SG11201901071TA - Cytokine fused to immunoglobulin fc heterodimer and pharmaceutical composition comprising same - Google Patents
Cytokine fused to immunoglobulin fc heterodimer and pharmaceutical composition comprising sameInfo
- Publication number
- SG11201901071TA SG11201901071TA SG11201901071TA SG11201901071TA SG11201901071TA SG 11201901071T A SG11201901071T A SG 11201901071TA SG 11201901071T A SG11201901071T A SG 11201901071TA SG 11201901071T A SG11201901071T A SG 11201901071TA SG 11201901071T A SG11201901071T A SG 11201901071TA
- Authority
- SG
- Singapore
- Prior art keywords
- heterodimeric
- region
- protein
- fused
- physiologically active
- Prior art date
Links
- 108060003951 Immunoglobulin Proteins 0.000 title abstract 3
- 102000018358 immunoglobulin Human genes 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 102000004127 Cytokines Human genes 0.000 title abstract 2
- 108090000695 Cytokines Proteins 0.000 title abstract 2
- 239000000833 heterodimer Substances 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 12
- 108090000623 proteins and genes Proteins 0.000 abstract 12
- 238000001727 in vivo Methods 0.000 abstract 2
- 230000001766 physiological effect Effects 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000005923 long-lasting effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5434—IL-12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/208—IL-12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E60/00—Enabling technologies; Technologies with a potential or indirect contribution to GHG emissions mitigation
- Y02E60/10—Energy storage using batteries
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Reproductive Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20160101823 | 2016-08-10 | ||
| PCT/KR2017/008676 WO2018030806A1 (ko) | 2016-08-10 | 2017-08-10 | 항체 중쇄불변부위 이종이중체에 융합된 사이토카인 및 이를 포함하는 약제학적 조성물 |
| KR1020170101594A KR102050463B1 (ko) | 2016-08-10 | 2017-08-10 | 항체 중쇄불변부위 이종이중체 (heterodimeric Fc)에 융합된 사이토카인 (heterodimeric Fc-fused cytokine) 및 이를 포함하는 약제학적 조성물 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201901071TA true SG11201901071TA (en) | 2019-03-28 |
Family
ID=61524969
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201901071TA SG11201901071TA (en) | 2016-08-10 | 2017-08-10 | Cytokine fused to immunoglobulin fc heterodimer and pharmaceutical composition comprising same |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US10696722B2 (es) |
| EP (1) | EP3511340A4 (es) |
| JP (3) | JP6993403B2 (es) |
| KR (4) | KR102050463B1 (es) |
| CN (1) | CN110267977A (es) |
| AU (2) | AU2017310163B2 (es) |
| BR (1) | BR112019002394B1 (es) |
| CA (1) | CA3033475A1 (es) |
| MX (2) | MX2019001651A (es) |
| SG (1) | SG11201901071TA (es) |
| ZA (1) | ZA201900772B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3511340A4 (en) * | 2016-08-10 | 2020-03-18 | Ajou University Industry-Academic Cooperation Foundation | CYTOKINE CONDENSED TO IMMUNOGLOBULIN-FC HETERODIMER AND PHARMACEUTICAL COMPOSITION THEREFOR |
| US11471490B2 (en) | 2017-07-03 | 2022-10-18 | Torque Therapeutics, Inc. | T cells surface-loaded with immunostimulatory fusion molecules and uses thereof |
| KR102285557B1 (ko) | 2018-02-14 | 2021-08-04 | 주식회사 엘지화학 | 촉매의 충진방법 및 이를 이용한 부타디엔의 제조방법 |
| CN110396133B (zh) * | 2018-04-25 | 2021-07-23 | 免疫靶向有限公司 | 一种以白介素12为活性成分的融合蛋白型药物前体 |
| WO2020072821A2 (en) * | 2018-10-03 | 2020-04-09 | Xencor, Inc. | Il-12 heterodimeric fc-fusion proteins |
| EP3870598A1 (en) | 2018-10-23 | 2021-09-01 | Dragonfly Therapeutics, Inc. | Heterodimeric fc-fused proteins |
| US11851466B2 (en) | 2019-10-03 | 2023-12-26 | Xencor, Inc. | Targeted IL-12 heterodimeric Fc-fusion proteins |
| IL303518A (en) * | 2020-12-10 | 2023-08-01 | Invenra Inc | Mutations orthogonal to heterodimerization |
| CA3234552A1 (en) * | 2021-10-20 | 2023-04-27 | Synthekine, Inc. | Heterodimeric fc cytokines and uses thereof |
| KR20230157760A (ko) * | 2022-05-10 | 2023-11-17 | 아주대학교산학협력단 | 인터루킨21 변이체, 이를 포함하는 융합단백질 및 이의 용도 |
| WO2024086739A1 (en) | 2022-10-20 | 2024-04-25 | Synthekine, Inc. | Methods and compositions of il12 muteins and il2 muteins |
| WO2024094755A1 (en) * | 2022-11-02 | 2024-05-10 | Synerkine Pharma B.V. | Engineered immunocytokines, fusion polypeptides, and il10 polypeptides |
| WO2024099445A1 (zh) * | 2022-11-10 | 2024-05-16 | 康立泰生物医药(青岛)有限公司 | 聚乙二醇定点修饰异源聚体蛋白或多肽及其制备方法与应用 |
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| WO2018030806A1 (ko) | 2016-08-10 | 2018-02-15 | 아주대학교산학협력단 | 항체 중쇄불변부위 이종이중체에 융합된 사이토카인 및 이를 포함하는 약제학적 조성물 |
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-
2017
- 2017-08-10 EP EP17839824.4A patent/EP3511340A4/en active Pending
- 2017-08-10 BR BR112019002394-1A patent/BR112019002394B1/pt active IP Right Grant
- 2017-08-10 CA CA3033475A patent/CA3033475A1/en active Pending
- 2017-08-10 KR KR1020170101594A patent/KR102050463B1/ko active IP Right Grant
- 2017-08-10 US US16/323,839 patent/US10696722B2/en active Active
- 2017-08-10 SG SG11201901071TA patent/SG11201901071TA/en unknown
- 2017-08-10 CN CN201780062851.0A patent/CN110267977A/zh active Pending
- 2017-08-10 MX MX2019001651A patent/MX2019001651A/es unknown
- 2017-08-10 JP JP2019506697A patent/JP6993403B2/ja active Active
- 2017-08-10 AU AU2017310163A patent/AU2017310163B2/en active Active
-
2019
- 2019-02-06 ZA ZA2019/00772A patent/ZA201900772B/en unknown
- 2019-02-08 MX MX2021010809A patent/MX2021010809A/es unknown
- 2019-11-25 KR KR1020190152270A patent/KR102416411B1/ko active IP Right Grant
-
2020
- 2020-05-28 US US16/886,184 patent/US11692019B2/en active Active
- 2020-05-28 US US16/886,177 patent/US11078249B2/en active Active
-
2021
- 2021-03-03 JP JP2021033816A patent/JP7111855B2/ja active Active
- 2021-11-26 AU AU2021273642A patent/AU2021273642A1/en active Pending
-
2022
- 2022-06-29 KR KR1020220079686A patent/KR102607285B1/ko active Application Filing
- 2022-07-21 JP JP2022116329A patent/JP7488854B2/ja active Active
-
2023
- 2023-05-24 US US18/323,124 patent/US20230416325A1/en active Pending
- 2023-11-23 KR KR1020230164332A patent/KR102652247B1/ko active IP Right Grant
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