BR112019002394A2 - citocina fundida com fc heterodimérico e composição farmacêutica compreendendo o mesmo - Google Patents
citocina fundida com fc heterodimérico e composição farmacêutica compreendendo o mesmoInfo
- Publication number
- BR112019002394A2 BR112019002394A2 BR112019002394A BR112019002394A BR112019002394A2 BR 112019002394 A2 BR112019002394 A2 BR 112019002394A2 BR 112019002394 A BR112019002394 A BR 112019002394A BR 112019002394 A BR112019002394 A BR 112019002394A BR 112019002394 A2 BR112019002394 A2 BR 112019002394A2
- Authority
- BR
- Brazil
- Prior art keywords
- heterodimeric
- protein
- region
- fused
- physiologically active
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 102000004127 Cytokines Human genes 0.000 title 1
- 108090000695 Cytokines Proteins 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 11
- 108090000623 proteins and genes Proteins 0.000 abstract 11
- 108060003951 Immunoglobulin Proteins 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 102000018358 immunoglobulin Human genes 0.000 abstract 2
- 238000001727 in vivo Methods 0.000 abstract 2
- 230000001766 physiological effect Effects 0.000 abstract 2
- 102000002067 Protein Subunits Human genes 0.000 abstract 1
- 108010001267 Protein Subunits Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5434—IL-12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/208—IL-12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E60/00—Enabling technologies; Technologies with a potential or indirect contribution to GHG emissions mitigation
- Y02E60/10—Energy storage using batteries
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Reproductive Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
a presente invenção refere-se a uma proteína fundida por fc heterodimérica compreendendo uma primeira região fc e uma segunda região fc de um par fc de imunoglobulina e uma proteína fisiologicamente ativa composta por duas ou mais subunidades diferentes, em que uma ou mais subunidades da proteína 5 fisiologicamente ativa estão ligados separadamente a uma ou mais extremidades do terminal n ou terminal c da primeira região fc e/ou da segunda região fc, e os domínios ch3 da primeira região fc e da segunda região fc são mutados de modo a promover a formação de fc heterodimérico. além disso, a presente invenção refere-se a uma composição farmacêutica compreendendo a proteína heterodimérica fundida com fc. a proteína 10 fundida por fc heterodimérico de acordo com a presente invenção tem uma vantagem na medida em que pode reter a atividade de uma proteína fisiologicamente ativa que ocorre naturalmente, tendo duas ou mais subunidades diferentes exibindo atividade fisiológica por formação de um complexo proteico, porque a proteína fisiologicamente ativa pode estar ligado a uma fc heterodimérica de imunoglobulina tal que a forma e estrutura de ocorrência natural da proteína fundida desta possam ser mantidas. quando a 15 proteína fundida por fc heterodimérica de acordo com a presente invenção é utilizada, existe uma vantagem em que a semi-vida in vivo da proteína fisiologicamente ativa contida na proteína fundida com fc heterodimérico pode ser significativamente aumentada devido ao fc- meia-vida longa mediada de tal modo que várias atividades fisiológicas da mesma in vivo podem ser de longa duração.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20160101823 | 2016-08-10 | ||
| KR10-2016-0101823 | 2016-08-10 | ||
| KR10-2017-0101594 | 2017-08-10 | ||
| KR1020170101594A KR102050463B1 (ko) | 2016-08-10 | 2017-08-10 | 항체 중쇄불변부위 이종이중체 (heterodimeric Fc)에 융합된 사이토카인 (heterodimeric Fc-fused cytokine) 및 이를 포함하는 약제학적 조성물 |
| PCT/KR2017/008676 WO2018030806A1 (ko) | 2016-08-10 | 2017-08-10 | 항체 중쇄불변부위 이종이중체에 융합된 사이토카인 및 이를 포함하는 약제학적 조성물 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112019002394A2 true BR112019002394A2 (pt) | 2019-06-04 |
| BR112019002394B1 BR112019002394B1 (pt) | 2021-12-21 |
Family
ID=61524969
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112019002394-1A BR112019002394B1 (pt) | 2016-08-10 | 2017-08-10 | Proteína heterodimérica fundida com fc e seu uso |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US10696722B2 (pt) |
| EP (1) | EP3511340B1 (pt) |
| JP (3) | JP6993403B2 (pt) |
| KR (4) | KR102050463B1 (pt) |
| CN (1) | CN110267977A (pt) |
| AU (2) | AU2017310163B2 (pt) |
| BR (1) | BR112019002394B1 (pt) |
| CA (1) | CA3033475A1 (pt) |
| MX (2) | MX2019001651A (pt) |
| SG (1) | SG11201901071TA (pt) |
| ZA (1) | ZA201900772B (pt) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110267977A (zh) | 2016-08-10 | 2019-09-20 | 亚洲大学校产学协力团 | 细胞因子免疫球蛋白Fc融合异二聚体和包含其的药物组合物 |
| EP3648786A4 (en) | 2017-07-03 | 2021-12-15 | Torque Therapeutics, Inc. | FUSION MOLECULES TARGETING IMMUNE REGULATORY CELLS AND THEIR USES |
| KR102285557B1 (ko) | 2018-02-14 | 2021-08-04 | 주식회사 엘지화학 | 촉매의 충진방법 및 이를 이용한 부타디엔의 제조방법 |
| CN110396133B (zh) * | 2018-04-25 | 2021-07-23 | 免疫靶向有限公司 | 一种以白介素12为活性成分的融合蛋白型药物前体 |
| US11358999B2 (en) | 2018-10-03 | 2022-06-14 | Xencor, Inc. | IL-12 heterodimeric Fc-fusion proteins |
| JP2022505871A (ja) | 2018-10-23 | 2022-01-14 | ドラゴンフライ セラピューティクス， インコーポレイテッド | ヘテロ二量体ｆｃ融合タンパク質 |
| CN115916233A (zh) * | 2019-10-03 | 2023-04-04 | Xencor股份有限公司 | 靶向IL-12异源二聚体Fc融合蛋白 |
| MX2023006899A (es) * | 2020-12-10 | 2023-09-04 | Invenra Inc | Mutaciones ortogonales para heterodimerización. |
| CA3234552A1 (en) * | 2021-10-20 | 2023-04-27 | Synthekine, Inc. | Heterodimeric fc cytokines and uses thereof |
| EP4419545A2 (en) | 2021-10-20 | 2024-08-28 | Synthekine, Inc. | Heterodimeric fc cytokines and uses thereof |
| KR20230157760A (ko) * | 2022-05-10 | 2023-11-17 | 아주대학교산학협력단 | 인터루킨21 변이체, 이를 포함하는 융합단백질 및 이의 용도 |
| WO2024086739A1 (en) | 2022-10-20 | 2024-04-25 | Synthekine, Inc. | Methods and compositions of il12 muteins and il2 muteins |
| WO2024094755A1 (en) * | 2022-11-02 | 2024-05-10 | Synerkine Pharma B.V. | Engineered immunocytokines, fusion polypeptides, and il10 polypeptides |
| WO2024099445A1 (zh) * | 2022-11-10 | 2024-05-16 | 康立泰生物医药(青岛)有限公司 | 聚乙二醇定点修饰异源聚体蛋白或多肽及其制备方法与应用 |
| CN117986386A (zh) * | 2024-02-06 | 2024-05-07 | 康立泰生物医药(青岛)有限公司 | 重组人白细胞介素-35及其制备方法和应用 |
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| WO2018007314A1 (en) | 2016-07-04 | 2018-01-11 | F. Hoffmann-La Roche Ag | Novel antibody format |
| WO2018030806A1 (ko) | 2016-08-10 | 2018-02-15 | 아주대학교산학협력단 | 항체 중쇄불변부위 이종이중체에 융합된 사이토카인 및 이를 포함하는 약제학적 조성물 |
| CN110267977A (zh) | 2016-08-10 | 2019-09-20 | 亚洲大学校产学协力团 | 细胞因子免疫球蛋白Fc融合异二聚体和包含其的药物组合物 |
| RU2019114175A (ru) | 2016-10-14 | 2020-11-16 | Ксенкор, Инк. | Биспецифические гетеродимерные слитые белки, содержащие fc-слитые белки il-15/il-15ra и фрагменты антитела к pd-1 |
| JP2019014449A (ja) | 2017-07-10 | 2019-01-31 | トヨタ自動車株式会社 | 車両用動力伝達装置 |
| EP3697441B1 (en) | 2017-10-20 | 2023-06-07 | F. Hoffmann-La Roche AG | Method for generating multispecific antibodies from monospecific antibodies |
| JP2022505871A (ja) | 2018-10-23 | 2022-01-14 | ドラゴンフライ セラピューティクス， インコーポレイテッド | ヘテロ二量体ｆｃ融合タンパク質 |
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2017
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