NO174102C - Analogifremgangsmåte til fremst. av et terapeutisk aktivt, stabilt, krystallinsk vannopplöselig salt av 2',3'-dideoksyinosinmonohydrat, 2',3'-dideoksy-2',3'-didehydrotymidinmonohydrat og 2',3'-dideoksy-2'-fluorinosinhemihydrat - Google Patents

Analogifremgangsmåte til fremst. av et terapeutisk aktivt, stabilt, krystallinsk vannopplöselig salt av 2',3'-dideoksyinosinmonohydrat, 2',3'-dideoksy-2',3'-didehydrotymidinmonohydrat og 2',3'-dideoksy-2'-fluorinosinhemihydrat

Info

Publication number
NO174102C
NO174102C NO902148A NO902148A NO174102C NO 174102 C NO174102 C NO 174102C NO 902148 A NO902148 A NO 902148A NO 902148 A NO902148 A NO 902148A NO 174102 C NO174102 C NO 174102C
Authority
NO
Norway
Prior art keywords
dideoxy
monohydrate
dideoxyinosine
stable
fluorinosine
Prior art date
Application number
NO902148A
Other languages
English (en)
Norwegian (no)
Other versions
NO902148L (no
NO174102B (no
NO902148D0 (no
Inventor
Murray Arthur Kaplan
Robert Kevin Perrone
Joseph Ballard Bogardus
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NO902148D0 publication Critical patent/NO902148D0/no
Publication of NO902148L publication Critical patent/NO902148L/no
Priority to NO933367A priority Critical patent/NO176609C/no
Publication of NO174102B publication Critical patent/NO174102B/no
Publication of NO174102C publication Critical patent/NO174102C/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/26Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28Oxygen atom
    • C07D473/30Oxygen atom attached in position 6, e.g. hypoxanthine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
NO902148A 1989-05-15 1990-05-15 Analogifremgangsmåte til fremst. av et terapeutisk aktivt, stabilt, krystallinsk vannopplöselig salt av 2',3'-dideoksyinosinmonohydrat, 2',3'-dideoksy-2',3'-didehydrotymidinmonohydrat og 2',3'-dideoksy-2'-fluorinosinhemihydrat NO174102C (no)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NO933367A NO176609C (no) 1989-05-15 1993-09-22 Fremgangsmåte til fremstilling av et sterkt vannlöselig, stabilt, krystallinsk salt av 2',3'-dideoksyinosin, 2',3'-dideoksy-2',3'didehydrotymidin eller 2',3'dideoksy-2'-fluorinosin

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35206589A 1989-05-15 1989-05-15
US51426190A 1990-05-01 1990-05-01

Publications (4)

Publication Number Publication Date
NO902148D0 NO902148D0 (no) 1990-05-15
NO902148L NO902148L (no) 1990-11-16
NO174102B NO174102B (no) 1993-12-06
NO174102C true NO174102C (no) 1994-03-16

Family

ID=26997373

Family Applications (2)

Application Number Title Priority Date Filing Date
NO902148A NO174102C (no) 1989-05-15 1990-05-15 Analogifremgangsmåte til fremst. av et terapeutisk aktivt, stabilt, krystallinsk vannopplöselig salt av 2',3'-dideoksyinosinmonohydrat, 2',3'-dideoksy-2',3'-didehydrotymidinmonohydrat og 2',3'-dideoksy-2'-fluorinosinhemihydrat
NO933367A NO176609C (no) 1989-05-15 1993-09-22 Fremgangsmåte til fremstilling av et sterkt vannlöselig, stabilt, krystallinsk salt av 2',3'-dideoksyinosin, 2',3'-dideoksy-2',3'didehydrotymidin eller 2',3'dideoksy-2'-fluorinosin

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO933367A NO176609C (no) 1989-05-15 1993-09-22 Fremgangsmåte til fremstilling av et sterkt vannlöselig, stabilt, krystallinsk salt av 2',3'-dideoksyinosin, 2',3'-dideoksy-2',3'didehydrotymidin eller 2',3'dideoksy-2'-fluorinosin

Country Status (16)

Country Link
EP (1) EP0398230B1 (ko)
KR (1) KR970001160B1 (ko)
CN (2) CN1027896C (ko)
AT (1) ATE162528T1 (ko)
AU (1) AU617614B2 (ko)
BG (1) BG60517B1 (ko)
DE (1) DE69031962T2 (ko)
DK (1) DK0398230T3 (ko)
EG (1) EG19154A (ko)
ES (1) ES2113851T3 (ko)
FI (1) FI95269C (ko)
GR (1) GR3025984T3 (ko)
HU (1) HU206628B (ko)
IE (1) IE81107B1 (ko)
NO (2) NO174102C (ko)
PT (1) PT94040B (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO920714L (no) * 1991-03-01 1992-09-02 Bristol Myers Squibb Co Tetrahydrofuran-mellomprodukt
US5221611A (en) * 1991-06-19 1993-06-22 Sigma Chemical Company Ddi immunoassays, derivatives, conjugates and antibodies
US5589587A (en) * 1992-05-12 1996-12-31 Merrell Pharmaceuticals Inc. Process for the preparation of ribonucleotide reductase inhibitors
HU217849B (hu) * 1994-01-07 2000-04-28 Merrell Pharmaceuticals Inc. (E)-2'-dezoxi-2'-(fluor-metilén)-citidin monohidrát
EP1765379A4 (en) * 2004-06-17 2009-05-27 Transform Pharmaceuticals Inc CO-CRISTAL PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF
JP5485140B2 (ja) 2008-04-10 2014-05-07 浜理薬品工業株式会社 5−メチルウリジンを出発原料とするエチニルチミジン化合物の製造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987001284A1 (en) * 1985-08-26 1987-03-12 United States Of America, Represented By The Unite Inhibition of in vitro infectivity and cytopathic effect of htlv-iii/lav by 2',3'-dideoxynosine, 2',3'-dideoxyguanosine, or 2',3'-dideoxyadenosine
KR960001372B1 (ko) * 1986-09-24 1996-01-26 예일 유니버시티 레트로비루스로 감염된 환자의 치료에 사용되는 2',3'-디디옥시사이티딘-2'-엔(2',3'-디디옥시-2',3'-디디하이드로사이티딘)의 항생물질
US4978655A (en) * 1986-12-17 1990-12-18 Yale University Use of 3'-deoxythymidin-2'-ene (3'deoxy-2',3'-didehydrothymidine) in treating patients infected with retroviruses
CA1340645C (en) * 1987-04-17 1999-07-13 Victor E. Marquez Acid stable dideoxynucleosides active against the cytopathic effects of human immunodeficiency virus
ES2075040T3 (es) * 1988-02-16 1995-10-01 Lilly Co Eli 2',3'-dideoxi-2',2'-difluoronucleosidos.
GB8823319D0 (en) * 1988-10-05 1988-11-09 Nycomed As Chemical compounds

Also Published As

Publication number Publication date
NO176609B (no) 1995-01-23
NO176609C (no) 1995-05-03
EP0398230B1 (en) 1998-01-21
FI902360A0 (fi) 1990-05-11
FI95269C (fi) 1996-01-10
DE69031962T2 (de) 1998-09-17
IE81107B1 (en) 2000-03-08
HU903038D0 (en) 1990-09-28
AU5501190A (en) 1990-11-15
NO902148L (no) 1990-11-16
PT94040A (pt) 1991-01-08
IE901734L (en) 1990-11-15
BG60517B1 (bg) 1995-07-28
BG92000A (bg) 1993-12-24
DK0398230T3 (da) 1998-09-21
ES2113851T3 (es) 1998-05-16
CN1047676A (zh) 1990-12-12
HUT53528A (en) 1990-11-28
CN1027896C (zh) 1995-03-15
EP0398230A3 (en) 1991-06-26
AU617614B2 (en) 1991-11-28
PT94040B (pt) 1996-12-31
NO174102B (no) 1993-12-06
DE69031962D1 (de) 1998-02-26
CN1109755A (zh) 1995-10-11
NO902148D0 (no) 1990-05-15
EP0398230A2 (en) 1990-11-22
HU206628B (en) 1992-12-28
EG19154A (en) 1994-09-29
ATE162528T1 (de) 1998-02-15
NO933367D0 (no) 1993-09-22
NO933367L (no) 1990-11-16
KR970001160B1 (ko) 1997-01-29
KR900017591A (ko) 1990-12-19
FI95269B (fi) 1995-09-29
GR3025984T3 (en) 1998-04-30
CN1057443C (zh) 2000-10-18

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