NO161439C - Analogifremgangsmaate for fremstilling av terapeutisk aktive n-imidazolylderivater av bicykliske forbindelser. - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive n-imidazolylderivater av bicykliske forbindelser.

Info

Publication number
NO161439C
NO161439C NO832437A NO832437A NO161439C NO 161439 C NO161439 C NO 161439C NO 832437 A NO832437 A NO 832437A NO 832437 A NO832437 A NO 832437A NO 161439 C NO161439 C NO 161439C
Authority
NO
Norway
Prior art keywords
preparation
therapeutic active
bicyclic compounds
imidazolyl derivatives
analogue procedure
Prior art date
Application number
NO832437A
Other languages
English (en)
Norwegian (no)
Other versions
NO161439B (no
NO832437L (no
Inventor
Paolo Cozzi
Germano Carganico
Antonio Pillan
Umberto Carlo Branzoli
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of NO832437L publication Critical patent/NO832437L/no
Publication of NO161439B publication Critical patent/NO161439B/no
Publication of NO161439C publication Critical patent/NO161439C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO832437A 1982-07-05 1983-07-04 Analogifremgangsmaate for fremstilling av terapeutisk aktive n-imidazolylderivater av bicykliske forbindelser. NO161439C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8219412 1982-07-05

Publications (3)

Publication Number Publication Date
NO832437L NO832437L (no) 1984-01-06
NO161439B NO161439B (no) 1989-05-08
NO161439C true NO161439C (no) 1989-08-16

Family

ID=10531484

Family Applications (1)

Application Number Title Priority Date Filing Date
NO832437A NO161439C (no) 1982-07-05 1983-07-04 Analogifremgangsmaate for fremstilling av terapeutisk aktive n-imidazolylderivater av bicykliske forbindelser.

Country Status (33)

Country Link
US (2) US4510149A (fr)
JP (1) JPS5927874A (fr)
KR (1) KR910000414B1 (fr)
AT (1) AT386201B (fr)
AU (1) AU557304B2 (fr)
BE (1) BE897207A (fr)
CA (1) CA1202030A (fr)
CH (1) CH655102A5 (fr)
CS (1) CS273310B2 (fr)
CZ (1) CZ413491A3 (fr)
DE (1) DE3324069C2 (fr)
DK (1) DK163359C (fr)
ES (1) ES523609A0 (fr)
FI (1) FI74466C (fr)
FR (1) FR2529547B1 (fr)
GR (1) GR77577B (fr)
HK (1) HK101187A (fr)
HU (1) HU193529B (fr)
IE (1) IE55894B1 (fr)
IL (1) IL69152A0 (fr)
IT (1) IT1163641B (fr)
LU (1) LU84895A1 (fr)
MY (1) MY104376A (fr)
NL (1) NL8302347A (fr)
NO (1) NO161439C (fr)
NZ (1) NZ204802A (fr)
PH (1) PH21115A (fr)
PT (1) PT76979B (fr)
SE (1) SE461791B (fr)
SG (1) SG73487G (fr)
SU (1) SU1342414A3 (fr)
YU (1) YU43545B (fr)
ZA (1) ZA834865B (fr)

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PH22076A (en) * 1983-08-25 1988-05-20 Daiichi Seiyaku Co Benzocycloalkane derivative
JPH062745B2 (ja) * 1984-07-16 1994-01-12 第一製薬株式会社 インダン誘導体
US4659730A (en) * 1984-06-18 1987-04-21 Eli Lilly And Company Aromatase inhibiting imidazole derivatives
GB2167408B (en) * 1984-11-23 1988-05-25 Farmos Oy Substituted imidazole derivatives and their preparation and use
GB8612796D0 (en) * 1986-05-27 1986-07-02 Fbc Ltd Fungicides
PH24144A (en) * 1987-06-03 1990-03-22 Erba Carlo Spa A method of treating nephropathies using n-imidazolyl derivatives of bicyclic compounds
US4992465A (en) * 1988-09-27 1991-02-12 Ciba-Geigy Corporation 3-amino-dihydro-(1)-benzopyrans
IL91542A0 (en) * 1988-10-06 1990-04-29 Erba Carlo Spa N-imidazolyl-and n-imidazolyl-methyl derivatives of substituted bicyclic compounds,their preparation and pharmaceutical compositions containing them
GB9025848D0 (en) * 1990-11-28 1991-01-09 Erba Carlo Spa Imidazol-2-yl derivatives of substituted bicyclic compounds and process for their preparation
GB9102862D0 (en) * 1991-02-11 1991-03-27 Erba Carlo Spa N-imidazolyl derivatives of substituted or alkoxymino tetrahydronaphthalenes and chromans
GB9127050D0 (en) * 1991-12-20 1992-02-19 Orion Yhtymae Oy Substituted imidazole derivatives and their preparation and use
GB9127430D0 (en) * 1991-12-27 1992-02-19 Scras Benzofuranylimidazole derivatives
US5837702A (en) * 1993-10-07 1998-11-17 Bristol-Myers Squibb Co. 4-arylamino-benzopyran and related compounds
US5559248A (en) * 1995-04-05 1996-09-24 Bristol-Myers Squibb Co. Retinoid-like heterocycles
US5612370A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phenylglycine and phenylalaninen amido benzopyran derivatives
US5869478A (en) * 1995-06-07 1999-02-09 Bristol-Myers Squibb Company Sulfonamido substituted benzopyran derivatives
US5612323A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phosphinic ester substituted benzopyran derivatives
US5629429A (en) * 1995-06-07 1997-05-13 Bristol-Myers Squibb Company Process for preparing 4-arylamino-benzopyran and related compounds
GB9520150D0 (en) 1995-10-03 1995-12-06 Orion Yhtymae Oy New imidazole derivatives
GC0000177A (en) * 1998-12-17 2006-03-29 Smithkline Beecham Thrombopoietin mimetics
CY2010012I2 (el) * 2000-05-25 2020-05-29 Novartis Ag Μιμητικα θρομβοποιητινης
US20110212054A1 (en) * 2000-05-25 2011-09-01 Glaxosmithkline Llc. Thrombopoietin mimetics
DE10054639B4 (de) * 2000-11-03 2004-05-06 Jenapharm Gmbh & Co. Kg Verwendung von RanBPM als Co-Modulator von Steroidhormonrezeptoren
JP2004527541A (ja) 2001-03-01 2004-09-09 スミスクライン・ビーチャム・コーポレイション トロンボポエチン模倣物
TWI280128B (en) 2002-05-22 2007-05-01 Smithkline Beecham Corp 3'-[(2Z)-[1-(3,4- dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid bis-(monoethanolamine)
JP4584913B2 (ja) * 2003-04-16 2010-11-24 ハンツマン・アドヴァンスト・マテリアルズ・（スイッツランド）・ゲーエムベーハー １−イミダゾリルメチル置換−２−ナフトールおよび低温硬化用促進剤としてのそれらの使用
TW200526638A (en) * 2003-10-22 2005-08-16 Smithkline Beecham Corp 2-(3,4-dimethylphenyl)-4-{[2-hydroxy-3'-(1H-tetrazol-5-yl)biphenyl-3-yl]-hydrazono}-5-methyl-2,4-dihydropyrazol-3-one choline
WO2006092430A1 (fr) * 2005-03-03 2006-09-08 Universität des Saarlandes Inhibiteurs selectifs de synthases de corticoides humaines
US20100041722A1 (en) * 2006-12-18 2010-02-18 Qi-Ying Hu Organic compounds
ECSP077628A (es) * 2007-05-03 2008-12-30 Smithkline Beechman Corp Nueva composición farmacéutica
WO2010138656A1 (fr) 2009-05-29 2010-12-02 Glaxosmithkline Llc Procédés d'administration de composés agonistes de la thrombopoïétine
WO2016022448A1 (fr) * 2014-08-08 2016-02-11 Merck Sharp & Dohme Corp. Composés bicycliques antidiabétiques

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US2443671A (en) * 1942-12-03 1948-06-22 Westinghouse Electric Corp Arc welding system
US3485917A (en) * 1966-04-14 1969-12-23 Janssen Pharmaceutica Nv Composition and method for combating fungus with imidazole carboxylates
US3541109A (en) * 1968-06-25 1970-11-17 Du Pont 1-substituted imidazoles useful in acth reserve assay
US3637731A (en) * 1968-07-18 1972-01-25 Du Pont 1-(alkylsubstituted phenyl)imidazoles useful in acth reserve assay
DE2418502C3 (de) * 1974-04-11 1980-04-24 Schering Ag, 1000 Berlin Und 4619 Bergkamen Dichlorbenzyl- [2-( a -imidazolylbutyl)-phenyl] -äther und -thioäther, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
IE40911B1 (en) * 1974-04-11 1979-09-12 Schering Ag Imidazole derivatives and process for their manufacture
US4284641A (en) * 1977-08-26 1981-08-18 Burroughs Wellcome Co. Pharmaceutically active imidazole derivatives
JPS55313A (en) * 1978-06-13 1980-01-05 Kissei Pharmaceut Co Ltd Imidazole derivative
JPS5681566A (en) * 1979-12-05 1981-07-03 Yoshitomi Pharmaceut Ind Ltd Imidazole derivative
ATE43335T1 (de) * 1980-02-14 1989-06-15 Sandoz Ag Peptide die einen (1s,2r,3r)- oder (1r,2s,3s)-1nitrilo-1-carbonyl-3-methyl-2-oxyheptan oder hept-5-en-rest enthalten brauchbar in totaler synsthese von cyclosporinen, und verfahren zu ihrer herstellung.
IL62122A0 (en) * 1980-03-04 1981-03-31 Erba Farmitalia N-imidazolyl derivatives of 1-chroman,their preparation and pharmaceutical compositions containing them
ZA81980B (en) * 1980-03-04 1982-02-24 Erba Farmitalia N-imidazolyl derivatives of 1-chroman and process for their preparation
GB2071655B (en) * 1980-03-04 1983-06-22 Erba Farmitalia N-amidazolyl derivatives of1-chroman and process for their preparation
ZA825142B (en) * 1981-07-23 1983-04-27 Erba Farmitalia N-imidazolyl derivatives of 1,2,3,j-tetrahydro-naphthalene, indan and 2-substituted-1-chroman, and process for their preparation
IL66242A0 (en) * 1981-07-23 1982-11-30 Erba Farmitalia N-imidazolyl derivatives of 1,2,3,4-tetrahydro-naphthalene,indan and 2-substituted-1-chroman,their preparation and pharmaceutical compositions containing them
ZA825413B (en) * 1981-08-26 1983-06-29 Pfizer Thromboxane synthetase inhibitors, processes for their production, and pharmaceutical compositions comprising them
JPS6081566A (ja) * 1983-10-07 1985-05-09 Nissan Motor Co Ltd ロツクアツプトルクコンバ−タのスリツプ制御装置

Also Published As

Publication number Publication date
PT76979B (en) 1986-01-09
NL8302347A (nl) 1984-02-01
YU144283A (en) 1986-10-31
CS509483A2 (en) 1990-08-14
MY104376A (en) 1994-03-31
DK307983D0 (da) 1983-07-04
PH21115A (en) 1987-07-16
IL69152A0 (en) 1983-11-30
GR77577B (fr) 1984-09-24
KR840005433A (ko) 1984-11-12
ATA247383A (de) 1987-12-15
HK101187A (en) 1988-01-08
IE55894B1 (en) 1991-02-14
IT1163641B (it) 1987-04-08
NO161439B (no) 1989-05-08
SG73487G (en) 1988-03-04
AU1654083A (en) 1984-01-12
NZ204802A (en) 1986-04-11
US4510149A (en) 1985-04-09
FR2529547A1 (fr) 1984-01-06
DK163359B (da) 1992-02-24
DE3324069A1 (de) 1984-01-26
CH655102A5 (de) 1986-03-27
LU84895A1 (fr) 1983-11-23
AT386201B (de) 1988-07-25
CA1202030A (fr) 1986-03-18
DK307983A (da) 1984-01-06
YU43545B (en) 1989-08-31
ES8503669A1 (es) 1985-03-01
SE8303824L (sv) 1984-01-06
US4602022A (en) 1986-07-22
SE8303824D0 (sv) 1983-07-04
JPH0454662B2 (fr) 1992-08-31
JPS5927874A (ja) 1984-02-14
NO832437L (no) 1984-01-06
KR910000414B1 (ko) 1991-01-25
IT8321886A0 (it) 1983-07-01
HU193529B (en) 1987-10-28
FI832420A0 (fi) 1983-07-01
AU557304B2 (en) 1986-12-18
DE3324069C2 (de) 1994-08-25
SE461791B (sv) 1990-03-26
ES523609A0 (es) 1985-03-01
BE897207A (fr) 1984-01-04
DK163359C (da) 1992-07-13
IE831564L (en) 1984-01-05
PT76979A (en) 1983-08-01
FI74466C (fi) 1988-02-08
CS273310B2 (en) 1991-03-12
ZA834865B (en) 1984-03-28
FI74466B (fi) 1987-10-30
FI832420L (fi) 1984-01-06
FR2529547B1 (fr) 1986-09-05
SU1342414A3 (ru) 1987-09-30
CZ413491A3 (en) 1993-10-13

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