MX9803706A - Metodo para transferir genes dentro de celulas objetivo, con retrovirus. - Google Patents

Metodo para transferir genes dentro de celulas objetivo, con retrovirus.

Info

Publication number
MX9803706A
MX9803706A MX9803706A MX9803706A MX9803706A MX 9803706 A MX9803706 A MX 9803706A MX 9803706 A MX9803706 A MX 9803706A MX 9803706 A MX9803706 A MX 9803706A MX 9803706 A MX9803706 A MX 9803706A
Authority
MX
Mexico
Prior art keywords
retrovirus
target cells
gene introduction
effective amount
functional substance
Prior art date
Application number
MX9803706A
Other languages
English (en)
Inventor
Kiyozo Asada
Takashi Uemori
Takashi Ueno
Nobuto Koyama
Kimikazu Hashino
Ikunoshin Kato
Original Assignee
Takara Shuzo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takara Shuzo Co filed Critical Takara Shuzo Co
Publication of MX9803706A publication Critical patent/MX9803706A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C12N9/1088—Glutathione transferase (2.5.1.18)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/13045—Special targeting system for viral vectors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se da a conocer un método para aumentar la eficiencia de la transferencia de genes en células objetivo, con un retrovirus. En este método, las células objetivo son infectadas con el retrovirus, en la presencia de o una mezcla de una cantidad efectiva de un material funciona, que tiene dominios de union de retrovirus, y una cantidad efectiva de otro material funcional, que tiene dominios de union de las células objetivo o una cantidad efectiva de un material funcional, que tiene estos dominios de union en la misma molécula. Los materiales funcionales se pueden usar sin inmovilizacion con inmovilizados sobre globulos. Este método es util, por ejemplo, en la terapia de genes.
MX9803706A 1995-11-13 1998-05-11 Metodo para transferir genes dentro de celulas objetivo, con retrovirus. MX9803706A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP29438295 1995-11-13
JP5184796 1996-03-08

Publications (1)

Publication Number Publication Date
MX9803706A true MX9803706A (es) 1998-09-30

Family

ID=26392431

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9803706A MX9803706A (es) 1995-11-13 1998-05-11 Metodo para transferir genes dentro de celulas objetivo, con retrovirus.

Country Status (13)

Country Link
US (5) US6472204B1 (es)
EP (1) EP0870839B1 (es)
JP (1) JP3343357B2 (es)
KR (2) KR100395420B1 (es)
CN (1) CN100390290C (es)
AT (1) ATE325884T1 (es)
AU (1) AU709831B2 (es)
CA (1) CA2235629A1 (es)
DE (1) DE69636122T2 (es)
EA (3) EA003195B1 (es)
ES (1) ES2259182T3 (es)
MX (1) MX9803706A (es)
WO (1) WO1997018318A1 (es)

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Also Published As

Publication number Publication date
ES2259182T3 (es) 2006-09-16
US20030087437A1 (en) 2003-05-08
KR100353115B1 (ko) 2003-01-06
CN100390290C (zh) 2008-05-28
EA003204B1 (ru) 2003-02-27
CA2235629A1 (en) 1997-05-22
EA199800369A1 (ru) 1998-12-24
AU7505896A (en) 1997-06-05
ATE325884T1 (de) 2006-06-15
KR19990067446A (ko) 1999-08-16
EA200200837A1 (ru) 2002-12-26
US7446170B2 (en) 2008-11-04
US6426042B1 (en) 2002-07-30
US6472204B1 (en) 2002-10-29
US7790849B2 (en) 2010-09-07
US6949623B2 (en) 2005-09-27
DE69636122D1 (de) 2006-06-14
DE69636122T2 (de) 2006-12-07
EA004928B1 (ru) 2004-10-28
US20090209730A1 (en) 2009-08-20
AU709831B2 (en) 1999-09-09
EP0870839A1 (en) 1998-10-14
EA200001110A1 (ru) 2001-06-25
WO1997018318A1 (en) 1997-05-22
CN1207774A (zh) 1999-02-10
KR100395420B1 (ko) 2003-08-21
JP3343357B2 (ja) 2002-11-11
EP0870839B1 (en) 2006-05-10
US20060030046A1 (en) 2006-02-09
EA003195B1 (ru) 2003-02-27
EP0870839A4 (en) 2000-01-19

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