NO170634C - Analogifremgangsmaate ved fremstilling av ved metylaminonitrogenet substituerte derivater av staurosporin - Google Patents
Analogifremgangsmaate ved fremstilling av ved metylaminonitrogenet substituerte derivater av staurosporinInfo
- Publication number
- NO170634C NO170634C NO882613A NO882613A NO170634C NO 170634 C NO170634 C NO 170634C NO 882613 A NO882613 A NO 882613A NO 882613 A NO882613 A NO 882613A NO 170634 C NO170634 C NO 170634C
- Authority
- NO
- Norway
- Prior art keywords
- substituted derivatives
- metylaminon
- staurosporine
- nitrogen
- preparation
- Prior art date
Links
- HKSZLNNOFSGOKW-FYTWVXJKSA-N staurosporine Chemical group C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1[C@H]1C[C@@H](NC)[C@@H](OC)[C@]4(C)O1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 0.000 title abstract 3
- HKSZLNNOFSGOKW-UHFFFAOYSA-N ent-staurosporine Natural products C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1C1CC(NC)C(OC)C4(C)O1 HKSZLNNOFSGOKW-UHFFFAOYSA-N 0.000 title abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 title 2
- 229910052757 nitrogen Inorganic materials 0.000 title 1
- CGPUWJWCVCFERF-UHFFFAOYSA-N staurosporine Natural products C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1C1CC(NC)C(OC)C4(OC)O1 CGPUWJWCVCFERF-UHFFFAOYSA-N 0.000 title 1
- 102000003923 Protein Kinase C Human genes 0.000 abstract 1
- 108090000315 Protein Kinase C Proteins 0.000 abstract 1
- 229940124639 Selective inhibitor Drugs 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH224487 | 1987-06-15 | ||
| CH144088 | 1988-04-19 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| NO882613D0 NO882613D0 (no) | 1988-06-14 |
| NO882613L NO882613L (no) | 1988-12-16 |
| NO170634B NO170634B (no) | 1992-08-03 |
| NO170634C true NO170634C (no) | 1992-11-11 |
Family
ID=25687663
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO882613A NO170634C (no) | 1987-06-15 | 1988-06-14 | Analogifremgangsmaate ved fremstilling av ved metylaminonitrogenet substituerte derivater av staurosporin |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0296110B1 (hu) |
| JP (1) | JP2708047B2 (hu) |
| KR (1) | KR970001529B1 (hu) |
| AT (1) | ATE134375T1 (hu) |
| AU (1) | AU617324B2 (hu) |
| CA (1) | CA1337763C (hu) |
| DE (1) | DE3855015D1 (hu) |
| DK (1) | DK175507B1 (hu) |
| ES (1) | ES2083956T3 (hu) |
| FI (1) | FI89362C (hu) |
| GR (1) | GR3019064T3 (hu) |
| HK (1) | HK1003788A1 (hu) |
| HU (1) | HU201329B (hu) |
| IE (1) | IE70523B1 (hu) |
| IL (1) | IL86632A0 (hu) |
| MY (1) | MY104316A (hu) |
| NO (1) | NO170634C (hu) |
| NZ (1) | NZ225018A (hu) |
| PT (1) | PT87719B (hu) |
| YU (1) | YU115488A (hu) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62220196A (ja) * | 1986-03-20 | 1987-09-28 | Kyowa Hakko Kogyo Co Ltd | 新規物質ｕｃｎ―０１ |
| WO1989007105A1 (en) * | 1988-02-04 | 1989-08-10 | Kyowa Hakko Kogyo Co., Ltd. | Staurosporin derivatives |
| IL89167A (en) * | 1988-02-10 | 1994-02-27 | Hoffmann La Roche | Substituted pyrroles, their manufacture and pharmaceutical compositions containing them |
| USRE36736E (en) * | 1989-02-06 | 2000-06-13 | Hoffman-La Roche Inc. | Substituted pyrroles |
| DE3924538A1 (de) * | 1989-07-25 | 1991-01-31 | Goedecke Ag | Indolocarbazol und dessen verwendung |
| US5618809A (en) * | 1989-12-14 | 1997-04-08 | Schering Corporation | Indolocarbazoles from saccharothrix aerocolonigenes copiosa subsp. nov SCC 1951 ATCC 53856 |
| US5292747A (en) * | 1990-08-07 | 1994-03-08 | Hoffman-La Roche Inc. | Substituted pyrroles |
| WO1993007153A1 (en) * | 1991-10-10 | 1993-04-15 | Schering Corporation | 4'-(n-substituted-n-oxide)staurosporine derivatives |
| EP0541486A1 (de) * | 1991-11-07 | 1993-05-12 | Ciba-Geigy Ag | Polycyclische Konjugate |
| WO1993018771A1 (fr) * | 1992-03-24 | 1993-09-30 | Asahi Kasei Kogyo Kabushiki Kaisha | INHIBITEUR DE L'AGGLUTINATION PLAQUETTAIRE CONTENANT UN DERIVE DE STAUROSPORINE η-LACTAME |
| US5756494A (en) * | 1992-07-24 | 1998-05-26 | Cephalon, Inc. | Protein kinase inhibitors for treatment of neurological disorders |
| US5621100A (en) * | 1992-07-24 | 1997-04-15 | Cephalon, Inc. | K-252a derivatives for treatment of neurological disorders |
| US5461146A (en) * | 1992-07-24 | 1995-10-24 | Cephalon, Inc. | Selected protein kinase inhibitors for the treatment of neurological disorders |
| US5621101A (en) * | 1992-07-24 | 1997-04-15 | Cephalon, Inc. | Protein kinase inhibitors for treatment of neurological disorders |
| US5674867A (en) * | 1992-09-21 | 1997-10-07 | Kyowa Hakko Kogyo Co., Ltd. | Indolocarbazole derivatives and therapeutic method for stimulating megakaicyocyte production |
| ATE485825T1 (de) | 1993-01-28 | 2010-11-15 | Boston Scient Ltd | Therapeutische inhibitoren der zellen der glatten gefässmuskulatur |
| US5981568A (en) | 1993-01-28 | 1999-11-09 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| PH30300A (en) * | 1993-05-07 | 1997-01-20 | Ciba Geigy Ag | Polycyclic compounds and processes for the preparation thereof |
| WO1995002057A1 (en) * | 1993-07-09 | 1995-01-19 | The Institute Of Cancer Research | Protein tyrosine kinase and ligands thereof |
| GB9325395D0 (en) * | 1993-12-11 | 1994-02-16 | Ciba Geigy Ag | Compositions |
| EP0711556A1 (de) * | 1994-11-09 | 1996-05-15 | Ciba-Geigy Ag | Intravenöse Lösungen für ein Staurosporinderivat |
| US6875865B1 (en) | 1996-06-03 | 2005-04-05 | Cephalon, Inc. | Selected derivatives of K-252a |
| UA67725C2 (en) | 1996-06-03 | 2004-07-15 | Cephalon Inc | K-252a derivatives and a method for improvement of functioning and cell survival enhancement |
| US6184217B1 (en) | 1996-06-25 | 2001-02-06 | Cephalon, Inc. | Use of K-252a derivative |
| BR9808109A (pt) | 1997-03-31 | 2000-03-08 | Neorx Corp | Inibidor terapêutico de células vasculares da musculatura lisa |
| JP2002530342A (ja) * | 1998-11-23 | 2002-09-17 | ノバルティス アクチエンゲゼルシャフト | 眼血管新生疾患の処置のためのスタウロスポリン誘導体の使用 |
| ES2728739T3 (es) | 2001-02-19 | 2019-10-28 | Novartis Pharma Ag | Derivado de rapamicina para el tratamiento de un tumor sólido asociado con angiogénesis desregulada |
| BR0209647A (pt) | 2001-05-16 | 2004-07-27 | Novartis Ag | Combinação que compreende n-{5-[4-(4-metil-piperazino-metil)-benzoilamido]-2-metil fenil}-4-(3-piridil)-2-pirimidina-amina e um agente quimioterapêutico |
| TWI302836B (en) * | 2001-10-30 | 2008-11-11 | Novartis Ag | Staurosporine derivatives as inhibitors of flt3 receptor tyrosine kinase activity |
| US6887864B2 (en) | 2002-03-12 | 2005-05-03 | Hoffmann-La Roche Inc. | Azepane derivatives |
| GB0206215D0 (en) | 2002-03-15 | 2002-05-01 | Novartis Ag | Organic compounds |
| CN1652757B (zh) | 2002-05-16 | 2012-02-08 | 诺瓦提斯公司 | Edg受体结合剂在癌症中的应用 |
| CN101897662B (zh) * | 2002-07-23 | 2013-05-22 | 诺瓦提斯公司 | 包含药物、软膏基质和增溶剂/分散剂的眼用软膏剂组合物 |
| US7417065B2 (en) | 2003-05-19 | 2008-08-26 | Irm Llc | Immunosuppressant compounds and compositions |
| MY150088A (en) | 2003-05-19 | 2013-11-29 | Irm Llc | Immunosuppressant compounds and compositions |
| US20040246627A1 (en) * | 2003-06-06 | 2004-12-09 | Durrum Thomas M. | Disc drive pivot bearing assembly |
| MXPA06001524A (es) | 2003-08-08 | 2006-05-15 | Novartis Ag | Combinaciones que comprenden estaurosporinas. |
| TW200538433A (en) | 2004-02-24 | 2005-12-01 | Irm Llc | Immunosuppressant compounds and compositiions |
| GB0512324D0 (en) | 2005-06-16 | 2005-07-27 | Novartis Ag | Organic compounds |
| CA2576926C (en) * | 2004-08-31 | 2012-10-02 | Novartis Ag | Use of midostaurin for treating gastrointestinal stromal tumors |
| JO2897B1 (en) * | 2004-11-05 | 2015-09-15 | نوفارتيس ايه جي | Organic compounds |
| KR20140012218A (ko) | 2005-11-21 | 2014-01-29 | 노파르티스 아게 | Ｍｔｏｒ 억제제를 사용하는 신경내분비 종양 치료법 |
| CN102256942B (zh) | 2008-12-18 | 2013-07-24 | 诺瓦提斯公司 | 1-(4-{1-[(e)-4-环己基-3-三氟甲基-苄氧基亚氨基]-乙基}-2-乙基-苄基)-氮杂环丁烷-3-甲酸的多晶型物 |
| RU2011129229A (ru) | 2008-12-18 | 2013-01-27 | Новартис Аг | Новые соли |
| SI2379497T1 (sl) | 2008-12-18 | 2013-12-31 | Novartis Ag | Hemifumaratna sol 1-(4-(1-(4-ciklohaksil-3-trifluorometil-benziloksiimino)-etil)-2-etil- benzil)azetidin-3-karboksilne kisline |
| EP2327706A1 (en) | 2009-11-30 | 2011-06-01 | Novartis AG | Polymorphous forms III and IV of N-benzoyl-staurosporine |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| US8846712B2 (en) | 2011-09-12 | 2014-09-30 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013167403A1 (en) | 2012-05-09 | 2013-11-14 | Sanofi | Substituted 6-(4-hydroxy-phenyl)-1h-pyrazolo[3,4-b]pyridine derivatives as kinase inhibitors |
| WO2019215759A1 (en) * | 2018-05-09 | 2019-11-14 | Alaparthi Lakshmi Prasad | An improved process for preparation of midostaurin |
| WO2021097256A1 (en) | 2019-11-14 | 2021-05-20 | Cohbar, Inc. | Cxcr4 antagonist peptides |
| IT202000004291A1 (it) * | 2020-03-02 | 2021-09-02 | Indena Spa | Processo per la purificazione di alcaloidi indolo carbazolici |
| CN112812129A (zh) * | 2020-12-31 | 2021-05-18 | 浙江海正药业股份有限公司 | 米哚妥林的新晶型及其制备方法和用途 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989007105A1 (en) * | 1988-02-04 | 1989-08-10 | Kyowa Hakko Kogyo Co., Ltd. | Staurosporin derivatives |
-
1988
- 1988-06-06 IL IL86632A patent/IL86632A0/xx not_active IP Right Cessation
- 1988-06-09 ES ES88810383T patent/ES2083956T3/es not_active Expired - Lifetime
- 1988-06-09 MY MYPI88000629A patent/MY104316A/en unknown
- 1988-06-09 DE DE3855015T patent/DE3855015D1/de not_active Expired - Lifetime
- 1988-06-09 EP EP88810383A patent/EP0296110B1/de not_active Expired - Lifetime
- 1988-06-09 AT AT88810383T patent/ATE134375T1/de not_active IP Right Cessation
- 1988-06-10 AU AU17571/88A patent/AU617324B2/en not_active Expired
- 1988-06-13 FI FI882808A patent/FI89362C/fi active IP Right Grant
- 1988-06-13 CA CA000569303A patent/CA1337763C/en not_active Expired - Lifetime
- 1988-06-14 PT PT87719A patent/PT87719B/pt not_active IP Right Cessation
- 1988-06-14 HU HU883048A patent/HU201329B/hu unknown
- 1988-06-14 NZ NZ225018A patent/NZ225018A/xx unknown
- 1988-06-14 NO NO882613A patent/NO170634C/no not_active IP Right Cessation
- 1988-06-14 DK DK198803248A patent/DK175507B1/da not_active IP Right Cessation
- 1988-06-14 IE IE178788A patent/IE70523B1/en not_active IP Right Cessation
- 1988-06-14 YU YU01154/88A patent/YU115488A/xx unknown
- 1988-06-14 KR KR1019880007102A patent/KR970001529B1/ko not_active IP Right Cessation
- 1988-06-15 JP JP63145937A patent/JP2708047B2/ja not_active Expired - Lifetime
-
1996
- 1996-02-22 GR GR960400221T patent/GR3019064T3/el unknown
-
1998
- 1998-04-04 HK HK98102862A patent/HK1003788A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK175507B1 (da) | 2004-11-15 |
| FI89362C (fi) | 1993-09-27 |
| EP0296110A3 (de) | 1991-02-27 |
| YU115488A (en) | 1989-12-31 |
| NO882613L (no) | 1988-12-16 |
| AU617324B2 (en) | 1991-11-28 |
| KR890000494A (ko) | 1989-03-15 |
| EP0296110B1 (de) | 1996-02-21 |
| NZ225018A (en) | 1990-09-26 |
| PT87719B (pt) | 1992-10-30 |
| HK1003788A1 (en) | 1998-11-06 |
| IE881787L (en) | 1988-12-15 |
| FI89362B (fi) | 1993-06-15 |
| EP0296110A2 (de) | 1988-12-21 |
| ATE134375T1 (de) | 1996-03-15 |
| ES2083956T3 (es) | 1996-05-01 |
| HU201329B (en) | 1990-10-28 |
| KR970001529B1 (ko) | 1997-02-11 |
| AU1757188A (en) | 1988-12-15 |
| CA1337763C (en) | 1995-12-19 |
| DK324888A (da) | 1988-12-16 |
| NO170634B (no) | 1992-08-03 |
| IL86632A0 (en) | 1988-11-30 |
| JP2708047B2 (ja) | 1998-02-04 |
| PT87719A (pt) | 1988-07-01 |
| NO882613D0 (no) | 1988-06-14 |
| JPS6434989A (en) | 1989-02-06 |
| DK324888D0 (da) | 1988-06-14 |
| FI882808A (fi) | 1988-12-16 |
| IE70523B1 (en) | 1996-12-11 |
| FI882808A0 (fi) | 1988-06-13 |
| MY104316A (en) | 1994-03-31 |
| DE3855015D1 (de) | 1996-03-28 |
| HUT47587A (en) | 1989-03-28 |
| GR3019064T3 (en) | 1996-05-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |