PL2714718T3 - Syntetyczne peptydoglikany wiążące kwas hialuronowy, otrzymywanie i sposoby zastosowania - Google Patents

Syntetyczne peptydoglikany wiążące kwas hialuronowy, otrzymywanie i sposoby zastosowania

Info

Publication number
PL2714718T3
PL2714718T3 PL12788776T PL12788776T PL2714718T3 PL 2714718 T3 PL2714718 T3 PL 2714718T3 PL 12788776 T PL12788776 T PL 12788776T PL 12788776 T PL12788776 T PL 12788776T PL 2714718 T3 PL2714718 T3 PL 2714718T3
Authority
PL
Poland
Prior art keywords
preparation
methods
hyaluronic acid
binding synthetic
synthetic peptidoglycans
Prior art date
Application number
PL12788776T
Other languages
English (en)
Inventor
Shaili Sharma
Alyssa Panitch
Jonathan C. Bernhard
John E. Paderi
Original Assignee
Symic Ip, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Symic Ip, Llc filed Critical Symic Ip, Llc
Publication of PL2714718T3 publication Critical patent/PL2714718T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645—Connective tissue
    • A61L27/3654—Cartilage, e.g. meniscus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4725—Proteoglycans, e.g. aggreccan
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Materials Engineering (AREA)
  • Toxicology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Polymers & Plastics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Composite Materials (AREA)
  • Vascular Medicine (AREA)
  • Botany (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
PL12788776T 2011-05-24 2012-05-24 Syntetyczne peptydoglikany wiążące kwas hialuronowy, otrzymywanie i sposoby zastosowania PL2714718T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161489602P 2011-05-24 2011-05-24
US201161550621P 2011-10-24 2011-10-24
EP12788776.8A EP2714718B1 (en) 2011-05-24 2012-05-24 Hyaluronic acid-binding synthetic peptidoglycans, preparation, and methods of use

Publications (1)

Publication Number Publication Date
PL2714718T3 true PL2714718T3 (pl) 2017-11-30

Family

ID=47218093

Family Applications (1)

Application Number Title Priority Date Filing Date
PL12788776T PL2714718T3 (pl) 2011-05-24 2012-05-24 Syntetyczne peptydoglikany wiążące kwas hialuronowy, otrzymywanie i sposoby zastosowania

Country Status (23)

Country Link
US (4) US9217016B2 (pl)
EP (2) EP3208278B1 (pl)
JP (3) JP6069307B2 (pl)
KR (1) KR102006036B1 (pl)
CN (2) CN103732614B (pl)
AU (1) AU2012258706B2 (pl)
BR (1) BR112013030086A2 (pl)
CA (1) CA2837096A1 (pl)
CY (1) CY1118885T1 (pl)
DK (1) DK2714718T3 (pl)
ES (2) ES2708076T3 (pl)
HR (1) HRP20170482T1 (pl)
HU (1) HUE031596T2 (pl)
IL (1) IL229539B (pl)
LT (1) LT2714718T (pl)
MX (1) MX349693B (pl)
PL (1) PL2714718T3 (pl)
PT (1) PT2714718T (pl)
RS (1) RS55823B1 (pl)
RU (1) RU2617844C2 (pl)
SG (2) SG195114A1 (pl)
SI (1) SI2714718T1 (pl)
WO (1) WO2012162534A2 (pl)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8846003B2 (en) 2008-03-27 2014-09-30 Symic Biomedical, Inc. Collagen-binding synthetic peptidoglycans, preparation, and methods of use
BR112013030086A2 (pt) 2011-05-24 2022-03-03 Purdue Research Foundation Peptideoglicanos sintéticos que se ligam ao ácido hialurônico, matriz de colágeno engenheirada e seus usos
US9688723B2 (en) 2012-11-08 2017-06-27 Phi Pharma Sa C4S proteoglycan specific transporter molecules
MX2015012608A (es) 2013-03-15 2016-07-06 Symic Biomedical Inc Peptidos sinteticos de union a matriz extracelular.
JP2016520585A (ja) * 2013-05-09 2016-07-14 シンガポール科学技術研究庁Ａｇｅｎｃｙ ｆｏｒ Ｓｃｉｅｎｃｅ， Ｔｅｃｈｎｏｌｏｇｙ ａｎｄ Ｒｅｓｅａｒｃｈ 修飾コラーゲン分子
US10772931B2 (en) 2014-04-25 2020-09-15 Purdue Research Foundation Collagen binding synthetic peptidoglycans for treatment of endothelial dysfunction
EP3142684A4 (en) * 2014-05-12 2018-05-23 Purdue Research Foundation Selectin and icam/vcam peptide ligand conjugates
WO2016061145A1 (en) 2014-10-13 2016-04-21 Symic Biomedical, Inc. Synthetic proteoglycans for preventing tissue adhesion
JP6693728B2 (ja) * 2014-11-14 2020-05-13 興和株式会社 新規な機能性ペプチド
WO2016168743A1 (en) * 2015-04-17 2016-10-20 Symic Ip, Llc Bioconjugates and uses thereof
CN110267977A (zh) 2016-08-10 2019-09-20 亚洲大学校产学协力团 细胞因子免疫球蛋白Fc融合异二聚体和包含其的药物组合物
WO2019010490A1 (en) 2017-07-07 2019-01-10 Symic Ip, Llc BIOCONJUGATES WITH CHEMICALLY MODIFIED SKELETONS
EP3648774A4 (en) 2017-07-07 2021-04-21 Symic IP, LLC SYNTHETIC ORGANIC CONJUGATES
CN109260457B (zh) * 2017-07-18 2023-06-13 苏州高泓利康生物科技有限公司 一种透明质酸-白介素10复合物、其制备方法及其应用
WO2020086758A1 (en) 2018-10-23 2020-04-30 Dragonfly Therapeutics, Inc. Heterodimeric fc-fused proteins
JP2023522972A (ja) 2020-04-22 2023-06-01 ドラゴンフライ セラピューティクス， インコーポレイテッド ヘテロ二量体Ｆｃ融合タンパク質のための製剤、投薬量レジメン、及び製造工程
JP2024506265A (ja) * 2021-01-26 2024-02-13 イミュニス， インコーポレイテッド 分子系超構造及びその利用方法
WO2024072942A2 (en) 2022-09-29 2024-04-04 Adora Animal Health Corporation Skin penetrating formulations of sulfated glycosaminoglycans and fragments derived therefrom for the treatment of pain and other medical conditions

Family Cites Families (132)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683298A (en) 1985-01-10 1987-07-28 British Columbia Research Council Process for the preparation of aminated polysaccharide derivatives
US5547936A (en) 1985-06-17 1996-08-20 La Jolla Cancer Research Foundation Inhibition of cell migration with synthetic peptides
KR910700063A (ko) 1988-12-20 1991-03-13 알. 더글라스 암스트롱 상처 치료 활성을 갖는 폴리펩티드-고분자 결합체
US5693625A (en) 1989-03-09 1997-12-02 Therapeutiques Substitutives Method of regenerating cells and tissues using functionalized dextrans
FR2644066B1 (fr) 1989-03-09 1994-05-13 Therapeutiques Substitutives Compositions stabilisees comprenant des fgfs, leur procede d'obtention et leurs applications therapeutiques, chirurgicales et cosmetologiques
EP0567575B1 (en) 1991-01-14 1999-10-13 New York University Cytokine-induced protein, tsg-6, dna coding therefor and uses thereof
JP2901787B2 (ja) 1991-07-15 1999-06-07 日本メジフィジックス株式会社 核磁気共鳴造影剤
FR2718023B1 (fr) 1994-03-30 1996-08-14 Paris Val Marne Universite Médicament et composition pharmaceutique pour le traitement de lésions du tractus digestif.
WO1997022371A1 (en) 1995-12-18 1997-06-26 Collagen Corporation Crosslinked polymer compositions and methods for their use
CA2299687C (en) 1997-08-04 2009-10-27 Bio Syntech Ltd. Temperature-controlled ph-dependant formation of ionic polysaccharide gels
US5997895A (en) 1997-09-16 1999-12-07 Integra Lifesciences Corporation Dural/meningeal repair product using collagen matrix
EP1032674B1 (en) 1997-11-21 2007-01-24 Serono Genetics Institute S.A. (chlamydia pneumoniae) genomic sequence and polypeptides, fragments thereof and uses thereof, in particular for the diagnosis, prevention and treatment of infection
US7691829B2 (en) 1998-03-24 2010-04-06 Petito George D Composition and method for healing tissues
FR2781485B1 (fr) 1998-07-21 2003-08-08 Denis Barritault Polymeres biocompatibles leur procede de preparation et les compositions les contenant
JP3103531B2 (ja) 1998-09-30 2000-10-30 延也 柳内 ヒト尿由来細胞接着糖蛋白質及びその製造方法
US6822071B1 (en) 1998-11-12 2004-11-23 The Regents Of The University Of California Polypeptides from Chlamydia pneumoniae and their use in the diagnosis, prevention and treatment of disease
US6703491B1 (en) 1999-03-17 2004-03-09 Exelixis, Inc. Drosophila sequences
US6864235B1 (en) * 1999-04-01 2005-03-08 Eva A. Turley Compositions and methods for treating cellular response to injury and other proliferating cell disorders regulated by hyaladherin and hyaluronans
US20110214206A1 (en) 1999-05-06 2011-09-01 La Rosa Thomas J Nucleic acid molecules and other molecules associated with plants
US20090087878A9 (en) 1999-05-06 2009-04-02 La Rosa Thomas J Nucleic acid molecules associated with plants
FR2794976B1 (fr) 1999-06-16 2004-05-07 Solutions Compositions pharmaceutiques a action cicatrisante ou anti-complementaire comprenant un derive de dextrane
EP1218027B1 (en) 1999-09-15 2010-01-20 The Bruce H. DeWoolfson Irrevocable Family Trust Composition for stabilizing corneal tissue during or after orthokeratological lens wear
FR2799465B1 (fr) 1999-10-12 2004-02-13 Centre Nat Rech Scient Peptides ayant une activite de stimulation de la reponse immunitaire et de regeneration tissulaire
WO2001041821A1 (en) 1999-12-09 2001-06-14 Biosyntech Canada Inc. Mineral-polymer hybrid composition
US20030158302A1 (en) 1999-12-09 2003-08-21 Cyric Chaput Mineral-polymer hybrid composition
AU2001288392A1 (en) 2000-08-30 2002-03-13 University Of Delaware Delivery system for heparin-binding growth factors
US7803905B2 (en) 2000-08-31 2010-09-28 University Of Delaware Bioactive peptide for cell adhesion
US7029655B2 (en) 2000-10-04 2006-04-18 California Institute Of Technology Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits
DE60125973D1 (de) 2000-11-15 2007-02-22 Biosyntech Canada Inc Verfahren zur wiederherstellung einer geschädigten bandscheibe
WO2003029401A2 (en) 2001-07-13 2003-04-10 Advanced Research And Technology Institute Peptidoglycan recognition protein encoding nucleic acids and methods of use thereof
ATE420654T1 (de) 2001-08-15 2009-01-15 Univ Brown Res Found Behandlung von muskeldystrophien und verwandter erkrankungen
US7098194B2 (en) 2001-11-15 2006-08-29 Biosyntech Canada, Inc. Composition and method to homogeneously modify or cross-link chitosan under neutral conditions
CA2412012C (en) * 2001-11-20 2011-08-02 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Resorbable extracellular matrix containing collagen i and collagen ii for reconstruction of cartilage
US20050108791A1 (en) 2001-12-04 2005-05-19 Edgerton Michael D. Transgenic plants with improved phenotypes
US20090100536A1 (en) 2001-12-04 2009-04-16 Monsanto Company Transgenic plants with enhanced agronomic traits
US20090158452A1 (en) 2001-12-04 2009-06-18 Johnson Richard G Transgenic plants with enhanced agronomic traits
CA2476656C (en) * 2002-02-21 2008-11-25 Encelle, Inc. Immobilized bioactive hydrogel matrices as surface coatings
CA2478675A1 (en) 2002-03-08 2003-09-18 Zymogenetics, Inc. Inhibitors for use in hemostasis
US7666852B2 (en) 2002-04-22 2010-02-23 Agenta Biotechnologies, Inc. Wound and cutaneous injury healing with a nucleic acid encoding a proteoglycan polypeptide
JP2005185101A (ja) 2002-05-30 2005-07-14 National Institute Of Agrobiological Sciences 植物の全長ｃＤＮＡおよびその利用
US8673333B2 (en) 2002-09-25 2014-03-18 The Johns Hopkins University Cross-linked polymer matrices, and methods of making and using same
US7862831B2 (en) 2002-10-09 2011-01-04 Synthasome, Inc. Method and material for enhanced tissue-biomaterial integration
US20090183270A1 (en) 2002-10-02 2009-07-16 Adams Thomas R Transgenic plants with enhanced agronomic traits
EP1570045A4 (en) 2002-10-04 2007-09-05 Univ Minnesota NUCLEIC ACID AND POLYPEPTIDE SEQUENCES FROM LAWSONIA INTRACELLULARIS AND METHOD OF USE
FR2846659B1 (fr) 2002-10-30 2005-02-18 Centre Nat Rech Scient Fragments peptidiques du facteur harp inhibant l'angiogenese
AU2003294318A1 (en) 2002-11-15 2004-06-15 Arizona Board Of Regents Arizona State University Therapeutic bioconjugates
CA2523178C (en) 2003-03-24 2012-10-23 Luitpold Pharmaceuticals, Inc. Materials and methods to potentiate cancer treatment
RU2249462C1 (ru) * 2003-08-21 2005-04-10 Севастьянов Виктор Иванович Универсальный гетерогенный коллагеновый матрикс для имплантации и способ его получения
US8198020B2 (en) 2003-08-22 2012-06-12 Potentia Pharmaceuticals, Inc. Compositions and methods for enhancing phagocytosis or phagocyte activity
EA010945B1 (ru) 2003-10-28 2008-12-30 Орган Тиссю Реженерасьон Репарасьон Рамплясман - Отр3 Применение биосовместимого полимера для изготовления медицинского устройства
FR2861308A1 (fr) 2003-10-28 2005-04-29 Organes Tissus Regeneration Re Utilisation de polymeres biocompatibles pour la preparation d'une composition pharmaceutique, dermatologique ou cosmetique destinee a la prevention, au soulagement ou au traitement des genes, desagrements et douleurs
WO2005055800A2 (en) 2003-12-15 2005-06-23 Technion Research & Development Foundation Ltd. Therapeutic drug-eluting endoluminal covering
US7842667B2 (en) 2003-12-22 2010-11-30 Regentis Biomaterials Ltd. Matrix composed of a naturally-occurring protein backbone cross linked by a synthetic polymer and methods of generating and using same
EP1722834B1 (en) 2003-12-22 2012-06-27 Regentis Biomaterials Ltd. Matrix comprising naturally-occurring crosslinked protein backbone
US7709439B2 (en) 2004-02-20 2010-05-04 Boston Scientific Scimed, Inc. Biomaterials for enhanced healing
US20060041961A1 (en) 2004-03-25 2006-02-23 Abad Mark S Genes and uses for pant improvement
EP1758931A1 (en) 2004-05-31 2007-03-07 National University of Singapore Peptides derived from decorin leucine rich repeats and uses thereof
US20060075522A1 (en) 2004-07-31 2006-04-06 Jaclyn Cleveland Genes and uses for plant improvement
EP1796690A4 (en) 2004-09-22 2011-08-03 Cartilix Inc KNORPELFÜLLVORRICHTUNG
EP1804844A4 (en) 2004-09-29 2012-02-29 Univ Singapore COMPOSITE, PROCESS FOR ITS MANUFACTURE AND ITS APPLICATIONS
US20060241022A1 (en) 2004-10-06 2006-10-26 Bowen Benjamin P Selectin targeting bioconjugates
WO2006047758A1 (en) 2004-10-27 2006-05-04 Massachusetts Institute Of Technology Novel technique to fabricate molded structures having a patterned porosity
US8283414B2 (en) 2004-11-23 2012-10-09 The Johns Hopkins University Compositions comprising modified collagen and uses therefor
WO2006089167A1 (en) 2005-02-18 2006-08-24 Cartilix, Inc. Glucosamine materials
WO2006089119A2 (en) 2005-02-18 2006-08-24 Cartilix, Inc. Biological adhesive
JP2008531733A (ja) 2005-03-04 2008-08-14 ノースウエスタン ユニバーシティ 血管新生性のヘパリン結合エピトープ、ペプチド両親媒性物質、自己集合組成物、および関連する使用法
GB2424223C (en) 2005-03-07 2011-02-02 Massachusetts Inst Technology Biomaterial.
US8367639B2 (en) 2005-03-31 2013-02-05 University Of Delaware Hydrogels with covalent and noncovalent crosslinks
US8338390B2 (en) 2005-03-31 2012-12-25 University Of Delaware Multifunctional and biologically active matrices from multicomponent polymeric solutions
US7737131B2 (en) 2005-03-31 2010-06-15 University Of Delaware Multifunctional and biologically active matrices from multicomponent polymeric solutions
US7732427B2 (en) 2005-03-31 2010-06-08 University Of Delaware Multifunctional and biologically active matrices from multicomponent polymeric solutions
US8415325B2 (en) 2005-03-31 2013-04-09 University Of Delaware Cell-mediated delivery and targeted erosion of noncovalently crosslinked hydrogels
WO2006138005A2 (en) 2005-05-10 2006-12-28 Monsanto Technology, Llc Genes and uses for plant improvement
US8044022B2 (en) * 2005-06-08 2011-10-25 Tadeusz Kolodka Hyaluronic acid binding peptides enhance host defense against pathogenic bacteria
US20080069774A1 (en) 2005-11-17 2008-03-20 Lance Liotta Proteomic antisense molecular shield and targeting
EP2172210A1 (en) * 2005-12-23 2010-04-07 Partnership&Corp. Technology Transfer Synthetic peptides for use as inhibitors of neurotransmitter secretion
EP1996115B1 (en) 2006-03-07 2014-11-26 Axle International Bioactive scaffold for therapeutic and adhesion prevention applications
US20070212385A1 (en) 2006-03-13 2007-09-13 David Nathaniel E Fluidic Tissue Augmentation Compositions and Methods
JP2009529967A (ja) 2006-03-15 2009-08-27 サーモディクス，インコーポレイティド 天然生分解性ポリサッカライドの疎水性誘導体及びそれらの使用
EP2090662A3 (en) 2006-04-05 2012-10-31 Metanomics GmbH Process for the production of a fine chemical
GB0610395D0 (en) 2006-05-25 2006-07-05 Ge Healthcare Ltd Novel imaging agents
US20090162436A1 (en) 2006-06-14 2009-06-25 Carson Daniel D Compositions and methods for repair of tissues
SI2068918T1 (sl) 2006-09-26 2012-09-28 Infectious Disease Res Inst Si - ep sestavek za cepljenje, ki vsebuje sintetiäśna pomagala
US7592009B2 (en) 2006-10-10 2009-09-22 Ecole Polytechnique Federale De Lausanne (Epfl) Polypeptide ligands for targeting cartilage and methods of use thereof
US8114835B2 (en) 2006-11-09 2012-02-14 Northwestern University Self-assembling peptide amphiphiles for tissue engineering
US8114834B2 (en) 2006-11-09 2012-02-14 Northwestern University Self-assembling peptide amphiphiles
WO2008066816A2 (en) 2006-11-28 2008-06-05 The Board Of Trustees Of The University Of Illinois Derivatization or ligaton of peptides
WO2008070179A2 (en) 2006-12-06 2008-06-12 Monsanto Technology, Llc Genes and uses for plant improvement
US8188220B2 (en) 2006-12-06 2012-05-29 Sanford-Burnham Medical Research Institute Methods and compositions related to targeting wounds, regenerating tissue, and tumors
PT2150282T (pt) 2007-04-16 2018-07-09 Regentis Biomaterials Ltd Composições e métodos para formação do suporte
WO2008146956A1 (en) 2007-05-06 2008-12-04 Byoung-Hyun Min Therapeutic composite for cartilage disorder using extracellular matrix (ecm) scaffold
US20100191215A1 (en) 2007-06-12 2010-07-29 By-Pass ,Inc. Pressure pulse actuating device for delivery systems
US20090075281A1 (en) 2007-07-10 2009-03-19 Regents Of The University Of California Mtbe genes
WO2009042514A1 (en) 2007-09-25 2009-04-02 Integra Lifesciences Corporation Flowable wound matrix and its preparation and use
WO2009048280A2 (en) 2007-10-09 2009-04-16 Postech Academy-Industry Foundation Long acting hyaluronic acid - peptide conjugate
WO2009099580A2 (en) 2008-02-05 2009-08-13 Monsanto Technology, Llc Isolated novel nucleic acid and protein molecules from soy and methods of using those molecules to generate transgenic plants with enhanced agronomic traits
US8846003B2 (en) * 2008-03-27 2014-09-30 Symic Biomedical, Inc. Collagen-binding synthetic peptidoglycans, preparation, and methods of use
US8343942B2 (en) 2008-04-04 2013-01-01 University Of Utah Research Foundation Methods for treating interstitial cystitis
CN102177180A (zh) 2008-04-04 2011-09-07 犹他州大学研究基金会 烷基化半合成的糖胺聚糖醚及其制备和使用方法
US20100004196A1 (en) 2008-06-17 2010-01-07 Hopitaux Universitaires De Geneve Heparan sulfate proteoglycan composition and use thereof
US8207264B2 (en) * 2008-07-11 2012-06-26 Tyco Healthcare Group Lp Functionalized inclusion complexes as crosslinkers
WO2010011857A2 (en) 2008-07-23 2010-01-28 The Johns Hopkins University Parenteral administration of a glucosamine
WO2010019769A1 (en) 2008-08-15 2010-02-18 The Trustees Of The University Of Pennsylvania Cross-linked polymer network formed by sequential cross-linking
US20130014292A1 (en) 2008-09-17 2013-01-10 Pennell Roger I Transgenic plants having increased biomass
FR2936247B1 (fr) 2008-09-24 2010-10-22 Ct Hospitalier Universitaire De Dijon Proteines recombinantes a activite hemostatique capables d'induire l'agregation plaquettaire.
US9072688B2 (en) 2008-10-31 2015-07-07 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
WO2010060485A1 (de) 2008-11-28 2010-06-03 Zetascience Gmbh Bioaktives hydrogel
KR101062068B1 (ko) 2008-12-01 2011-09-02 포항공과대학교 산학협력단 유착방지용 조성물
IL195764A0 (en) 2008-12-07 2009-11-18 Technion Res & Dev Foundation Compositions and methods for drug delivery
WO2010083179A2 (en) 2009-01-16 2010-07-22 Monsanto Technology Llc Isolated novel nucleic acid and protein molecules from soybeans and methods of using those molecules to generate transgenic plants with enhanced agronomic traits
WO2010115156A2 (en) 2009-04-03 2010-10-07 Synthetic Genomics, Inc. Endophytic fungus and uses therefor
JP2012523463A (ja) 2009-04-13 2012-10-04 ノースウエスタン ユニバーシティ 軟骨再生のための新規なペプチドベースの足場およびその使用方法
FI20095452A0 (fi) 2009-04-23 2009-04-23 Suomen Punainen Risti Veripalv Uudet haaraiset sokerianalyysit
US20120100106A1 (en) 2009-05-04 2012-04-26 Purdue Research Foundation Collagen-binding synthetic peptidoglycans for wound healing
GB0909671D0 (en) * 2009-06-04 2009-07-22 Xention Discovery Ltd Compounds
CN101906163B (zh) * 2009-06-05 2012-06-27 上海交通大学医学院 一种免疫避孕的合成肽和嵌合肽及其应用
US20130052155A1 (en) 2009-11-09 2013-02-28 Drexel University Compositions and Methods for Treating a Disorder or Defect in Soft Tissue
EA201290442A1 (ru) 2009-12-04 2012-11-30 Юклид Системз Корпорэйшн Композиция и способы профилактики и лечения макулярной дегенерации, диабетической ретинопатии и диабетического макулярного отека
CN106039401A (zh) 2009-12-16 2016-10-26 瑞吉恩提斯生物材料有限公司 由聚合物‑蛋白质结合物形成的支架，产生该支架的方法及其用途
US20130035307A1 (en) 2010-01-26 2013-02-07 University Of Utah Research Foundation Methods for treating or preventing the spread of cancer using semi-synthetic glycosaminoglycosan ethers
EP2538957B1 (en) 2010-02-26 2019-07-24 Vascular Biosciences, Inc. Car peptide for homing, diagnosis,&targeted therapy for pulmonary and fibrotic disorders
AU2011270862B2 (en) 2010-06-23 2017-05-11 Purdue Research Foundation Collagen-binding synthetic peptidoglycans for use in vascular intervention
US9173919B2 (en) 2011-02-16 2015-11-03 Purdue Research Foundation Collagen-targeted nanoparticles
US20130101628A1 (en) 2011-04-29 2013-04-25 Northwestern University Novel vegf mimetic peptide-based scaffolds for therapeutic angiogenesis and methods for their use
BR112013030086A2 (pt) 2011-05-24 2022-03-03 Purdue Research Foundation Peptideoglicanos sintéticos que se ligam ao ácido hialurônico, matriz de colágeno engenheirada e seus usos
WO2013110056A1 (en) 2012-01-19 2013-07-25 The Johns Hopkins University Biomaterials comprising hyaluronic acid binding peptides and bifunctional biopolymer molecules for hyaluronic acid retention and tissue engineering applications
US9827321B2 (en) 2012-08-14 2017-11-28 The Trustees Of The University Of Pennsylvania Stabilizing shear-thinning hydrogels
WO2014038866A1 (ko) 2012-09-05 2014-03-13 아주대학교산학협력단 연골세포 유래 세포외 기질막을 이용한 신생혈관질환 치료용 조성물 및 각막 또는 결막 이식재
DE102012108560B4 (de) 2012-09-13 2018-12-20 Leibniz-Institut Für Polymerforschung Dresden E.V. Nichtkovalente selbstorganisierende Hydrogelmatrix für biotechnologische Anwendungen
EP2915001A4 (en) 2012-11-01 2016-05-04 Univ Johns Hopkins CONTACT LENS SURFACE MODIFICATION BY HYALURONIC ACID (HA) BINDING PEPTIDE FOR ACCUMULATION AND HA RETENTION
EP2935589A1 (en) 2012-12-18 2015-10-28 Novartis AG Compositions and methods that utilize a peptide tag that binds to hyaluronan
MX2015012608A (es) 2013-03-15 2016-07-06 Symic Biomedical Inc Peptidos sinteticos de union a matriz extracelular.

Also Published As

Publication number Publication date
US20210188915A1 (en) 2021-06-24
RS55823B1 (sr) 2017-08-31
EP2714718B1 (en) 2017-01-11
CN103732614A (zh) 2014-04-16
EP2714718A2 (en) 2014-04-09
CA2837096A1 (en) 2012-11-29
PT2714718T (pt) 2017-04-19
RU2013157191A (ru) 2015-06-27
WO2012162534A3 (en) 2013-07-11
NZ618430A (en) 2016-05-27
BR112013030086A2 (pt) 2022-03-03
SG10201604171WA (en) 2016-07-28
CY1118885T1 (el) 2018-01-10
CN103732614B (zh) 2016-08-17
JP2017095475A (ja) 2017-06-01
US20160222064A1 (en) 2016-08-04
MX349693B (es) 2017-08-09
WO2012162534A2 (en) 2012-11-29
EP3208278A1 (en) 2017-08-23
IL229539A0 (en) 2014-01-30
JP2014518879A (ja) 2014-08-07
IL229539B (en) 2019-08-29
AU2012258706A1 (en) 2013-12-19
JP6502311B2 (ja) 2019-04-17
US20190330276A1 (en) 2019-10-31
HUE031596T2 (en) 2017-07-28
DK2714718T3 (en) 2017-04-24
US9217016B2 (en) 2015-12-22
ES2708076T3 (es) 2019-04-08
MX2013013706A (es) 2015-02-04
ES2619688T3 (es) 2017-06-26
CN106117318A (zh) 2016-11-16
AU2012258706B2 (en) 2017-05-18
EP3208278B1 (en) 2018-10-31
SG195114A1 (en) 2013-12-30
JP6069307B2 (ja) 2017-02-01
RU2617844C2 (ru) 2017-04-28
HRP20170482T1 (hr) 2017-05-19
US20140301983A1 (en) 2014-10-09
SI2714718T1 (sl) 2017-06-30
KR20140041579A (ko) 2014-04-04
LT2714718T (lt) 2017-04-10
EP2714718A4 (en) 2015-01-14
KR102006036B1 (ko) 2019-07-31
JP2019142877A (ja) 2019-08-29

Similar Documents

Publication Publication Date Title
SG10201604171WA (en) Hyaluronic acid-binding synthetic peptidoglycans, preparation, and methods of use
HK1245491A1 (zh) 計算機可讀介質
WO2012119051A9 (en) Enhanced biodistribution of oligomers
GB201418086D0 (en) Methods of transfering discrete articles
EP2706957A4 (en) PROCEDURE FOR NETWORK SKIN PROTESTS
EP2736985A4 (en) SUPERHYDROPHOPE SURFACES
PL2882779T3 (pl) Pochodna kwasu hialuronowego, sposób jej wytwarzania, sposób jej modyfikacji i jej zastosowanie
HRP20181599T1 (hr) Proizvodnja i upotreba bakterijskog histamina
IL228078A0 (en) Methods for administration of cell 7 integrin antagonists
EP2773687A4 (en) FUSED THIOPHENES, PROCESSES FOR MAKING FUSED THIOPHENES AND USES THEREOF
EP2718331A4 (en) N, N, N-TRIALKYL POLYMERS, METHODS FOR THEIR PREPARATION, AND USES THEREOF
EP2731429A4 (en) COMPOUNDS, METHODS OF PREPARATION AND METHODS OF USE
EP2691396A4 (en) ENOPEPTINES, USES THEREOF, AND METHODS OF SYNTHESIZING THE SAME
ZA201308268B (en) Herbicidal composition comprising pinoxaden and fluroxypyrester, and methods of use thereof
GB201117106D0 (en) Prosthesis and methods and uses involving said prosthesis
HK1198587A1 (en) Isothiazolopyridine-2-carboxamides and their use as pharmaceuticals -2-
IL233354A (en) 2, 6-Dihlo-5-Alkoxy-4-Converted-Pyrimidine, Pyrimidine-Carbaldehyde and Production and Use Methods
GB201118937D0 (en) Prothesis
AU2011901049A0 (en) Catalysts and Methods of Use
GB201104632D0 (en) Use of medicament
GB201120509D0 (en) Novel products and products
PL120305U1 (pl) Przegub podlokietnika
GB201108947D0 (en) Novel use
GB201103770D0 (en) Novel use