MY122531A - N-(indolecarbonyl) piperazine derivatives - Google Patents

N-(indolecarbonyl) piperazine derivatives

Info

Publication number
MY122531A
MY122531A MYPI20003320A MYPI20003320A MY122531A MY 122531 A MY122531 A MY 122531A MY PI20003320 A MYPI20003320 A MY PI20003320A MY PI20003320 A MYPI20003320 A MY PI20003320A MY 122531 A MY122531 A MY 122531A
Authority
MY
Malaysia
Prior art keywords
disease
indolecarbonyl
disorders
piperazine derivatives
psychoses
Prior art date
Application number
MYPI20003320A
Other languages
English (en)
Inventor
Bottcher Dr Henning
Greiner Dr Hartmut
Harting Dr Jurgen
Bartoszyk Gerd
Seyfried Dr Christoph
Amsterdam Dr Van Christoph
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of MY122531A publication Critical patent/MY122531A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/08Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
MYPI20003320A 1999-07-22 2000-07-20 N-(indolecarbonyl) piperazine derivatives MY122531A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19934433A DE19934433A1 (de) 1999-07-22 1999-07-22 N-(Indolcarbonyl-)piperazinderivate

Publications (1)

Publication Number Publication Date
MY122531A true MY122531A (en) 2006-04-29

Family

ID=7915702

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI20003320A MY122531A (en) 1999-07-22 2000-07-20 N-(indolecarbonyl) piperazine derivatives

Country Status (26)

Country Link
US (2) US6838461B1 (enExample)
EP (1) EP1198453B9 (enExample)
JP (2) JP5242871B2 (enExample)
KR (1) KR100779207B1 (enExample)
CN (1) CN1229345C (enExample)
AR (1) AR024819A1 (enExample)
AT (1) ATE236877T1 (enExample)
AU (1) AU770411B2 (enExample)
BR (1) BR0012607A (enExample)
CA (1) CA2383779C (enExample)
CZ (1) CZ300510B6 (enExample)
DE (2) DE19934433A1 (enExample)
DK (1) DK1198453T5 (enExample)
ES (1) ES2192535T3 (enExample)
HK (1) HK1048636B (enExample)
HU (1) HUP0201988A3 (enExample)
MX (1) MXPA02000730A (enExample)
MY (1) MY122531A (enExample)
NO (1) NO322154B1 (enExample)
PL (1) PL201893B1 (enExample)
PT (1) PT1198453E (enExample)
RU (1) RU2251548C2 (enExample)
SK (1) SK286066B6 (enExample)
UA (1) UA73518C2 (enExample)
WO (1) WO2001007435A2 (enExample)
ZA (1) ZA200201486B (enExample)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6589954B1 (en) * 1998-05-22 2003-07-08 Scios, Inc. Compounds and methods to treat cardiac failure and other disorders
IL146309A (en) 1999-05-21 2008-03-20 Scios Inc Derivatives of the indole type and pharmaceutical preparations containing them as inhibitors of kinase p38
DE19934432A1 (de) * 1999-07-22 2001-02-01 Merck Patent Gmbh Indolderivate
DE19934433A1 (de) * 1999-07-22 2001-01-25 Merck Patent Gmbh N-(Indolcarbonyl-)piperazinderivate
US8465468B1 (en) 2000-06-29 2013-06-18 Becton, Dickinson And Company Intradermal delivery of substances
US20020095134A1 (en) * 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
US20020156453A1 (en) * 1999-10-14 2002-10-24 Pettis Ronald J. Method and device for reducing therapeutic dosage
DE10102053A1 (de) * 2001-01-17 2002-07-18 Merck Patent Gmbh Piperazinylcarbonylchinoline und -isochinoline
MXPA03011638A (es) * 2001-06-15 2004-04-02 Hoffmann La Roche Nuevos derivados de 4-piperazinil indol con afinidad por el receptor 5-ht6.
CA2451816A1 (en) * 2001-06-29 2003-01-09 Becton, Dickinson And Company Intradermal delivery of vaccines and gene therapeutic agents via microcannula
DE10157673A1 (de) * 2001-11-24 2003-06-05 Merck Patent Gmbh Verwendung von N-(Indolcarbonyl-)piperazinderivaten
GB0203811D0 (en) 2002-02-18 2002-04-03 Glaxo Group Ltd Compounds
DE10212564B4 (de) * 2002-03-12 2007-04-19 Neurobiotec Gmbh 1-Allyl-ergotalkaloid-Derivate und ihre Verwendung zur Prophylaxe und Therapie von Migräne
DE10217006A1 (de) * 2002-04-16 2003-11-06 Merck Patent Gmbh Substituierte Indole
CA2497086A1 (en) * 2002-08-30 2004-03-11 Becton, Dickinson And Company Method of controlling pharmacokinetics of immunomodulatory compounds
DE10246357A1 (de) * 2002-10-04 2004-04-15 Merck Patent Gmbh Verwendung von 5-HT2Rezeptorantagonisten
WO2005016401A2 (en) * 2003-06-13 2005-02-24 Becton Dickinson And Company Improved intra-dermal delivery of biologically active agents
JP2007503435A (ja) * 2003-08-26 2007-02-22 ベクトン・ディキンソン・アンド・カンパニー 治療薬の皮内送達法
WO2005091922A2 (en) * 2004-03-03 2005-10-06 Becton, Dickinson And Company Methods and devices for improving delivery of a substance to skin
WO2005108378A2 (en) * 2004-04-15 2005-11-17 Samaritan Pharmaceuticals, Inc. Use of (4-alkylpiperazinyl) (phenyl) methanones in the treatment of alzheimer’s disease
EP1744784A2 (en) * 2004-05-11 2007-01-24 Becton, Dickinson and Company Formulations of anti-pain agents and methods of using the same
DE102004047517A1 (de) * 2004-09-28 2006-03-30 Merck Patent Gmbh Neuartige Kristallform von (3-Cyan-1H-indol-7-yl)-[4-(4-fluorphenethyl)-piperazin-1-yl]-methanon, Hydrochlorid
KR100901035B1 (ko) * 2004-12-21 2009-06-04 에프. 호프만-라 로슈 아게 테트랄린 및 인단 유도체 및 이의 용도
GT200600042A (es) 2005-02-10 2006-09-27 Aventis Pharma Inc Compuestos de bis arilo y heteroarilo sustituido como antagonistas selectivos de 5ht2a
CA2652215A1 (en) * 2006-05-05 2007-11-15 Merck Patent Gesellschaft Mit Beschraenkter Haftung Crystalline (3-cyano-1h-indol-7-yl)-[4-(4-fluorophenethyl)piperazin-1-yl]methanone phosphate
US7514433B2 (en) * 2006-08-03 2009-04-07 Hoffmann-La Roche Inc. 1H-indole-6-yl-piperazin-1-yl-methanone derivatives
RU2460731C2 (ru) * 2007-05-14 2012-09-10 Ск Байофармасьютикалз Ко., Лтд. Карбамоилоксиарилалканоиларилпиперазиновое соединение, фармацевтические композиции, содержащие его, и способ лечения боли, беспокойства и депрессии
EP2008656A1 (en) * 2007-06-28 2008-12-31 Bergen Teknologioverforing AS Compositions for the treatment of hyperphenylalaninemia
US9567327B2 (en) * 2007-08-15 2017-02-14 Arena Pharmaceuticals, Inc. Imidazo[1,2-a]pyridine derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
KR101062376B1 (ko) * 2008-04-10 2011-09-06 한국화학연구원 신규 인돌 카르복실산 비스피리딜 카르복사마이드 유도체,이의 제조방법 및 이를 유효성분으로 함유하는 조성물
US9308323B2 (en) 2011-11-15 2016-04-12 Smiths Medical Asd, Inc. Systems and methods for illuminated medical tubing detection and management indicating a characteristic of at least one infusion pump
RU2549963C1 (ru) * 2014-04-08 2015-05-10 Государственное бюджетное образовательное учреждение высшего профессионального образования "Дальневосточный государственный медицинский университет" Министерства здравоохранения Российской Федерации (ГБОУ ВПО "ДВГМУ" Минздрава России) Способ прогнозирования развития критической печеночной недостаточности на основании сывороточного уровня селена
WO2017144637A1 (en) 2016-02-25 2017-08-31 Asceneuron S. A. Acid addition salts of piperazine derivatives
GB2554371B (en) * 2016-09-22 2019-10-09 Resolute Energy Solutions Ltd Well apparatus and associated methods

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE209919T1 (de) 1987-09-24 2001-12-15 Jencap Res Ltd Oestrogen und progestin enthaltende verhütungspackungen
US5093341A (en) * 1987-12-17 1992-03-03 Merrell Dow Pharmaceuticals Inc. N-aralkyl piperidine derivatives useful as antithrombolytic agents
US5032604A (en) * 1989-12-08 1991-07-16 Merck & Co., Inc. Class III antiarrhythmic agents
US5032598A (en) * 1989-12-08 1991-07-16 Merck & Co., Inc. Nitrogens containing heterocyclic compounds as class III antiarrhythmic agents
US5330986A (en) 1992-11-24 1994-07-19 Hoechst-Roussel Pharmaceuticals Inc. Indole-7-carboxamide derivatives
ZA954689B (en) 1994-06-08 1996-01-29 Lundbeck & Co As H 4-Aryl-1-(indanmethyl dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl) piperidines tetrahydropyridines or piperazines
JP2001506230A (ja) 1996-08-09 2001-05-15 スミスクライン・ビーチャム・コーポレイション 新規ピペラジン含有化合物
GB9718712D0 (en) 1997-09-03 1997-11-12 Merck Sharp & Dohme Theraputic Agents
DE19934432A1 (de) * 1999-07-22 2001-02-01 Merck Patent Gmbh Indolderivate
DE19934433A1 (de) * 1999-07-22 2001-01-25 Merck Patent Gmbh N-(Indolcarbonyl-)piperazinderivate
JPWO2005099240A1 (ja) * 2004-04-07 2008-03-06 松下電器産業株式会社 情報交換支援装置、情報交換支援方法、及び情報交換支援プログラム

Also Published As

Publication number Publication date
AR024819A1 (es) 2002-10-23
AU770411B2 (en) 2004-02-19
KR20020019513A (ko) 2002-03-12
PL353446A1 (en) 2003-11-17
DK1198453T5 (da) 2005-01-31
BR0012607A (pt) 2002-04-09
CN1229345C (zh) 2005-11-30
JP2003505458A (ja) 2003-02-12
DK1198453T3 (da) 2003-07-21
MXPA02000730A (es) 2002-08-20
CA2383779A1 (en) 2001-02-01
ES2192535T3 (es) 2003-10-16
DE19934433A1 (de) 2001-01-25
HK1048636A1 (en) 2003-04-11
HUP0201988A3 (en) 2003-12-29
US7084143B2 (en) 2006-08-01
PT1198453E (pt) 2003-08-29
KR100779207B1 (ko) 2007-11-27
AU6270400A (en) 2001-02-13
ZA200201486B (en) 2003-07-30
JP5242871B2 (ja) 2013-07-24
SK286066B6 (sk) 2008-02-05
US6838461B1 (en) 2005-01-04
ATE236877T1 (de) 2003-04-15
SK512002A3 (en) 2002-05-09
CZ300510B6 (cs) 2009-06-03
NO20020307D0 (no) 2002-01-21
DE50001729D1 (de) 2003-05-15
WO2001007435A3 (de) 2001-08-16
JP2012006940A (ja) 2012-01-12
PL201893B1 (pl) 2009-05-29
EP1198453B9 (de) 2004-11-10
UA73518C2 (en) 2005-08-15
NO322154B1 (no) 2006-08-21
NO20020307L (no) 2002-03-21
CN1364157A (zh) 2002-08-14
RU2251548C2 (ru) 2005-05-10
CA2383779C (en) 2011-03-29
CZ200268A3 (cs) 2002-04-17
WO2001007435A2 (de) 2001-02-01
EP1198453B1 (de) 2003-04-09
HUP0201988A2 (hu) 2002-11-28
HK1048636B (zh) 2006-08-11
EP1198453A2 (de) 2002-04-24
US20050096330A1 (en) 2005-05-05

Similar Documents

Publication Publication Date Title
MY122531A (en) N-(indolecarbonyl) piperazine derivatives
TW200503713A (en) Novel compounds
MXPA02008056A (es) Derivados de 2-oxo-1 pirrolidina, proceso para prepararlos y sus aplicaciones.
MY136270A (en) Processes and intermediates for preparing anti-cancer compounds
MY140693A (en) [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
TW200503710A (en) Novel compounds
GEP20074171B (en) N,n'−substituted−1,3−diamino−2−hydroxypropane derivatives
BR0107578A (pt) Derivados de piperidina e piperazina
TW200514781A (en) Novel compounds
MY123686A (en) Indole derivatives and their use as 5ht2a ligands
DK1636239T3 (da) Indolderivater med en forbedret antipsykotisk aktivitet
MXPA05004273A (es) Derivados de fenilalquil y piridilalquil piperazina.
BG105710A (en) 5ht1 antagonists for antidepressant therapy
MXPA04000036A (es) Benzofuranos sustituidos con (hetero) arilo como ligandos 5-ht.
CA2411412A1 (en) Indole derivatives useful for the treatment of cns disorders
DE60200135D1 (de) 4-(2-Pyridyl)piperazine als Agonisten des 5HT7 Rezeptors
PL361741A1 (en) Piperazinylcarbonylquinolines and -isoquinolines
WO2002088143A3 (en) Dihydroimidazo[4,5-e]indole and 7h-pyrrolo[3,2-f]quinoxaline derivatives as nicotinic acetylcholine receptor ligands and/or serotonergic ligands
BG107471A (en) Indole derivatives useful for the treatment of cns disorders
NO20020827L (no) Piperidinalkoholer
ATE270287T1 (de) 2,3-dihydro-1h-isoindolderivate, verfahren zu ihrer herstellung und ihre verwendung als hemmer der serotoninwiederaufnahme
CA2416212A1 (en) Indole derivatives useful for the treatment of cns disorders
MXPA05013084A (es) Preparacion de quinoxalinas sustituidas a partir de la dianilina con 2,3-dihidroxi-1,4-dioxano.
PT1373218E (pt) Derivados de imidazolilo úteis como ligandos do receptor h3 de histamina
BG105247A (en) N-substituted azabicycloheptane derivatives, production and use thereof