DK163520C - Substitueret androsta-1,4-dien-3,17-dioner, fremgangsmaade til fremstilling deraf, praeparater indeholdende saadanne forbindelser samt anvendelsen af disse til fremstilling af farmaceutiske praeparater - Google Patents

Substitueret androsta-1,4-dien-3,17-dioner, fremgangsmaade til fremstilling deraf, praeparater indeholdende saadanne forbindelser samt anvendelsen af disse til fremstilling af farmaceutiske praeparater

Info

Publication number
DK163520C
DK163520C DK324386A DK324386A DK163520C DK 163520 C DK163520 C DK 163520C DK 324386 A DK324386 A DK 324386A DK 324386 A DK324386 A DK 324386A DK 163520 C DK163520 C DK 163520C
Authority
DK
Denmark
Prior art keywords
diones
dien
procedures
compounds
preparation
Prior art date
Application number
DK324386A
Other languages
Danish (da)
English (en)
Other versions
DK324386A (da
DK163520B (da
DK324386D0 (da
Inventor
Franco Buzzetti
Natale Barbugian
Paolo Lombardi
Enrico Di Salle
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10582036&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK163520(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of DK324386D0 publication Critical patent/DK324386D0/da
Publication of DK324386A publication Critical patent/DK324386A/da
Publication of DK163520B publication Critical patent/DK163520B/da
Application granted granted Critical
Publication of DK163520C publication Critical patent/DK163520C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK324386A 1985-07-09 1986-07-08 Substitueret androsta-1,4-dien-3,17-dioner, fremgangsmaade til fremstilling deraf, praeparater indeholdende saadanne forbindelser samt anvendelsen af disse til fremstilling af farmaceutiske praeparater DK163520C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858517360A GB8517360D0 (en) 1985-07-09 1985-07-09 Substituted androsta-1,4-diene-3,17-diones
GB8517360 1985-07-09

Publications (4)

Publication Number Publication Date
DK324386D0 DK324386D0 (da) 1986-07-08
DK324386A DK324386A (da) 1987-01-10
DK163520B DK163520B (da) 1992-03-09
DK163520C true DK163520C (da) 1992-07-27

Family

ID=10582036

Family Applications (1)

Application Number Title Priority Date Filing Date
DK324386A DK163520C (da) 1985-07-09 1986-07-08 Substitueret androsta-1,4-dien-3,17-dioner, fremgangsmaade til fremstilling deraf, praeparater indeholdende saadanne forbindelser samt anvendelsen af disse til fremstilling af farmaceutiske praeparater

Country Status (38)

Country Link
US (2) US4808616A (sv)
JP (1) JPS6212797A (sv)
KR (1) KR950003614B1 (sv)
CN (1) CN86104664B (sv)
AT (1) AT395157B (sv)
AU (1) AU578840B2 (sv)
BE (1) BE905067A (sv)
BG (1) BG61370B2 (sv)
BR (1) BR1100240A (sv)
CA (1) CA1277656C (sv)
CH (1) CH668599A5 (sv)
CS (2) CS258498B2 (sv)
CZ (1) CZ413591A3 (sv)
DE (1) DE10199030I1 (sv)
DK (1) DK163520C (sv)
ES (2) ES8801304A1 (sv)
FI (1) FI83424C (sv)
FR (1) FR2584725B1 (sv)
GB (2) GB8517360D0 (sv)
GR (1) GR861780B (sv)
HK (1) HK94190A (sv)
HU (1) HU194274B (sv)
IE (1) IE58949B1 (sv)
IL (1) IL79336A (sv)
IT (1) IT1196436B (sv)
MY (1) MY102294A (sv)
NL (2) NL193616C (sv)
NO (2) NO165547C (sv)
NZ (1) NZ216763A (sv)
PH (1) PH21785A (sv)
PT (1) PT82944B (sv)
SE (1) SE468988B (sv)
SG (1) SG80490G (sv)
SK (1) SK413591A3 (sv)
SU (2) SU1442077A3 (sv)
UA (1) UA6046A1 (sv)
YU (2) YU44585B (sv)
ZA (1) ZA865079B (sv)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8517360D0 (en) * 1985-07-09 1985-08-14 Erba Farmitalia Substituted androsta-1,4-diene-3,17-diones
GB8617107D0 (en) * 1986-07-14 1986-08-20 Erba Farmitalia 6-/7-methylenandrosta-1 4-diene-3 17-dione derivatives
GB8622330D0 (en) * 1986-09-17 1986-10-22 Erba Farmitalia 4-substituted 6-alkylidenandrostene-3,17-dione derivatives
DE3715869A1 (de) * 1987-05-07 1988-11-17 Schering Ag Verfahren zur herstellung von 1-methyl-androsta-1,4-dien-3,17-dion und die neuen zwischenprodukte fuer dieses verfahren
GB8721384D0 (en) * 1987-09-11 1987-10-21 Erba Farmitalia 17-substituted andro-sta-1 4-dien-3-one derivatives
GB8721383D0 (en) * 1987-09-11 1987-10-21 Erba Farmitalia Preparation of methylene derivatives
GB8801697D0 (en) * 1988-01-26 1988-02-24 Erba Farmitalia Improvements in synthesis of 6-methylene derivatives of androsta-1 4-diene-3 17-dione
KR0180008B1 (ko) * 1991-03-28 1999-04-01 야마구찌 다까시 신규 옥사-또는 아자스테로이드 유체
CH683151A5 (de) * 1991-04-24 1994-01-31 Ciba Geigy Ag Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus.
GB9201224D0 (en) * 1992-01-21 1992-03-11 Erba Carlo Spa Difluoromethylenandrostenone derivatives and process for their preparation
US5539127A (en) * 1992-09-30 1996-07-23 Teikoku Hormone Mfg. Co., Ltd. 7-substituted oxa- or azasteroid compound
US6407082B1 (en) * 1996-09-13 2002-06-18 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a vitamin D compound
GB9313420D0 (en) * 1993-06-29 1993-08-11 Erba Carlo Spa Fluorinated 6-methylenandrosta-1,4-dien-3-one-derivatives and process for their preparations
US6511970B1 (en) 1996-09-13 2003-01-28 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
US6034074A (en) 1996-09-13 2000-03-07 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a Vitamin D compound
US6028064A (en) * 1996-09-13 2000-02-22 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of progestin products
US6765002B2 (en) 2000-03-21 2004-07-20 Gustavo Rodriguez Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
AU5873300A (en) * 1999-07-07 2001-01-30 Pharmacia & Upjohn Company Process to prepare exemestane
GB9930839D0 (en) * 1999-12-30 2000-02-16 Pharmacia & Upjohn Spa Process for treating gynecomastia
GB0005257D0 (en) * 2000-03-03 2000-04-26 Pharmacia & Upjohn Spa Breast cancer hormonal therapy
US20010044431A1 (en) * 2000-03-21 2001-11-22 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
GB0017635D0 (en) * 2000-07-18 2000-09-06 Pharmacia & Upjohn Spa Antitumor combined therapy
JP2004505909A (ja) * 2000-08-09 2004-02-26 フアルマシア・イタリア・エツセ・ピー・アー アロマターゼ阻害薬の併用型組成物
AU8986501A (en) * 2000-09-08 2002-03-22 Pharmacia & Upjohn Spa Exemestane as chemopreventing agent
US20040082557A1 (en) * 2001-01-26 2004-04-29 Wajszczuk Charles Paul Methods for treating estrogen-dependent disorders
EP1377298B1 (en) * 2001-01-26 2006-08-30 Pfizer Italia S.r.l. Exemestane for treating hormono-dependent disorders
LT3351246T (lt) 2001-02-19 2019-07-10 Novartis Pharma Ag Rapamicino darinys, skirtas kieto naviko, susijusio su nereguliuojama angiogeneze, gydymui
SK14042003A3 (sk) 2001-05-16 2004-05-04 Novartis Ag Kombinácia N-{5-[4-metylpiperazinometyl)benzoylamido]-2- metylfenyl}-4-(3-pyridyl)-2-pyrimidínamínu chemoterapeutického činidla a farmaceutický prostriedok, ktorý ju obsahuje
GB0120147D0 (en) * 2001-08-17 2001-10-10 Metris Therapeutics Ltd Treatment method
US20040043938A1 (en) * 2001-11-06 2004-03-04 Dinesh Purandare Combination therapy for estrogen-dependent disorders
GB0128510D0 (en) * 2001-11-28 2002-01-23 Novartis Ag Organic compounds
EP1944026B1 (en) 2002-05-16 2013-06-26 Novartis AG Use of EDG receptor binding agents in cancer
CN1304413C (zh) * 2002-10-24 2007-03-14 上海华拓医药科技发展有限公司 一种抗癌药物依西美坦制备方法
CN1317293C (zh) * 2002-10-24 2007-05-23 南京长澳医药科技有限公司 一种依西美坦的合成工艺
US20040186160A1 (en) * 2002-12-13 2004-09-23 Sugen, Inc. Hexahydro-cyclohepta-pyrrole oxindole as potent kinase inhibitors
WO2005027916A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and aromatase inhibitors
US20050101579A1 (en) * 2003-11-06 2005-05-12 Shippen Eugene R. Endometriosis treatment protocol
WO2005070951A1 (en) * 2004-01-16 2005-08-04 Cedarburg Pharmaceuticals, Inc. Exemestane and its intermediates and methods of making the same
US7435757B2 (en) * 2004-07-02 2008-10-14 Schering Ag 2-substituted D-homo-estra-1,3,5(10)-trienes as inhibitors of 17β-hydroxy steroid dehydrogenase type 1
US20080119447A1 (en) * 2005-09-30 2008-05-22 James Yarger 6-alkoxyalkyl estradiol derivatives and methods of use
US10174070B2 (en) 2005-09-30 2019-01-08 Endece Llc 6-substituted estradiol derivatives and methods of use
EP1931385B1 (en) 2005-09-30 2018-02-28 Endece, LLC (s)-6-methyloxaalkyl exemestane compounds and related methods of use
US8168621B2 (en) 2005-09-30 2012-05-01 Endece, Llc 6-substituted estradiol derivatives and methods of use
DE102006008074B4 (de) * 2006-02-22 2013-08-14 RUHR-UNIVERSITäT BOCHUM Behandlung von Krebs mit Geruchsrezeptor-Liganden
WO2007128820A1 (en) 2006-05-09 2007-11-15 Novartis Ag Combination comprising an iron chelator and an anti-neoplastic agent and use thereof
US20080161324A1 (en) * 2006-09-14 2008-07-03 Johansen Lisa M Compositions and methods for treatment of viral diseases
US20080275259A1 (en) * 2007-05-04 2008-11-06 Scinopharm Taiwan, Ltd Process for preparing aromatase inhibitors
NZ591955A (en) 2007-10-16 2011-10-28 Repros Therapeutics Inc Trans-clomiphene for diabetes mellitus type 2
EP2070943A1 (en) * 2007-12-14 2009-06-17 Crystal Pharma, S.A. Process for obtaining 6-Alkylidenandrost-1,4-diene-3one
CN101468023B (zh) * 2007-12-26 2011-02-02 上海复星医药（集团）股份有限公司 依西美坦片及其制备工艺
WO2009093262A2 (en) * 2008-01-21 2009-07-30 Cadila Healthcare Limited Process for preparing aromatase inhibitor exemestane
GB0813628D0 (en) * 2008-07-25 2008-09-03 Arrow Int Ltd Stable coated anti-cancer agent
WO2010076811A2 (en) * 2008-12-30 2010-07-08 Ind-Swift Laboratories Limited Process for the preparation of exemestane
ES2587977T3 (es) 2009-05-01 2016-10-28 Celloxess Llc Tratamiento de la infertilidad masculina secundaria al estrés oxidativo de esperma
DE102010003494A1 (de) * 2010-03-31 2011-10-06 Bayer Schering Pharma Aktiengesellschaft Parenterales Abgabesystem, das Aromatasehemmer und Gestagene freisetzt, für die Behandlung von Endometriose
CA2794565C (en) 2010-04-08 2018-08-21 Emory University Substituted androst-4-ene diones
JP2013525296A (ja) 2010-04-16 2013-06-20 ノバルティス アーゲー 内分泌療法抵抗性乳癌の処置
JP5981434B2 (ja) 2010-09-14 2016-08-31 エンディース エルエルシーＥｎｄｅｃｅ，Ｌｌｃ 選択的ＥＲ−βアゴニストとしての６−置換デメチル−エストラジオール誘導体
ES2681023T3 (es) 2012-02-29 2018-09-11 Repros Therapeutics Inc. Terapia de combinación para tratar el déficit de andrógenos
JP2017505345A (ja) * 2014-02-11 2017-02-16 ノバルティス アーゲー がんの処置のためのｐｉ３ｋ阻害剤を含む組合せ医薬
EP3373967B9 (en) 2015-11-10 2023-10-04 Paracrine Therapeutics AB Treatment of er-negative breast cancer with an pdgf-cc inhibitor and an anti estrogen
CN112409432B (zh) * 2020-11-16 2023-07-07 陕西理工大学 一种依西美坦的合成方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB929985A (sv) *
US2744120A (en) * 1953-01-14 1956-05-01 Olin Mathieson 1-dehydrotestololactone
US3112305A (en) * 1960-11-07 1963-11-26 British Drug Houses Ltd 6-methylene-3-oxo-delta4-steroids and process for their preparation
GB1042291A (en) * 1961-11-08 1966-09-14 Organon Labor Ltd í¸-6ª‡-amino steroids and the preparation thereof
DK120154B (da) * 1968-02-29 1971-04-19 Schering Ag Fremgangsmåde til fremstilling af N-substituerede 4-amino-3-oxosteroid-4,6-diener af androstan- eller pregnanrækken eller deres ammoniumsalte.
BE759143A (fr) * 1969-11-19 1971-05-19 Upjohn Co Procede de preparation d'un nouveau compose steroide
US4235893A (en) * 1978-05-08 1980-11-25 Brodie Angela M Ester derivatives of 4-hydroxy-4-androstene-3,17-dione and a method for inhibiting estrogen biosynthesis
DE3004508C2 (de) * 1980-02-05 1981-12-10 Schering Ag Berlin Und Bergkamen, 1000 Berlin Verfahren zur Herstellung von 6-Methylensteroiden
DE3322285A1 (de) * 1983-06-18 1984-12-20 Schering AG, 1000 Berlin und 4709 Bergkamen 1-alkyl-androsta-1,4-dien-3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
US4512986A (en) * 1983-07-26 1985-04-23 Research Triangle Institute Progrestationally active steroids
GB8517360D0 (en) * 1985-07-09 1985-08-14 Erba Farmitalia Substituted androsta-1,4-diene-3,17-diones

Also Published As

Publication number Publication date
NL193616B (nl) 1999-12-01
US4904650A (en) 1990-02-27
HU194274B (en) 1988-01-28
SU1501923A3 (ru) 1989-08-15
GR861780B (en) 1986-11-11
NL193616C (nl) 2000-04-04
SE8603046L (sv) 1987-01-10
HK94190A (en) 1990-11-23
CA1277656C (en) 1990-12-11
NO862753D0 (no) 1986-07-08
GB8616585D0 (en) 1986-08-13
SU1442077A3 (ru) 1988-11-30
CS258498B2 (en) 1988-08-16
PH21785A (en) 1988-02-24
AU5979986A (en) 1987-01-15
YU103687A (en) 1988-08-31
BR1100240A (pt) 1999-12-28
AT395157B (de) 1992-10-12
IL79336A (en) 1991-06-10
JPH0443919B2 (sv) 1992-07-20
MY102294A (en) 1992-05-15
YU44628B (en) 1990-10-31
SE468988B (sv) 1993-04-26
SE8603046D0 (sv) 1986-07-08
CN86104664A (zh) 1987-02-18
CS521486A2 (en) 1987-09-17
CZ413591A3 (en) 1994-03-16
ATA181986A (de) 1992-02-15
GB2177700B (en) 1988-12-07
KR870001140A (ko) 1987-03-11
CN86104664B (zh) 1988-06-29
GB8517360D0 (en) 1985-08-14
NL300017I1 (nl) 2000-11-01
CS257794B2 (en) 1988-06-15
IE861821L (en) 1987-01-09
ES8801304A1 (es) 1987-12-16
NO2000009I1 (no) 2000-10-05
GB2177700A (en) 1987-01-28
UA6046A1 (uk) 1994-12-29
ES8802429A1 (es) 1988-06-01
BG61370B2 (bg) 1997-06-30
DK324386A (da) 1987-01-10
AU578840B2 (en) 1988-11-03
NO165547C (no) 1991-02-27
DE10199030I1 (de) 2001-10-04
NZ216763A (en) 1988-05-30
PT82944B (pt) 1989-01-30
NL300017I2 (nl) 2001-01-02
NL8601785A (nl) 1987-02-02
ES556550A0 (es) 1987-12-16
FR2584725B1 (fr) 1988-05-13
HUT42780A (en) 1987-08-28
CH668599A5 (de) 1989-01-13
IT1196436B (it) 1988-11-16
FI862871A (fi) 1987-01-10
DK163520B (da) 1992-03-09
NO862753L (no) 1987-01-12
US4808616A (en) 1989-02-28
SG80490G (en) 1990-11-23
PT82944A (en) 1986-08-01
KR950003614B1 (ko) 1995-04-17
ZA865079B (en) 1987-03-25
BE905067A (fr) 1987-01-08
FI83424B (fi) 1991-03-28
IL79336A0 (en) 1986-10-31
IE58949B1 (en) 1993-12-01
YU120186A (en) 1988-02-29
IT8621004A0 (it) 1986-07-02
FR2584725A1 (fr) 1987-01-16
ES557466A0 (es) 1988-06-01
YU44585B (en) 1990-10-31
SK413591A3 (en) 1995-07-11
FI862871A0 (fi) 1986-07-07
JPS6212797A (ja) 1987-01-21
FI83424C (sv) 1991-07-10
DK324386D0 (da) 1986-07-08
NO165547B (no) 1990-11-19

Similar Documents

Publication Publication Date Title
DK163520C (da) Substitueret androsta-1,4-dien-3,17-dioner, fremgangsmaade til fremstilling deraf, praeparater indeholdende saadanne forbindelser samt anvendelsen af disse til fremstilling af farmaceutiske praeparater
DK160992C (da) Antibiotiske makrolidforbindelser, praeparater indeholdende disse, fremgangmaader til fremstilling af forbindelserne samt fremgangsmaade til anvendelse af forbindelserne eller praeparaterne
DK163991C (da) Dichloranilinderivater, fremgangsmaade til fremstilling af disse, samt farmaceutiske praeparater indeholdende derivaterne
DK214090D0 (da) 5-aminosulfonylalkyl-indolderivater, fremgangsmaade og mellemprodukt til fremstilling deraf samt farmaceutiske praeparater indeholdende disse
DK158587D0 (da) Thiazepinforbindelser, fremgangsmaader til fremstilling deraf samt farmaceutiske, praeparater, der indeholder disse forbindelser
NO820200L (no) Fremgangsmaate til fremstilling av fosforylforbindelser, i foerste rekke heksapyranoseforbindelser samt farmasoeytiske preparater inneholdende disse
DK166149C (da) Antipsykotiske 1-fluorphenylbutyl-4-(2-pyrimidinyl)-piperazinderivater, farmaceutiske praeparater indeholdende saadanne derivater samt fremgangsmaade til fremstilling af derivaterne
DK160492C (da) Pyrimidinderivater, fremgangsmaader til fremstilling heraf samt farmaceutiske praeparater indeholdende disse derivater
DK160981C (da) Arylsulfonylurinstof-derivater, fremgangsmaade til fremstilling deraf, anvendelse af disse som terapeutisk og antineoplastisk middel samt farmaceutiske midler indeholdende saadanne derivater
DK526586A (da) Tetraalkylethenylidenbisphosphonater, fremgangsmaade til fremstilling af disse samt farmaceutisk sammensaetning indeholdende samme
DK83386D0 (da) Disaccharid- og trisaccharid-derivater af aelipid aae-typen, praeparaterder indeholder disse samt fremgangsmaade til fremstilling af disse
DK164594C (da) 1,4-dihydro-pyridin-3,5-yl-dicarboxylsyrederivater, farmaceutiske praeparater indeholdende disse derivater samt fremgangsmaade til fremstilling deraf
DK284585D0 (da) 1,4-dihydropyrinderivater, fremgangsmaade til fremstilling af saadanneforbindelser samt laegemiddel indeholdende disse
DK314887A (da) Kompleksforbindelser, farmaceutiske midler med indhold heraf samt fremgangsmaade til fremstilling heraf
DK506386D0 (da) Flavonderivater, fremgangsmaader til fremstilling heraf samt farmaceutiske midler indeholdende disse
DK538885D0 (da) Imidazolylalkylguanidinderivater, fremgangsmaade til fremstilling herafsamt laegemidler indeholdende disse forbindelser
DK188286A (da) Phenylalkyl-2,3-dihydrobenzofuraner og analoge heraf samt praeparater indeholdende disse forbindelser
DK165951C (da) Imidazolderivater, fremgangsmaade til fremstilling heraf samt laegemidler indeholdende disse
DK102990D0 (da) Thieno-triazolodiazepinderivater, fremgangsmaade til fremstilling af saadanne forbindelser og laegemiddel indeholdende disse
DK307085A (da) 4-phenyl-2-trifluormethyl-1,3-dioxan-5-ylheptensyrederivater, fremgangsmaade til fremstilling deraf samt farmaceutiske midler indeholdende disse
DK191086D0 (da) Benzisoselenazolonylderivater, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende disse
DK165885D0 (da) Peptider, fremgangsmaade til fremstilling deraf, samt farmaceutiske praeparater, indeholdende disse peptider
DK160885A (da) Benzazepinderivater, fremgangsmaade til fremstilling deraf samt praeparater indeholdende disse
DK369088A (da) Fremgangsmaade til fremstilling af nukleinsyrederivater og fremgangsmaade til fremstilling af farmaceutiske praeparater indeholdende disse
DK141784D0 (da) Penemforbindelser,fremgangsmaader til deres fremstilling samt farmaceutiske praeparater indeholdende disse

Legal Events

Date Code Title Description
CTFF Application for supplementary protection certificate (spc) filed

Spc suppl protection certif: CA 2000 00007

Filing date: 20000316

Extension date: 20110708

PUP Patent expired