MX2019001651A - Citocina fusionada a fc heterodimerico, y composicion farmaceutica que comprende la misma. - Google Patents
Citocina fusionada a fc heterodimerico, y composicion farmaceutica que comprende la misma.Info
- Publication number
- MX2019001651A MX2019001651A MX2019001651A MX2019001651A MX2019001651A MX 2019001651 A MX2019001651 A MX 2019001651A MX 2019001651 A MX2019001651 A MX 2019001651A MX 2019001651 A MX2019001651 A MX 2019001651A MX 2019001651 A MX2019001651 A MX 2019001651A
- Authority
- MX
- Mexico
- Prior art keywords
- protein
- region
- heterodimeric
- fused
- heterodimer
- Prior art date
Links
- 108060003951 Immunoglobulin Proteins 0.000 title abstract 2
- 239000000833 heterodimer Substances 0.000 title abstract 2
- 102000018358 immunoglobulin Human genes 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 102000004127 Cytokines Human genes 0.000 title 1
- 108090000695 Cytokines Proteins 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 14
- 108090000623 proteins and genes Proteins 0.000 abstract 14
- 230000004071 biological effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 210000004899 c-terminal region Anatomy 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5434—IL-12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/208—IL-12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E60/00—Enabling technologies; Technologies with a potential or indirect contribution to GHG emissions mitigation
- Y02E60/10—Energy storage using batteries
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Reproductive Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invencion se refiere a una proteina fusionada a un Fc heterodimerico que comprende una primera region de Fc y una segunda region de Fc de un par de Fc de inmunoglobulina y una proteina fisiologicamente activa compuesta de dos o mas subunidades diferentes, en donde una o mas subunidades de la proteina fisiologicamente activa son enlazadas por separado a uno o mas extremos del extremo N-terminal o C-terminal de la primera region de Fc y/o la segunda region de Fc, y los dominios CH3 de la primera region de Fc y la segunda region de Fc son mutados a fin de promover la formacion del Fc heterodimerico; ademas, la presente invencion se refiere a una composicion farmaceutica que comprende la proteina fusionada al Fc heterodimerico; la proteina fusionada al Fc heterodimerico de conformidad con la presente invención tiene la ventaja de que puede retener la actividad de una proteina fisiologicamente activa de ocurrencia natural, cuyas dos o mas subunidades diferentes exhiben actividad fisiologica mediante la formacion de un complejo de proteinas, debido a que la proteina fisiologicamente activa puede ser enlazada a un Fc heterodimerico de inmunoglobulina de modo que puede mantenerse la forma y estructura de ocurrencia natural de la proteina fusionada de la misma; cuando se usa la proteína fusionada al Fc heterodimerico de conformidad con la presente invencion, existe una ventaja porque la vida media in vivo de la proteina fisiologicamente activa contenida en la proteina fusionada al Fc heterodimerico puede ser incrementada significativamente debido a la larga vida media mediada por el Fc, de modo que varias actividades fisiologicas de la misma in vivo pueden ser de larga duracion.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20160101823 | 2016-08-10 | ||
| PCT/KR2017/008676 WO2018030806A1 (ko) | 2016-08-10 | 2017-08-10 | 항체 중쇄불변부위 이종이중체에 융합된 사이토카인 및 이를 포함하는 약제학적 조성물 |
| KR1020170101594A KR102050463B1 (ko) | 2016-08-10 | 2017-08-10 | 항체 중쇄불변부위 이종이중체 (heterodimeric Fc)에 융합된 사이토카인 (heterodimeric Fc-fused cytokine) 및 이를 포함하는 약제학적 조성물 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019001651A true MX2019001651A (es) | 2019-09-04 |
Family
ID=61524969
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019001651A MX2019001651A (es) | 2016-08-10 | 2017-08-10 | Citocina fusionada a fc heterodimerico, y composicion farmaceutica que comprende la misma. |
| MX2021010809A MX2021010809A (es) | 2016-08-10 | 2019-02-08 | Citocina fusionada a fc heterodimerico, y composicion farmaceutica que comprende la misma. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2021010809A MX2021010809A (es) | 2016-08-10 | 2019-02-08 | Citocina fusionada a fc heterodimerico, y composicion farmaceutica que comprende la misma. |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US10696722B2 (es) |
| EP (1) | EP3511340A4 (es) |
| JP (3) | JP6993403B2 (es) |
| KR (4) | KR102050463B1 (es) |
| CN (1) | CN110267977A (es) |
| AU (2) | AU2017310163B2 (es) |
| BR (1) | BR112019002394B1 (es) |
| CA (1) | CA3033475A1 (es) |
| MX (2) | MX2019001651A (es) |
| SG (1) | SG11201901071TA (es) |
| ZA (1) | ZA201900772B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10696722B2 (en) | 2016-08-10 | 2020-06-30 | Ajou University Industry-Academic Cooperation Foundation | Heterodimeric Fc-fused cytokine and pharmaceutical composition comprising the same |
| EP3675892A4 (en) | 2017-07-03 | 2021-10-06 | Torque Therapeutics, Inc. | IMMUNOSTIMULATORY FUSION MOLECULES AND THEIR USES |
| CN111356524B (zh) | 2018-02-14 | 2022-03-15 | 株式会社Lg化学 | 催化剂填充方法和使用该方法制备丁二烯的方法 |
| CN110396133B (zh) * | 2018-04-25 | 2021-07-23 | 免疫靶向有限公司 | 一种以白介素12为活性成分的融合蛋白型药物前体 |
| AU2019355971A1 (en) | 2018-10-03 | 2021-05-06 | Xencor, Inc. | IL-12 heterodimeric Fc-fusion proteins |
| WO2020086758A1 (en) | 2018-10-23 | 2020-04-30 | Dragonfly Therapeutics, Inc. | Heterodimeric fc-fused proteins |
| AU2020358979A1 (en) * | 2019-10-03 | 2022-04-21 | Xencor, Inc. | Targeted IL-12 heterodimeric Fc-fusion proteins |
| AU2021397322A1 (en) * | 2020-12-10 | 2023-07-06 | Invenra Inc. | Orthogonal mutations for heterodimerization |
| WO2023070056A2 (en) * | 2021-10-20 | 2023-04-27 | Synthekine, Inc. | Heterodimeric fc cytokines and uses thereof |
| KR20230157760A (ko) * | 2022-05-10 | 2023-11-17 | 아주대학교산학협력단 | 인터루킨21 변이체, 이를 포함하는 융합단백질 및 이의 용도 |
| WO2024086739A1 (en) | 2022-10-20 | 2024-04-25 | Synthekine, Inc. | Methods and compositions of il12 muteins and il2 muteins |
| WO2024094755A1 (en) * | 2022-11-02 | 2024-05-10 | Synerkine Pharma B.V. | Engineered immunocytokines, fusion polypeptides, and il10 polypeptides |
| WO2024099445A1 (zh) * | 2022-11-10 | 2024-05-16 | 康立泰生物医药(青岛)有限公司 | 聚乙二醇定点修饰异源聚体蛋白或多肽及其制备方法与应用 |
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-
2017
- 2017-08-10 US US16/323,839 patent/US10696722B2/en active Active
- 2017-08-10 KR KR1020170101594A patent/KR102050463B1/ko active IP Right Grant
- 2017-08-10 BR BR112019002394-1A patent/BR112019002394B1/pt active IP Right Grant
- 2017-08-10 CN CN201780062851.0A patent/CN110267977A/zh active Pending
- 2017-08-10 CA CA3033475A patent/CA3033475A1/en active Pending
- 2017-08-10 AU AU2017310163A patent/AU2017310163B2/en active Active
- 2017-08-10 JP JP2019506697A patent/JP6993403B2/ja active Active
- 2017-08-10 SG SG11201901071TA patent/SG11201901071TA/en unknown
- 2017-08-10 EP EP17839824.4A patent/EP3511340A4/en active Pending
- 2017-08-10 MX MX2019001651A patent/MX2019001651A/es unknown
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2019
- 2019-02-06 ZA ZA2019/00772A patent/ZA201900772B/en unknown
- 2019-02-08 MX MX2021010809A patent/MX2021010809A/es unknown
- 2019-11-25 KR KR1020190152270A patent/KR102416411B1/ko active IP Right Grant
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2020
- 2020-05-28 US US16/886,177 patent/US11078249B2/en active Active
- 2020-05-28 US US16/886,184 patent/US11692019B2/en active Active
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2021
- 2021-03-03 JP JP2021033816A patent/JP7111855B2/ja active Active
- 2021-11-26 AU AU2021273642A patent/AU2021273642A1/en active Pending
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2022
- 2022-06-29 KR KR1020220079686A patent/KR102607285B1/ko active Application Filing
- 2022-07-21 JP JP2022116329A patent/JP7488854B2/ja active Active
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2023
- 2023-05-24 US US18/323,124 patent/US20230416325A1/en active Pending
- 2023-11-23 KR KR1020230164332A patent/KR102652247B1/ko active IP Right Grant
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