DK155003C - Analogifremgangsmaade til fremstilling af amidin-derivater eller farmaceutisk acceptable syreadditionssalte deraf - Google Patents
Analogifremgangsmaade til fremstilling af amidin-derivater eller farmaceutisk acceptable syreadditionssalte derafInfo
- Publication number
- DK155003C DK155003C DK410681A DK410681A DK155003C DK 155003 C DK155003 C DK 155003C DK 410681 A DK410681 A DK 410681A DK 410681 A DK410681 A DK 410681A DK 155003 C DK155003 C DK 155003C
- Authority
- DK
- Denmark
- Prior art keywords
- addition salts
- acid addition
- acceptable acid
- analogue
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Superconductors And Manufacturing Methods Therefor (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Power Steering Mechanism (AREA)
- Pyridine Compounds (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Heat Treatment Of Sheet Steel (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12826980A JPS5753454A (en) | 1980-09-16 | 1980-09-16 | Guanidinobenzoate and anticomplementary agent |
JP12826980 | 1980-09-16 | ||
JP6494281A JPS57179146A (en) | 1981-04-28 | 1981-04-28 | Amidine compound |
JP6494281 | 1981-04-28 |
Publications (3)
Publication Number | Publication Date |
---|---|
DK410681A DK410681A (da) | 1982-03-17 |
DK155003B DK155003B (da) | 1989-01-23 |
DK155003C true DK155003C (da) | 1989-05-29 |
Family
ID=26406084
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK410681A DK155003C (da) | 1980-09-16 | 1981-09-15 | Analogifremgangsmaade til fremstilling af amidin-derivater eller farmaceutisk acceptable syreadditionssalte deraf |
Country Status (17)
Country | Link |
---|---|
US (2) | US4454338A (de) |
EP (1) | EP0048433B1 (de) |
KR (1) | KR860000264B1 (de) |
AT (1) | ATE20051T1 (de) |
AU (1) | AU527371B2 (de) |
CA (1) | CA1177488A (de) |
CS (1) | CS228534B2 (de) |
DD (1) | DD201779A5 (de) |
DE (1) | DE3174717D1 (de) |
DK (1) | DK155003C (de) |
ES (1) | ES8206443A1 (de) |
FI (1) | FI73975C (de) |
GB (1) | GB2083818B (de) |
HU (1) | HU185956B (de) |
NO (1) | NO153568C (de) |
PH (1) | PH18109A (de) |
SU (1) | SU1176832A3 (de) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU527371B2 (en) * | 1980-09-16 | 1983-03-03 | Torii & Co., Ltd. | Amidine |
FR2500825B1 (fr) * | 1981-02-27 | 1985-08-23 | Torii & Co Ltd | Nouveau carboxylate de 4-amidino-phenyle substitue, son procede de preparation et agent anti-complement en comprenant |
JPS57179147A (en) * | 1981-04-28 | 1982-11-04 | Torii Yakuhin Kk | Amidine derivative |
JPS59139357A (ja) * | 1983-01-28 | 1984-08-10 | Torii Yakuhin Kk | アミジン誘導体 |
US4818273A (en) * | 1983-11-14 | 1989-04-04 | The Dow Chemical Company | Substituted 1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamides, compositions containing them, and their utility as herbicides |
US4563527A (en) * | 1984-07-19 | 1986-01-07 | Torii & Co., Ltd. | Amidine compounds |
JPS6133173A (ja) * | 1984-07-25 | 1986-02-17 | Torii Yakuhin Kk | アミジン化合物 |
GB2162171B (en) * | 1984-07-26 | 1988-01-27 | Torii & Co Ltd | Amidine compounds |
FR2568253B1 (fr) * | 1984-07-26 | 1987-01-30 | Torii Co | Nouvelle amidine |
DE3427865A1 (de) * | 1984-07-27 | 1986-02-06 | Torii & Co., Tokio/Tokyo | Amidinoverbindungen, verfahren zu deren herstellung und diese verbindungen enthaltende pharmazeutische mittel |
US4709082A (en) * | 1984-10-25 | 1987-11-24 | Nissan Chemical Industries, Ltd. | 2-phenylpropionic acid esters, method for optical resolution thereof and optically active substance thereof |
AU584502B2 (en) * | 1987-03-30 | 1989-05-25 | Shosuke Okamoto | Phenylalanine derivatives and proteinase inhibitor |
US4990537A (en) * | 1988-07-11 | 1991-02-05 | Banyu Pharmaceutical Co., Ltd. | Anti influenza agent |
EP0435235B1 (de) * | 1989-12-28 | 1995-03-08 | Snow Brand Milk Products Co., Ltd. | Isochinolinderivate und ihre Salze als Proteasehemmer |
US5116985A (en) * | 1989-12-28 | 1992-05-26 | Snow Brand Milk Products Co., Ltd. | Isoquinoline derivatives and salts thereof |
JPH078789B2 (ja) * | 1990-04-05 | 1995-02-01 | 鳥居薬品株式会社 | 脳血管攣縮治療剤 |
US5238964A (en) * | 1990-04-05 | 1993-08-24 | Torii & Co., Ltd. | Agent for treatment of cerebrovascular contraction |
DE4102024A1 (de) * | 1991-01-24 | 1992-07-30 | Thomae Gmbh Dr K | Biphenylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
ZA928276B (en) * | 1991-10-31 | 1993-05-06 | Daiichi Seiyaku Co | Aromatic amidine derivates and salts thereof. |
ES2132535T3 (es) * | 1994-09-20 | 1999-08-16 | Ono Pharmaceutical Co | Derivados de amidinofenol como inhibidores de proteasa. |
US5869501A (en) * | 1994-12-02 | 1999-02-09 | Yamanouchi Pharmaceutical Co. Ltd | Amidinonaphthyl derivative or salt thereof |
CA2208032C (en) * | 1995-01-05 | 2003-12-23 | Torii Pharmaceutical Co., Ltd. | Substituted amidinonaphthyl ester derivative |
WO1997037969A1 (fr) | 1996-04-10 | 1997-10-16 | Ono Pharmaceutical Co., Ltd. | Inhibiteur de tryptase derives de guanidino |
US6653340B1 (en) | 1997-06-03 | 2003-11-25 | Biocryst Pharmaceuticals, Inc. | Compounds useful in the complement, coagulat and kallikrein pathways and method for their preparation |
AU1208999A (en) * | 1997-11-10 | 1999-05-31 | Array Biopharma, Inc. | Compounds which inhibit tryptase activity |
US6066673A (en) * | 1998-03-12 | 2000-05-23 | The Procter & Gamble Company | Enzyme inhibitors |
AU736951C (en) | 1998-03-19 | 2003-02-20 | Bristol-Myers Squibb Company | Biphasic controlled release delivery system for high solubility pharmaceuticals and method |
EP1066272A4 (de) * | 1998-03-27 | 2002-03-13 | Biocryst Pharm Inc | Neue verbindungen, die im komplement-, koagulat- und kallikrein-reaktionsweg nützlich sind und verfahren zu ihrer herstellung |
WO1999055661A1 (en) * | 1998-04-24 | 1999-11-04 | Proteus Molecular Design Limited | Aminomethyl-benzoic ester derivatives as tryptase inhibitors |
US6362216B1 (en) | 1998-10-27 | 2002-03-26 | Array Biopharma Inc. | Compounds which inhibit tryptase activity |
AR037097A1 (es) | 2001-10-05 | 2004-10-20 | Novartis Ag | Compuestos acilsulfonamidas, composiciones farmaceuticas y el uso de dichos compuestos para la preparacion de un medicamento |
JP2006096668A (ja) * | 2002-11-08 | 2006-04-13 | Ono Pharmaceut Co Ltd | エラスターゼ阻害剤と血液凝固系および/または線溶系酵素阻害剤との組み合わせからなる医薬 |
KR101188292B1 (ko) | 2002-11-27 | 2012-10-09 | 디엠아이 바이오사이언시스, 인크 | 인산화 증가로 인한 질병 및 증상의 치료방법 |
US20050192348A1 (en) * | 2003-09-25 | 2005-09-01 | David Bar-Or | Methods and products which utilize N-acyl-L-aspartic acid |
ES2361932T3 (es) * | 2005-05-17 | 2011-06-24 | Santen Pharmaceutical Co., Ltd. | Inhibidor de angiogénesis que contiene un derivado de amina como ingrediente activo. |
EP2119440A1 (de) * | 2005-05-17 | 2009-11-18 | Santen Pharmaceutical Co., Ltd. | Amidinderivate zur Verwendung in der Vorbeugung oder Therapie der Retinitis pigmentosa und der Leber'schen Krankheit |
GB2445920A (en) * | 2007-01-25 | 2008-07-30 | Mucokinetica Ltd | Amidino compounds for treatment of respiratory disease |
KR20110036833A (ko) * | 2008-07-11 | 2011-04-11 | 아지노모토 가부시키가이샤 | 아미딘 유도체 |
AU2009305563C1 (en) | 2008-10-17 | 2015-09-03 | Signature Therapeutics, Inc. | Pharmaceutical compositions with attenuated release of phenolic opioids |
BR112012005124B1 (pt) | 2009-09-08 | 2021-11-09 | Signature Therapeutics, Inc. | Pro-fármaco de opioide modificado por cetona, seu método de preparação, sua composição farmacêutica, sua unidade de dose, métodos e usos |
DK2560486T3 (en) | 2010-04-21 | 2019-02-04 | Signature Therapeutics Inc | COMPOSITIONS COMPREHENSIVE ENZYM-TENDABLE AMPHETAMINE PRODRUGS AND ITS INHIBITORS |
US20110262355A1 (en) | 2010-04-21 | 2011-10-27 | Jenkins Thomas E | Compositions comprising enzyme-cleavable opioid prodrugs and inhibitors thereof |
US9238020B2 (en) | 2010-04-21 | 2016-01-19 | Signature Therapeutics, Inc. | Compositions comprising enzyme-cleavable phenol-modified tapentadol prodrug |
EP2590634B1 (de) | 2010-07-09 | 2016-03-09 | BHV Pharma, Inc. | Abgabesystem mit kombinierter sofortiger/verzögerter freisetzung von pharmazeutika mit kurzer halbwertzeit, darunter remogliflozin |
CA2814763C (en) | 2011-01-11 | 2019-05-28 | Signature Therapeutics, Inc. | Compositions comprising enzyme-cleavable oxycodone prodrug |
WO2012096886A1 (en) | 2011-01-11 | 2012-07-19 | Signature Therapeutics, Inc. | Compositions comprising enzyme-cleavable oxycodone prodrug |
JP6148182B2 (ja) | 2011-03-09 | 2017-06-14 | シグネーチャー セラピューティクス, インク.Signature Therapeutics, Inc. | 複素環式リンカーを有する活性薬剤プロドラッグ |
WO2012122420A2 (en) | 2011-03-09 | 2012-09-13 | Pharmacofore, Inc. | Opioid prodrugs with heterocyclic linkers |
EP2757093B1 (de) | 2011-09-15 | 2016-12-07 | Astellas Pharma Inc. | Guanidinobenzoesäureverbindung |
CN103012214A (zh) * | 2011-09-28 | 2013-04-03 | 南京长澳医药科技有限公司 | 一种萘莫司他盐酸盐及萘莫司他甲磺酸盐的制备方法 |
AU2014230583B2 (en) | 2013-03-13 | 2017-09-28 | Takeda Pharmaceutical Company Limited | Guanidinobenzoic acid ester compound |
CN103641749B (zh) * | 2013-12-02 | 2016-02-10 | 山东永泰化工有限公司 | 一种甲磺酸萘莫司他的制备方法 |
US9346776B2 (en) | 2014-02-13 | 2016-05-24 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compound |
US9428470B2 (en) | 2014-02-13 | 2016-08-30 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
CN110330447B (zh) * | 2019-07-16 | 2022-04-15 | 北京赛升药业股份有限公司 | 一种甲磺酸萘莫司他中间体的制备方法及其应用 |
CN111803483B (zh) * | 2020-01-21 | 2021-04-06 | 中国人民解放军军事科学院军事医学研究院 | 苯甲酸酯类化合物在治疗SARS-CoV-2感染方面的应用 |
WO2021209563A1 (en) | 2020-04-16 | 2021-10-21 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus |
CN111574409A (zh) * | 2020-05-14 | 2020-08-25 | 河北省医疗器械与药品包装材料检验研究院(河北省医疗器械技术审评中心) | 一种甲磺酸萘莫司他的重结晶工艺方法 |
CN113999145B (zh) * | 2021-11-12 | 2023-02-03 | 开封明仁药业有限公司 | 一种甲磺酸萘莫司他的合成方法 |
WO2023118896A1 (en) | 2021-12-23 | 2023-06-29 | Subintro Limited | Novel antiviral compositions comprising oleic acid |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DD89611A (de) * | ||||
DE1905813A1 (de) * | 1968-07-04 | 1970-03-05 | Akad Wissenschaften Ddr | 3- oder 4-Guanidobenzoesaeurebenzyl- oder -phenylestern und deren Verwendung als Inhibitoren |
GB1472700A (en) * | 1974-11-01 | 1977-05-04 | Ono Pharmaceutical Co | Guanidinobehzoic acid derivatives and process for preparing the same |
AU527371B2 (en) * | 1980-09-16 | 1983-03-03 | Torii & Co., Ltd. | Amidine |
-
1981
- 1981-09-08 AU AU75062/81A patent/AU527371B2/en not_active Expired
- 1981-09-09 US US06/300,534 patent/US4454338A/en not_active Expired - Lifetime
- 1981-09-10 CA CA000385570A patent/CA1177488A/en not_active Expired
- 1981-09-14 ES ES505460A patent/ES8206443A1/es not_active Expired
- 1981-09-15 PH PH26206A patent/PH18109A/en unknown
- 1981-09-15 EP EP81107274A patent/EP0048433B1/de not_active Expired
- 1981-09-15 DE DE8181107274T patent/DE3174717D1/de not_active Expired
- 1981-09-15 AT AT81107274T patent/ATE20051T1/de not_active IP Right Cessation
- 1981-09-15 NO NO813138A patent/NO153568C/no unknown
- 1981-09-15 DK DK410681A patent/DK155003C/da not_active IP Right Cessation
- 1981-09-15 FI FI812876A patent/FI73975C/fi not_active IP Right Cessation
- 1981-09-15 GB GB8127837A patent/GB2083818B/en not_active Expired
- 1981-09-15 SU SU813384251A patent/SU1176832A3/ru active
- 1981-09-15 CS CS816809A patent/CS228534B2/cs unknown
- 1981-09-15 HU HU812665A patent/HU185956B/hu unknown
- 1981-09-15 KR KR1019810003427A patent/KR860000264B1/ko active
- 1981-09-16 DD DD81233339A patent/DD201779A5/de not_active IP Right Cessation
-
1984
- 1984-01-20 US US06/572,269 patent/US4532255A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0048433A2 (de) | 1982-03-31 |
GB2083818A (en) | 1982-03-31 |
DK410681A (da) | 1982-03-17 |
NO813138L (no) | 1982-03-17 |
SU1176832A3 (ru) | 1985-08-30 |
PH18109A (en) | 1985-03-22 |
DE3174717D1 (en) | 1986-07-03 |
CA1177488A (en) | 1984-11-06 |
DD201779A5 (de) | 1983-08-10 |
EP0048433A3 (en) | 1982-07-21 |
NO153568B (no) | 1986-01-06 |
ATE20051T1 (de) | 1986-06-15 |
FI812876L (fi) | 1982-03-17 |
CS228534B2 (en) | 1984-05-14 |
US4454338A (en) | 1984-06-12 |
DK155003B (da) | 1989-01-23 |
FI73975B (fi) | 1987-08-31 |
GB2083818B (en) | 1984-05-10 |
AU7506281A (en) | 1982-03-25 |
NO153568C (no) | 1986-05-21 |
HU185956B (en) | 1985-04-28 |
KR860000264B1 (ko) | 1986-03-22 |
ES505460A0 (es) | 1982-08-16 |
KR830007527A (ko) | 1983-10-21 |
ES8206443A1 (es) | 1982-08-16 |
EP0048433B1 (de) | 1986-05-28 |
AU527371B2 (en) | 1983-03-03 |
FI73975C (fi) | 1987-12-10 |
US4532255A (en) | 1985-07-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUP | Patent expired |