MX393707B - Monocitos/macrofagos modificados que expresan receptores de antigeno quimerico y sus usos. - Google Patents

Monocitos/macrofagos modificados que expresan receptores de antigeno quimerico y sus usos.

Info

Publication number
MX393707B
MX393707B MX2018001182A MX2018001182A MX393707B MX 393707 B MX393707 B MX 393707B MX 2018001182 A MX2018001182 A MX 2018001182A MX 2018001182 A MX2018001182 A MX 2018001182A MX 393707 B MX393707 B MX 393707B
Authority
MX
Mexico
Prior art keywords
chimeric antigen
antigen receptors
expressing chimeric
modified
cell
Prior art date
Application number
MX2018001182A
Other languages
English (en)
Spanish (es)
Other versions
MX2018001182A (es
Inventor
Carl H June
Michael Klichinsky
Saar Gill
Original Assignee
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Publication of MX2018001182A publication Critical patent/MX2018001182A/es
Publication of MX393707B publication Critical patent/MX393707B/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001103—Receptors for growth factors
    • A61K39/001106—Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ErbB4
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    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
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    • A61K39/0011—Cancer antigens
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
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  • Health & Medical Sciences (AREA)
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  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
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  • Cell Biology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
MX2018001182A 2015-07-28 2016-07-28 Monocitos/macrofagos modificados que expresan receptores de antigeno quimerico y sus usos. MX393707B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562197675P 2015-07-28 2015-07-28
PCT/US2016/044440 WO2017019848A1 (en) 2015-07-28 2016-07-28 Modified monocytes/macrophage expressing chimeric antigen receptors and uses thereof

Publications (2)

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MX2018001182A MX2018001182A (es) 2018-04-20
MX393707B true MX393707B (es) 2025-03-24

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MX2018001182A MX393707B (es) 2015-07-28 2016-07-28 Monocitos/macrofagos modificados que expresan receptores de antigeno quimerico y sus usos.
MX2022008288A MX2022008288A (es) 2015-07-28 2018-01-26 Monocitos/macrofagos modificados que expresan receptores de antigeno quimerico y sus usos.

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US (12) US11034749B2 (cg-RX-API-DMAC7.html)
EP (1) EP3328402A4 (cg-RX-API-DMAC7.html)
JP (4) JP7032304B2 (cg-RX-API-DMAC7.html)
KR (2) KR102697827B1 (cg-RX-API-DMAC7.html)
CN (2) CN108025024B (cg-RX-API-DMAC7.html)
AU (2) AU2016298229B2 (cg-RX-API-DMAC7.html)
BR (1) BR112018001858B1 (cg-RX-API-DMAC7.html)
HK (1) HK1256141A1 (cg-RX-API-DMAC7.html)
IL (4) IL315940A (cg-RX-API-DMAC7.html)
MX (2) MX393707B (cg-RX-API-DMAC7.html)
RU (1) RU2766690C2 (cg-RX-API-DMAC7.html)
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US10434153B1 (en) 2015-05-20 2019-10-08 Kim Leslie O'Neill Use of car and bite technology coupled with an scFv from an antibody against human thymidine kinase 1 to specifically target tumors
BR112018001858B1 (pt) * 2015-07-28 2022-02-08 The Trustees Of The University Of Pennsylvania Composições compreendendo células modificadas que compreendem um receptor de antígeno quimérico (car), seus usos terapêuticos e método para modificar uma célula
US11352439B2 (en) * 2015-08-13 2022-06-07 Kim Leslie O'Neill Macrophage CAR (MOTO-CAR) in immunotherapy
EP3347026A4 (en) 2015-09-09 2019-05-08 Seattle Children's Hospital (DBA Seattle Children's Research Institute) GENEMANIPULATION OF MACROPHAGES FOR IMMUNOTHERAPY
EP3334764A2 (en) * 2015-10-13 2018-06-20 Brigham Young University Macrophage chimeric antigen receptor (moto-car) in imunotherapy
US10875919B2 (en) * 2016-04-26 2020-12-29 Alector Llc Chimeric receptors and methods of use thereof
JOP20190009A1 (ar) 2016-09-21 2019-01-27 Alx Oncology Inc أجسام مضادة ضد بروتين ألفا منظم للإشارات وطرق استخدامها
AU2017335634A1 (en) 2016-09-27 2019-03-14 Cero Therapeutics, Inc. Chimeric engulfment receptor molecules
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KR20240132100A (ko) 2024-09-02
US20220033468A1 (en) 2022-02-03
BR112018001858A2 (pt) 2018-09-18
RU2018107047A3 (cg-RX-API-DMAC7.html) 2020-02-27
US11332511B2 (en) 2022-05-17
JP7032304B2 (ja) 2022-03-08
NZ739224A (en) 2025-02-28
CN108025024B (zh) 2022-11-29
RU2018107047A (ru) 2019-08-28
ZA201800611B (en) 2023-05-31
KR20180028533A (ko) 2018-03-16
IL256892A (en) 2018-03-29
WO2017019848A1 (en) 2017-02-02
US20220002375A1 (en) 2022-01-06
EP3328402A1 (en) 2018-06-06
RU2766690C2 (ru) 2022-03-15
MX2018001182A (es) 2018-04-20
US20220033465A1 (en) 2022-02-03
US20230279074A1 (en) 2023-09-07
CN108025024A (zh) 2018-05-11
IL256892B (en) 2022-06-01
US20220033467A1 (en) 2022-02-03

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