MX386014B - Citocina fusionada a fc heterodimérico, y composición farmacéutica que comprende la misma. - Google Patents
Citocina fusionada a fc heterodimérico, y composición farmacéutica que comprende la misma.Info
- Publication number
- MX386014B MX386014B MX2019001651A MX2019001651A MX386014B MX 386014 B MX386014 B MX 386014B MX 2019001651 A MX2019001651 A MX 2019001651A MX 2019001651 A MX2019001651 A MX 2019001651A MX 386014 B MX386014 B MX 386014B
- Authority
- MX
- Mexico
- Prior art keywords
- protein
- heterodimeric
- region
- fused
- biologically active
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5434—IL-12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/208—IL-12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E60/00—Enabling technologies; Technologies with a potential or indirect contribution to GHG emissions mitigation
- Y02E60/10—Energy storage using batteries
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Reproductive Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente invencion se refiere a una proteina fusionada a un Fc heterodimerico que comprende una primera region de Fc y una segunda region de Fc de un par de Fc de inmunoglobulina y una proteina fisiologicamente activa compuesta de dos o mas subunidades diferentes, en donde una o mas subunidades de la proteina fisiologicamente activa son enlazadas por separado a uno o mas extremos del extremo N-terminal o C-terminal de la primera region de Fc y/o la segunda region de Fc, y los dominios CH3 de la primera region de Fc y la segunda region de Fc son mutados a fin de promover la formacion del Fc heterodimerico; ademas, la presente invencion se refiere a una composicion farmaceutica que comprende la proteina fusionada al Fc heterodimerico; la proteina fusionada al Fc heterodimerico de conformidad con la presente invención tiene la ventaja de que puede retener la actividad de una proteina fisiologicamente activa de ocurrencia natural, cuyas dos o mas subunidades diferentes exhiben actividad fisiologica mediante la formacion de un complejo de proteinas, debido a que la proteina fisiologicamente activa puede ser enlazada a un Fc heterodimerico de inmunoglobulina de modo que puede mantenerse la forma y estructura de ocurrencia natural de la proteina fusionada de la misma; cuando se usa la proteína fusionada al Fc heterodimerico de conformidad con la presente invencion, existe una ventaja porque la vida media in vivo de la proteina fisiologicamente activa contenida en la proteina fusionada al Fc heterodimerico puede ser incrementada significativamente debido a la larga vida media mediada por el Fc, de modo que varias actividades fisiologicas de la misma in vivo pueden ser de larga duracion.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20160101823 | 2016-08-10 | ||
| KR1020170101594A KR102050463B1 (ko) | 2016-08-10 | 2017-08-10 | 항체 중쇄불변부위 이종이중체 (heterodimeric Fc)에 융합된 사이토카인 (heterodimeric Fc-fused cytokine) 및 이를 포함하는 약제학적 조성물 |
| PCT/KR2017/008676 WO2018030806A1 (ko) | 2016-08-10 | 2017-08-10 | 항체 중쇄불변부위 이종이중체에 융합된 사이토카인 및 이를 포함하는 약제학적 조성물 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2019001651A MX2019001651A (es) | 2019-09-04 |
| MX386014B true MX386014B (es) | 2025-03-18 |
Family
ID=61524969
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019001651A MX386014B (es) | 2016-08-10 | 2017-08-10 | Citocina fusionada a fc heterodimérico, y composición farmacéutica que comprende la misma. |
| MX2021010809A MX2021010809A (es) | 2016-08-10 | 2019-02-08 | Citocina fusionada a fc heterodimerico, y composicion farmaceutica que comprende la misma. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2021010809A MX2021010809A (es) | 2016-08-10 | 2019-02-08 | Citocina fusionada a fc heterodimerico, y composicion farmaceutica que comprende la misma. |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US10696722B2 (es) |
| EP (2) | EP4470552A3 (es) |
| JP (3) | JP6993403B2 (es) |
| KR (4) | KR102050463B1 (es) |
| CN (1) | CN110267977A (es) |
| AU (2) | AU2017310163B2 (es) |
| BR (1) | BR112019002394B1 (es) |
| CA (1) | CA3033475A1 (es) |
| DK (1) | DK3511340T3 (es) |
| ES (1) | ES3000558T3 (es) |
| IL (1) | IL264692B2 (es) |
| MX (2) | MX386014B (es) |
| SG (1) | SG11201901071TA (es) |
| ZA (1) | ZA201900772B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES3000558T3 (en) | 2016-08-10 | 2025-02-28 | Univ Ajou Ind Academic Coop Found | Heterodimeric fc-fused cytokine and pharmaceutical composition comprising the same |
| CA3069105A1 (en) | 2017-07-03 | 2019-01-10 | Torque Therapeutics, Inc. | Polynucleotides encoding immunostimulatory fusion molecules and uses thereof |
| KR102285557B1 (ko) | 2018-02-14 | 2021-08-04 | 주식회사 엘지화학 | 촉매의 충진방법 및 이를 이용한 부타디엔의 제조방법 |
| CN110396133B (zh) * | 2018-04-25 | 2021-07-23 | 免疫靶向有限公司 | 一种以白介素12为活性成分的融合蛋白型药物前体 |
| SG11202103192RA (en) | 2018-10-03 | 2021-04-29 | Xencor Inc | Il-12 heterodimeric fc-fusion proteins |
| AU2019366956B2 (en) | 2018-10-23 | 2025-10-30 | Dragonfly Therapeutics, Inc. | Heterodimeric Fc-fused proteins |
| CA3157024A1 (en) * | 2019-10-03 | 2021-04-08 | Xencor, Inc. | Targeted il-12 heterodimeric fc-fusion proteins |
| IL297495A (en) * | 2020-04-22 | 2022-12-01 | Dragonfly Therapeutics Inc | Dosing regimen, formulation and manufacturing process for fc fusion heterodimeric proteins |
| JP2024500354A (ja) | 2020-12-10 | 2024-01-09 | インベンラ， インコーポレイテッド | ヘテロ二量体化のための直交変異 |
| AU2022369312A1 (en) * | 2021-10-20 | 2024-05-02 | Synthekine, Inc. | Heterodimeric fc cytokines and uses thereof |
| KR102796245B1 (ko) * | 2022-05-10 | 2025-04-18 | 아주대학교산학협력단 | 인터루킨21 변이체, 이를 포함하는 융합단백질 및 이의 용도 |
| WO2024086739A1 (en) | 2022-10-20 | 2024-04-25 | Synthekine, Inc. | Methods and compositions of il12 muteins and il2 muteins |
| EP4612165A1 (en) * | 2022-11-02 | 2025-09-10 | Synerkine Pharma B.V. | Engineered immunocytokines, fusion polypeptides, and il10 polypeptides |
| CN119768414A (zh) * | 2022-11-10 | 2025-04-04 | 康立泰生物医药(青岛)有限公司 | 聚乙二醇定点修饰异源聚体蛋白或多肽及其制备方法与应用 |
| WO2024249320A1 (en) * | 2023-05-26 | 2024-12-05 | University Of Florida Research Foundation, Incorporated | In vivo optimization of biologics |
| CN117986386B (zh) * | 2024-02-06 | 2024-11-29 | 康立泰生物医药(青岛)有限公司 | 重组人白细胞介素-35及其制备方法和应用 |
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- 2017-08-10 ES ES17839824T patent/ES3000558T3/es active Active
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