|
US5354768A
(en)
*
|
1988-07-26 |
1994-10-11 |
Sankyo Company, Limited |
Use of imidazopyrazole derivatives as analgesics and anti-inflammatory agents
|
|
US6277969B1
(en)
*
|
1991-03-18 |
2001-08-21 |
New York University |
Anti-TNF antibodies and peptides of human tumor necrosis factor
|
|
US5356897A
(en)
*
|
1991-09-09 |
1994-10-18 |
Fujisawa Pharmaceutical Co., Ltd. |
3-(heteroaryl)-pyrazololi[1,5-a]pyrimidines
|
|
GB9303993D0
(en)
*
|
1993-02-26 |
1993-04-14 |
Fujisawa Pharmaceutical Co |
New heterocyclic derivatives
|
|
EP0621036B1
(en)
*
|
1993-04-22 |
1999-03-17 |
Senju Pharmaceutical Co., Ltd. |
Aqueous compositions comprising argatroban and cyclodextrin or caffeine
|
|
CA2166721C
(en)
*
|
1993-07-06 |
1999-07-27 |
Allen Jacob Duplantier |
Bicyclic tetrahydro pyrazolopyridines
|
|
US6262277B1
(en)
|
1994-09-13 |
2001-07-17 |
G.D. Searle And Company |
Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
|
|
US6642268B2
(en)
|
1994-09-13 |
2003-11-04 |
G.D. Searle & Co. |
Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
|
|
US6268392B1
(en)
|
1994-09-13 |
2001-07-31 |
G. D. Searle & Co. |
Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
|
|
US6228871B1
(en)
|
1995-07-10 |
2001-05-08 |
Merck & Co., Inc. |
Angiogenesis inhibitors
|
|
RU2147584C1
(ru)
*
|
1995-10-27 |
2000-04-20 |
Американ Цианамид Компани |
Способ получения дигалоидазолопиримидинов и способ получения дигидроксиазолопиримидинов
|
|
US5714607A
(en)
*
|
1995-12-01 |
1998-02-03 |
American Cyanamid Company |
Process improvement in the synthesis of N- 3-(3-cyano-pyrazolo 1,5-a!pyrimidin-7-yl)phenyl!-N-ethylacetamide
|
|
EP0913392B1
(en)
|
1996-04-25 |
2003-07-02 |
Nissan Chemical Industries, Limited |
Ethylene derivatives and pest controlling agents
|
|
FR2750048B1
(fr)
*
|
1996-06-21 |
1998-08-14 |
Oreal |
Compositions de teinture des fibres keratiniques contenant des derives pyrazolo-(1, 5-a)-pyrimidine, procede de teinture, nouveaux derives pyrazolo-(1, 5-a)-pyrimidine et leur procede de preparation
|
|
WO1998002430A1
(en)
|
1996-07-11 |
1998-01-22 |
Pfizer Pharmaceuticals Inc. |
Pyridylpyrrole compounds useful as interleukin- and tnf antagonists
|
|
US6060478A
(en)
*
|
1996-07-24 |
2000-05-09 |
Dupont Pharmaceuticals |
Azolo triazines and pyrimidines
|
|
CZ299451B6
(cs)
*
|
1996-07-24 |
2008-07-30 |
Bristol-Myers Squibb Pharma Company |
[1,5-a]-Pyrazolo-1,3,5- triaziny jejich použití afarmaceutické kompozice na jejich bázi
|
|
US7094782B1
(en)
|
1996-07-24 |
2006-08-22 |
Bristol-Myers Squibb Company |
Azolo triazines and pyrimidines
|
|
US6313124B1
(en)
|
1997-07-23 |
2001-11-06 |
Dupont Pharmaceuticals Company |
Tetrazine bicyclic compounds
|
|
US6191131B1
(en)
|
1997-07-23 |
2001-02-20 |
Dupont Pharmaceuticals Company |
Azolo triazines and pyrimidines
|
|
DK0915880T3
(da)
*
|
1996-07-24 |
2008-02-11 |
Bristol Myers Squibb Pharma Co |
Azolotriaziner og pyrimidiner
|
|
US6124289A
(en)
*
|
1996-07-24 |
2000-09-26 |
Dupont Pharmaceuticals Co. |
Azolo triazines and pyrimidines
|
|
US6514977B1
(en)
|
1997-05-22 |
2003-02-04 |
G.D. Searle & Company |
Substituted pyrazoles as p38 kinase inhibitors
|
|
US6087496A
(en)
|
1998-05-22 |
2000-07-11 |
G. D. Searle & Co. |
Substituted pyrazoles suitable as p38 kinase inhibitors
|
|
JP2002502380A
(ja)
|
1997-05-22 |
2002-01-22 |
ジー.ディー.サール アンド カンパニー |
p38キナーゼ阻害剤としてのピラゾール誘導体
|
|
US6979686B1
(en)
|
2001-12-07 |
2005-12-27 |
Pharmacia Corporation |
Substituted pyrazoles as p38 kinase inhibitors
|
|
JP2002502379A
(ja)
*
|
1997-05-22 |
2002-01-22 |
ジー.ディー.サール アンド カンパニー |
p38キナーゼインヒビターとしての3(5)−ヘテロアリール置換ピラゾール
|
|
US6235741B1
(en)
*
|
1997-05-30 |
2001-05-22 |
Merck & Co., Inc. |
Angiogenesis inhibitors
|
|
AU1367599A
(en)
*
|
1997-11-03 |
1999-05-24 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Aromatic heterocyclic compounds as anti-inflammatory agents
|
|
EP1473292A1
(en)
*
|
1997-11-03 |
2004-11-03 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Aromatic heterocyclic compounds as anti-inflammatory agents
|
|
US6380203B1
(en)
*
|
1998-01-14 |
2002-04-30 |
Merck & Co., Inc. |
Angiogenesis inhibitors
|
|
PT1140184E
(pt)
|
1998-12-23 |
2003-10-31 |
Searle Llc |
Combinacoes de inibidores de proteina de transferencia de ester de colesterilo com derivados de acido nicotinico para indicacoes cardiovasculares
|
|
ES2200588T3
(es)
|
1998-12-23 |
2004-03-01 |
G.D. Searle Llc |
Combinacion de inhibidores del transporte de oxido biliar ileal y de derivados de acido fibrico para indicaciones cardiovasculares.
|
|
PL348508A1
(en)
|
1998-12-23 |
2002-05-20 |
Searle Llc |
Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications
|
|
WO2000038722A1
(en)
|
1998-12-23 |
2000-07-06 |
G.D. Searle & Co. |
COMBINATIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS AND HMG CoA REDUCTASE INHIBITORS FOR CARDIOVASCULAR INDICATIONS
|
|
NZ512534A
(en)
|
1998-12-23 |
2003-11-28 |
G |
Combinations of cholesteryl ester transfer protein inhibitors and fibric acid derivatives for cardiovascular indications
|
|
EP1140185B1
(en)
|
1998-12-23 |
2003-06-04 |
G.D. Searle LLC. |
Combinations of cholesteryl ester transfer protein inhibitors and bile acid sequestering agents for cardiovascular indications
|
|
DK1140190T3
(da)
|
1998-12-23 |
2002-12-23 |
Searle Llc |
Kombinationer af ileumgaldesyretransport-inhibitorer og galdesyre-sekvestreringsmidler til cardiovaskulære indikatorer
|
|
WO2000059908A2
(en)
|
1999-04-06 |
2000-10-12 |
Du Pont Pharmaceuticals Company |
Pyrazolopyrimidines as crf antagonists
|
|
WO2000059907A2
(en)
|
1999-04-06 |
2000-10-12 |
Du Pont Pharmaceuticals Company |
Pyrazolotriazines as crf antagonists
|
|
AU2006203676B2
(en)
*
|
1999-08-13 |
2010-04-22 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of c-JUN N-Terminal Kinases (JNK) and Other Protein Kinases
|
|
AR032130A1
(es)
|
1999-08-13 |
2003-10-29 |
Vertex Pharma |
Un compuesto inhibidor de quinasas proteicas, una composicion farmaceutica que lo incluye, y un metodo para tratar afecciones con dicho compuesto
|
|
US6472416B1
(en)
|
1999-08-27 |
2002-10-29 |
Abbott Laboratories |
Sulfonylphenylpyrazole compounds useful as COX-2 inhibitors
|
|
ATE267830T1
(de)
*
|
1999-08-27 |
2004-06-15 |
Abbott Lab |
Als cox-hemmer verwendbare sulfonylphenylpyrazol- verbindungen
|
|
EP1208748A4
(en)
*
|
1999-08-31 |
2002-11-20 |
Fujisawa Pharmaceutical Co |
PRESERVATIVES FOR ORGANS
|
|
CN1377354A
(zh)
*
|
1999-09-30 |
2002-10-30 |
纽罗杰有限公司 |
某些亚烷基二胺一取代的吡唑并[1,5-a]-1,5-嘧啶和吡唑并[1,5-a]-1,3,5-三嗪
|
|
WO2001068637A2
(en)
|
2000-03-10 |
2001-09-20 |
Pharmacia Corporation |
Method for the preparation of tetrahydrobenzothiepines
|
|
US6630476B2
(en)
|
2000-07-07 |
2003-10-07 |
Bristol-Myers Squibb Pharma Company |
Pyrrolo [3,4-d] pyrimidines as corticotropin releasing factor (CRF) antagonists
|
|
DE10153344A1
(de)
*
|
2001-10-29 |
2003-05-15 |
Gruenenthal Gmbh |
Verwendung von substituierten Pyrazolopyrimidinen als Liganden von Nucleosid-Transport-Proteinen und/oder von Purinorezeptoren
|
|
DK1397364T3
(da)
*
|
2001-05-24 |
2007-11-26 |
Lilly Co Eli |
Hidtil ukendte pyrrolderivater som farmaceutiske midler
|
|
WO2003004497A1
(en)
*
|
2001-07-05 |
2003-01-16 |
Sumitomo Pharmaceuticals Company, Limited |
Novel heterocyclic compound
|
|
US6740663B2
(en)
|
2001-11-02 |
2004-05-25 |
G.D. Searle, Llc |
Mono- and di-fluorinated benzothiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (ASBT) and taurocholate uptake
|
|
WO2003053976A1
(en)
*
|
2001-12-20 |
2003-07-03 |
Biovitrum Ab |
PIPAZOLO [1,5-a] PYRIMIDINE DERIVATIVES AS MODULATORS OF PPAR
|
|
US6852753B2
(en)
|
2002-01-17 |
2005-02-08 |
Pharmacia Corporation |
Alkyl/aryl hydroxy or keto thiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (ASBT) and taurocholate uptake
|
|
JP2005529919A
(ja)
*
|
2002-05-10 |
2005-10-06 |
スミスクライン ビーチャム コーポレーション |
治療用化合物
|
|
CZ293015B6
(cs)
*
|
2002-10-25 |
2004-01-14 |
Léčiva, A.S. |
Způsob výroby N-ethyl-N-[3-(3-methyl-pyrazolo[1,5-a]pyrimidin-7-yl)-fenyl]-acetamidu (zaleplonu)
|
|
EP1567528A1
(en)
*
|
2002-11-21 |
2005-08-31 |
Eli Lilly And Company |
Mixed lineage kinase modulators
|
|
UA80571C2
(en)
|
2002-11-22 |
2007-10-10 |
Lilly Co Eli |
Quinolinyl-pyrrolopyrazoles
|
|
WO2004110454A1
(ja)
*
|
2003-06-13 |
2004-12-23 |
Ishihara Sangyo Kaisha, Ltd. |
アデノシンA2a受容体アゴニストの投与が必要な疾患を治療又は予防するための組成物
|
|
DE10332487A1
(de)
*
|
2003-07-16 |
2005-02-10 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Ambroxol für die Behandlung von chronisch nozizeptiven Schmerzen
|
|
US7511065B2
(en)
|
2003-11-12 |
2009-03-31 |
Eli Lilly And Company |
Mixed lineage kinase modulators
|
|
WO2006115509A2
(en)
|
2004-06-24 |
2006-11-02 |
Novartis Vaccines And Diagnostics Inc. |
Small molecule immunopotentiators and assays for their detection
|
|
TW200639163A
(en)
*
|
2005-02-04 |
2006-11-16 |
Genentech Inc |
RAF inhibitor compounds and methods
|
|
AU2006279794B2
(en)
|
2005-08-12 |
2011-04-07 |
Synta Pharmaceuticals Corp. |
Pyrazole compounds that modulate HSP90 activity
|
|
KR20080049758A
(ko)
*
|
2005-09-01 |
2008-06-04 |
아스텔라스세이야쿠 가부시키가이샤 |
통증 치료용으로 사용되는 피리다지논 유도체
|
|
WO2007129195A2
(en)
*
|
2006-05-04 |
2007-11-15 |
Pfizer Products Inc. |
4-pyrimidine-5-amino-pyrazole compounds
|
|
WO2007139951A2
(en)
|
2006-05-25 |
2007-12-06 |
Synta Pharmaceuticals Corp. |
Method for treating proliferative disorders associated with protooncogene products
|
|
US20090082354A1
(en)
*
|
2007-09-20 |
2009-03-26 |
Wyeth |
Pyrazolo[5, 1-c] [1,2,4] triazines, methods for preparation and use thereof
|
|
CN101889012A
(zh)
*
|
2007-12-12 |
2010-11-17 |
杜邦公司 |
杀真菌二环吡唑
|
|
WO2010096115A1
(en)
*
|
2008-10-29 |
2010-08-26 |
Apath, Llc |
Compounds, compositions and methods for control of hepatitis c viral infections
|
|
RU2543386C2
(ru)
|
2010-02-26 |
2015-02-27 |
Мицубиси Танабе Фарма Коропорейшн |
Производные пиразолопиримидина и их применение в качестве ингибиторов pde10
|
|
WO2011133520A1
(en)
|
2010-04-19 |
2011-10-27 |
Synta Pharmaceuticals Corp. |
Cancer therapy using a combination of a hsp90 inhibitory compounds and a egfr inhibitor
|
|
EP2402344A1
(en)
*
|
2010-06-29 |
2012-01-04 |
Basf Se |
Pyrazole fused bicyclic compounds
|
|
EP2402339A1
(en)
*
|
2010-06-29 |
2012-01-04 |
Basf Se |
Pyrazolopyridine compounds
|
|
EP2402345A1
(en)
*
|
2010-06-29 |
2012-01-04 |
Basf Se |
Pyrazole fused bicyclic compounds
|
|
CN104039785A
(zh)
|
2011-10-06 |
2014-09-10 |
拜耳知识产权有限责任公司 |
作为杀真菌剂的杂环基吡(嘧)啶基吡唑
|
|
US20140286902A1
(en)
|
2011-11-02 |
2014-09-25 |
Synta Pharmaceuticals Corp. |
Combination therapy of hsp90 inhibitors with platinum-containing agents
|
|
WO2013067162A1
(en)
|
2011-11-02 |
2013-05-10 |
Synta Pharmaceuticals Corp. |
Cancer therapy using a combination of hsp90 inhibitors with topoisomerase i inhibitors
|
|
US9402831B2
(en)
|
2011-11-14 |
2016-08-02 |
Synta Pharmaceutical Corp. |
Combination therapy of HSP90 inhibitors with BRAF inhibitors
|
|
JO3407B1
(ar)
|
2012-05-31 |
2019-10-20 |
Eisai R&D Man Co Ltd |
مركبات رباعي هيدرو بيرازولو بيريميدين
|
|
CN105188694B
(zh)
|
2013-03-15 |
2018-07-31 |
卓莫赛尔公司 |
用于治疗疼痛的钠通道调节剂
|
|
CA2922925A1
(en)
|
2013-09-05 |
2015-03-12 |
Genentech, Inc. |
Antiproliferative compounds
|
|
CN105611923B
(zh)
|
2013-09-10 |
2019-08-23 |
卓莫赛尔公司 |
用于治疗疼痛和糖尿病的钠通道调节剂
|
|
EA031639B1
(ru)
*
|
2014-03-27 |
2019-01-31 |
Янссен Фармацевтика Нв |
ЗАМЕЩЕННЫЕ 4,5,6,7-ТЕТРАГИДРОПИРАЗОЛО[1,5-а]ПИРИМИДИНОВЫЕ ПРОИЗВОДНЫЕ И 2,3-ДИГИДРО-1H-ИМИДАЗО[1,2-b]ПИРАЗОЛЬНЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ ROS1
|
|
JP6522646B2
(ja)
|
2014-03-27 |
2019-05-29 |
ヤンセン ファーマシューティカ エヌ.ベー. |
ROS1阻害剤としての置換4,5,6,7−テトラヒドロ−ピラゾロ[1,5−α]ピラジン誘導体および5,6,7,8−テトラヒドロ−4H−ピラゾロ[1,5−α][1,4]ジアゼピン誘導体
|
|
CN104140427A
(zh)
*
|
2014-07-05 |
2014-11-12 |
湖南华腾制药有限公司 |
一种四氢吡唑并[1,5-a]嘧啶的制备方法
|
|
JP2017527573A
(ja)
*
|
2014-09-09 |
2017-09-21 |
クロモセル コーポレーション |
糖尿病の治療用の選択的NaV1.7阻害剤
|
|
KR102384652B1
(ko)
*
|
2015-02-03 |
2022-04-27 |
솔루스첨단소재 주식회사 |
유기 화합물 및 이를 포함하는 유기 전계 발광 소자
|
|
CA3034705C
(en)
|
2016-08-31 |
2021-08-03 |
Agios Pharmaceuticals, Inc. |
Inhibitors of cellular metabolic processes
|
|
US12479816B2
(en)
|
2019-02-08 |
2025-11-25 |
University of Pittsburgh—of the Commonwealth System of Higher Education |
20-HETE formation inhibitors
|
|
BR112022010924A2
(pt)
|
2019-12-06 |
2022-09-06 |
Vertex Pharma |
Tetra-hidrofuranos substituídos como moduladores de canais de sódio
|
|
CA3181354A1
(en)
*
|
2020-05-07 |
2021-11-11 |
AdoRx Therapeutics Limited |
Antagonists of the adenosine a2a receptor
|
|
CA3188730A1
(en)
|
2020-08-12 |
2022-02-17 |
Christopher Barnes |
Methods and compositions for treating polycystic ovary syndrome
|
|
KR20240031300A
(ko)
|
2021-06-04 |
2024-03-07 |
버텍스 파마슈티칼스 인코포레이티드 |
나트륨 채널 조절제로서의 n-(하이드록시알킬 (헤테로)아릴) 테트라하이드로푸란 카르복스아미드
|
|
TW202404969A
(zh)
|
2022-04-22 |
2024-02-01 |
美商維泰克斯製藥公司 |
用於治療疼痛之雜芳基化合物
|