NL8105824A - Werkwijze en verbindingen voor het behandelen van ingewandsontstekingen. - Google Patents
Werkwijze en verbindingen voor het behandelen van ingewandsontstekingen. Download PDFInfo
- Publication number
- NL8105824A NL8105824A NL8105824A NL8105824A NL8105824A NL 8105824 A NL8105824 A NL 8105824A NL 8105824 A NL8105824 A NL 8105824A NL 8105824 A NL8105824 A NL 8105824A NL 8105824 A NL8105824 A NL 8105824A
- Authority
- NL
- Netherlands
- Prior art keywords
- salt
- azobis
- salicylic acid
- asa
- compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims description 32
- 238000000034 method Methods 0.000 title claims description 14
- 206010061218 Inflammation Diseases 0.000 title claims description 5
- 230000004054 inflammatory process Effects 0.000 title claims description 5
- 150000003839 salts Chemical class 0.000 claims description 22
- 229960004889 salicylic acid Drugs 0.000 claims description 18
- 206010022678 Intestinal infections Diseases 0.000 claims description 13
- 239000003814 drug Substances 0.000 claims description 8
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims description 7
- 230000000968 intestinal effect Effects 0.000 claims description 3
- 241000124008 Mammalia Species 0.000 claims description 2
- 150000001342 alkaline earth metals Chemical class 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 159000000007 calcium salts Chemical group 0.000 claims 1
- 159000000003 magnesium salts Chemical group 0.000 claims 1
- 229940126601 medicinal product Drugs 0.000 claims 1
- 159000000008 strontium salts Chemical group 0.000 claims 1
- UETNIIAIRMUTSM-UHFFFAOYSA-N Jacareubin Natural products CC1(C)OC2=CC3Oc4c(O)c(O)ccc4C(=O)C3C(=C2C=C1)O UETNIIAIRMUTSM-UHFFFAOYSA-N 0.000 description 28
- NCEXYHBECQHGNR-QZQOTICOSA-N sulfasalazine Chemical compound C1=C(O)C(C(=O)O)=CC(\N=N\C=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-QZQOTICOSA-N 0.000 description 28
- 229960001940 sulfasalazine Drugs 0.000 description 28
- NCEXYHBECQHGNR-UHFFFAOYSA-N sulfasalazine Natural products C1=C(O)C(C(=O)O)=CC(N=NC=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-UHFFFAOYSA-N 0.000 description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 15
- 210000003608 fece Anatomy 0.000 description 14
- 241000700159 Rattus Species 0.000 description 11
- 239000000203 mixture Substances 0.000 description 10
- 239000012153 distilled water Substances 0.000 description 9
- 241000894006 Bacteria Species 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- -1 alkaline earth metal salts Chemical class 0.000 description 7
- 210000001072 colon Anatomy 0.000 description 7
- QQBDLJCYGRGAKP-UHFFFAOYSA-N olsalazine Chemical class C1=C(O)C(C(=O)O)=CC(N=NC=2C=C(C(O)=CC=2)C(O)=O)=C1 QQBDLJCYGRGAKP-UHFFFAOYSA-N 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 239000002253 acid Substances 0.000 description 6
- 241001465754 Metazoa Species 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 239000011777 magnesium Substances 0.000 description 5
- 239000000523 sample Substances 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 4
- 230000001580 bacterial effect Effects 0.000 description 4
- 229910052791 calcium Inorganic materials 0.000 description 4
- 239000011575 calcium Substances 0.000 description 4
- 229910052749 magnesium Inorganic materials 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 210000000813 small intestine Anatomy 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 239000011343 solid material Substances 0.000 description 4
- 229910052712 strontium Inorganic materials 0.000 description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 3
- 208000025865 Ulcer Diseases 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 206010009887 colitis Diseases 0.000 description 3
- 239000000706 filtrate Substances 0.000 description 3
- 230000002757 inflammatory effect Effects 0.000 description 3
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 description 3
- GECHUMIMRBOMGK-UHFFFAOYSA-N sulfapyridine Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=CC=CC=N1 GECHUMIMRBOMGK-UHFFFAOYSA-N 0.000 description 3
- 229960002211 sulfapyridine Drugs 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 2
- 239000005995 Aluminium silicate Substances 0.000 description 2
- 229910000014 Bismuth subcarbonate Inorganic materials 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- RBOWOCXZOFQLTD-UHFFFAOYSA-J [Ca+2].[Ca+2].N(=NC1=CC=C(C(C(=O)[O-])=C1)O)C1=CC=C(C(C(=O)[O-])=C1)O.N(=NC1=CC=C(C(C(=O)[O-])=C1)O)C1=CC=C(C(C(=O)[O-])=C1)O Chemical compound [Ca+2].[Ca+2].N(=NC1=CC=C(C(C(=O)[O-])=C1)O)C1=CC=C(C(C(=O)[O-])=C1)O.N(=NC1=CC=C(C(C(=O)[O-])=C1)O)C1=CC=C(C(C(=O)[O-])=C1)O RBOWOCXZOFQLTD-UHFFFAOYSA-J 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 235000012211 aluminium silicate Nutrition 0.000 description 2
- 229940092732 belladonna alkaloid Drugs 0.000 description 2
- GERIGMSHTUAXSI-UHFFFAOYSA-N bis(8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 4-phenyl-2,3-dihydro-1h-naphthalene-1,4-dicarboxylate Chemical compound CN1C(C2)CCC1CC2OC(=O)C(C1=CC=CC=C11)CCC1(C(=O)OC1CC2CCC(N2C)C1)C1=CC=CC=C1 GERIGMSHTUAXSI-UHFFFAOYSA-N 0.000 description 2
- MGLUJXPJRXTKJM-UHFFFAOYSA-L bismuth subcarbonate Chemical compound O=[Bi]OC(=O)O[Bi]=O MGLUJXPJRXTKJM-UHFFFAOYSA-L 0.000 description 2
- 229940036358 bismuth subcarbonate Drugs 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 2
- 239000000920 calcium hydroxide Substances 0.000 description 2
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 244000005709 gut microbiome Species 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 2
- 210000002429 large intestine Anatomy 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229960004963 mesalazine Drugs 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000397 ulcer Toxicity 0.000 description 2
- 238000002371 ultraviolet--visible spectrum Methods 0.000 description 2
- 241001106067 Atropa Species 0.000 description 1
- 241000606124 Bacteroides fragilis Species 0.000 description 1
- 208000019838 Blood disease Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 101000628535 Homo sapiens Metalloreductase STEAP2 Proteins 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 description 1
- 241000588748 Klebsiella Species 0.000 description 1
- 241000588747 Klebsiella pneumoniae Species 0.000 description 1
- 102100026711 Metalloreductase STEAP2 Human genes 0.000 description 1
- 102100022365 NAD(P)H dehydrogenase [quinone] 1 Human genes 0.000 description 1
- 241000011102 Thera Species 0.000 description 1
- 241000906446 Theraps Species 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- DMLAVOWQYNRWNQ-UHFFFAOYSA-N azobenzene Chemical class C1=CC=CC=C1N=NC1=CC=CC=C1 DMLAVOWQYNRWNQ-UHFFFAOYSA-N 0.000 description 1
- 108010066657 azoreductase Proteins 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 231100001015 blood dyscrasias Toxicity 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 description 1
- 239000003246 corticosteroid Substances 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 208000014951 hematologic disease Diseases 0.000 description 1
- 208000018706 hematopoietic system disease Diseases 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 206010022694 intestinal perforation Diseases 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- YWXYYJSYQOXTPL-SLPGGIOYSA-N isosorbide mononitrate Chemical compound [O-][N+](=O)O[C@@H]1CO[C@@H]2[C@@H](O)CO[C@@H]21 YWXYYJSYQOXTPL-SLPGGIOYSA-N 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- KBOPZPXVLCULAV-UHFFFAOYSA-N mesalamine Chemical compound NC1=CC=C(O)C(C(O)=O)=C1 KBOPZPXVLCULAV-UHFFFAOYSA-N 0.000 description 1
- 239000000401 methanolic extract Substances 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 150000004682 monohydrates Chemical class 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 206010034674 peritonitis Diseases 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 239000003223 protective agent Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 238000012154 short term therapy Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000007143 thioglycolate medium Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 108010050327 trypticase-soy broth Proteins 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
- C07C245/02—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides
- C07C245/06—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings
- C07C245/08—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings with the two nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings, e.g. azobenzene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B63/00—Lakes
- C09B63/005—Metal lakes of dyes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23981381 | 1981-03-02 | ||
| US06/239,813 US4312806A (en) | 1981-03-02 | 1981-03-02 | Method and compounds for treating inflammatory bowel disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL8105824A true NL8105824A (nl) | 1982-10-01 |
Family
ID=22903854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL8105824A NL8105824A (nl) | 1981-03-02 | 1981-12-23 | Werkwijze en verbindingen voor het behandelen van ingewandsontstekingen. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US4312806A (no) |
| JP (1) | JPS57144219A (no) |
| AT (1) | AT375637B (no) |
| AU (1) | AU545804B2 (no) |
| BE (1) | BE891583A (no) |
| CA (1) | CA1167031A (no) |
| CH (1) | CH647409A5 (no) |
| DE (1) | DE3149359A1 (no) |
| DK (1) | DK540581A (no) |
| ES (1) | ES507811A0 (no) |
| FI (1) | FI813919L (no) |
| FR (1) | FR2500824B1 (no) |
| GB (1) | GB2093833B (no) |
| GR (1) | GR76684B (no) |
| IE (1) | IE52898B1 (no) |
| IL (1) | IL64459A0 (no) |
| IT (1) | IT1147821B (no) |
| NL (1) | NL8105824A (no) |
| NO (1) | NO153099C (no) |
| NZ (1) | NZ199273A (no) |
| PH (1) | PH17040A (no) |
| SE (1) | SE8107292L (no) |
| ZA (1) | ZA818507B (no) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4960765A (en) * | 1980-03-20 | 1990-10-02 | Farmaceutisk Laboratorium Ferring A/S | Pharmaceutical composition and method for the treatment of colitis ulcerosa and Crohn's disease by oral administration |
| WO1981002671A1 (en) * | 1980-03-20 | 1981-10-01 | Ferring Farma Lab | Pharmaceutical composition and method for the treatment of colitis ulcerosa and crohn's disease by oral administration |
| SE8002322L (sv) * | 1980-03-26 | 1981-09-27 | Pharmacia Ab | Medel for behandling av inflammatoriska tarmsjukdomar |
| DE3151196A1 (de) * | 1981-12-23 | 1983-06-30 | Kurt Heinz Prof. Dr. 7800 Freiburg Bauer | Verfahren zur herstellung von gut loeslichen 5-aminosalicylsaeure-arzneimittelzubereitungen |
| SE8303399D0 (sv) * | 1983-06-15 | 1983-06-15 | Pharmacia Ab | Azo-bis-salicyl syra och salt derav, deras farmaceutiska beredning samt framstellning av syran |
| SE8303400D0 (sv) * | 1983-06-15 | 1983-06-15 | Pharmacia Ab | Azo-bis-salicylsyra och salt derav samt deras farmaceutiska beredning och anvendning |
| SE8405924L (sv) * | 1984-11-23 | 1986-05-24 | Pharmacia Ab | Nya azoforeningar |
| US5120306A (en) * | 1990-03-21 | 1992-06-09 | Gosselin Leon F | Direct delivery of anti-inflammatories to the proximal small bowel |
| ES2106682B1 (es) * | 1995-09-08 | 1998-07-01 | Uriach & Cia Sa J | Nuevos derivados azo del acido 5-aminosalicilico. |
| ES2104513B1 (es) * | 1995-10-11 | 1998-07-01 | Uriach & Cia Sa J | Nuevos derivados del acido 5-aminosalicilico. |
| ES2155621T3 (es) * | 1995-09-08 | 2001-05-16 | Uriach & Cia Sa J | Derivados azo del acido 5-aminosalicilico para el tratamiento de la enfermedad inflamatoria intestinal. |
| US6358939B1 (en) | 1999-12-21 | 2002-03-19 | Northern Lights Pharmaceuticals, Llc | Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease |
| US6989377B2 (en) | 1999-12-21 | 2006-01-24 | Wisconsin Alumni Research Foundation | Treating vitamin D responsive diseases |
| ES2165803B1 (es) * | 2000-04-10 | 2003-09-16 | Uriach & Cia Sa J | Nueva sal de un derivado azo del acido 5-aminosalicilico |
| CA2359812C (en) | 2000-11-20 | 2004-02-10 | The Procter & Gamble Company | Pharmaceutical dosage form with multiple coatings for reduced impact of coating fractures |
| CN1918178B (zh) | 2004-01-12 | 2012-08-22 | 应用分子进化公司 | Fc区变体 |
| WO2010042933A2 (en) | 2008-10-10 | 2010-04-15 | Northwestern University | Inhibition and treatment of prostate cancer metastasis |
| JP2017534627A (ja) | 2014-11-06 | 2017-11-24 | ノースウエスタン ユニバーシティＮｏｒｔｈｗｅｓｔｅｒｎ Ｕｎｉｖｅｒｓｉｔｙ | 癌細胞運動性の阻害 |
| CN105985259B (zh) * | 2015-02-04 | 2018-07-27 | 中国科学院化学研究所 | 偶氮苯甲酸类化合物及其制备方法和应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1157169A (en) * | 1914-11-03 | 1915-10-19 | Geigy Ag J R | Mordant-dyeing azo dye. |
| GB408676A (en) * | 1931-10-17 | 1934-04-16 | Ig Farbenindustrie Ag | The manufacture of symmetrically substituted azobenzene compounds |
| US2894984A (en) * | 1958-05-15 | 1959-07-14 | Pennsalt Chemicals Corp | 4-trifluoromethyl salicylic acids and their preparation |
| US3413225A (en) * | 1966-06-27 | 1968-11-26 | Monsanto Co | Functional fluid containing azo benzene derivatives as antioxidants |
| US3674844A (en) * | 1970-04-20 | 1972-07-04 | Merck & Co Inc | Salicylic acid derivatives |
| US4190716A (en) * | 1978-12-20 | 1980-02-26 | Dynapol | Polymeric agent for releasing 5-aminosalicylic acid or its salts into the gastrointestinal tract |
| SE8002322L (sv) * | 1980-03-26 | 1981-09-27 | Pharmacia Ab | Medel for behandling av inflammatoriska tarmsjukdomar |
-
1981
- 1981-03-02 US US06/239,813 patent/US4312806A/en not_active Expired - Lifetime
- 1981-12-04 AU AU78286/81A patent/AU545804B2/en not_active Ceased
- 1981-12-04 IL IL64459A patent/IL64459A0/xx unknown
- 1981-12-07 GR GR66714A patent/GR76684B/el unknown
- 1981-12-07 DK DK540581A patent/DK540581A/da not_active Application Discontinuation
- 1981-12-07 SE SE8107292A patent/SE8107292L/ not_active Application Discontinuation
- 1981-12-07 FI FI813919A patent/FI813919L/fi not_active Application Discontinuation
- 1981-12-08 ZA ZA818507A patent/ZA818507B/xx unknown
- 1981-12-09 PH PH26605A patent/PH17040A/en unknown
- 1981-12-09 ES ES507811A patent/ES507811A0/es active Granted
- 1981-12-11 CA CA000392062A patent/CA1167031A/en not_active Expired
- 1981-12-12 DE DE19813149359 patent/DE3149359A1/de not_active Withdrawn
- 1981-12-14 CH CH7953/81A patent/CH647409A5/de not_active IP Right Cessation
- 1981-12-15 NZ NZ199273A patent/NZ199273A/en unknown
- 1981-12-17 AT AT0540681A patent/AT375637B/de not_active IP Right Cessation
- 1981-12-18 GB GB8138217A patent/GB2093833B/en not_active Expired
- 1981-12-22 FR FR8123969A patent/FR2500824B1/fr not_active Expired
- 1981-12-22 BE BE0/206907A patent/BE891583A/fr not_active IP Right Cessation
- 1981-12-22 JP JP56207925A patent/JPS57144219A/ja active Pending
- 1981-12-23 NL NL8105824A patent/NL8105824A/nl not_active Application Discontinuation
- 1981-12-23 NO NO814424A patent/NO153099C/no unknown
- 1981-12-31 IE IE3104/81A patent/IE52898B1/en not_active IP Right Cessation
-
1982
- 1982-03-02 IT IT47894/82A patent/IT1147821B/it active
Also Published As
| Publication number | Publication date |
|---|---|
| FI813919L (fi) | 1982-09-03 |
| DK540581A (da) | 1982-09-03 |
| IT1147821B (it) | 1986-11-26 |
| IE52898B1 (en) | 1988-04-13 |
| ES8500894A1 (es) | 1984-11-01 |
| GB2093833A (en) | 1982-09-08 |
| IL64459A0 (en) | 1982-03-31 |
| AT375637B (de) | 1984-08-27 |
| JPS57144219A (en) | 1982-09-06 |
| ES507811A0 (es) | 1984-11-01 |
| IE813104L (en) | 1982-09-02 |
| AU545804B2 (en) | 1985-08-01 |
| CA1167031A (en) | 1984-05-08 |
| NO153099C (no) | 1986-01-15 |
| SE8107292L (sv) | 1982-09-03 |
| PH17040A (en) | 1984-05-17 |
| NZ199273A (en) | 1985-03-20 |
| ATA540681A (de) | 1984-01-15 |
| ZA818507B (en) | 1983-07-27 |
| DE3149359A1 (de) | 1982-09-16 |
| GB2093833B (en) | 1985-01-23 |
| FR2500824B1 (fr) | 1985-07-19 |
| IT8247894A0 (it) | 1982-03-02 |
| AU7828681A (en) | 1982-09-09 |
| NO153099B (no) | 1985-10-07 |
| FR2500824A1 (fr) | 1982-09-03 |
| NO814424L (no) | 1982-09-03 |
| US4312806A (en) | 1982-01-26 |
| CH647409A5 (de) | 1985-01-31 |
| BE891583A (fr) | 1982-06-22 |
| GR76684B (no) | 1984-08-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A85 | Still pending on 85-01-01 | ||
| CNR | Transfer of rights (patent application after its laying open for public inspection) |
Free format text: PHARMACIA AB |
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| CNR | Transfer of rights (patent application after its laying open for public inspection) |
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| BA | A request for search or an international-type search has been filed | ||
| BB | A search report has been drawn up | ||
| BV | The patent application has lapsed |