NO153568C - Analogifremgangsmaate for fremstilling av fysiologisk aktive amidinderivater. - Google Patents
Analogifremgangsmaate for fremstilling av fysiologisk aktive amidinderivater.Info
- Publication number
- NO153568C NO153568C NO813138A NO813138A NO153568C NO 153568 C NO153568 C NO 153568C NO 813138 A NO813138 A NO 813138A NO 813138 A NO813138 A NO 813138A NO 153568 C NO153568 C NO 153568C
- Authority
- NO
- Norway
- Prior art keywords
- preparation
- physiologically active
- amidino
- amidine derivatives
- analogy procedure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Superconductors And Manufacturing Methods Therefor (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pyridine Compounds (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Heat Treatment Of Sheet Steel (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Power Steering Mechanism (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12826980A JPS5753454A (en) | 1980-09-16 | 1980-09-16 | Guanidinobenzoate and anticomplementary agent |
| JP6494281A JPS57179146A (en) | 1981-04-28 | 1981-04-28 | Amidine compound |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO813138L NO813138L (no) | 1982-03-17 |
| NO153568B NO153568B (no) | 1986-01-06 |
| NO153568C true NO153568C (no) | 1986-05-21 |
Family
ID=26406084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO813138A NO153568C (no) | 1980-09-16 | 1981-09-15 | Analogifremgangsmaate for fremstilling av fysiologisk aktive amidinderivater. |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US4454338A (de) |
| EP (1) | EP0048433B1 (de) |
| KR (1) | KR860000264B1 (de) |
| AT (1) | ATE20051T1 (de) |
| AU (1) | AU527371B2 (de) |
| CA (1) | CA1177488A (de) |
| CS (1) | CS228534B2 (de) |
| DD (1) | DD201779A5 (de) |
| DE (1) | DE3174717D1 (de) |
| DK (1) | DK155003C (de) |
| ES (1) | ES8206443A1 (de) |
| FI (1) | FI73975C (de) |
| GB (1) | GB2083818B (de) |
| HU (1) | HU185956B (de) |
| NO (1) | NO153568C (de) |
| PH (1) | PH18109A (de) |
| SU (1) | SU1176832A3 (de) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU527371B2 (en) * | 1980-09-16 | 1983-03-03 | Torii & Co., Ltd. | Amidine |
| FR2500825B1 (fr) * | 1981-02-27 | 1985-08-23 | Torii & Co Ltd | Nouveau carboxylate de 4-amidino-phenyle substitue, son procede de preparation et agent anti-complement en comprenant |
| JPS57179147A (en) * | 1981-04-28 | 1982-11-04 | Torii Yakuhin Kk | Amidine derivative |
| JPS59139357A (ja) * | 1983-01-28 | 1984-08-10 | Torii Yakuhin Kk | アミジン誘導体 |
| US4818273A (en) * | 1983-11-14 | 1989-04-04 | The Dow Chemical Company | Substituted 1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamides, compositions containing them, and their utility as herbicides |
| US4563527A (en) * | 1984-07-19 | 1986-01-07 | Torii & Co., Ltd. | Amidine compounds |
| JPS6133173A (ja) * | 1984-07-25 | 1986-02-17 | Torii Yakuhin Kk | アミジン化合物 |
| GB2162171B (en) * | 1984-07-26 | 1988-01-27 | Torii & Co Ltd | Amidine compounds |
| FR2568253B1 (fr) * | 1984-07-26 | 1987-01-30 | Torii Co | Nouvelle amidine |
| DE3427865A1 (de) * | 1984-07-27 | 1986-02-06 | Torii & Co., Tokio/Tokyo | Amidinoverbindungen, verfahren zu deren herstellung und diese verbindungen enthaltende pharmazeutische mittel |
| US4709082A (en) * | 1984-10-25 | 1987-11-24 | Nissan Chemical Industries, Ltd. | 2-phenylpropionic acid esters, method for optical resolution thereof and optically active substance thereof |
| EP0284632A1 (de) * | 1987-03-30 | 1988-10-05 | Shosuke Okamoto | Phenylalaninabkömmling und Inhibitor von Proteinase |
| US4990537A (en) * | 1988-07-11 | 1991-02-05 | Banyu Pharmaceutical Co., Ltd. | Anti influenza agent |
| US5116985A (en) * | 1989-12-28 | 1992-05-26 | Snow Brand Milk Products Co., Ltd. | Isoquinoline derivatives and salts thereof |
| ATE119523T1 (de) * | 1989-12-28 | 1995-03-15 | Snow Brand Milk Products Co Ltd | Isochinolinderivate und ihre salze als proteasehemmer. |
| JPH078789B2 (ja) * | 1990-04-05 | 1995-02-01 | 鳥居薬品株式会社 | 脳血管攣縮治療剤 |
| US5238964A (en) * | 1990-04-05 | 1993-08-24 | Torii & Co., Ltd. | Agent for treatment of cerebrovascular contraction |
| DE4102024A1 (de) * | 1991-01-24 | 1992-07-30 | Thomae Gmbh Dr K | Biphenylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| ZA928276B (en) * | 1991-10-31 | 1993-05-06 | Daiichi Seiyaku Co | Aromatic amidine derivates and salts thereof. |
| DE69508875T2 (de) * | 1994-09-20 | 1999-09-16 | Ono Pharmaceutical Co | Amidinophenol-Derivate als Protease-hemmende Verbindungen |
| US5869501A (en) * | 1994-12-02 | 1999-02-09 | Yamanouchi Pharmaceutical Co. Ltd | Amidinonaphthyl derivative or salt thereof |
| JP3817263B2 (ja) * | 1995-01-05 | 2006-09-06 | 鳥居薬品株式会社 | 置換アミジノナフチルエステル誘導体 |
| WO1997037969A1 (fr) | 1996-04-10 | 1997-10-16 | Ono Pharmaceutical Co., Ltd. | Inhibiteur de tryptase derives de guanidino |
| AU7808198A (en) | 1997-06-03 | 1998-12-21 | Biocryst Pharmaceuticals, Inc. | Novel compounds useful in the complement, coagulat and kallikrein pathways and method for their preparation |
| EP1030844A1 (de) * | 1997-11-10 | 2000-08-30 | Array Biopharma Inc. | Verbindungen, die die aktivität von tryptase hemmen |
| US6066673A (en) * | 1998-03-12 | 2000-05-23 | The Procter & Gamble Company | Enzyme inhibitors |
| AP1224A (en) | 1998-03-19 | 2003-11-14 | Bristol Myers Squibb Co | Biphasic controlled release delivery system for high solubility pharmaceuticals and method. |
| EP1066272A4 (de) * | 1998-03-27 | 2002-03-13 | Biocryst Pharm Inc | Neue verbindungen, die im komplement-, koagulat- und kallikrein-reaktionsweg nützlich sind und verfahren zu ihrer herstellung |
| WO1999055661A1 (en) * | 1998-04-24 | 1999-11-04 | Proteus Molecular Design Limited | Aminomethyl-benzoic ester derivatives as tryptase inhibitors |
| US6362216B1 (en) | 1998-10-27 | 2002-03-26 | Array Biopharma Inc. | Compounds which inhibit tryptase activity |
| AR037097A1 (es) | 2001-10-05 | 2004-10-20 | Novartis Ag | Compuestos acilsulfonamidas, composiciones farmaceuticas y el uso de dichos compuestos para la preparacion de un medicamento |
| JP2006096668A (ja) * | 2002-11-08 | 2006-04-13 | Ono Pharmaceut Co Ltd | エラスターゼ阻害剤と血液凝固系および／または線溶系酵素阻害剤との組み合わせからなる医薬 |
| CN1980948B (zh) * | 2002-11-27 | 2011-08-10 | Dmi生物科学公司 | 治疗由增强磷酸化介导的疾病和病况 |
| CN1886126A (zh) * | 2003-09-25 | 2006-12-27 | Dmi生物科学公司 | 利用n－酰基－l－天冬氨酸的方法和产品 |
| EP2119439A3 (de) * | 2005-05-17 | 2010-01-27 | Santen Pharmaceutical Co., Ltd. | Angiogenese-Hemmer zur Behandlung von Makuladegeneration |
| EP2119440A1 (de) * | 2005-05-17 | 2009-11-18 | Santen Pharmaceutical Co., Ltd. | Amidinderivate zur Verwendung in der Vorbeugung oder Therapie der Retinitis pigmentosa und der Leber'schen Krankheit |
| GB2445920A (en) * | 2007-01-25 | 2008-07-30 | Mucokinetica Ltd | Amidino compounds for treatment of respiratory disease |
| EP2311810A4 (de) * | 2008-07-11 | 2012-04-04 | Ajinomoto Kk | Amidderivate |
| CA2739936C (en) | 2008-10-17 | 2017-12-12 | Pharmacofore, Inc. | Pharmaceutical compositions with attenuated release of phenolic opioids |
| CN102695545B (zh) | 2009-09-08 | 2016-08-17 | 特色疗法股份有限公司 | 包括酶可剪切的酮改性的阿片样物质药物前体以及其可任选的抑制剂的组合物 |
| US20110262355A1 (en) | 2010-04-21 | 2011-10-27 | Jenkins Thomas E | Compositions comprising enzyme-cleavable opioid prodrugs and inhibitors thereof |
| US9238020B2 (en) | 2010-04-21 | 2016-01-19 | Signature Therapeutics, Inc. | Compositions comprising enzyme-cleavable phenol-modified tapentadol prodrug |
| EP2560486B1 (de) | 2010-04-21 | 2018-11-21 | Signature Therapeutics, Inc. | Zusammensetzungen aus enzymspaltbaren amphetamin-prodrugs und hemmern dafür |
| CA2804926C (en) | 2010-07-09 | 2019-01-08 | James Trinca Green | Combination immediate/delayed release delivery system for short half-life pharmaceuticals including remogliflozin |
| US8497237B2 (en) | 2011-01-11 | 2013-07-30 | Signature Therapeutics, Inc. | Compositions comprising enzyme-cleavable oxycodone prodrug |
| EP2663187B1 (de) | 2011-01-11 | 2016-06-01 | Signature Therapeutics, Inc. | Zusammensetzungen mit einem enzymspaltbaren oxycodon-prodrug |
| WO2012122420A2 (en) | 2011-03-09 | 2012-09-13 | Pharmacofore, Inc. | Opioid prodrugs with heterocyclic linkers |
| CA2827662C (en) | 2011-03-09 | 2020-07-14 | Signature Therapeutics, Inc. | Active agent prodrugs with heterocyclic linkers |
| CA2848561C (en) | 2011-09-15 | 2019-04-02 | Astellas Pharma Inc. | Guanidinobenzoic acid compound |
| CN103012214A (zh) * | 2011-09-28 | 2013-04-03 | 南京长澳医药科技有限公司 | 一种萘莫司他盐酸盐及萘莫司他甲磺酸盐的制备方法 |
| MY194604A (en) * | 2013-03-13 | 2022-12-06 | Takeda Pharmaceuticals Co | Guanidinobenzoic acid ester compound |
| CN103641749B (zh) * | 2013-12-02 | 2016-02-10 | 山东永泰化工有限公司 | 一种甲磺酸萘莫司他的制备方法 |
| US9346776B2 (en) | 2014-02-13 | 2016-05-24 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compound |
| US9428470B2 (en) | 2014-02-13 | 2016-08-30 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| CN110330447B (zh) * | 2019-07-16 | 2022-04-15 | 北京赛升药业股份有限公司 | 一种甲磺酸萘莫司他中间体的制备方法及其应用 |
| CN111803483B (zh) * | 2020-01-21 | 2021-04-06 | 中国人民解放军军事科学院军事医学研究院 | 苯甲酸酯类化合物在治疗SARS-CoV-2感染方面的应用 |
| WO2021209563A1 (en) | 2020-04-16 | 2021-10-21 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus |
| CN111574409A (zh) * | 2020-05-14 | 2020-08-25 | 河北省医疗器械与药品包装材料检验研究院(河北省医疗器械技术审评中心) | 一种甲磺酸萘莫司他的重结晶工艺方法 |
| CN113999145B (zh) * | 2021-11-12 | 2023-02-03 | 开封明仁药业有限公司 | 一种甲磺酸萘莫司他的合成方法 |
| WO2023118896A1 (en) | 2021-12-23 | 2023-06-29 | Subintro Limited | Novel antiviral compositions comprising oleic acid |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD89611A (de) * | ||||
| DE1905813A1 (de) * | 1968-07-04 | 1970-03-05 | Akad Wissenschaften Ddr | 3- oder 4-Guanidobenzoesaeurebenzyl- oder -phenylestern und deren Verwendung als Inhibitoren |
| GB1472700A (en) * | 1974-11-01 | 1977-05-04 | Ono Pharmaceutical Co | Guanidinobehzoic acid derivatives and process for preparing the same |
| AU527371B2 (en) * | 1980-09-16 | 1983-03-03 | Torii & Co., Ltd. | Amidine |
-
1981
- 1981-09-08 AU AU75062/81A patent/AU527371B2/en not_active Expired
- 1981-09-09 US US06/300,534 patent/US4454338A/en not_active Expired - Lifetime
- 1981-09-10 CA CA000385570A patent/CA1177488A/en not_active Expired
- 1981-09-14 ES ES505460A patent/ES8206443A1/es not_active Expired
- 1981-09-15 NO NO813138A patent/NO153568C/no unknown
- 1981-09-15 DE DE8181107274T patent/DE3174717D1/de not_active Expired
- 1981-09-15 KR KR1019810003427A patent/KR860000264B1/ko active
- 1981-09-15 DK DK410681A patent/DK155003C/da not_active IP Right Cessation
- 1981-09-15 CS CS816809A patent/CS228534B2/cs unknown
- 1981-09-15 HU HU812665A patent/HU185956B/hu unknown
- 1981-09-15 AT AT81107274T patent/ATE20051T1/de not_active IP Right Cessation
- 1981-09-15 GB GB8127837A patent/GB2083818B/en not_active Expired
- 1981-09-15 FI FI812876A patent/FI73975C/fi not_active IP Right Cessation
- 1981-09-15 SU SU813384251A patent/SU1176832A3/ru active
- 1981-09-15 EP EP81107274A patent/EP0048433B1/de not_active Expired
- 1981-09-15 PH PH26206A patent/PH18109A/en unknown
- 1981-09-16 DD DD81233339A patent/DD201779A5/de not_active IP Right Cessation
-
1984
- 1984-01-20 US US06/572,269 patent/US4532255A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DK155003B (da) | 1989-01-23 |
| FI73975C (fi) | 1987-12-10 |
| SU1176832A3 (ru) | 1985-08-30 |
| NO813138L (no) | 1982-03-17 |
| CA1177488A (en) | 1984-11-06 |
| ATE20051T1 (de) | 1986-06-15 |
| ES505460A0 (es) | 1982-08-16 |
| CS228534B2 (en) | 1984-05-14 |
| AU7506281A (en) | 1982-03-25 |
| FI73975B (fi) | 1987-08-31 |
| US4532255A (en) | 1985-07-30 |
| DK155003C (da) | 1989-05-29 |
| EP0048433A2 (de) | 1982-03-31 |
| GB2083818A (en) | 1982-03-31 |
| ES8206443A1 (es) | 1982-08-16 |
| PH18109A (en) | 1985-03-22 |
| HU185956B (en) | 1985-04-28 |
| NO153568B (no) | 1986-01-06 |
| DK410681A (da) | 1982-03-17 |
| DD201779A5 (de) | 1983-08-10 |
| KR830007527A (ko) | 1983-10-21 |
| EP0048433A3 (en) | 1982-07-21 |
| DE3174717D1 (en) | 1986-07-03 |
| US4454338A (en) | 1984-06-12 |
| FI812876L (fi) | 1982-03-17 |
| GB2083818B (en) | 1984-05-10 |
| KR860000264B1 (ko) | 1986-03-22 |
| AU527371B2 (en) | 1983-03-03 |
| EP0048433B1 (de) | 1986-05-28 |
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