NO170595C - Fremgangsmaate for fremstilling av biologisk aktiv human vevtypeplasminogenaktivator - Google Patents

Fremgangsmaate for fremstilling av biologisk aktiv human vevtypeplasminogenaktivator

Info

Publication number
NO170595C
NO170595C NO872395A NO872395A NO170595C NO 170595 C NO170595 C NO 170595C NO 872395 A NO872395 A NO 872395A NO 872395 A NO872395 A NO 872395A NO 170595 C NO170595 C NO 170595C
Authority
NO
Norway
Prior art keywords
plasminogen activator
human tissue
procedure
active human
tissue plasminogen
Prior art date
Application number
NO872395A
Other languages
English (en)
Norwegian (no)
Other versions
NO872395D0 (no
NO872395L (no
NO170595B (no
Inventor
William R Arathoon
Stuart E Builder
Anthony S Lubiniecki
Robert D Van Reis
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of NO872395D0 publication Critical patent/NO872395D0/no
Publication of NO872395L publication Critical patent/NO872395L/no
Publication of NO170595B publication Critical patent/NO170595B/no
Publication of NO170595C publication Critical patent/NO170595C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NO872395A 1986-06-06 1987-06-05 Fremgangsmaate for fremstilling av biologisk aktiv human vevtypeplasminogenaktivator NO170595C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87164286A 1986-06-06 1986-06-06

Publications (4)

Publication Number Publication Date
NO872395D0 NO872395D0 (no) 1987-06-05
NO872395L NO872395L (no) 1987-12-07
NO170595B NO170595B (no) 1992-07-27
NO170595C true NO170595C (no) 1992-11-04

Family

ID=25357832

Family Applications (1)

Application Number Title Priority Date Filing Date
NO872395A NO170595C (no) 1986-06-06 1987-06-05 Fremgangsmaate for fremstilling av biologisk aktiv human vevtypeplasminogenaktivator

Country Status (21)

Country Link
US (1) US5053334A (cs)
EP (1) EP0248675B1 (cs)
JP (1) JPS6332484A (cs)
KR (1) KR930002888B1 (cs)
AT (1) ATE75775T1 (cs)
AU (1) AU601984B2 (cs)
DD (1) DD257087A5 (cs)
DE (2) DE3778758D1 (cs)
DK (1) DK175366B1 (cs)
ES (1) ES2032444T3 (cs)
FI (1) FI91886C (cs)
FR (1) FR2599625B1 (cs)
GB (1) GB2191493B (cs)
GR (1) GR3005245T3 (cs)
HU (1) HU205171B (cs)
IE (1) IE60485B1 (cs)
IL (1) IL82746A (cs)
NO (1) NO170595C (cs)
NZ (1) NZ220547A (cs)
PT (1) PT84991B (cs)
ZA (1) ZA874054B (cs)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL82746A (en) * 1986-06-06 1994-10-07 Genentech Inc Process for producing biologically active tissue-type plasminogen activator
JP2576200B2 (ja) * 1988-03-09 1997-01-29 味の素株式会社 生理活性タンパク質の製造法
EP0338716A3 (en) * 1988-04-21 1990-04-11 Berlex Laboratories, Inc. Method and system for the production of non-degraded proteins from mammalian cells
DE3829244A1 (de) * 1988-08-29 1990-03-01 Boehringer Mannheim Gmbh Verfahren zur herstellung von einkettigem t-pa
EP0391080A3 (de) * 1989-03-07 1990-11-07 Roche Diagnostics GmbH Verfahren zur Herstellung von zweikettigem t-PA
GB2249099B (en) * 1990-09-26 1995-05-03 Squibb & Sons Inc Squalene synthetase
US5677184A (en) * 1994-04-19 1997-10-14 Takeda Chemical Industries, Ltd. CHO cells that express human LH-RH receptor
US6077940A (en) * 1997-12-24 2000-06-20 Genentech, Inc. Free solution ligand interaction molecular separation method
ES2713559T3 (es) * 2002-04-08 2019-05-22 Octane Biotech Inc Sistema automatizado de ingeniería de tejidos
PL2343362T5 (pl) * 2006-07-14 2024-12-02 Patheon Holdings I B.V. Ulepszony proces hodowli komórek
EP3327132A3 (en) * 2007-08-09 2018-07-18 Wyeth LLC Use of perfusion to enhance production of fed-batch cell culture in bioreactors
EP2525899A1 (en) * 2010-01-22 2012-11-28 Lonza Walkersville, Inc. High yield method and apparatus for volume reduction and washing of therapeutic cells using tangential flow filtration
US10934519B2 (en) * 2011-07-29 2021-03-02 Global Life Sciences Solutions Usa Llc Systems, methods and control laws for cell harvesting
EP2885392A1 (en) * 2012-08-20 2015-06-24 Terumo BCT, Inc. Concentrating components of fluid circulated through a cell growth chamber
IL272914B2 (en) 2017-09-01 2025-02-01 Lonza Walkersville Inc Total automation of cell therapy
JP7598864B2 (ja) 2018-12-21 2024-12-12 ロンザ ウォーカーズヴィル，インコーポレーテッド ウイルスベクターの自動産生方法
KR20210107749A (ko) 2018-12-21 2021-09-01 옥테인 바이오테크 인코포레이티드 모듈식 생물학적 생산 유닛들을 위한 캐러셀
KR102810534B1 (ko) 2018-12-28 2025-05-22 옥테인 바이오테크 인코포레이티드 제어된 환경 존을 포함하는 세포 배양 및 조직 공학 시스템
JP7536026B2 (ja) 2019-02-08 2024-08-19 ロンザ ウォーカーズヴィル，インコーポレーテッド 自動化バイオリアクターにおける使用のための細胞濃縮方法および細胞濃縮デバイス
WO2021081170A1 (en) 2019-10-24 2021-04-29 Octane Biotech Inc. Cell culture chamber with improved cell-contacting surfaces
CA3159567A1 (en) 2019-11-11 2021-05-20 Lonza Walkersville, Inc. Quality control methods for automated cell processing
CA3224150A1 (en) 2021-07-02 2023-01-05 Combangio, Inc. Processes for making and using a cellular fibronectin composition

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3904480A (en) * 1972-10-24 1975-09-09 Lilly Co Eli Enhanced production of plasminogen activator
JPS5329985A (en) * 1976-08-27 1978-03-20 Kanegafuchi Chem Ind Co Ltd High concentration culturing of yeast
JPS5571496A (en) * 1978-11-24 1980-05-29 Asahi Chem Ind Co Ltd Preparation of living substance
US4409331A (en) * 1979-03-28 1983-10-11 Damon Corporation Preparation of substances with encapsulated cells
US4232124A (en) * 1979-04-23 1980-11-04 Mann George F Method of producing plasminogen activator
DE3015699C2 (de) * 1979-04-26 1982-07-15 Asahi Kasei Kogyo K.K., Osaka Herstellung eines Plasminogen-Aktivators
JPS5642584A (en) * 1979-09-18 1981-04-20 Asahi Chem Ind Co Ltd Cell cultivation method
US4420398A (en) * 1981-08-13 1983-12-13 American National Red Cross Filteration method for cell produced antiviral substances
IL68561A (en) * 1982-05-05 1991-01-31 Genentech Inc Preparation of polypeptide with human tissue plasminogen activator function,processes for making it,and dna and transformed cell intermediates thereof
JPS5951220A (ja) * 1982-08-02 1984-03-24 Asahi Chem Ind Co Ltd 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤
US4537860A (en) * 1982-12-08 1985-08-27 Monsanto Company Static cell culture maintenance system
NZ206699A (en) * 1982-12-30 1989-08-29 Bio Response Inc Process for the production of serum independent cell lines
IE56716B1 (en) * 1983-01-19 1991-11-20 Genentech Inc Method for producing human tpa and expression vectors therefor
JPS59121172U (ja) * 1983-02-04 1984-08-15 ミネソタ・マイニング・アンド・マニユフアクチユアリング・コンパニ− ケーブル電線被覆の剥離部分のカバー装置
US4546083A (en) * 1983-04-22 1985-10-08 Stolle Research & Development Corporation Method and device for cell culture growth
DD229151A5 (de) * 1983-11-21 1985-10-30 Ciba Geigy Ag Verfahren zur herstellung von gewebeplasminogenaktivatoren
US4740461A (en) * 1983-12-27 1988-04-26 Genetics Institute, Inc. Vectors and methods for transformation of eucaryotic cells
US4888115A (en) * 1983-12-29 1989-12-19 Cuno, Incorporated Cross-flow filtration
US4757005A (en) * 1984-04-19 1988-07-12 Miles Inc. Method and cell line for obtaining plasminogen activators
WO1986005514A1 (en) * 1985-03-22 1986-09-25 Chiron Corporation EXPRESSION OF tPA IN MAMMALIAN CELLS
AU593264B2 (en) * 1985-07-10 1990-02-08 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Chromosomal DNA sequence, expression vector for human tissue plasminogen activating factor, cultured cells transfected with same and method of producing said activating factor
EP0238551A4 (en) * 1985-09-06 1988-02-01 Codon METHODS OF RECOVERING A TISSUE PLASMINOGEN ACTIVATOR.
JPH07110232B2 (ja) * 1985-10-14 1995-11-29 株式会社日立製作所 遺伝子組換え大腸菌の遺伝子生産物を採取する方法および装置
IL82746A (en) * 1986-06-06 1994-10-07 Genentech Inc Process for producing biologically active tissue-type plasminogen activator

Also Published As

Publication number Publication date
DK288187A (da) 1987-12-07
IL82746A (en) 1994-10-07
DE3718939C2 (de) 1998-09-17
JPS6332484A (ja) 1988-02-12
JPH0574346B2 (cs) 1993-10-18
EP0248675B1 (en) 1992-05-06
NO872395D0 (no) 1987-06-05
IL82746A0 (en) 1987-12-20
DD257087A5 (de) 1988-06-01
FI91886B (fi) 1994-05-13
PT84991A (en) 1987-07-01
IE871504L (en) 1987-12-06
NZ220547A (en) 1990-01-29
KR880000590A (ko) 1988-03-28
FI872526A0 (fi) 1987-06-05
DE3778758D1 (de) 1992-06-11
ES2032444T3 (es) 1993-02-16
FI91886C (fi) 1994-08-25
IE60485B1 (en) 1994-07-27
DE3718939A1 (de) 1987-12-17
AU601984B2 (en) 1990-09-27
GB2191493B (en) 1991-02-27
GB8713267D0 (en) 1987-07-08
ZA874054B (en) 1989-02-22
KR930002888B1 (ko) 1993-04-12
FR2599625A1 (fr) 1987-12-11
FI872526L (fi) 1987-12-07
AU7387287A (en) 1987-12-10
ATE75775T1 (de) 1992-05-15
US5053334A (en) 1991-10-01
HU205171B (en) 1992-03-30
NO872395L (no) 1987-12-07
EP0248675A1 (en) 1987-12-09
GR3005245T3 (cs) 1993-05-24
HUT43875A (en) 1987-12-28
FR2599625B1 (fr) 1992-03-13
PT84991B (pt) 1990-03-08
DK288187D0 (da) 1987-06-04
DK175366B1 (da) 2004-09-13
GB2191493A (en) 1987-12-16
NO170595B (no) 1992-07-27

Similar Documents

Publication Publication Date Title
NO170595C (no) Fremgangsmaate for fremstilling av biologisk aktiv human vevtypeplasminogenaktivator
DE69020850D1 (de) Pflanzengewebekulturverfahren zur Transformation von Pflanzenzellen.
DE69740002D1 (de) Tierzellen und verfahren für die replikation von influenza viren
DE3786898D1 (de) Transformation und expression eines fremden gens in -i(brassica) spezies.
ATE43633T1 (de) Verfahren und vorrichtung zum kultivieren von humanen, tierischen, pflanzlichen sowie hybriden zellen und mikroorganismen.
ATE76898T1 (de) Nebel-zellkultur.
JPS57105191A (en) Production of human urogastrone
IT1164025B (it) Procedimento di produzione di una sostanza presentante un'attivita' batteriostatica
DE3877669D1 (de) Verfahren zur kristallmorphologischen blut- und harnanalyse, zur fruehdiagnose und zur herstellung von arzneimitteln.
ATE15693T1 (de) Zellkultur-verfahren.
EP0380692A4 (en) Plant tissue culture process
SE7608103L (sv) Forfarande for behandling av cellprotein
SE8402742D0 (sv) The growth of human diploid fibroblasts as aggregates with cellulose fibers in suspension
DE3485610D1 (de) Verfahren zur erhaltung und vermehrung von defekten, nicht-infektioesen virusgenomen.
EP0249772A3 (en) Method and composition for plant tissue and cell culture
DE3576163D1 (de) Absorbierendes polymeres material und dessen herstellung.
IL80901A0 (en) Growth-promoting cell culture medium and process for the cultivation of cells employing the same
ZA869449B (en) Growth-promoting cell culture medium and process for the cultivation of cells employing the same
RU96108645A (ru) Способ выделения и очистки ферментного комплекса из культивируемых растительных клеток
SU1692145A1 (ru) Способ получения клеточной культуры
PL285546A1 (en) Biological culture medium for cell cultures and method of culturing human keratocytes as well as proteinous concentrate