MY157119A - Process for the production of alpha-tocotrienol and derivatives - Google Patents
Process for the production of alpha-tocotrienol and derivativesInfo
- Publication number
- MY157119A MY157119A MYPI2011001873A MYPI20111873A MY157119A MY 157119 A MY157119 A MY 157119A MY PI2011001873 A MYPI2011001873 A MY PI2011001873A MY PI20111873 A MYPI20111873 A MY PI20111873A MY 157119 A MY157119 A MY 157119A
- Authority
- MY
- Malaysia
- Prior art keywords
- tocotrienol
- alpha
- production
- derivatives
- enrichment
- Prior art date
Links
- 229940064063 alpha tocotrienol Drugs 0.000 title abstract 3
- 239000011730 α-tocotrienol Substances 0.000 title abstract 3
- RZFHLOLGZPDCHJ-DLQZEEBKSA-N alpha-Tocotrienol Natural products Oc1c(C)c(C)c2O[C@@](CC/C=C(/CC/C=C(\CC/C=C(\C)/C)/C)\C)(C)CCc2c1C RZFHLOLGZPDCHJ-DLQZEEBKSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- RZFHLOLGZPDCHJ-XZXLULOTSA-N α-Tocotrienol Chemical compound OC1=C(C)C(C)=C2O[C@@](CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)(C)CCC2=C1C RZFHLOLGZPDCHJ-XZXLULOTSA-N 0.000 title abstract 2
- 235000019145 α-tocotrienol Nutrition 0.000 title abstract 2
- GJJVAFUKOBZPCB-ZGRPYONQSA-N (r)-3,4-dihydro-2-methyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-2h-1-benzopyran-6-ol Chemical class OC1=CC=C2OC(CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)(C)CCC2=C1 GJJVAFUKOBZPCB-ZGRPYONQSA-N 0.000 abstract 1
- 239000000284 extract Substances 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000011731 tocotrienol Substances 0.000 abstract 1
- 229930003802 tocotrienol Natural products 0.000 abstract 1
- 235000019148 tocotrienols Nutrition 0.000 abstract 1
- 229940068778 tocotrienols Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
- C07C46/02—Preparation of quinones by oxidation giving rise to quinoid structures
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
- C07C46/02—Preparation of quinones by oxidation giving rise to quinoid structures
- C07C46/06—Preparation of quinones by oxidation giving rise to quinoid structures of at least one hydroxy group on a six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19758508P | 2008-10-28 | 2008-10-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY157119A true MY157119A (en) | 2016-05-13 |
Family
ID=42118126
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI2014003438A MY185183A (en) | 2008-10-28 | 2009-10-27 | Process for the production of alpha-tocotrienol and derivatives |
| MYPI2011001873A MY157119A (en) | 2008-10-28 | 2009-10-27 | Process for the production of alpha-tocotrienol and derivatives |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI2014003438A MY185183A (en) | 2008-10-28 | 2009-10-27 | Process for the production of alpha-tocotrienol and derivatives |
Country Status (17)
| Country | Link |
|---|---|
| US (6) | US8106223B2 (OSRAM) |
| EP (3) | EP2362875B1 (OSRAM) |
| JP (7) | JP5775459B2 (OSRAM) |
| CN (2) | CN102264730B (OSRAM) |
| BR (1) | BRPI0920414B1 (OSRAM) |
| CA (2) | CA2741767C (OSRAM) |
| DK (2) | DK2362875T3 (OSRAM) |
| EA (2) | EA026417B1 (OSRAM) |
| ES (2) | ES2553557T3 (OSRAM) |
| HU (1) | HUE041714T2 (OSRAM) |
| MX (1) | MX2011004440A (OSRAM) |
| MY (2) | MY185183A (OSRAM) |
| PL (2) | PL2963006T3 (OSRAM) |
| PT (2) | PT2362875E (OSRAM) |
| SI (1) | SI2963006T1 (OSRAM) |
| TR (1) | TR201819154T4 (OSRAM) |
| WO (1) | WO2010051277A1 (OSRAM) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2580584C (en) | 2003-09-19 | 2015-07-28 | Galileo Pharmaceuticals, Inc. | Use of alpha-tocotrienol for treatment of mitochondrial diseases |
| MX2007015006A (es) | 2005-06-01 | 2008-03-18 | Edison Pharmaceuticals Inc | Sustancias terapeuticas activas redox para el tratamiento de enfermedades mitocondriales y otras condiciones o modulacion de biomarcadores de energia. |
| JP5374162B2 (ja) | 2006-02-22 | 2013-12-25 | エジソン ファーマシューティカルズ， インコーポレイテッド | ミトコンドリア病および他の症状の処置のためのレドックス活性化治療の側鎖変異体およびエネルギーバイオマーカーの調節 |
| PL3456707T3 (pl) | 2007-11-06 | 2020-09-21 | Ptc Therapeutics, Inc. | Pochodne 4-(p-chinonylo)-2-hydroksybutanamidu do leczenia chorób mitochondrialnych |
| JP5649454B2 (ja) | 2008-01-08 | 2015-01-07 | エジソン ファーマシューティカルズ， インコーポレイテッド | ミトコンドリア病の処置のための（ヘテロ）アリール−ｐ−キノン誘導体 |
| JP5710277B2 (ja) | 2008-03-05 | 2015-04-30 | エジソン ファーマシューティカルズ， インコーポレイテッド | 酸化ストレス疾患の処置のための２−置換−ｐ−キノン誘導体 |
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| MX363223B (es) | 2008-09-10 | 2019-03-15 | Bioelectron Tech Corp | Tratamiento de trastornos generalizados del desarrollo con terapeuticos con actividad redox. |
| CA2740773A1 (en) | 2008-10-14 | 2010-04-22 | Edison Pharmaceuticals, Inc. | Treatment of oxidative stress disorders including contrast nephropathy, radiation damage and disruptions in the function of red cells |
| DK2362875T3 (en) | 2008-10-28 | 2015-11-30 | Edison Pharmaceuticals Inc | METHOD OF PRODUCING ALPHA-tocotrienol AND DERIVATIVES |
| EP3332766A1 (en) | 2009-04-28 | 2018-06-13 | BioElectron Technology Corporation | Treatment of leber's hereditary optic neuropathy and dominant optic atrophy with tocotrienol quinones |
| PL2470168T3 (pl) | 2009-08-26 | 2018-06-29 | Bioelectron Technology Corporation | Sposoby zapobiegania i leczenia niedokrwienia mózgu |
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