NL193616C - Gesubstitueerde androsta-1,4-dieen-3,17-dionen, alsmede farmaceutische preparaten die dergelijke verbindingen bevatten. - Google Patents

Gesubstitueerde androsta-1,4-dieen-3,17-dionen, alsmede farmaceutische preparaten die dergelijke verbindingen bevatten. Download PDF

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Publication number
NL193616C
NL193616C NL8601785A NL8601785A NL193616C NL 193616 C NL193616 C NL 193616C NL 8601785 A NL8601785 A NL 8601785A NL 8601785 A NL8601785 A NL 8601785A NL 193616 C NL193616 C NL 193616C
Authority
NL
Netherlands
Prior art keywords
dione
diene
methyleneandrosta
compounds
compound
Prior art date
Application number
NL8601785A
Other languages
English (en)
Dutch (nl)
Other versions
NL193616B (nl
NL8601785A (nl
Inventor
Franco Buzzetti
Paolo Lombardi
Natale Barbugian
Enrico Di Salle
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10582036&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NL193616(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Publication of NL8601785A publication Critical patent/NL8601785A/nl
Publication of NL193616B publication Critical patent/NL193616B/xx
Application granted granted Critical
Publication of NL193616C publication Critical patent/NL193616C/nl

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J1/00Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J1/00Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003Androstane derivatives
    • C07J1/0011Androstane derivatives substituted in position 17 by a keto group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NL8601785A 1985-07-09 1986-07-08 Gesubstitueerde androsta-1,4-dieen-3,17-dionen, alsmede farmaceutische preparaten die dergelijke verbindingen bevatten. NL193616C (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858517360A GB8517360D0 (en) 1985-07-09 1985-07-09 Substituted androsta-1,4-diene-3,17-diones
GB8517360 1985-07-09

Publications (3)

Publication Number Publication Date
NL8601785A NL8601785A (nl) 1987-02-02
NL193616B NL193616B (nl) 1999-12-01
NL193616C true NL193616C (nl) 2000-04-04

Family

ID=10582036

Family Applications (2)

Application Number Title Priority Date Filing Date
NL8601785A NL193616C (nl) 1985-07-09 1986-07-08 Gesubstitueerde androsta-1,4-dieen-3,17-dionen, alsmede farmaceutische preparaten die dergelijke verbindingen bevatten.
NL300017C NL300017I2 (nl) 1985-07-09 2000-09-14 Gesubstitueerde androsta-1,4-dieen-3,17-dionen, alsmede farmaceutische preparaten die dergelijke verbindingen bevatten.

Family Applications After (1)

Application Number Title Priority Date Filing Date
NL300017C NL300017I2 (nl) 1985-07-09 2000-09-14 Gesubstitueerde androsta-1,4-dieen-3,17-dionen, alsmede farmaceutische preparaten die dergelijke verbindingen bevatten.

Country Status (38)

Country Link
US (2) US4808616A (sv)
JP (1) JPS6212797A (sv)
KR (1) KR950003614B1 (sv)
CN (1) CN86104664B (sv)
AT (1) AT395157B (sv)
AU (1) AU578840B2 (sv)
BE (1) BE905067A (sv)
BG (1) BG61370B2 (sv)
BR (1) BR1100240A (sv)
CA (1) CA1277656C (sv)
CH (1) CH668599A5 (sv)
CS (2) CS258498B2 (sv)
CZ (1) CZ413591A3 (sv)
DE (1) DE10199030I1 (sv)
DK (1) DK163520C (sv)
ES (2) ES8801304A1 (sv)
FI (1) FI83424C (sv)
FR (1) FR2584725B1 (sv)
GB (2) GB8517360D0 (sv)
GR (1) GR861780B (sv)
HK (1) HK94190A (sv)
HU (1) HU194274B (sv)
IE (1) IE58949B1 (sv)
IL (1) IL79336A (sv)
IT (1) IT1196436B (sv)
MY (1) MY102294A (sv)
NL (2) NL193616C (sv)
NO (2) NO165547C (sv)
NZ (1) NZ216763A (sv)
PH (1) PH21785A (sv)
PT (1) PT82944B (sv)
SE (1) SE468988B (sv)
SG (1) SG80490G (sv)
SK (1) SK413591A3 (sv)
SU (2) SU1442077A3 (sv)
UA (1) UA6046A1 (sv)
YU (2) YU44585B (sv)
ZA (1) ZA865079B (sv)

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GB8617107D0 (en) * 1986-07-14 1986-08-20 Erba Farmitalia 6-/7-methylenandrosta-1 4-diene-3 17-dione derivatives
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GB8721384D0 (en) * 1987-09-11 1987-10-21 Erba Farmitalia 17-substituted andro-sta-1 4-dien-3-one derivatives
GB8801697D0 (en) * 1988-01-26 1988-02-24 Erba Farmitalia Improvements in synthesis of 6-methylene derivatives of androsta-1 4-diene-3 17-dione
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GB9201224D0 (en) * 1992-01-21 1992-03-11 Erba Carlo Spa Difluoromethylenandrostenone derivatives and process for their preparation
DE69324595T2 (de) * 1992-09-30 1999-08-19 Teikoku Hormone Mfg Co Ltd 7-substituierte oxa-steroid verbindung
US6407082B1 (en) * 1996-09-13 2002-06-18 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a vitamin D compound
GB9313420D0 (en) * 1993-06-29 1993-08-11 Erba Carlo Spa Fluorinated 6-methylenandrosta-1,4-dien-3-one-derivatives and process for their preparations
US6028064A (en) 1996-09-13 2000-02-22 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of progestin products
US6511970B1 (en) 1996-09-13 2003-01-28 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
US6034074A (en) 1996-09-13 2000-03-07 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a Vitamin D compound
US6765002B2 (en) 2000-03-21 2004-07-20 Gustavo Rodriguez Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
WO2001004342A1 (en) * 1999-07-07 2001-01-18 Pharmacia & Upjohn Company Process to prepare exemestane
GB9930839D0 (en) * 1999-12-30 2000-02-16 Pharmacia & Upjohn Spa Process for treating gynecomastia
GB0005257D0 (en) * 2000-03-03 2000-04-26 Pharmacia & Upjohn Spa Breast cancer hormonal therapy
US20010044431A1 (en) * 2000-03-21 2001-11-22 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
GB0017635D0 (en) * 2000-07-18 2000-09-06 Pharmacia & Upjohn Spa Antitumor combined therapy
JP2004505909A (ja) * 2000-08-09 2004-02-26 フアルマシア・イタリア・エツセ・ピー・アー アロマターゼ阻害薬の併用型組成物
AU8986501A (en) * 2000-09-08 2002-03-22 Pharmacia & Upjohn Spa Exemestane as chemopreventing agent
PT1377298E (pt) * 2001-01-26 2006-12-29 Pharmacia & Upjohn Co Llc Exemestano para o tratamento de perturbações hormono-dependentes.
US20040082557A1 (en) * 2001-01-26 2004-04-29 Wajszczuk Charles Paul Methods for treating estrogen-dependent disorders
ES2705016T3 (es) 2001-02-19 2019-03-21 Novartis Int Pharmaceutical Ag Derivado de rapamicina para el tratamiento de cáncer de pulmón
BR0209647A (pt) 2001-05-16 2004-07-27 Novartis Ag Combinação que compreende n-{5-[4-(4-metil-piperazino-metil)-benzoilamido]-2-metil fenil}-4-(3-piridil)-2-pirimidina-amina e um agente quimioterapêutico
GB0120147D0 (en) * 2001-08-17 2001-10-10 Metris Therapeutics Ltd Treatment method
US20040043938A1 (en) * 2001-11-06 2004-03-04 Dinesh Purandare Combination therapy for estrogen-dependent disorders
GB0128510D0 (en) * 2001-11-28 2002-01-23 Novartis Ag Organic compounds
NZ560662A (en) 2002-05-16 2009-09-25 Novartis Ag Use of EDG receptor binding agents in cancer
CN1304413C (zh) * 2002-10-24 2007-03-14 上海华拓医药科技发展有限公司 一种抗癌药物依西美坦制备方法
CN1317293C (zh) * 2002-10-24 2007-05-23 南京长澳医药科技有限公司 一种依西美坦的合成工艺
US20040186160A1 (en) * 2002-12-13 2004-09-23 Sugen, Inc. Hexahydro-cyclohepta-pyrrole oxindole as potent kinase inhibitors
WO2005027916A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and aromatase inhibitors
US20050101579A1 (en) * 2003-11-06 2005-05-12 Shippen Eugene R. Endometriosis treatment protocol
US8183401B2 (en) * 2004-01-16 2012-05-22 Cedarburg Pharmaceuticals, Inc. Exemestane and its intermediates and methods of making the same
US7435757B2 (en) * 2004-07-02 2008-10-14 Schering Ag 2-substituted D-homo-estra-1,3,5(10)-trienes as inhibitors of 17β-hydroxy steroid dehydrogenase type 1
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US10174070B2 (en) * 2005-09-30 2019-01-08 Endece Llc 6-substituted estradiol derivatives and methods of use
US8168621B2 (en) 2005-09-30 2012-05-01 Endece, Llc 6-substituted estradiol derivatives and methods of use
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JP2009536180A (ja) 2006-05-09 2009-10-08 ノバルティス アクチエンゲゼルシャフト 鉄キレート剤と抗新生物剤を含む組合せ剤およびそれらの使用
WO2008033466A2 (en) * 2006-09-14 2008-03-20 Combinatorx (Singapore) Pre. Ltd. Compositions and methods for treatment of viral diseases
US20080275259A1 (en) * 2007-05-04 2008-11-06 Scinopharm Taiwan, Ltd Process for preparing aromatase inhibitors
CA2702710C (en) 2007-10-16 2013-05-07 Repros Therapeutics, Inc. Trans-clomiphene for metabolic syndrome
EP2070943A1 (en) * 2007-12-14 2009-06-17 Crystal Pharma, S.A. Process for obtaining 6-Alkylidenandrost-1,4-diene-3one
CN101468023B (zh) * 2007-12-26 2011-02-02 上海复星医药(集团)股份有限公司 依西美坦片及其制备工艺
EP2231691B1 (en) * 2008-01-21 2014-04-09 Cadila Healthcare Limited Process for preparing aromatase inhibitor exemestane
GB0813628D0 (en) * 2008-07-25 2008-09-03 Arrow Int Ltd Stable coated anti-cancer agent
WO2010076811A2 (en) * 2008-12-30 2010-07-08 Ind-Swift Laboratories Limited Process for the preparation of exemestane
WO2010127297A1 (en) 2009-05-01 2010-11-04 Parviz Gharagozloo Treating male infertility secondary to sperm oxidative stress
DE102010003494A1 (de) * 2010-03-31 2011-10-06 Bayer Schering Pharma Aktiengesellschaft Parenterales Abgabesystem, das Aromatasehemmer und Gestagene freisetzt, für die Behandlung von Endometriose
WO2011127232A2 (en) 2010-04-08 2011-10-13 Emory University Substituted androst-4-ene diones
EP2558098A2 (en) 2010-04-16 2013-02-20 Novartis AG Treatment of endocrine resistant breast cancer
DK2616477T3 (en) 2010-09-14 2017-02-20 Endece Llc 6-substituted demethyl estradiol derivatives as agonists of the type ER-BETA
CA2865234A1 (en) 2012-02-29 2013-09-06 Repros Therapeutics Inc. Combination therapy for treating androgen deficiency
KR20160110963A (ko) 2014-02-11 2016-09-23 노파르티스 아게 암 치료를 위한 pi3k 억제제를 포함하는 제약 조합물
AU2016352592B2 (en) 2015-11-10 2023-04-27 Paracrine Therapeutics Ab Treatment of ER-negative breast cancer with an PDGF-CC inhibitor and an anti estrogen
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GB929985A (sv) *
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Also Published As

Publication number Publication date
FR2584725B1 (fr) 1988-05-13
FI83424C (sv) 1991-07-10
PH21785A (en) 1988-02-24
AT395157B (de) 1992-10-12
SE468988B (sv) 1993-04-26
CA1277656C (en) 1990-12-11
KR950003614B1 (ko) 1995-04-17
PT82944A (en) 1986-08-01
CS257794B2 (en) 1988-06-15
US4808616A (en) 1989-02-28
AU578840B2 (en) 1988-11-03
NZ216763A (en) 1988-05-30
HU194274B (en) 1988-01-28
GB2177700A (en) 1987-01-28
CZ413591A3 (en) 1994-03-16
IL79336A0 (en) 1986-10-31
IE58949B1 (en) 1993-12-01
MY102294A (en) 1992-05-15
NL193616B (nl) 1999-12-01
GB8517360D0 (en) 1985-08-14
NL8601785A (nl) 1987-02-02
GB8616585D0 (en) 1986-08-13
NO2000009I1 (no) 2000-10-05
NL300017I1 (nl) 2000-11-01
HUT42780A (en) 1987-08-28
SG80490G (en) 1990-11-23
CN86104664B (zh) 1988-06-29
IL79336A (en) 1991-06-10
GR861780B (en) 1986-11-11
ATA181986A (de) 1992-02-15
IT8621004A0 (it) 1986-07-02
ES556550A0 (es) 1987-12-16
BE905067A (fr) 1987-01-08
ES8802429A1 (es) 1988-06-01
NO165547C (no) 1991-02-27
YU103687A (en) 1988-08-31
JPH0443919B2 (sv) 1992-07-20
DE10199030I1 (de) 2001-10-04
NO165547B (no) 1990-11-19
JPS6212797A (ja) 1987-01-21
YU44628B (en) 1990-10-31
ES557466A0 (es) 1988-06-01
SE8603046D0 (sv) 1986-07-08
DK163520B (da) 1992-03-09
FI862871A (fi) 1987-01-10
SU1501923A3 (ru) 1989-08-15
SU1442077A3 (ru) 1988-11-30
KR870001140A (ko) 1987-03-11
HK94190A (en) 1990-11-23
US4904650A (en) 1990-02-27
AU5979986A (en) 1987-01-15
BG61370B2 (bg) 1997-06-30
NL300017I2 (nl) 2001-01-02
IT1196436B (it) 1988-11-16
DK163520C (da) 1992-07-27
GB2177700B (en) 1988-12-07
ES8801304A1 (es) 1987-12-16
FI83424B (fi) 1991-03-28
BR1100240A (pt) 1999-12-28
CH668599A5 (de) 1989-01-13
ZA865079B (en) 1987-03-25
DK324386D0 (da) 1986-07-08
SE8603046L (sv) 1987-01-10
PT82944B (pt) 1989-01-30
CN86104664A (zh) 1987-02-18
FI862871A0 (fi) 1986-07-07
YU120186A (en) 1988-02-29
CS258498B2 (en) 1988-08-16
CS521486A2 (en) 1987-09-17
SK413591A3 (en) 1995-07-11
IE861821L (en) 1987-01-09
DK324386A (da) 1987-01-10
FR2584725A1 (fr) 1987-01-16
NO862753D0 (no) 1986-07-08
NO862753L (no) 1987-01-12
UA6046A1 (uk) 1994-12-29
YU44585B (en) 1990-10-31

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