との相関付け
US5928906A (en) 1996-05-09 1999-07-27 Sequenom, Inc. Process for direct sequencing during template amplification
JP2000512497A (ja) * 1996-06-10 2000-09-26 ユニバーシティ・オブ・ユタ・リサーチ・ファウンデイション エレクトロスプレー質量分析法による迅速で正確な変異体dna配列の同定
US5777324A (en) 1996-09-19 1998-07-07 Sequenom, Inc. Method and apparatus for maldi analysis
WO1998012355A1 (en) * 1996-09-19 1998-03-26 Genetrace Systems Methods of preparing nucleic acids for mass spectrometric analysis
US6024925A (en) 1997-01-23 2000-02-15 Sequenom, Inc. Systems and methods for preparing low volume analyte array elements
DE69706187T2 (de) 1996-11-06 2002-04-11 Sequenom, Inc. Zusammensetzungen und verfahren zur immobilisierung von nukleinsäure auf festträgern
ATE259056T1 (de) 1996-11-06 2004-02-15 Sequenom Inc Verfahren zur massenspektrometrie
WO1998024935A1 (en) * 1996-12-06 1998-06-11 Urocor, Inc. Diagnosis of disease state using mrna profiles
US6059724A (en) * 1997-02-14 2000-05-09 Biosignal, Inc. System for predicting future health
EP0985148A4 (de) * 1997-05-28 2004-03-10 Inst Medical W & E Hall Diagnose von nukleinsäuren durch massenspektrometrie, massentrennung und basenspezifischer spaltung
US5976806A (en) 1997-06-25 1999-11-02 Pioneer Hi-Bred International, Inc. DNA ligase assay
JP2001511529A (ja) 1997-07-25 2001-08-14 アフィメトリックス インコーポレイテッド バイオインフォマティクスデータベースを提供するための方法および装置
US5888795A (en) 1997-09-09 1999-03-30 Becton, Dickinson And Company Thermostable uracil DNA glycosylase and methods of use
DE19754482A1 (de) * 1997-11-27 1999-07-01 Epigenomics Gmbh Verfahren zur Herstellung komplexer DNA-Methylierungs-Fingerabdrücke
WO1999030167A1 (en) * 1997-12-06 1999-06-17 Genox Research, Inc. Sample data managing system
AU748022B2 (en) 1997-12-12 2002-05-30 Digene Corporation Universal collection medium
US6054276A (en) 1998-02-23 2000-04-25 Macevicz; Stephen C. DNA restriction site mapping
US6132476A (en) 1998-04-20 2000-10-17 Southern Mills, Inc. Flame and shrinkage resistant fabric blends and method for making same
PT1071811E (pt) 1998-04-22 2002-08-30 Entpr Ireland Trad As Biores I Metodo para a caracterizacao de moleculas de acido nucleico envolvendo a producao de fragmentos extensiveis a montante resultantes da clivagem de acido nucleico num sitio abasico
US6723564B2 (en) 1998-05-07 2004-04-20 Sequenom, Inc. IR MALDI mass spectrometry of nucleic acids using liquid matrices
US6099553A (en) 1998-05-21 2000-08-08 Applied Medical Resources Corporation Suture clinch
GB9904585D0 (en) * 1999-02-26 1999-04-21 Gemini Research Limited Clinical and diagnostic database
US7493698B2 (en) 2006-12-14 2009-02-24 Hsin-Chih Chung Lee Keyless clamp device for reciprocating saw
US9720195B2 (en) 2010-04-30 2017-08-01 Corning Optical Communications LLC Apparatuses and related components and methods for attachment and release of fiber optic housings to and from an equipment rack

Also Published As

Publication number Publication date
DE60043076D1 (de) 2009-11-12
WO2001027857A3 (en) 2002-10-03
WO2001027857A2 (en) 2001-04-19
IL148930A0 (en) 2002-09-12
JP2004158005A (ja) 2004-06-03
EP1261932A2 (de) 2002-12-04
EP2088209B1 (de) 2017-05-31
CA2387035A1 (en) 2001-04-19
AU776811B2 (en) 2004-09-23
AU776811C (en) 2005-07-28
JP2003519829A (ja) 2003-06-24
KR20020064298A (ko) 2002-08-07
EP1261932B1 (de) 2009-09-30
WO2001027857A9 (en) 2002-12-05
EP2088209A1 (de) 2009-08-12
AU1084801A (en) 2001-04-23

Similar Documents

Publication Publication Date Title
ATE444532T1 (de) Verfahren zur identifizierung von polymorphen genetischen markern
US6403319B1 (en) Analysis of sequence tags with hairpin primers
DE60029323D1 (de) Verfahren zur analyse der dna-methylierung mit hoher durchsatzrate
NO20005311D0 (no) FremgangsmÕte til karakterisering av nukleinsyremolekyler som innbefatter dannelse av utvidbare oppstrøms DNA fragmenter som resulterer fra spalting av nukleinsyre pÕ et abasisk sete
WO2005098050A3 (en) Base specific cleavage of methylation-specific amplification products in combination with mass analysis
WO2002086163A8 (en) Methods for high throughput genome analysis using restriction site tagged microarrays
DK1330546T3 (da) Fremgangsmåde til amplifikation og eventuel karakterisering af nucleinsyrer
DE69816286D1 (de) Verfahren zur Erkennung von Nukleinsäuremethylierungen durch AFLP
ATE358733T1 (de) Schnell-verfahren zur detektion von mikroorganismen in lebensmittelproben
US10829813B2 (en) Methods of sequencing with linked fragments
CN101605909A (zh) 使用质谱法的生物分子检测和定量
WO2006017083A3 (en) Methods and compositions for phenotype identification based on nucleic acid methylation
KR101820440B1 (ko) 표적핵산의 검출방법
US20200048691A1 (en) Switch-like isothermal dna amplification demonstrating a non-linear amplification rate
Ahn et al. Abasic Site‐Assisted Inhibition of Nicking Endonuclease Activity for the Sensitive Determination of Uracil DNA Glycosylase
ATE393242T1 (de) Verfahren zur identifizierung sulforeduzierender bakterien
DE60332468D1 (de) Analytnachweis
WO2004008841A3 (en) Dna fingerprinting for cannabis sativa (marijuana) using short tandem repeat (str) markers
WO2008009365A3 (en) A method for determining the methylation rate of a nucleic acid
JP2006075126A (ja) 一塩基変異を検出する方法および検出用プローブ
Dunn et al. Genome‐wide expression analysis of recently processed formalin‐fixed paraffin embedded human prostate tissues
ATE518006T1 (de) Verfahren zur quantitativen analyse von methylcytosin in dna und verwendungen davon
ATE320507T1 (de) Methoden zur dns vervielfältigung und material dafür
JP2006149334A (ja) メチル化検出方法
RU2000129527A (ru) Способ получения характеристик молекул нуклеиновой кислоты, включающий создание удлиняемых направленных вверх фрагментов днк, получаемых как следствие расщепления нуклеиновой кислоты в лишенном основания звене

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties