NL194373C - Werkwijze voor de bereiding van 3-hydroxy-ML-236B derivaten, bekend als M-4 en M-4'. - Google Patents
Werkwijze voor de bereiding van 3-hydroxy-ML-236B derivaten, bekend als M-4 en M-4'. Download PDFInfo
- Publication number
- NL194373C NL194373C NL8204505A NL8204505A NL194373C NL 194373 C NL194373 C NL 194373C NL 8204505 A NL8204505 A NL 8204505A NL 8204505 A NL8204505 A NL 8204505A NL 194373 C NL194373 C NL 194373C
- Authority
- NL
- Netherlands
- Prior art keywords
- nocardia
- ferm
- compound
- microorganism
- lactone
- Prior art date
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- 238000000034 method Methods 0.000 title claims description 39
- 238000002360 preparation method Methods 0.000 title claims description 6
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/365—Nocardia
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/872—Nocardia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Urology & Nephrology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56186641A JPS5889191A (ja) | 1981-11-20 | 1981-11-20 | ３−ヒドロキシ−ｍｌ−２３６ｂ誘導体の製造法 |
| JP18664181 | 1981-11-20 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NL8204505A NL8204505A (nl) | 1983-06-16 |
| NL194373B NL194373B (nl) | 2001-10-01 |
| NL194373C true NL194373C (nl) | 2002-02-04 |
Family
ID=16192138
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL8204505A NL194373C (nl) | 1981-11-20 | 1982-11-19 | Werkwijze voor de bereiding van 3-hydroxy-ML-236B derivaten, bekend als M-4 en M-4'. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4537859A (fi) |
| JP (1) | JPS5889191A (fi) |
| KR (1) | KR880002483B1 (fi) |
| AT (1) | AT387585B (fi) |
| AU (1) | AU551720B2 (fi) |
| BE (1) | BE895080A (fi) |
| CA (1) | CA1186647A (fi) |
| CH (1) | CH651065A5 (fi) |
| DE (1) | DE3242849A1 (fi) |
| DK (1) | DK159328C (fi) |
| ES (1) | ES8402350A1 (fi) |
| FI (1) | FI70925C (fi) |
| FR (1) | FR2516935A1 (fi) |
| GB (1) | GB2111052B (fi) |
| IT (1) | IT1191235B (fi) |
| NL (1) | NL194373C (fi) |
| SE (1) | SE453996B (fi) |
| ZA (1) | ZA828535B (fi) |
Families Citing this family (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE69602T1 (de) * | 1985-09-13 | 1991-12-15 | Sankyo Co | Hydroxy-ml-236b-derivate, deren herstellung und anwendung. |
| USRE36481E (en) * | 1986-06-23 | 2000-01-04 | Merck & Co., Inc. | HMG-CoA reductase inhibitors |
| US5116870A (en) * | 1986-06-23 | 1992-05-26 | Merck & Co., Inc. | HMG-CoA reductase inhibitors |
| US4940727A (en) * | 1986-06-23 | 1990-07-10 | Merck & Co., Inc. | Novel HMG-CoA reductase inhibitors |
| US4833258A (en) * | 1987-02-17 | 1989-05-23 | Merck & Co., Inc. | Intermediates useful in the preparation of HMG-COA reductase inhibitors |
| DE3869282D1 (de) * | 1987-09-02 | 1992-04-23 | Merck & Co Inc | Inhibitoren von hmg-coa-reduktase. |
| US4997848A (en) | 1987-10-27 | 1991-03-05 | Sankyo Company, Limited | Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition |
| US4997755A (en) * | 1988-04-15 | 1991-03-05 | Merck & Co., Inc. | HMG-CoA reductase inhibitors produced by Nocardia sp. (MA 6455) |
| EP0337548A3 (en) * | 1988-04-15 | 1991-08-14 | Merck & Co. Inc. | HMG-COA reductase inhibitors produced by nocardia SP. (MA6455)(ATCC 53695) |
| US4963538A (en) * | 1988-06-29 | 1990-10-16 | Merck & Co., Inc. | 5-oxygenated HMG-CoA reductase inhibitors |
| US5001241A (en) * | 1989-06-09 | 1991-03-19 | Merck & Co., Inc. | 3-KETO HMG-CoA reductase inhibitors |
| US5041562A (en) * | 1989-06-09 | 1991-08-20 | Merck & Co., Inc. | 3-keto HMG-CoA reductase inhibitors |
| US4937259A (en) * | 1989-06-09 | 1990-06-26 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| US4970231A (en) * | 1989-06-09 | 1990-11-13 | Merck & Co., Inc. | 4-substituted HMG-CoA reductase inhibitors |
| US5010105A (en) * | 1989-06-09 | 1991-04-23 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| US4997849A (en) * | 1989-06-23 | 1991-03-05 | Merck & Co., Inc. | Microbial transformation of simvastatin |
| US4965200A (en) * | 1989-06-23 | 1990-10-23 | Merck & Co., Inc. | Process for the preparation of 3-keto, 5-hydroxy simvastatin analogs |
| US5112857A (en) * | 1990-09-04 | 1992-05-12 | Merck & Co., Inc. | Hmg-coa reductase inhibitor metabolites |
| NZ250609A (en) * | 1992-12-28 | 1995-07-26 | Sankyo Co | Hexahydronaphthalene esters and ring closed lactones; preparation and medicaments |
| IL108432A (en) * | 1993-01-29 | 1997-09-30 | Sankyo Co | DERIVATIVES OF 3, 5-DIHYDROXY-7- £1, 2, 6, 7, 8, 8a-HEXAHYDRO-2- METHYL-8- (SUBSTITUTED ALKANOYLOXY)-1-NAPHTHYL| HEPTANOIC ACID AND THEIR LACTONES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| US6043064A (en) * | 1993-10-22 | 2000-03-28 | Bristol-Myers Squibb Company | Enzymatic hydroxylation process for the preparation of HMG-CoA reductase inhibitors and intermediates thereof |
| US5942423A (en) | 1995-06-07 | 1999-08-24 | Massachusetts Institute Of Technology | Conversion of compactin to pravastatin by actinomadura |
| SI9800144A (sl) * | 1998-05-21 | 1999-12-31 | LEK, tovarna farmacevtskih in kemičnih izdelkov, d.d. | Nov biotehnološki postopek pridobivanja 3-hidroksi-ML-236B derivatov poznanih kot M-4 in M-4' |
| SI20305A (sl) * | 1999-08-06 | 2001-02-28 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Kristali natrijeve soli pravastatina |
| CN1240844C (zh) | 1999-01-20 | 2006-02-08 | 协和发酵工业株式会社 | HMG－CoA还原酶抑制剂的制备方法 |
| JP4668420B2 (ja) | 1999-01-29 | 2011-04-13 | 協和発酵バイオ株式会社 | ＨＭＧ−ＣｏＡレダクターゼ阻害剤の製造法 |
| US6682913B1 (en) * | 1999-02-03 | 2004-01-27 | Institute For Drug Research Ltd. | Microbial process for preparing pravastatin |
| HUP9902352A1 (hu) * | 1999-07-12 | 2000-09-28 | Gyógyszerkutató Intézet Kft. | Eljárás pravasztatin mikrobiológiai előállítására |
| HRP20030347A2 (en) * | 2000-10-05 | 2005-04-30 | Teva Gy�gyszergy�r R�szv�nyt�rsas�g | Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same |
| JP3236282B1 (ja) * | 2000-10-16 | 2001-12-10 | 三共株式会社 | プラバスタチンを精製する方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3392171A (en) * | 1964-03-20 | 1968-07-09 | Upjohn Co | 4-morpholino-4'-hydroxy bicyclohexyls |
| US3281330A (en) * | 1964-03-20 | 1966-10-25 | Upjohn Co | Microbiological process for the oxygenation of cycloalkanes |
| DK149080C (da) * | 1980-06-06 | 1986-07-28 | Sankyo Co | Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre |
-
1981
- 1981-11-20 JP JP56186641A patent/JPS5889191A/ja active Granted
-
1982
- 1982-11-16 AU AU90610/82A patent/AU551720B2/en not_active Expired
- 1982-11-16 CA CA000415650A patent/CA1186647A/en not_active Expired
- 1982-11-18 SE SE8206580A patent/SE453996B/sv not_active IP Right Cessation
- 1982-11-18 US US06/442,840 patent/US4537859A/en not_active Expired - Lifetime
- 1982-11-19 FI FI823978A patent/FI70925C/fi not_active IP Right Cessation
- 1982-11-19 BE BE0/209527A patent/BE895080A/fr unknown
- 1982-11-19 ZA ZA828535A patent/ZA828535B/xx unknown
- 1982-11-19 ES ES517542A patent/ES8402350A1/es not_active Expired
- 1982-11-19 FR FR8219433A patent/FR2516935A1/fr active Granted
- 1982-11-19 DE DE19823242849 patent/DE3242849A1/de active Granted
- 1982-11-19 DK DK516182A patent/DK159328C/da not_active IP Right Cessation
- 1982-11-19 NL NL8204505A patent/NL194373C/nl not_active IP Right Cessation
- 1982-11-19 CH CH6754/82A patent/CH651065A5/de not_active IP Right Cessation
- 1982-11-20 KR KR8205250A patent/KR880002483B1/ko not_active Expired
- 1982-11-22 AT AT0425182A patent/AT387585B/de not_active IP Right Cessation
- 1982-11-22 GB GB08233267A patent/GB2111052B/en not_active Expired
- 1982-11-22 IT IT68359/82A patent/IT1191235B/it active Protection Beyond IP Right Term
Also Published As
| Publication number | Publication date |
|---|---|
| CA1186647A (en) | 1985-05-07 |
| ATA425182A (de) | 1988-07-15 |
| DE3242849A1 (de) | 1983-06-01 |
| NL8204505A (nl) | 1983-06-16 |
| IT1191235B (it) | 1988-02-24 |
| FR2516935A1 (fr) | 1983-05-27 |
| SE453996B (sv) | 1988-03-21 |
| DK159328B (da) | 1990-10-01 |
| AU551720B2 (en) | 1986-05-08 |
| CH651065A5 (de) | 1985-08-30 |
| DK516182A (da) | 1983-05-21 |
| FI70925B (fi) | 1986-07-18 |
| DE3242849C2 (fi) | 1989-01-05 |
| FR2516935B1 (fi) | 1985-02-08 |
| AU9061082A (en) | 1983-05-26 |
| AT387585B (de) | 1989-02-10 |
| KR880002483B1 (ko) | 1988-11-19 |
| US4537859A (en) | 1985-08-27 |
| BE895080A (fr) | 1983-03-16 |
| SE8206580L (sv) | 1983-05-21 |
| IT8268359A0 (it) | 1982-11-22 |
| SE8206580D0 (sv) | 1982-11-18 |
| JPS5889191A (ja) | 1983-05-27 |
| KR840002451A (ko) | 1984-07-02 |
| ES517542A0 (es) | 1984-01-16 |
| ZA828535B (en) | 1983-10-26 |
| GB2111052A (en) | 1983-06-29 |
| GB2111052B (en) | 1985-05-09 |
| FI70925C (fi) | 1986-10-27 |
| DK159328C (da) | 1991-02-25 |
| JPH0371116B2 (fi) | 1991-11-12 |
| NL194373B (nl) | 2001-10-01 |
| ES8402350A1 (es) | 1984-01-16 |
| FI823978L (fi) | 1983-05-21 |
| FI823978A0 (fi) | 1982-11-19 |
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| Date | Code | Title | Description |
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| BA | A request for search or an international-type search has been filed | ||
| BB | A search report has been drawn up | ||
| A85 | Still pending on 85-01-01 | ||
| BC | A request for examination has been filed | ||
| V4 | Discontinued because of reaching the maximum lifetime of a patent |
Effective date: 20021119 |